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References
103
Referenced
301
-
Bedell, M. A., Jenkins, N. A. & Copeland, N. G. Mouse models of human disease. I. Techniques and resources for genetic analysis of mice. Genes Dev. 11, 1–10 (1997).
(
10.1101/gad.11.1.1
) / Genes Dev. by MA Bedell (1997) -
Bedell, M. A., Largaespada, D. A., Jenkins, N. A. & Copeland, N. G. Mouse models fo human disease. II. Recent progress and future directions. Genes Dev. 11, 11–43 (1997).
(
10.1101/gad.11.1.11
) / Genes Dev. by MA Bedell (1997) -
Hustad, C. M. et al. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140, 255–265 (1995).
(
10.1093/genetics/140.1.255
) / Genetics by CM Hustad (1995) -
Siracusa, L. D. et al. Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. J. Hered. 86, 121–128 (1995).
(
10.1093/oxfordjournals.jhered.a111541
) / J. Hered. by LD Siracusa (1995) -
Duhl, D. M., Vrieling, H., Miller, K. A., Wolff, G. L. & Barsh, G. S. Neomorphic agouti mutations in obese yellow mice. Nature Genet. 8, 59–65 (1994).
(
10.1038/ng0994-59
) / Nature Genet. by DM Duhl (1994) - Silver, L. M. Mouse Genetics: Concepts and Applications (Oxford Univ. Press, New York, 1995). / Mouse Genetics: Concepts and Applications by LM Silver (1995)
-
Russell, L. B. et al. Chlorambucil effectively induces deletion mutations in mouse germ cells. Proc. Natl Acad. Sci. USA 86, 3704–3708 (1989).
(
10.1073/pnas.86.10.3704
) / Proc. Natl Acad. Sci. USA by LB Russell (1989) -
Russell, W. L. et al. Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc. Natl Acad. Sci. USA 76, 5818–5819 (1979).
(
10.1073/pnas.76.11.5818
) / Proc. Natl Acad. Sci. USA by WL Russell (1979) -
Justice, M. J. Capitalizing on large-scale mouse mutagenesis screens. Nature Rev. Genet. 1, 109–115 (2000).
(
10.1038/35038549
) / Nature Rev. Genet. by MJ Justice (2000) -
Jaenisch, R. Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc. Natl Acad. Sci. USA 73, 1260–1264 (1976).
(
10.1073/pnas.73.4.1260
) / Proc. Natl Acad. Sci. USA by R Jaenisch (1976) - Spence, S. E., Gilbert, D. J., Swing, D. A., Copeland, N. G. & Jenkins, N. A. Spontaneous germ line virus infection and retroviral insertional mutagenesis in eighteen transgenic Srev lines of mice. Mol. Cell. Biol. 9, 177–184 (1989). / Mol. Cell. Biol. by SE Spence (1989)
-
Jenkins, N. A. & Copeland, N. G. High frequency germline acquisition of ecotropic MuLV proviruses in SWR/J-RF/J hybrid mice. Cell 43, 811–819 (1985).
(
10.1016/0092-8674(85)90254-5
) / Cell by NA Jenkins (1985) -
Costantini, F. & Lacy, E. Introduction of a rabbit β-globin gene into the mouse germ line. Nature 294, 92–94 (1981).
(
10.1038/294092a0
) / Nature by F Costantini (1981) -
Gordon, J. W. & Ruddle, F. H. Integration and stable germ line transmission of genes injected into mouse pronuclei. Science 214, 1244–1246 (1981).
(
10.1126/science.6272397
) / Science by JW Gordon (1981) -
Harbers, K., Jahner, D. & Jaenisch, R. Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal. Nature 293, 540–542 (1981).
(
10.1038/293540a0
) / Nature by K Harbers (1981) -
Wagner, E. F., Stewart, T. A. & Mintz, B. The human β-globin gene and a functional viral thymidine kinase gene in developing mice. Proc. Natl Acad. Sci. USA 78, 5016–5020 (1981).
(
10.1073/pnas.78.8.5016
) / Proc. Natl Acad. Sci. USA by EF Wagner (1981) -
Doetschman, T. et al. Targeted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 330, 576–578 (1987).
(
10.1038/330576a0
) / Nature by T Doetschman (1987) -
Thomas, K. R. & Capecchi, M. R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503–512 (1987).
(
10.1016/0092-8674(87)90646-5
) / Cell by KR Thomas (1987) -
Lakso, M. et al. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl Acad. Sci. USA 89, 6232–6236 (1992).
(
10.1073/pnas.89.14.6232
) / Proc. Natl Acad. Sci. USA by M Lakso (1992) -
Orban, P. C., Chui, D. & Marth, J. D. Tissue- and site-specific DNA recombination in transgenic mice. Proc. Natl Acad. Sci. USA 89, 6861–6865 (1992).
(
10.1073/pnas.89.15.6861
) / Proc. Natl Acad. Sci. USA by PC Orban (1992) -
Dymecki, S. M. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc. Natl Acad. Sci. USA 93, 6191–6196 (1996).
(
10.1073/pnas.93.12.6191
) / Proc. Natl Acad. Sci. USA by SM Dymecki (1996) -
Weber, F., de Villiers, J. & Schaffner, W. An SV40 'enhancer trap' incorporates exogenous enhancers or generates enhancers from its own sequences. Cell 36, 983–992 (1984).
(
10.1016/0092-8674(84)90048-5
) / Cell by F Weber (1984) -
O' Kane, C. J. & Gehring, W. J. Detection in situ of genomic regulatory elements in Drosophila. Proc. Natl Acad. Sci. USA 84, 9123–9127 (1987).
(
10.1073/pnas.84.24.9123
) / Proc. Natl Acad. Sci. USA by CJ O' Kane (1987) -
Allen, N. D. et al. Transgenes as probes for active chromosomal domains in mouse development. Nature 333, 852–855 (1988).
(
10.1038/333852a0
) / Nature by ND Allen (1988) -
Kothary, R. et al. A transgene containing lacZ inserted into the dystonia locus is expressed in the neural tube. Nature 335, 435–437 (1988).
(
10.1038/335435a0
) / Nature by R Kothary (1988) -
Gossler, A., Joyner, A. L., Rossant, J. & Skarnes, W. C. Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244, 463–465 (1989).The first example of enhancer-trap and gene-trap mutagenesis in mouse ES cells, and of ES-cell-derived mice. It was published the same year as the first targeted mutagenesis of non-selectable genes.
(
10.1126/science.2497519
) / Science by A Gossler (1989) -
Korn, R. et al. Enhancer trap integrations in mouse embryonic stem cells give rise to staining patterns in chimaeric embryos with a high frequency and detect endogenous genes. Mech. Dev. 39, 95–109 (1992).
(
10.1016/0925-4773(92)90029-J
) / Mech. Dev. by R Korn (1992) -
von Melchner, H. & Ruley, H. E. Identification of cellular promoters by using a retrovirus promoter trap. J. Virol. 63, 3227–3233 (1989).
(
10.1128/jvi.63.8.3227-3233.1989
) / J. Virol. by H von Melchner (1989) -
Friedrich, G. & Soriano, P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5, 1513–1523 (1991). The development of the ROSA β-geo vectors and the first application of gene trapping to isolate lethal mutations.
(
10.1101/gad.5.9.1513
) / Genes Dev. by G Friedrich (1991) - Reddy, S., DeGregori, J. V., von Melchner, H. & Ruley, H. E. Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells. J. Virol. 19, 17–23 (1991). / J. Virol. by S Reddy (1991)
-
von Melchner, H. et al. Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 6, 919–927 (1992).This paper provided the foundation for the current promoter-trapping efforts.
(
10.1101/gad.6.6.919
) / Genes Dev. by H von Melchner (1992) -
Frohman, M. A., Dush, M. K. & Martin, G. R. Rapid production of full-length cDNAs from rare transcripts: amplification using a single-gene specific oligonucleotide primer. Proc. Natl Acad. Sci. USA 85, 8998–9002 (1988).
(
10.1073/pnas.85.23.8998
) / Proc. Natl Acad. Sci. USA by MA Frohman (1988) -
Skarnes, W. C., Auerbach, B. A. & Joyner, A. L. A gene trap approach in mouse embryonic stem cells: the lacZ reporter is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev. 6, 903–918 (1992).
(
10.1101/gad.6.6.903
) / Genes Dev. by WC Skarnes (1992) -
Stanford, W. L. et al. Expression trapping: identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells. Blood 92, 4622–4631 (1998).
(
10.1182/blood.V92.12.4622
) / Blood by WL Stanford (1998) -
McClive, P. et al. Gene trap integrations expressed in the developing heart: insertion site affects splicing of the PT1-ATG vector. Dev. Dyn. 212, 267–276 (1998).
(
10.1002/(SICI)1097-0177(199806)212:2<267::AID-AJA11>3.0.CO;2-1
) / Dev. Dyn. by P McClive (1998) -
Evans, M. J. Gene trapping — a preface. Dev. Dyn. 212, 167–169 (1998).
(
10.1002/(SICI)1097-0177(199806)212:2<167::AID-AJA1>3.0.CO;2-F
) / Dev. Dyn. by MJ Evans (1998) -
Niwa, H. et al. An efficient gene-trap method using poly A trap vectors and characterization of gene-trap events. J. Biochem. 113, 343–349 (1993).
(
10.1093/oxfordjournals.jbchem.a124049
) / J. Biochem. by H Niwa (1993) -
Yoshida, M. et al. A new strategy of gene trapping in ES cells using 3′RACE. Trans. Res. 4, 277–287 (1995).
(
10.1007/BF01969122
) / Trans. Res. by M Yoshida (1995) -
Salminen, M., Meyer, B. I. & Gruss, P. Efficient Poly A trap approach allows the capture of genes specifically active in differentiated embryonic stem cells and in mouse embryos. Dev. Dyn. 212, 326–333 (1998).
(
10.1002/(SICI)1097-0177(199806)212:2<326::AID-AJA17>3.0.CO;2-1
) / Dev. Dyn. by M Salminen (1998) -
Zambrowicz, B. P. et al. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392, 608–611 (1998).
(
10.1038/33423
) / Nature by BP Zambrowicz (1998) -
Hicks, G. G. et al. Functional genomics in mice by tagged sequence mutagenesis. Nature Genet. 16, 338–344 (1997).The first large-scale, genotype-driven gene-trap screen, which also introduces an elegant method of cloning trapped sequences. This project has also evolved into one of the gene-trap resource centres.
(
10.1038/ng0897-338
) / Nature Genet. by GG Hicks (1997) -
Skarnes, W. C., Moss, J. E., Hurtley, S. M. & Beddington, R. S. Capturing genes encoding membrane and secreted proteins important for mouse development. Proc. Natl Acad. Sci. USA 92, 6592–6596 (1995).An elegant method to trap a specific class of gene. This project has evolved into one of the gene-trap resource centres.
(
10.1073/pnas.92.14.6592
) / Proc. Natl Acad. Sci. USA by WC Skarnes (1995) - Araki, K. et al. Exchangeable gene trap using the Cre/mutated lox system. Cell. Mol. Biol. 45, 737–750 (1999). / Cell. Mol. Biol. by K Araki (1999)
-
Hardouin, N. & Nagy, A. Gene-trap-based target site for Cre-mediated transgenic insertion. Genesis 26, 245–252 (2000).
(
10.1002/(SICI)1526-968X(200004)26:4<245::AID-GENE50>3.0.CO;2-9
) / Genesis by N Hardouin (2000) -
Enver, T. & Greaves, M. Loops, lineage, and leukemia. Cell 94, 9–12 (1998).
(
10.1016/S0092-8674(00)81215-5
) / Cell by T Enver (1998) -
Donoviel, D. B. et al. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol. Cell. Biol. 21, 4829–4836 (2001).
(
10.1128/MCB.21.14.4829-4836.2001
) / Mol. Cell. Biol. by DB Donoviel (2001) -
Breitman, M. L. et al. Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science 238, 1563–1565 (1987).
(
10.1126/science.3685993
) / Science by ML Breitman (1987) -
Westerman, K. A. & Leboulch, P. Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination. Proc. Natl Acad. Sci. USA 93, 8971–8976 (1996).
(
10.1073/pnas.93.17.8971
) / Proc. Natl Acad. Sci. USA by KA Westerman (1996) -
Mitchell, K. J. et al. Functional analysis of secreted and transmembrane proteins critical to mouse development. Nature Genet. 28, 241–249 (2001).
(
10.1038/90074
) / Nature Genet. by KJ Mitchell (2001) -
Wurst, W. et al. A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice. Genetics 139, 889–899 (1995).This work served as proof of principle for high-throughput gene-trap screens.
(
10.1093/genetics/139.2.889
) / Genetics by W Wurst (1995) -
Stoykova, A., Chowdhury, K., Bonaldo, P., Torres, M. & Gruss, P. Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system. Dev. Dyn. 212, 198–213 (1998).
(
10.1002/(SICI)1097-0177(199806)212:2<198::AID-AJA5>3.0.CO;2-C
) / Dev. Dyn. by A Stoykova (1998) -
Leighton, P. A. et al. Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature 410, 174–179 (2001).
(
10.1038/35065539
) / Nature by PA Leighton (2001) -
Tropepe, V. et al. Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30, 65–78 (2001).
(
10.1016/S0896-6273(01)00263-X
) / Neuron by V Tropepe (2001) - Doetschman, T. C., Eistetter, H., Katz, M., Schmidt, W. & Kemler, R. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morphol. 87, 27–45 (1985). / J. Embryol. Exp. Morphol. by TC Doetschman (1985)
-
Wang, R., Clark, R. & Bautch, V. L. Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development. Development 114, 303–316 (1992).
(
10.1242/dev.114.2.303
) / Development by R Wang (1992) -
Nakano, T., Kodama, H. & Honjo, T. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 265, 1098–1101 (1994).
(
10.1126/science.8066449
) / Science by T Nakano (1994) -
Choi, K., Kennedy, M., Kazarov, A., Papadimitriou, J. C. & Keller, G. A common precursor for hematopoietic and endothelial cells. Development 125, 725–732 (1998).
(
10.1242/dev.125.4.725
) / Development by K Choi (1998) -
Schmitt, R. M., Bruyns, E. & Snodgrass, H. R. Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression. Genes Dev. 5, 728–740 (1991).
(
10.1101/gad.5.5.728
) / Genes Dev. by RM Schmitt (1991) -
Bautch, V. L. et al. Blood island formation in attached cultures of murine embryonic stem cells. Dev. Dyn. 205, 1–12 (1996).
(
10.1002/(SICI)1097-0177(199601)205:1<1::AID-AJA1>3.0.CO;2-M
) / Dev. Dyn. by VL Bautch (1996) -
Abe, K. et al. Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies. Exp. Cell Res. 229, 27–34 (1996).
(
10.1006/excr.1996.0340
) / Exp. Cell Res. by K Abe (1996) -
Schuldiner, M., Yanuka, O., Itskovitz-Eldor, J., Melton, D. A. & Benvenisty, N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc. Natl Acad. Sci. USA 97, 11307–11312 (2000).
(
10.1073/pnas.97.21.11307
) / Proc. Natl Acad. Sci. USA by M Schuldiner (2000) -
Weiss, M. J., Keller, G. & Orkin, S. H. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1− embryonic stem cells. Genes Dev. 8, 1184–1197 (1994).
(
10.1101/gad.8.10.1184
) / Genes Dev. by MJ Weiss (1994) -
Shalaby, F. et al. A requirement for Flk-1 in primitive and definitive hematopoiesis, and vasculogenesis. Cell 89, 981–990 (1997).
(
10.1016/S0092-8674(00)80283-4
) / Cell by F Shalaby (1997) -
Narita, N., Bielinska, M. & Wilson, D. B. Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells. Development 122, 3755–3764 (1996).
(
10.1242/dev.122.12.3755
) / Development by N Narita (1996) -
Joza, N. et al. Essential role of the mitochondrial apoptosis inducing factor in programmed cell death. Nature 410, 549–554 (2001).
(
10.1038/35069004
) / Nature by N Joza (2001) -
Muth, K., Bruyns, R., Thorey, I. S. & von Melchner, H. Disruption of genes regulated during hematopoietic differentiation of mouse embryonic stem cells. Dev. Dyn. 212, 277–283 (1998).
(
10.1002/(SICI)1097-0177(199806)212:2<277::AID-AJA12>3.0.CO;2-1
) / Dev. Dyn. by K Muth (1998) -
Hidaka, M. et al. Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells. Mech. Dev. 90, 3–15 (2000).
(
10.1016/S0925-4773(99)00234-8
) / Mech. Dev. by M Hidaka (2000) -
Baker, R. K. et al. In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev. Biol. 185, 201–214 (1997).
(
10.1006/dbio.1997.8541
) / Dev. Biol. by RK Baker (1997) -
Shirai, M. et al. A gene trap strategy for identifying the gene expressed in the embryonic nervous system. Zool. Sci. 13, 277–283 (1996).
(
10.2108/zsj.13.277
) / Zool. Sci. by M Shirai (1996) -
Forrester, L. et al. Induction gene trapping in ES cells: identification of developmentally regulated genes that respond to retinoic acid. Proc. Natl Acad. Sci. USA 93, 1677–1682 (1996).The first high-throughput induction-trap screen.
(
10.1073/pnas.93.4.1677
) / Proc. Natl Acad. Sci. USA by L Forrester (1996) -
Sam, M. et al. Aquarius, a novel gene isolated by gene trapping with an RNA-dependent polymerase motif. Dev. Dyn. 212, 304–317 (1998).
(
10.1002/(SICI)1097-0177(199806)212:2<304::AID-AJA15>3.0.CO;2-3
) / Dev. Dyn. by M Sam (1998) -
Gajovic, S., Chowdhury, K. & Gruss, P. Genes expressed after retinoic acid-mediated differentiation of embryoid bodies are likely to be expressed during embryo development. Exp. Cell Res. 242, 138–143 (1998).
(
10.1006/excr.1998.4058
) / Exp. Cell Res. by S Gajovic (1998) -
Komada, M., McLean, D. J., Griswold, M. D., Russell, L. D. & Soriano, P. E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Genes Dev. 14, 1332–1342 (2000).
(
10.1101/gad.14.11.1332
) / Genes Dev. by M Komada (2000) -
Mainguy, G. et al. An induction gene trap for identifying a homeoprotein-regulated locus. Nature Biotechnol. 18, 746–749 (2000).A powerful use of gene trapping to isolate genes downstream of a transcription factor.
(
10.1038/77312
) / Nature Biotechnol. by G Mainguy (2000) - Vallis, K. A., Chen, Z., Stanford, W. L., Hill, R. P. & Bernstein, A. Idenitification of ionizing radiation-responsive genes: a large-scale, induction gene trap strategy in embryonic stem cells. Radiat. Res. (in the press).
-
Kerr, W. G., Heller, M. & Herzenberg, L. A. Analysis of lipopolysaccharide-response genes in B-lineage cells demonstrates that they can have differentiation stage-restricted expression and contain SH2 domains. Proc. Natl Acad. Sci. USA 93, 3947–3952 (1996).
(
10.1073/pnas.93.9.3947
) / Proc. Natl Acad. Sci. USA by WG Kerr (1996) -
Russ, A. P. et al. Identification of genes induced by factor deprivation in hematopoietic cells undergoing apoptosis using gene-trap mutagenesis and site-specific recombination. Proc. Natl Acad. Sci. USA 93, 15279–15284 (1996).This paper shows a use of gene trapping other than for mutagenesis.
(
10.1073/pnas.93.26.15279
) / Proc. Natl Acad. Sci. USA by AP Russ (1996) -
Andreu, T., Beckers, T., Thoenes, E., Hilgard, P. & von Melchner, H. Gene trapping identifies inhibitors of oncogenic transformation. The tissue inhibitor of metalloproteinases-3 (TIMP3) and collagen type I α2 (COL1A2) are epidermal growth factor-regulated growth repressors. J. Biol. Chem. 273, 13848–13854 (1998).
(
10.1074/jbc.273.22.13848
) / J. Biol. Chem. by T Andreu (1998) -
Akiyama, N., Matsuo, Y., Sai, H., Noda, M. & Kizaka-Kondoh, S. Identification of a series of transforming growth factor β-responsive genes by retrovirus-mediated gene trap screening. Mol. Cell. Biol. 20, 3266–3273 (2000).
(
10.1128/MCB.20.9.3266-3273.2000
) / Mol. Cell. Biol. by N Akiyama (2000) -
Vidal, F. et al. Gene trap analysis of germ cell signaling to Sertoli cells: NGF-TrkA mediated induction of Fra1 and Fos by post-meiotic germ cells. J. Cell. Sci. 114, 435–443 (2001).
(
10.1242/jcs.114.2.435
) / J. Cell. Sci. by F Vidal (2001) -
Skarnes, W. C. Gene trapping methods for the identification and functional analysis of cell surface proteins. Methods Enzymol. 328, 592–615 (2000).
(
10.1016/S0076-6879(00)28420-6
) / Methods Enzymol. by WC Skarnes (2000) -
Townley, D. J., Avery, B. J., Rosen, B. & Skarnes, W. C. Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice. Genome Res. 7, 293–298 (1997).
(
10.1101/gr.7.3.293
) / Genome Res. by DJ Townley (1997) -
Nadeau, J. H. et al. Sequence interpretation. Functional annotation of mouse genome sequences. Science 291, 1251–1255 (2001).
(
10.1126/science.1058244
) / Science by JH Nadeau (2001) -
Pinson, K. I., Brennan, J., Monkley, S., Avery, B. J. & Skarnes, W. C. An LDL receptor-related protein mediates Wnt signaling in mice. Nature 407, 535–538 (2000).
(
10.1038/35035124
) / Nature by KI Pinson (2000) -
Hildebrand, J. D. & Soriano, P. Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. Cell 99, 485–497 (1999).
(
10.1016/S0092-8674(00)81537-8
) / Cell by JD Hildebrand (1999) -
Medico, E., Gambarotta, G., Gentile, A., Comoglio, P. M. & Soriano, P. A gene trap vector system for identifying transcriptionally responsive genes. Nature Biotechnol. 19, 579–582 (2001).
(
10.1038/89343
) / Nature Biotechnol. by E Medico (2001) -
Harrington, J. J. et al. Creation of genome-wide protein expression libraries using random activation of gene expression. Nature Biotechnol. 19, 440–445 (2001).
(
10.1038/88107
) / Nature Biotechnol. by JJ Harrington (2001) -
Lefebvre, L., Dionne, N., Karaskova, J., Squire, J. & Nagy, A. Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity. Nature Genet. 27, 257–258 (2001).
(
10.1038/85808
) / Nature Genet. by L Lefebvre (2001) -
Harbers, K., Kuehn, M., Delius, H. & Jaenisch, R. Insertion of retrovirus into the first intron of α1(I) collagen gene leads to embryonic lethal mutation in mice. Proc. Natl Acad. Sci. USA 81, 1504–1508 (1984).
(
10.1073/pnas.81.5.1504
) / Proc. Natl Acad. Sci. USA by K Harbers (1984) -
Vijaya, S., Steffen, D. L. & Robinson, H. L. Acceptor sites for retroviral integrations map near DNaseI-hypersensitive sites in chromatin. J. Virol. 60, 683–692 (1986).
(
10.1128/jvi.60.2.683-692.1986
) / J. Virol. by S Vijaya (1986) -
Soriano, P., Gridley, T. & Jaenisch, R. Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death. Genes Dev. 1, 366–375 (1987).
(
10.1101/gad.1.4.366
) / Genes Dev. by P Soriano (1987) -
Chowdhury, K., Bonaldo, P., Torres, M., Stoykova, A. & Gruss, P. Evidence for the stochastic integration of gene trap vectors into the mouse germline. Nucleic Acids Res. 25, 1531–1536 (1997).
(
10.1093/nar/25.8.1531
) / Nucleic Acids Res. by K Chowdhury (1997) -
Hrabe de Angelis, M. H. et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nature Genet. 25, 444–447 (2000).
(
10.1038/78146
) / Nature Genet. by MH Hrabe de Angelis (2000) -
Wiles, M. V. et al. Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells. Nature Genet. 24, 13–14 (2000).This paper describes the first set of clones from the largest academic gene-trap library.
(
10.1038/71622
) / Nature Genet. by MV Wiles (2000) -
Bellen, H. J. et al. P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev. 3, 1288–1300 (1989).
(
10.1101/gad.3.9.1288
) / Genes Dev. by HJ Bellen (1989) -
Wilson, C. et al. P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev. 3, 1301–1313 (1989).
(
10.1101/gad.3.9.1301
) / Genes Dev. by C Wilson (1989) -
Bier, E. et al. Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. Genes Dev. 3, 1273–1287 (1989).
(
10.1101/gad.3.9.1273
) / Genes Dev. by E Bier (1989) -
Spradling, A. C. et al. The Berkeley Drosophila Genome Project Gene Disruption Project: single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153, 135–177 (1999).
(
10.1093/genetics/153.1.135
) / Genetics by AC Spradling (1999) -
Claes, B., Smalle, J., Dekeyser, R., Van Montagu, M. & Caplan, A. Organ-dependent regulation of a plant promoter isolated from rice by 'promoter-trapping' in tobacco. Plant J. 1, 15–26 (1991).
(
10.1111/j.1365-313X.1991.00015.x
) / Plant J. by B Claes (1991) -
Meissner, R. et al. A high throughput system for transposon tagging and promoter trapping in tomato. Plant J. 22, 265–274 (2000).
(
10.1046/j.1365-313x.2000.00735.x
) / Plant J. by R Meissner (2000) -
Amsterdam, A. et al. A large-scale insertional mutagenesis screen in zebrafish. Genes Dev. 13, 2713–2724 (1999).
(
10.1101/gad.13.20.2713
) / Genes Dev. by A Amsterdam (1999) -
Talbot, W. S. & Hopkins, N. Zebrafish mutations and functional analysis of the vertebrate genome. Genes Dev. 14, 755–762 (2000).
(
10.1101/gad.14.7.755
) / Genes Dev. by WS Talbot (2000) - Zachgo, J. & Gossler, A. in Mammalian Development (ed. Lonai, P.) 321–337 (Harwood Academic Publishers, Amsterdam, 1996). / Mammalian Development by J Zachgo (1996)
Dates
Type | When |
---|---|
Created | 22 years, 11 months ago (Sept. 20, 2002, 3:57 p.m.) |
Deposited | 3 years, 4 months ago (April 19, 2022, 1:12 p.m.) |
Indexed | 2 days, 2 hours ago (Sept. 3, 2025, 6:54 a.m.) |
Issued | 23 years, 11 months ago (Oct. 1, 2001) |
Published | 23 years, 11 months ago (Oct. 1, 2001) |
Published Print | 23 years, 11 months ago (Oct. 1, 2001) |
@article{Stanford_2001, title={Gene-trap mutagenesis: past, present and beyond}, volume={2}, ISSN={1471-0064}, url={http://dx.doi.org/10.1038/35093548}, DOI={10.1038/35093548}, number={10}, journal={Nature Reviews Genetics}, publisher={Springer Science and Business Media LLC}, author={Stanford, William L. and Cohn, Jason B. and Cordes, Sabine P.}, year={2001}, month=oct, pages={756–768} }