Prions: health scare and biological challenge
10.1038/35052063
Crossref journal-article
Springer Science and Business Media LLC
Nature Reviews Molecular Cell Biology (297)
Bibliography

Aguzzi, A., Montrasio, F., & Kaeser, P. S. (2001). Prions: health scare and biological challenge. Nature Reviews Molecular Cell Biology, 2(2), 118–126.

Authors 3
  1. Adriano Aguzzi (first)
  2. Fabio Montrasio (additional)
  3. Pascal S. Kaeser (additional)
References 91 Referenced 113
  1. Cohen, C. H. & Valleron, A. J. When did bovine spongiform encephalopathy (BSE) start? Implications on the prediction of a new variant of Creutzfeldt-Jakob disease (nvCJD) epidemic. Int. J. Epidemiol. 28, 526?531 (1999). (10.1093/ije/28.3.526) / Int. J. Epidemiol. by CH Cohen (1999)
  2. Anderson, R. M. et al. Transmission dynamics and epidemiology of BSE in British cattle . Nature 382, 779?788 (1996). (10.1038/382779a0) / Nature by RM Anderson (1996)
  3. Ferguson, N. M., Donnelly, C. A., Woolhouse, M. E. & Anderson, R. M. Estimation of the basic reproduction number of BSE: the intensity of transmission in British cattle. Proc. R Soc. Lond. B 266, 23?32 (1999). (10.1098/rspb.1999.0599) / Proc. R Soc. Lond. B by NM Ferguson (1999)
  4. Doherr, M. G., Heim, D., Vandevelde, M. & Fatzer, R. Modelling the expected numbers of preclinical and clinical cases of bovine spongiform encephalopathy in Switzerland. Vet. Rec. 145, 155? 160 (1999). (10.1136/vr.145.6.155) / Vet. Rec. by MG Doherr (1999)
  5. Donnelly, C. A., Santos, R., Ramos, M., Galo, A. & Simas, J. P. BSE in Portugal: anticipating the decline of an epidemic . J. Epidemiol. Biostat. 4, 277? 283 (1999). / J. Epidemiol. Biostat. by CA Donnelly (1999)
  6. Aguzzi, A. & Weissmann, C. Prion research: the next frontiers . Nature 389, 795?798 (1997).Most of the points that were unresolved when this review article was written continue to constitute the next frontiers. (10.1038/39758) / Nature by A Aguzzi (1997)
  7. Serio, T. R. et al. Nucleated conformational conversion and the replication of conformational information by a prion determinant. Science 289, 1317?1321 (2000). (10.1126/science.289.5483.1317) / Science by TR Serio (2000)
  8. Kocisko, D. A. et al. Cell-free formation of protease-resistant prion protein. Nature 370, 471?474 ( 1994).A milestone discovery in mammalian prion biochemistry: the first demonstration that PrPC can be made protease-resistant by PrPScin vitro. (10.1038/370471a0) / Nature by DA Kocisko (1994)
  9. Bessen, R. A. et al. Non-genetic propagation of strain-specific properties of scrapie prion protein Nature 375, 698? 700 (1995). (10.1038/375698a0) / Nature by RA Bessen (1995)
  10. Raymond, G. J. et al. Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature 388, 285 ?288 (1997). (10.1038/40876) / Nature by GJ Raymond (1997)
  11. Telling, G. C. et al. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein . Cell 83, 79?90 (1995). (10.1016/0092-8674(95)90236-8) / Cell by GC Telling (1995)
  12. Peyrin, J. M. et al. Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines. Neuroreport 10 , 723?729 (1999). (10.1097/00001756-199903170-00012) / Neuroreport by JM Peyrin (1999)
  13. Brown, D. R., Schmidt, B. & Kretzschmar, H. A. Role of microglia and host protein in neurotoxicity of a prion protein fragment. Nature 380, 345?347 (1996). (10.1038/380345a0) / Nature by DR Brown (1996)
  14. Kunz, B., Sandmeier, E. & Christen, P. Neurotoxicity of prion peptide 106?126 not confirmed . FEBS Lett. 458, 65?68 (1999). (10.1016/S0014-5793(99)01123-0) / FEBS Lett. by B Kunz (1999)
  15. Büeler, H. R. et al. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356, 577 ?582 (1992). (10.1038/356577a0) / Nature by HR Büeler (1992)
  16. Büeler, H. R. et al. Mice devoid of PrP are resistant to scrapie. Cell 73, 1339?1347 ( 1993). A 'citation classic', whose title says it all. (10.1016/0092-8674(93)90360-3) / Cell by HR Büeler (1993)
  17. Sailer, A., Büeler, H., Fischer, M., Aguzzi, A. & Weissmann, C. No propagation of prions in mice devoid of PrP. Cell 77, 967? 968 (1994). (10.1016/0092-8674(94)90436-7) / Cell by A Sailer (1994)
  18. Brandner, S. et al. Normal host prion protein necessary for scrapie-induced neurotoxicity . Nature 379, 339?343 (1996).The normal prion protein is not only necessary for prion propagation, but also for induction of neurotoxicity. (10.1038/379339a0) / Nature by S Brandner (1996)
  19. Horiuchi, M. & Caughey, B. Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state. EMBO J. 18, 3193?3203 (1999). (10.1093/emboj/18.12.3193) / EMBO J. by M Horiuchi (1999)
  20. Lopez, C. D., Yost, C. S., Prusiner, S. B., Myers, R. M. & Lingappa, V. R. Unusual topogenic sequence directs prion protein biogenesis. Science 248, 226 ?229 (1990). (10.1126/science.1970195) / Science by CD Lopez (1990)
  21. Yost, C. S., Lopez, C. D., Prusiner, S. B., Myers, R. M. & Lingappa, V. R. Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein. Nature 343, 669?672 (1990). (10.1038/343669a0) / Nature by CS Yost (1990)
  22. Hegde, R. S. et al. A transmembrane form of the prion protein in neurodegenerative disease. Science 279, 827? 834 (1998). (10.1126/science.279.5352.827) / Science by RS Hegde (1998)
  23. Hegde, R. S. et al. Transmissible and genetic prion diseases share a common pathway of neurodegeneration. Nature 402, 822? 826 (1999). (10.1038/45574) / Nature by RS Hegde (1999)
  24. Cashman, N. R. et al. Cellular isoform of the scrapie agent protein participates in lymphocyte activation. Cell 61, 185? 192 (1990). (10.1016/0092-8674(90)90225-4) / Cell by NR Cashman (1990)
  25. Kitamoto, T., Muramoto, T., Mohri, S., Doh ura, K. & Tateishi, J. Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease. J. Virol. 65, 6292?6295 (1991).This paper showed that FDCs accumulate disease-associated prion protein, and kick-started the whole field of prion neural immunology. (10.1128/JVI.65.11.6292-6295.1991) / J. Virol. by T Kitamoto (1991)
  26. Brandner, S., Isenmann, S., Kuhne, G. & Aguzzi, A. Identification of the end stage of scrapie using infected neural grafts. Brain Pathol. 8, 19?27 ( 1998). (10.1111/j.1750-3639.1998.tb00130.x) / Brain Pathol. by S Brandner (1998)
  27. Blättler, T. et al. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 389, 69? 73 (1997). (10.1038/37981) / Nature by T Blättler (1997)
  28. Brandner, S. et al. Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proc. Natl Acad. Sci. USA 93, 13148?13151 (1996). (10.1073/pnas.93.23.13148) / Proc. Natl Acad. Sci. USA by S Brandner (1996)
  29. Aguzzi, A. Neuro-immune connection in spread of prions in the body? Lancet 349, 742?743 ( 1997). (10.1016/S0140-6736(97)22011-8) / Lancet by A Aguzzi (1997)
  30. Fischer, M. et al. Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J. 15, 1255?1264 (1996). (10.1002/j.1460-2075.1996.tb00467.x) / EMBO J. by M Fischer (1996)
  31. Race, R., Oldstone, M. & Chesebro, B. Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen. J. Virol. 74, 828?833 (2000). (10.1128/JVI.74.2.828-833.2000) / J. Virol. by R Race (2000)
  32. Brown, K. L. et al. Scrapie replication in lymphoid tissues depends on prion protein- expressing follicular dendritic cells. Nature Med. 5, 1308?1312 (1999). (10.1038/15264) / Nature Med. by KL Brown (1999)
  33. Klein, M. A. et al. A crucial role for B cells in neuroinvasive scrapie. Nature 390, 687?690 ( 1997). (10.1038/37789) / Nature by MA Klein (1997)
  34. Manuelidis, L. et al. Follicular dendritic cells and dissemination of Creutzfeldt-Jakob disease. J. Virol. 74, 8614? 8622 (2000). (10.1128/JVI.74.18.8614-8622.2000) / J. Virol. by L Manuelidis (2000)
  35. Montrasio, F. et al. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science 288, 1257?1259 (2000). (10.1126/science.288.5469.1257) / Science by F Montrasio (2000)
  36. Mabbott, N. A., Mackay, F., Minns, F. & Bruce, M. E. Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nature Med. 6, 719?720 ( 2000). (10.1038/77401) / Nature Med. by NA Mabbott (2000)
  37. Klein, M. A. et al. A role for complement in early prion pathogenesis. (submitted).
  38. Klein, M. A. et al. PrP expression in B lymphocytes is not required for prion neuroinvasion. Nature Med. 4, 1429? 1433 (1998). (10.1038/4022) / Nature Med. by MA Klein (1998)
  39. Baldauf, E., Beekes, M. & Diringer, H. Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord. J. Gen. Virol. 78, 1187?1197 ( 1997). (10.1099/0022-1317-78-5-1187) / J. Gen. Virol. by E Baldauf (1997)
  40. Glatzel, M. et al. Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system. Proc. Natl Acad. Sci. USA 97, 442?447 (2000). (10.1073/pnas.97.1.442) / Proc. Natl Acad. Sci. USA by M Glatzel (2000)
  41. Glatzel, M. & Aguzzi, A. PrPC expression in the peripheral nervous system is a determinant of prion neuroinvasion. J. Gen. Virol. 81, 2813?2821 (2000). (10.1099/0022-1317-81-11-2813) / J. Gen. Virol. by M Glatzel (2000)
  42. Collins, S. et al. Surgical treatment and risk of sporadic Creutzfeldt-Jakob disease: a case-control study. Lancet 353, 693?697 (1999). (10.1016/S0140-6736(98)08138-0) / Lancet by S Collins (1999)
  43. Will, R. et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 347, 921?925 ( 1996). (10.1016/S0140-6736(96)91412-9) / Lancet by R Will (1996)
  44. Government report on the epidemiology of CJD. http://www.doh.gov.uk/cjd/stats/sept00.htm . (Department of Health, United Kingdom, 2000).
  45. Creutzfeldt, H. G. Über eine eigenartige herdförmige Erkrankung des Zentralnervensystems . Z. ges. Neurol. Psychiatr. 57, 1? 19 (1920). (10.1007/BF02866081) / Z. ges. Neurol. Psychiatr. by HG Creutzfeldt (1920)
  46. Jakob, A. Über eigenartige Erkrankungen des Zentralnervensystems mit bemerkenswertem anatomischem Befunde. (Spastische Pseudosklerose-Encephalomyelopathie mit disseminierten Degenerationsherden). Z. ges. Neurol. Psychiatr. 64, 147?228 ( 1921). (10.1007/BF02870932) / Z. ges. Neurol. Psychiatr. by A Jakob (1921)
  47. Politopoulou, G., Seebach, J. D., Schmugge, M., Schwarz, H. P. & Aguzzi, A. Age-related expression of the cellular prion protein in human peripheral blood leukocytes. Haematologica 85, 580?587 ( 2000). / Haematologica by G Politopoulou (2000)
  48. Zeidler, M. et al. New variant Creutzfeldt-Jakob disease: psychiatric features . Lancet 350, 908?910 (1997). (10.1016/S0140-6736(97)03148-6) / Lancet by M Zeidler (1997)
  49. Aguzzi, A. Between cows and monkeys. Nature 381, 734 (1996). (10.1038/381734a0) / Nature by A Aguzzi (1996)
  50. Zeidler, M. et al. The pulvinar sign on magnetic resonance imaging in variant Creutzfeldt-Jakob disease. Lancet 355, 1412 ?1418 (2000). (10.1016/S0140-6736(00)02140-1) / Lancet by M Zeidler (2000)
  51. Hill, A. F., Zeidler, M., Ironside, J. & Collinge, J. Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy. Lancet 349, 99?100 ( 1997). A short communication with far-reaching consequences for public health. (10.1016/S0140-6736(97)24002-X) / Lancet by AF Hill (1997)
  52. Hill, A. F. et al. Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet 353, 183?189 (1999). (10.1016/S0140-6736(98)12075-5) / Lancet by AF Hill (1999)
  53. Collinge, J. Variant Creutzfeldt-Jakob disease. Lancet 354, 317?323 (1999). (10.1016/S0140-6736(99)05128-4) / Lancet by J Collinge (1999)
  54. Palmer, M. S., Dryden, A. J., Hughes, J. T. & Collinge, J. Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease. Nature 352, 340? 342 (1991). (10.1038/352340a0) / Nature by MS Palmer (1991)
  55. Parchi, P. et al. Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann. Neurol. 46, 224?233 ( 1999). (10.1002/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W) / Ann. Neurol. by P Parchi (1999)
  56. Fraser, H. & Dickinson, A. G. Distribution of experimentally induced scrapie lesions in the brain. Nature 216, 1310?1311 (1967). (10.1038/2161310a0) / Nature by H Fraser (1967)
  57. Bruce, M. E. et al. Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature 389, 498? 501 (1997). (10.1038/39057) / Nature by ME Bruce (1997)
  58. Aguzzi, A. & Weissmann, C. Spongiform encephalopathies: a suspicious signature. Nature 383, 666? 667 (1996). (10.1038/383666a0) / Nature by A Aguzzi (1996)
  59. Collinge, J., Sidle, K. C., Meads, J., Ironside, J. & Hill, A. F. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 383, 685?690 (1996). (10.1038/383685a0) / Nature by J Collinge (1996)
  60. Hill, A. F. et al. The same prion strain causes vCJD and BSE. Nature 389, 448?450 ( 1997). (10.1038/38925) / Nature by AF Hill (1997)
  61. Chazot, G. et al. New variant of Creutzfeldt-Jakob disease in a 26-year-old French man. Lancet 347, 1181 ( 1996). (10.1016/S0140-6736(96)90638-8) / Lancet by G Chazot (1996)
  62. Lasmézas, C. I. et al. BSE Transmission to Macaques. Nature 381, 743?744 (1996). (10.1038/381743a0) / Nature by CI Lasmézas (1996)
  63. Safar, J. et al. Eight prion strains have PrPSc molecules with different conformations. Nature Med. 4, 1157?1165 (1998). (10.1038/2654) / Nature Med. by J Safar (1998)
  64. Aguzzi, A. Protein conformation dictates prion strain. Nature Med. 4, 1125?1126 (1998). (10.1038/2621) / Nature Med. by A Aguzzi (1998)
  65. Ghani, A. C., Donnelly, C. A., Ferguson, N. M. & Anderson, R. M. Assessment of the prevalence of vCJD through testing tonsils and appendices for abnormal prion protein. Proc. R Soc. Lond. B 267 , 23?29 (2000). (10.1098/rspb.2000.0961) / Proc. R Soc. Lond. B by AC Ghani (2000)
  66. Ghani, A. C., Ferguson, N. M., Donnelly, C. A., Hagenaars, T. J. & Anderson, R. M. Estimation of the number of people incubating variant CJD. Lancet 352, 1353?1354 (1998). (10.1016/S0140-6736(05)60744-1) / Lancet by AC Ghani (1998)
  67. Race, R. & Chesebro, B. Scrapie infectivity found in resistant species. Nature 392, 770 ( 1998). (10.1038/33834) / Nature by R Race (1998)
  68. Aguzzi, A. & Weissmann, C. Spongiform encephalopathies. The prion's perplexing persistence. Nature 392, 763?764 (1998). (10.1038/33812) / Nature by A Aguzzi (1998)
  69. Hill, A. F. et al. Species-barrier-independent prion replication in apparently resistant species. Proc. Natl Acad. Sci. USA 97, 10248?10253 (2000). (10.1073/pnas.97.18.10248) / Proc. Natl Acad. Sci. USA by AF Hill (2000)
  70. Frigg, R., Klein, M. A., Hegyi, I., Zinkernagel, R. M. & Aguzzi, A. Scrapie pathogenesis in subclinically infected B-cell-deficient mice. J. Virol. 73, 9584? 9588 (1999). (10.1128/JVI.73.11.9584-9588.1999) / J. Virol. by R Frigg (1999)
  71. Aguzzi, A. Prion diseases, blood and the immune system: concerns and reality. Haematologica 85, 3?10 ( 2000). / Haematologica by A Aguzzi (2000)
  72. Hilton, D. A., Fathers, E., Edwards, P., Ironside, J. W. & Zajicek, J. Prion immunoreactivity in appendix before clinical onset of variant Creutzfeldt-Jakob disease. Lancet 352, 703?704 (1998). (10.1016/S0140-6736(98)24035-9) / Lancet by DA Hilton (1998)
  73. Schreuder, B. E., van Keulen, L. J., Vromans, M. E., Langeveld, J. P. & Smits, M. A. Tonsillar biopsy and PrPSc detection in the preclinical diagnosis of scrapie . Vet. Rec. 142, 564?568 (1998). (10.1136/vr.142.21.564) / Vet. Rec. by BE Schreuder (1998)
  74. Schreuder, B. E., van Keulen, L. J., Smits, M. A., Langeveld, J. P. & Stegeman, J. A. Control of scrapie eventually possible? Vet. Q. 19, 105?113 (1997). (10.1080/01652176.1997.9694752) / Vet. Q. by BE Schreuder (1997)
  75. Vankeulen, L. J. M. et al. Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. J. Clin. Microbiol. 34, 1228?1231 (1996). (10.1128/JCM.34.5.1228-1231.1996) / J. Clin. Microbiol. by LJM Vankeulen (1996)
  76. Raeber, A. J. et al. PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice. EMBO J. 18, 2702?2706 (1999). (10.1093/emboj/18.10.2702) / EMBO J. by AJ Raeber (1999)
  77. Gidon-Jeangirard, C. et al. Annexin V delays apoptosis while exerting an external constraint preventing the release of CD4+ and PrPC+ membrane particles in a human T lymphocyte model. J. Immunol. 162, 5712?5718 (1999). (10.4049/jimmunol.162.10.5712) / J. Immunol. by C Gidon-Jeangirard (1999)
  78. Ironside, J. W. et al. Retrospective study of prion-protein accumulation in tonsil and appendix tissues. Lancet 355, 1693? 1694 (2000). (10.1016/S0140-6736(00)02243-1) / Lancet by JW Ironside (2000)
  79. Fischer, M. B., Roeckl, C., Parizek, P., Schwarz, H. P. & Aguzzi, A. Binding of disease-associated prion protein to plasminogen . Nature 408, 479?483 (2000).Plasminogen seems to be the first endogenous protein that discriminates between normal and pathological prion proteins. (10.1038/35044100) / Nature by MB Fischer (2000)
  80. Priola, S. A., Raines, A. & Caughey, W. S. Porphyrin and phthalocyanine antiscrapie compounds . Science 287, 1503?1506 (2000). (10.1126/science.287.5457.1503) / Science by SA Priola (2000)
  81. Soto, C. et al. Reversion of prion protein conformational changes by synthetic β-sheet breaker peptides. Lancet 355, 192? 197 (2000). (10.1016/S0140-6736(99)11419-3) / Lancet by C Soto (2000)
  82. Aguzzi, A. & Collinge, J. Post-exposure prophylaxis after accidental prion inoculation. Lancet 350, 1519?1520 (1997). (10.1016/S0140-6736(05)63941-4) / Lancet by A Aguzzi (1997)
  83. Paushkin, S. V., Kushnirov, V. V., Smirnov, V. N. & Ter-Avanesyan, M. D. In vitro propagation of the prion-like state of yeast Sup35 protein. Science 277, 381?383 ( 1997). (10.1126/science.277.5324.381) / Science by SV Paushkin (1997)
  84. Sparrer, H. E., Santoso, A., Szoka, F. C. Jr, & Weissman, J. S. Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein. Science 289, 595?599 ( 2000).In this paper, yeast geneticists have achieved what continues to be a Holy Grail for mammalian prion science: de novo generation of recombinant, infectious prions. (10.1126/science.289.5479.595) / Science by HE Sparrer (2000)
  85. Taylor, K. L., Cheng, N., Williams, R. W., Steven, A. C. & Wickner, R. B. Prion domain initiation of amyloid formation in vitro from native Ure2p. Science 283, 1339?1343 (1999). (10.1126/science.283.5406.1339) / Science by KL Taylor (1999)
  86. Wickner, R. B. [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae Science 264, 566? 569 (1994). The first suggestion that prions exist in yeast. (10.1126/science.7909170) / Science by RB Wickner (1994)
  87. True, H. L. & Lindquist, S. L. A yeast prion provides a mechanism for genetic variation and phenotypic diversity. Nature 407, 477?483 (2000). (10.1038/35035005) / Nature by HL True (2000)
  88. Hope, J. Spongiform encephalopathies. Breech?birth prions. Nature 402, 737?739 ( 1999). (10.1038/45413) / Nature by J Hope (1999)
  89. Shmerling, D. et al. Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell 93, 203?214 (1998). (10.1016/S0092-8674(00)81572-X) / Cell by D Shmerling (1998)
  90. Moore, R. C. et al. Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP?like protein doppel. J. Mol. Biol. 292, 797?817 (1999). (10.1006/jmbi.1999.3108) / J. Mol. Biol. by RC Moore (1999)
  91. Endras, R. et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin β receptor by radioresistant stromal cells and of lymphotoxin β and tumor necrosis factor by B cells. J. Exp. Med. 189, 159?167 (1999). (10.1084/jem.189.1.159) / J. Exp. Med. by R Endras (1999)
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Created 23 years, 1 month ago (July 26, 2002, 4:48 a.m.)
Deposited 2 years, 3 months ago (May 16, 2023, 9:46 p.m.)
Indexed 3 months, 2 weeks ago (May 19, 2025, 8:30 a.m.)
Issued 24 years, 7 months ago (Feb. 1, 2001)
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@article{Aguzzi_2001, title={Prions: health scare and biological challenge}, volume={2}, ISSN={1471-0080}, url={http://dx.doi.org/10.1038/35052063}, DOI={10.1038/35052063}, number={2}, journal={Nature Reviews Molecular Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Aguzzi, Adriano and Montrasio, Fabio and Kaeser, Pascal S.}, year={2001}, month=feb, pages={118–126} }