DOI: 10.1038/35065638. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

10.1038/35065638

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Tissenbaum, H. A., & Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature, 410(6825), 227â230.

Authors 2

Heidi A. Tissenbaum (first)
Leonard Guarente (additional)

References 27 Referenced 1,543

Kimura, K., Tissenbaum, H. A., Liu, Y. & Ruvkun, G. The daf-2 insulin receptor family member regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942–946 (1997). (10.1126/science.277.5328.942) / Science by K Kimura (1997)
Morris, J. Z., Tissenbaum, H. A. & Ruvkun, G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536–539 (1996). (10.1038/382536a0) / Nature by JZ Morris (1996)
Larsen, P. L., Albert, P. S. & Riddle, D. L. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567–1583 (1995). (10.1093/genetics/139.4.1567) / Genetics by PL Larsen (1995)
Friedman, D. B. & Johnson, T. E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118, 75–86 (1988). (10.1093/genetics/118.1.75) / Genetics by DB Friedman (1988)
Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. A C. elegans mutant that lives twice as long as wild type. Nature 366, 461–464 (1993). (10.1038/366461a0) / Nature by C Kenyon (1993)
Dorman, J. B., Albinder, B., Shroyer, T. & Kenyon, C. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399–1406 (1995). (10.1093/genetics/141.4.1399) / Genetics by JB Dorman (1995)
Ogg, S. et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994–999 (1997). (10.1038/40194) / Nature by S Ogg (1997)
Lin, K., Dorman, J. B., Rodan, A. & Kenyon, C. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319–1322 (1997). (10.1126/science.278.5341.1319) / Science by K Lin (1997)
Lithgow, G. J., White, T. M., Melov, S. & Johnson, T. E. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl Acad. Sci. USA 92, 7540–7544 (1995). (10.1073/pnas.92.16.7540) / Proc. Natl Acad. Sci. USA by GJ Lithgow (1995)
Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570–2580 (1999). (10.1101/gad.13.19.2570) / Genes Dev. by M Kaeberlein (1999)
Imai, S., Armstrong, C. M., Kaeberlein, M. & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795–800 (2000). (10.1038/35001622) / Nature by S Imai (2000)
Smith, J. S. et al. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl Acad. Sci. USA 97, 6658–6663 (2000). (10.1073/pnas.97.12.6658) / Proc. Natl Acad. Sci. USA by JS Smith (2000)
Landry, J. et al. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl Acad. Sci. USA 97, 5807–5811 (2000). (10.1073/pnas.110148297) / Proc. Natl Acad. Sci. USA by J Landry (2000)
Frye, R. A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Comm. 273, 793–798 (2000). (10.1006/bbrc.2000.3000) / Biochem. Biophys. Res. Comm. by RA Frye (2000)
Herman, R. K., Madl, J. E. & Cari, C. K. Duplications in Caenorhabditis elegans. Dev. Biol. 49, 200–219 (1979). / Dev. Biol. by RK Herman (1979)
Paradis, S., Ailion, M., Toker, A., Thomas, J. H. & Ruvkun, G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 13, 1438–1452 (1999). (10.1101/gad.13.11.1438) / Genes Dev. by S Paradis (1999)
Lakowski, B. & Hekimi, S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 1010–1013 (1996). (10.1126/science.272.5264.1010) / Science by B Lakowski (1996)
Gems, D. et al. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150, 129–155 (1998). (10.1093/genetics/150.1.129) / Genetics by D Gems (1998)
Tissenbaum, H. A. & Ruvkun, G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703–717 (1998). (10.1093/genetics/148.2.703) / Genetics by HA Tissenbaum (1998)
Ailion, M., Inoue, T., Weaver, C. I., Holdcraft, R. W. & Thomas, J. H. Neurosecretory control of aging in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 96, 7394–7397 (1999). (10.1073/pnas.96.13.7394) / Proc. Natl Acad. Sci. USA by M Ailion (1999)
Riddle, D. L. & Albert, P. S. in C. elegans II (eds Riddle, D. L., Blumenthal, T., Meyer, B. J. & Priess, J. R.) 739–768 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1997). / C. elegans II by DL Riddle (1997)
Lin, S. J., Defossez, P. A. & Guarente, L. Lifespan extension in S. cerevisiae by calorie restriction requires NAD and SIR2. Science 289, 2126–2128 (2000). (10.1126/science.289.5487.2126) / Science by SJ Lin (2000)
Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71–94 (1974). (10.1093/genetics/77.1.71) / Genetics by S Brenner (1974)
Sulston, J. & Hodgkin, J. in The Nematode Caenorhabditis elegans (ed. Wood, W. B.) 587–602 (Cold Spring Harbor Laboratory, Cold Spring Harbor, 1988). / The Nematode Caenorhabditis elegans by J Sulston (1988)
Mello, C. C., Kramer, J. M., Stinchcomb, D. & Ambros, V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959–3970 (1991). (10.1002/j.1460-2075.1991.tb04966.x) / EMBO J. by CC Mello (1991)
Apfeld, J. & Kenyon, C. Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and lifespan. Cell 95, 199–210 (1998). (10.1016/S0092-8674(00)81751-1) / Cell by J Apfeld (1998)
Hedgecock, E. M. & Herman, R. K. The ncl-1 gene and genetic mosaics of Caenorhabditis elegans. Genetics 141, 989–1006 (1995). (10.1093/genetics/141.3.989) / Genetics by EM Hedgecock (1995)

Dates

Type	When
Created	23 years ago (July 26, 2002, 4:48 a.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 9:52 p.m.)
Indexed	2 days, 6 hours ago (Aug. 22, 2025, 12:45 a.m.)
Issued	24 years, 5 months ago (March 1, 2001)
Published	24 years, 5 months ago (March 1, 2001)
Published Print	24 years, 5 months ago (March 1, 2001)

Funders 0

None

BibTeX

@article{Tissenbaum_2001, title={Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans}, volume={410}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35065638}, DOI={10.1038/35065638}, number={6825}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Tissenbaum, Heidi A. and Guarente, Leonard}, year={2001}, month=mar, pages={227–230} }

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