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Wills-Karp, M., Santeliz, J., & Karp, C. L. (2001). The germless theory of allergic disease: revisiting the hygiene hypothesis. Nature Reviews Immunology, 1(1), 69–75.

Authors 3
  1. Marsha Wills-Karp (first)
  2. Joanna Santeliz (additional)
  3. Christopher L. Karp (additional)
References 86 Referenced 574
  1. Anonymous. Surveillance for asthma — United States, 1960–1995. Morb. Mort. Wkly Rep. 47, 1–28 (1998).
  2. Nicolai, T. & von Mutius, E. Pollution and the development of allergy: the East and West Germany story. Arch. Toxicol. Suppl. 19, 201–206 (1997). (10.1007/978-3-642-60682-3_18) / Arch. Toxicol. Suppl. by T Nicolai (1997)
  3. Crater, S. E. & Platts-Mills, T. A. Searching for the cause of the increase in asthma. Curr. Opin. Pediatr. 10, 594–599 (1998). (10.1097/00008480-199810060-00010) / Curr. Opin. Pediatr. by SE Crater (1998)
  4. Strachan, D. P. Hay fever, hygiene, and household size. Br. Med. J. 299, 1259–1260 (1989). | PubMed | (10.1136/bmj.299.6710.1259) / Br. Med. J. by DP Strachan (1989)
  5. Bodner, C., Godden, D. & Seaton, A. Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group. Thorax 53, 28–32 (1998). (10.1136/thx.53.1.28) / Thorax by C Bodner (1998)
  6. Matricardi, P. M. et al. Sibship size, birth order, and atopy in 11,371 Italian young men. J. Allergy Clin. Immunol. 101, 439–444 (1998). (10.1016/S0091-6749(98)70350-1) / J. Allergy Clin. Immunol. by PM Matricardi (1998)
  7. Ball, T. M. et al. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N. Engl. J. Med. 343, 538–543 (2000). (10.1056/NEJM200008243430803) / N. Engl. J. Med. by TM Ball (2000)
  8. Kilpelainen, M., Terho, E. O., Helenius, H. & Koskenvuo, M. Farm environment in childhood prevents the development of allergies. Clin. Exp. Allergy 30, 201–208 (2000). (10.1046/j.1365-2222.2000.00800.x) / Clin. Exp. Allergy by M Kilpelainen (2000)
  9. Downs, S. H. et al. Having lived on a farm and protection against allergic diseases in Australia. Clin. Exp. Allergy 31, 570–575 (2001). (10.1046/j.1365-2222.2001.01070.x) / Clin. Exp. Allergy by SH Downs (2001)
  10. Forastiere, F. et al. Socioeconomic status, number of siblings, and respiratory infections in early life as determinants of atopy in children. Epidemiology 8, 566–570 (1997). (10.1097/00001648-199709000-00015) / Epidemiology by F Forastiere (1997)
  11. Eggleston, P. A. et al. The environment and asthma in U. S. inner cities. Environ. Health Perspect. 107, 439–450 (1999). (10.1289/ehp.99107s3439) / Environ. Health Perspect. by PA Eggleston (1999)
  12. Strachan, D. P. Family size, infection and atopy: the first decade of the “hygiene hypothesis”. Thorax 55, S2–S10 (2000). (10.1136/thorax.55.suppl_1.S2) / Thorax by DP Strachan (2000)
  13. Strachan, D. P., Taylor, E. M. & Carpenter, R. G. Family structure, neonatal infection, and hay fever in adolescence. Arch. Dis. Child. 74, 422–446 (1996). (10.1136/adc.74.5.422) / Arch. Dis. Child. by DP Strachan (1996)
  14. Backman, A., Bjorksten, F., Ilmonen, S., Juntunen, K. & Suoniemi, I. Do infections in infancy affect sensitization to airborne allergens and development of atopic disease? A retrospective study of seven-year-old children. Allergy 39, 309–315 (1984). (10.1111/j.1398-9995.1984.tb00867.x) / Allergy by A Backman (1984)
  15. Matricardi, P. M. et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. Br. Med. J. 320, 412–417 (2000).| PubMed | (10.1136/bmj.320.7232.412) / Br. Med. J. by PM Matricardi (2000)
  16. Shirakawa, T., Enomoto, T., Shimazu, S. & Hopkin, J. M. The inverse association between tuberculin responses and atopic disorder. Science 275, 77–79 (1997). (10.1126/science.275.5296.77) / Science by T Shirakawa (1997)
  17. Aaby, P. et al. Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clin. Exp. Allergy 30, 644–650 (2000). (10.1046/j.1365-2222.2000.00803.x) / Clin. Exp. Allergy by P Aaby (2000)
  18. Alm, J. S., Lilja, G., Pershagen, G. & Scheynius, A. Early BCG vaccination and development of atopy. Lancet 350, 400–403 (1997). (10.1016/S0140-6736(97)02207-1) / Lancet by JS Alm (1997)
  19. Shaheen, S. O. et al. Measles and atopy in Guinea-Bissau. Lancet 347, 1792–1796 (1996). (10.1016/S0140-6736(96)91617-7) / Lancet by SO Shaheen (1996)
  20. Lewis, S. A. & Britton, J. R. Measles infection, measles vaccination and the effect of birth order in the aetiology of hay fever. Clin. Exp. Allergy 28, 1493–1500 (1998). (10.1046/j.1365-2222.1998.00436.x) / Clin. Exp. Allergy by SA Lewis (1998)
  21. Paunio, M. et al. Measles history and atopic diseases: a population-based cross-sectional study. J. Am. Med. Assoc. 283, 343–346 (2000). (10.1001/jama.283.3.343) / J. Am. Med. Assoc. by M Paunio (2000)
  22. Martinez, F. D. Viral infections and the development of asthma. Am. J. Respir. Crit. Care Med. 151, 1644–1647 (1995). (10.1164/ajrccm/151.5_Pt_1.1644) / Am. J. Respir. Crit. Care Med. by FD Martinez (1995)
  23. Busse, W. W. The relationship between viral infections and onset of allergic diseases and asthma. Clin. Exp. Allergy 19, 1–9 (1989). (10.1111/j.1365-2222.1989.tb02336.x) / Clin. Exp. Allergy by WW Busse (1989)
  24. Adlerberth, I. et al. Intestinal colonization with Enterobacteriaceae in Pakistani and Swedish hospital-delivered infants. Acta Paediatr. Scand. 80, 602–610 (1991). (10.1111/j.1651-2227.1991.tb11917.x) / Acta Paediatr. Scand. by I Adlerberth (1991)
  25. Adlerberth, I. et al. High turnover rate of Escherichia coli strains in the intestinal flora of infants in Pakistan. Epidemiol. Infect. 3, 587–598 (1998). | PubMed | (10.1017/S0950268898001484) / Epidemiol. Infect. by I Adlerberth (1998)
  26. Bottcher, M. F., Nordin, E. K., Sandin, A., Midtvedt, T. & Bjorksten, B. Microflora-associated characteristics in faeces from allergic and nonallergic infants. Clin. Exp. Allergy 30, 1590–1596 (2000). (10.1046/j.1365-2222.2000.00982.x) / Clin. Exp. Allergy by MF Bottcher (2000)
  27. Kalliomaki, M. et al. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J. Allergy Clin. Immunol. 107, 129–134 (2001). (10.1067/mai.2001.111237) / J. Allergy Clin. Immunol. by M Kalliomaki (2001)
  28. Bjorksten, B., Naaber, P., Sepp, E. & Mikelsaar, M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin. Exp. Allergy 29, 342–346 (1999). (10.1046/j.1365-2222.1999.00560.x) / Clin. Exp. Allergy by B Bjorksten (1999)
  29. Kalliomaki, M. et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357, 1076–1079 (2001). (10.1016/S0140-6736(00)04259-8) / Lancet by M Kalliomaki (2001)
  30. Majamaa, H. & Isolauri, E. Probiotics: a novel approach in the management of food allergy. J. Allergy Clin. Immunol. 99, 179–185 (1997). (10.1016/S0091-6749(97)70093-9) / J. Allergy Clin. Immunol. by H Majamaa (1997)
  31. Farooqi, I. S. & Hopkin, J. M. Early childhood infection and atopic disorder. Thorax 53, 927–932 (1998). (10.1136/thx.53.11.927) / Thorax by IS Farooqi (1998)
  32. Wickens, K., Pearce, N., Crane, J. & Beasley, R. Antibiotic use in early childhood and the development of asthma. Clin. Exp. Allergy 29, 766–771 (1999). (10.1046/j.1365-2222.1999.00536.x) / Clin. Exp. Allergy by K Wickens (1999)
  33. Godfrey, R. C. Asthma and IgE levels in rural and urban communities of The Gambia. Clin. Allergy 5, 201–207 (1975). (10.1111/j.1365-2222.1975.tb01853.x) / Clin. Allergy by RC Godfrey (1975)
  34. Lynch, N. R. et al. Effect of anthelminthic treatment on the allergic reactivity of children in a tropical slum. J. Allergy Clin. Immunol. 92, 404–411 (1993). (10.1016/0091-6749(93)90119-Z) / J. Allergy Clin. Immunol. by NR Lynch (1993)
  35. Barrios, C. et al. Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a TH2-biased pattern which persists after adult boosting. Eur. J. Immunol. 26, 1489–1496 (1996). (10.1002/eji.1830260713) / Eur. J. Immunol. by C Barrios (1996)
  36. Prescott, S. L. et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the TH2 cytokine profile. J. Immunol. 160, 4730–4737 (1998). (10.4049/jimmunol.160.10.4730) / J. Immunol. by SL Prescott (1998)
  37. Prescott, S. L. et al. Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants. Clin. Exp. Allergy 28, 39–44 (1998). (10.1046/j.1365-2222.1998.028s5039.x) / Clin. Exp. Allergy by SL Prescott (1998)
  38. Chougnet, C. et al. Influence of human immunodeficiency virus-infected maternal environment on development of infant interleukin-12 production. J. Infect. Dis. 181, 1590–1597 (2000). (10.1086/315458) / J. Infect. Dis. by C Chougnet (2000)
  39. Erb, K. J., Kirman, J., Delahunt, B., Moll, H. & Le Gros, G. Infection of mice with Mycobacterium bovis-BCG induces both TH1 and TH2 immune responses in the absence of interferon-γ signalling. Eur. Cytokine Netw. 10, 147–154 (1999). / Eur. Cytokine Netw. by KJ Erb (1999)
  40. Arkwright, P. D. & David, T. J. Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease. J. Allergy Clin. Immunol. 107, 531–534 (2001). (10.1067/mai.2001.113081) / J. Allergy Clin. Immunol. by PD Arkwright (2001)
  41. Griffin, D. E. & Ward, B. J. Differential CD4 T cell activation in measles. J. Infect. Dis. 168, 275–281 (1993). (10.1093/infdis/168.2.275) / J. Infect. Dis. by DE Griffin (1993)
  42. Atabani, S. F. et al. Natural measles causes prolonged suppression of interleukin-12 production. J. Infect. Dis. 184, 1–9 (2001). (10.1086/321009) / J. Infect. Dis. by SF Atabani (2001)
  43. Wang, C. C., Nolan, T. J., Schad, G. A. & Abraham, D. Infection of mice with the helminth Strongyloides stercoralis suppresses pulmonary allergic responses to ovalbumin. Clin. Exp. Allergy 31, 495–503 (2001). (10.1046/j.1365-2222.2001.01044.x) / Clin. Exp. Allergy by CC Wang (2001)
  44. Hansen, G., Berry, G, DeKruyff, R. H. & Umetsu, D. T. Allergen-specific TH1 cells fail to counterbalance TH2 cell-induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103, 175–183 (1999). (10.1172/JCI5155) / J. Clin. Invest. by G Hansen (1999)
  45. Bryan, S. A. et al. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic repsonse. Lancet 356, 2149–2153 (2000). (10.1016/S0140-6736(00)03497-8) / Lancet by SA Bryan (2000)
  46. Larrick, J. W. et al. Does hyperimmunoglobulinemia-E protect tropical populations from allergic disease? J. Allergy Clin. Immunol. 71, 184–188 (1983). (10.1016/0091-6749(83)90097-0) / J. Allergy Clin. Immunol. by JW Larrick (1983)
  47. van den Biggelaar, A. H. et al. Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 356, 1723–1727 (2000). (10.1016/S0140-6736(00)03206-2) / Lancet by AH van den Biggelaar (2000)
  48. King, C. L. et al. Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. J. Immunol. 156, 4715–4721 (1996). (10.4049/jimmunol.156.12.4715) / J. Immunol. by CL King (1996)
  49. Cooper, P. J., Espinel, I., Paredes, W., Guderian, R. H. & Nutman, T. B. Impaired tetanus-specific cellular and humoral responses following tetanus vaccination in human onchocerciasis: a possible role for interleukin-10. J. Infect. Dis. 178, 1133–1138 (1998). (10.1086/515661) / J. Infect. Dis. by PJ Cooper (1998)
  50. Yazdanbakhsh, M., van den Biggerlaar, A. & Maizels, R. M. TH2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. Trends Immunol. 22, 372–377 (2001). (10.1016/S1471-4906(01)01958-5) / Trends Immunol. by M Yazdanbakhsh (2001)
  51. Moore, K. W., de Waal Malefyt, R., Coffman, R. L. & O'Gara, A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683–765 (2001). (10.1146/annurev.immunol.19.1.683) / Annu. Rev. Immunol. by KW Moore (2001)
  52. Moritani, M. et al. Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. Int. Immunol. 6, 1927–1936 (1994). (10.1093/intimm/6.12.1927) / Int. Immunol. by M Moritani (1994)
  53. Cannella, B., Gao, Y. L., Brosnan, C. & Raine, C. S. IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45, 735–746 (1996). (10.1002/(SICI)1097-4547(19960915)45:6<735::AID-JNR10>3.0.CO;2-V) / J. Neurosci. Res. by B Cannella (1996)
  54. Berg, D. J. et al. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 96, 2339–2347 (1995). (10.1172/JCI118290) / J. Clin. Invest. by DJ Berg (1995)
  55. Hoffmann, K. F., Cheever, A. W. & Wynn, T. A. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J. Immunol. 164, 6406–6416 (2000). (10.4049/jimmunol.164.12.6406) / J. Immunol. by KF Hoffmann (2000)
  56. Gazzinelli, R. T. et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. J. Immunol. 157, 798–805 (1996). (10.4049/jimmunol.157.2.798) / J. Immunol. by RT Gazzinelli (1996)
  57. Suzuki, Y. et al. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J. Immunol. 164, 5375–5382 (2000). (10.4049/jimmunol.164.10.5375) / J. Immunol. by Y Suzuki (2000)
  58. Lamblin, C., Desreumaux, P., Colombel, J. F., Tonnel, A. B. & Wallaert, B. Overexpression of IL-10 mRNA in gut mucosa of patients with allergic asthma. J. Allergy Clin. Immunol. 107, 739–741 (2001). (10.1067/mai.2001.114111) / J. Allergy Clin. Immunol. by C Lamblin (2001)
  59. Robinson, D. S. et al. Increased interleukin-10 messenger RNA expression in atopic allergy and asthma. Am. J. Respir. Cell Mol. Biol. 14, 113–117 (1996). (10.1165/ajrcmb.14.2.8630259) / Am. J. Respir. Cell Mol. Biol. by DS Robinson (1996)
  60. Borish, L. et al. Interleukin-10 regulation in normal subjects and patients with asthma. J. Allergy Clin. Immunol. 97, 1288–1296 (1996). (10.1016/S0091-6749(96)70197-5) / J. Allergy Clin. Immunol. by L Borish (1996)
  61. Hobbs, K., Negri, J., Klinnert, M., Rosenwasser, L. J. & Borish, L. Interleukin-10 and transforming growth factor-β promoter polymorphisms in allergies and asthma. Am. J. Respir. Crit. Care Med. 158, 1958–1962 (1998). (10.1164/ajrccm.158.6.9804011) / Am. J. Respir. Crit. Care Med. by K Hobbs (1998)
  62. Zuany-Amorim, C. et al. Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice. J. Clin. Invest. 95, 2644–2651 (1995). (10.1172/JCI117966) / J. Clin. Invest. by C Zuany-Amorim (1995)
  63. Grunig, G. et al. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J. Exp. Med. 185, 1089–1099 (1997). (10.1084/jem.185.6.1089) / J. Exp. Med. by G Grunig (1997)
  64. Makela, M. J. et al. IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc. Natl Acad. Sci. USA 97, 6007–6012 (2000). (10.1073/pnas.100118997) / Proc. Natl Acad. Sci. USA by MJ Makela (2000)
  65. Barnes, P. F. et al. Cytokine production at the site of disease in human tuberculosis. Infect. Immun. 61, 3482–3489 (1993). (10.1128/IAI.61.8.3482-3489.1993) / Infect. Immun. by PF Barnes (1993)
  66. Kaufmann, S. H., Ladel, C. H. & Flesch, I. E. T cells and cytokines in intracellular bacterial infections: experience with Mycobacterium bovis BCG. CIBA Found. Symp. 195, 123–132 (1995). / CIBA Found. Symp. by SH Kaufmann (1995)
  67. Azim, T. et al. Immune response of children who develop persistent diarrhea following rotavirus infection. Clin. Diagn. Lab. Immunol. 6, 690–695 (1999). (10.1128/CDLI.6.5.690-695.1999) / Clin. Diagn. Lab. Immunol. by T Azim (1999)
  68. Raqib, R. et al. Persistence of local cytokine production in shigellosis in acute and convalescent stages. Infect. Immun. 63, 289–296 (1995). (10.1128/IAI.63.1.289-296.1995) / Infect. Immun. by R Raqib (1995)
  69. Braunstein, J., Qiao, L., Autschbach, F., Schurmann, G. & Meuer, S. T cells of the human intestinal lamina propria are high producers of interleukin-10. Gut 41, 215–220 (1997). (10.1136/gut.41.2.215) / Gut by J Braunstein (1997)
  70. Iwasaki, A. & Kelsall, B. L. Unique functions of CD11b+, CD8α+, and double-negative Peyer's patch dendritic cells. J. Immunol. 166, 4884–4890 (2001). (10.4049/jimmunol.166.8.4884) / J. Immunol. by A Iwasaki (2001)
  71. Autschbach, F. et al. In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease. Am. J. Pathol. 153, 121–130 (1998). (10.1016/S0002-9440(10)65552-6) / Am. J. Pathol. by F Autschbach (1998)
  72. Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263–274 (1993). (10.1016/0092-8674(93)80068-P) / Cell by R Kuhn (1993)
  73. Wilson, A. F., Novey, H. S., Berke, R. A. & Surprenant, E. L. Deposition of inhaled pollen and pollen extract in human airways. N. Engl. J. Med. 288, 1056–1058 (1973). (10.1056/NEJM197305172882006) / N. Engl. J. Med. by AF Wilson (1973)
  74. Sudo, N. et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol. 159, 1739–1745 (1997). (10.4049/jimmunol.159.4.1739) / J. Immunol. by N Sudo (1997)
  75. Kim, J. H. & Ohsawa, M. Oral tolerance to ovalbumin in mice as a model for detecting modulators of the immunologic tolerance to a specific antigen. Biol. Pharm. Bull. 18, 854–858 (1995). (10.1248/bpb.18.854) / Biol. Pharm. Bull. by JH Kim (1995)
  76. Gereda, J. E. et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 355, 1680–1683 (2000). (10.1016/S0140-6736(00)02239-X) / Lancet by JE Gereda (2000)
  77. Pessi, T., Sutas, Y., Hurme, M. & Isolauri, E. Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG. Clin. Exp. Allergy 30, 1804–1808 (2000). (10.1046/j.1365-2222.2000.00948.x) / Clin. Exp. Allergy by T Pessi (2000)
  78. Matricardi, P. M. & Bonini, S. High microbial turnover rate preventing atopy: a solution to inconsistencies impinging on the hygiene hypothesis? Clin. Exp. Allergy 30, 1506–1510 (2000). (10.1046/j.1365-2222.2000.00994.x) / Clin. Exp. Allergy by PM Matricardi (2000)
  79. Schevach, E. M. Certified professionals: CD4+CD25+ suppressor T cells. J. Exp. Med. 193, F41–F45 (2001). (10.1084/jem.193.11.F41) / J. Exp. Med. by EM Schevach (2001)
  80. Cottrez, F., Hurst, S. D., Coffman, R. L. & Groux, H. T regulatory cells 1 inhibit a TH2 specific response in vivo. J. Immunol. 165, 4848–4853 (2000). (10.4049/jimmunol.165.9.4848) / J. Immunol. by F Cottrez (2000)
  81. Stene, L. C. & Nafstad, P. Relation between occurrence of type 1 diabetes and asthma. Lancet 357, 607–608 (2001). (10.1016/S0140-6736(00)04067-8) / Lancet by LC Stene (2001)
  82. EURODIAB Substudy 2 Study Group. Infections and vaccinations as risk factors for childhood type I (insulin-dependent) diabetes mellitus: a multicentre case-control investigation. Diabetologia 43, 47–53 (2000). | PubMed | (10.1007/s001250050006)
  83. Bingley, P. J., Douek, I. F., Rogers, C. A. & Gale, E. A. Influence of maternal age at delivery and birth order on risk of type 1 diabetes in childhood: prospective population based family study. Bart's–Oxford Family Study Group. Br. Med. J. 321, 420–424 (2000). | PubMed | (10.1136/bmj.321.7258.420) / Br. Med. J. by PJ Bingley (2000)
  84. McKinney, P. A. et al. Early social mixing and childhood type 1 diabetes mellitus: a case control study in Yorkshire, UK. Diabet. Med. 17, 236–242 (2000). (10.1046/j.1464-5491.2000.00220.x) / Diabet. Med. by PA McKinney (2000)
  85. Rivas, J. M. & Ullrich, S. E. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J. Immunol. 149, 3865–3871 (1992). (10.4049/jimmunol.149.12.3865) / J. Immunol. by JM Rivas (1992)
  86. Mencken, H. L. in A Mencken Chrestomathy 158 (Knopf, New York, 1949). / A Mencken Chrestomathy by HL Mencken (1949)
Dates
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Created 22 years, 11 months ago (Sept. 20, 2002, 4:06 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 11:33 p.m.)
Indexed 2 days, 7 hours ago (Aug. 31, 2025, 7:16 p.m.)
Issued 23 years, 11 months ago (Oct. 1, 2001)
Published 23 years, 11 months ago (Oct. 1, 2001)
Published Print 23 years, 11 months ago (Oct. 1, 2001)
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@article{Wills_Karp_2001, title={The germless theory of allergic disease: revisiting the hygiene hypothesis}, volume={1}, ISSN={1474-1741}, url={http://dx.doi.org/10.1038/35095579}, DOI={10.1038/35095579}, number={1}, journal={Nature Reviews Immunology}, publisher={Springer Science and Business Media LLC}, author={Wills-Karp, Marsha and Santeliz, Joanna and Karp, Christopher L.}, year={2001}, month=oct, pages={69–75} }