DOI: 10.1038/35084141. Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

10.1038/35084141

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Perutz, M. F., & Windle, A. H. (2001). Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats. Nature, 412(6843), 143â144.

Authors 2

M. F. Perutz (first)
A. H. Windle (additional)

References 17 Referenced 156

Gusella, J. F. & Macdonald, M. E. Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease. Nature Rev. Neurosci. 1, 109– 115 (2000). (10.1038/35039051) / Nature Rev. Neurosci. by JF Gusella (2000)
Perutz, M. F., Johnston, T., Suzuki, M. & Finch, J. T. Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc. Natl Acad. Sci. USA 91, 5355– 5358 (1994). (10.1073/pnas.91.12.5355) / Proc. Natl Acad. Sci. USA by MF Perutz (1994)
Davies, S. W. et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537– 548 (1997). (10.1016/S0092-8674(00)80513-9) / Cell by SW Davies (1997)
DiFiglia, M. et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990– 1993 (1993). (10.1126/science.277.5334.1990) / Science by M DiFiglia (1993)
Clarke, G. et al. A one-hit model of cell death in inherited neuronal degenerations. Nature 406, 195– 199 (2000). (10.1038/35018098) / Nature by G Clarke (2000)
Mullins, J. W. Crystallisation 2nd edn (Butterworth, London, 1972). / Crystallisation by JW Mullins (1972)
Skinner, P. J. et al. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature 389, 971– 974 (1997). (10.1038/40153) / Nature by PJ Skinner (1997)
Saudou, F., Finkbeiner, S., Devys, D. & Greenberg, M. E. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear aggregates. Cell 95, 55– 66 (1998). (10.1016/S0092-8674(00)81782-1) / Cell by F Saudou (1998)
Kuemmerle, S. et al. Huntingtin aggregates may not predict neuronal death in Huntington's disease. Neurology 46, 842– 849 (1999). / Neurology by S Kuemmerle (1999)
Carmichael, J. et al. Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease. Proc. Natl Acad. Sci. USA 97, 9701– 9705 (2000). (10.1073/pnas.170280697) / Proc. Natl Acad. Sci. USA by J Carmichael (2000)
Perutz, M. F. Glutamine repeats and neurodegenerative diseases: molecular aspects. Trends Biochem. Sci. 24, 58– 63 (1999). (10.1016/S0968-0004(98)01350-4) / Trends Biochem. Sci. by MF Perutz (1999)
Nucifora, F. C. Jr et al. Interference by huntingtin and atrophin-1 with CPB-mediated transcription leading to cellular toxicity. Science 291, 2423– 2428 (2001). (10.1126/science.1056784) / Science by FC Nucifora Jr (2001)
Narain, Y., Wittenbach, A., Rankin, J., Furlong, R. A. & Rubinsztein, D. C. A molecular investigation of true dominance in Huntington's disease. J. Med. Genet. 36, 739– 746 (1999). (10.1136/jmg.36.10.739) / J. Med. Genet. by Y Narain (1999)
Kazantsev, A. et al. A polypeptide inhibitor of aggregation suppresses pathogenesis in a Drosophila model of polyglutamine repeat disease. Cell (submitted).
Yamamoto, A., Lucas, J. J. & Hen, R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 101, 57– 66 (2000). (10.1016/S0092-8674(00)80623-6) / Cell by A Yamamoto (2000)
Scherzinger, E. et al. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vivo and in vitro. Cell 90, 549– 558 (1997). (10.1016/S0092-8674(00)80514-0) / Cell by E Scherzinger (1997)
Huang, C. C. et al. Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins. Somat. Cell Mol. Genet. 24, 217– 233 (1998). (10.1023/B:SCAM.0000007124.19463.e5) / Somat. Cell Mol. Genet. by CC Huang (1998)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:32 a.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:03 p.m.)
Indexed	1 month, 1 week ago (July 26, 2025, 5:27 a.m.)
Issued	24 years, 2 months ago (July 1, 2001)
Published	24 years, 2 months ago (July 1, 2001)
Published Print	24 years, 2 months ago (July 1, 2001)

Funders 0

None

BibTeX

@article{Perutz_2001, title={Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats}, volume={412}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35084141}, DOI={10.1038/35084141}, number={6843}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Perutz, M. F. and Windle, A. H.}, year={2001}, month=jul, pages={143–144} }

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