The gating mechanism of the large mechanosensitive channel MscL
10.1038/35055559
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Sukharev, S., Betanzos, M., Chiang, C.-S., & Guy, H. R. (2001). The gating mechanism of the large mechanosensitive channel MscL. Nature, 409(6821), 720–724.

Authors 4
  1. Sergei Sukharev (first)
  2. Monica Betanzos (additional)
  3. Chien-Sung Chiang (additional)
  4. H. Robert Guy (additional)
References 21 Referenced 317
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  2. Levina, N. et al. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. EMBO J. 18, 1730–1737 (1999). (10.1093/emboj/18.7.1730) / EMBO J. by N Levina (1999)
  3. Moe, P. C., Blount, P. & Kung, C. Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation. Mol. Microbiol. 28, 583–592 (1998). (10.1046/j.1365-2958.1998.00821.x) / Mol. Microbiol. by PC Moe (1998)
  4. Blount, P. & Moe, P. C. Bacterial mechanosensitive channels: integrating physiology, structure and function. Trends Microbiol. 7, 420–424 (1999). (10.1016/S0966-842X(99)01594-2) / Trends Microbiol. by P Blount (1999)
  5. Spencer, R. H., Chang, G. & Rees, D. C. ‘Feeling the pressure’: structural insights into a gated mechanosensitive channel. Curr. Opin. Struct. Biol. 9, 448–454 (1999). (Erratum, Curr. Opin. Struct. Biol. 9, 650–651 (1999).) (10.1016/S0959-440X(99)00022-6) / Curr. Opin. Struct. Biol. by RH Spencer (1999)
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  8. Cruickshank, C. C., Minchin, R. F., Le Dain, A. C. & Martinac, B. Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli. Biophys. J. 73, 1925–1931 (1997). (10.1016/S0006-3495(97)78223-7) / Biophys. J. by CC Cruickshank (1997)
  9. Batiza, A. F., Rayment, I. & Kung, C. Channel gate! Tension, leak and disclosure. Structure Fold. Des. 7, R99–R103 (1999). (10.1016/S0969-2126(99)80061-6) / Structure Fold. Des. by AF Batiza (1999)
  10. Blount, P., Sukharev, S. I., Moe, P. C., Nagle, S. K. & Kung, C. Towards an understanding of the structural and functional properties of MscL, a mechanosensitive channel in bacteria. Biol. Cell 87, 1–8 (1996). (10.1111/j.1768-322X.1996.tb00961.x) / Biol. Cell by P Blount (1996)
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  12. Sukharev, S. I., Durell, S. R. & Guy, H. R. Molecular modeling of the gating transition of the large mechanosensitive channel, MscL. Biophys. J. (submitted).
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  16. Yoshimura, K., Batiza, A., Schroeder, M., Blount, P. & Kung, C. Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity. Biophys. J. 77, 1960–1972 (1999). (10.1016/S0006-3495(99)77037-2) / Biophys. J. by K Yoshimura (1999)
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  20. Blount, P., Sukharev, S. I., Schroeder, M. J., Nagle, S. K. & Kung, C. Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli. Proc. Natl Acad. Sci. USA 93, 11652–11657 (1996). (10.1073/pnas.93.21.11652) / Proc. Natl Acad. Sci. USA by P Blount (1996)
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Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:48 a.m.)
Deposited 2 years, 3 months ago (May 16, 2023, 9:48 p.m.)
Indexed 1 month ago (July 30, 2025, 10:20 a.m.)
Issued 24 years, 7 months ago (Feb. 1, 2001)
Published 24 years, 7 months ago (Feb. 1, 2001)
Published Print 24 years, 7 months ago (Feb. 1, 2001)
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@article{Sukharev_2001, title={The gating mechanism of the large mechanosensitive channel MscL}, volume={409}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35055559}, DOI={10.1038/35055559}, number={6821}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Sukharev, Sergei and Betanzos, Monica and Chiang, Chien-Sung and Guy, H. Robert}, year={2001}, month=feb, pages={720–724} }