Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Schulman, B. A., Carrano, A. C., Jeffrey, P. D., Bowen, Z., Kinnucan, E. R. E., Finnin, M. S., Elledge, S. J., Harper, J. W., Pagano, M., & Pavletich, N. P. (2000). Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex. Nature, 408(6810), 381–386.

Authors 10
  1. Brenda A. Schulman (first)
  2. Andrea C. Carrano (additional)
  3. Philip D. Jeffrey (additional)
  4. Zachary Bowen (additional)
  5. Elspeth R. E. Kinnucan (additional)
  6. Michael S. Finnin (additional)
  7. Stephen J. Elledge (additional)
  8. J. Wade Harper (additional)
  9. Michele Pagano (additional)
  10. Nikola P. Pavletich (additional)
References 30 Referenced 505
  1. Patton, E. E., Willems, A. R. & Tyers, M. Combinatorial control in ubiquitin-dependent proteolysis: don’t Skp the F-box hypothesis. Trends Genet. 14, 236–243 (1998). (10.1016/S0168-9525(98)01473-5) / Trends Genet. by EE Patton (1998)
  2. Koepp, D. M., Harper, J. W. & Elledge, S. J. How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell 97, 431– 434 (1999). (10.1016/S0092-8674(00)80753-9) / Cell by DM Koepp (1999)
  3. Deshaies, R. J. SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15, 435–467 ( 1999). (10.1146/annurev.cellbio.15.1.435) / Annu. Rev. Cell Dev. Biol. by RJ Deshaies (1999)
  4. Skowyra, D., Craig, K. L., Tyers, M., Elledge, S. J. & Harper, J. W. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209–219 (1997). (10.1016/S0092-8674(00)80403-1) / Cell by D Skowyra (1997)
  5. Feldman, R. M., Correll, C. C., Kaplan, K. B. & Deshaies, R. J. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221–230 (1997). (10.1016/S0092-8674(00)80404-3) / Cell by RM Feldman (1997)
  6. Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86 , 263–274 (1996). (10.1016/S0092-8674(00)80098-7) / Cell by C Bai (1996)
  7. Zhang, H., Kobayashi, R., Galaktionov, K. & Beach, D. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82, 915–925 (1995). (10.1016/0092-8674(95)90271-6) / Cell by H Zhang (1995)
  8. Sutterlüty, H. et al. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nature Cell Biol. 1, 207 –214 (1999). (10.1038/12027) / Nature Cell Biol. by H Sutterlüty (1999)
  9. Carrano, A. C., Eytan, E., Hershko, A. & Pagano, M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nature Cell Biol. 1, 193–199 ( 1999). (10.1038/12013) / Nature Cell Biol. by AC Carrano (1999)
  10. Tsvetkov, L. M., Yeh, K. H., Lee, S. J., Sun, H. & Zhang, H. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr. Biol. 9 , 661–664 (1999). (10.1016/S0960-9822(99)80290-5) / Curr. Biol. by LM Tsvetkov (1999)
  11. Nakayama, K. et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069–2081 ( 2000). (10.1093/emboj/19.9.2069) / EMBO J. by K Nakayama (2000)
  12. Aravind, L. & Koonin, E. V. Fold prediction and evolutionary analysis of the POZ domain: structural and evolutionary relationship with the potassium channel tetramerization domain. J. Mol. Biol. 285, 1353–1361 (1999). (10.1006/jmbi.1998.2394) / J. Mol. Biol. by L Aravind (1999)
  13. Kobe, B. & Deisenhofer, J. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature 366, 751–756 ( 1993). (10.1038/366751a0) / Nature by B Kobe (1993)
  14. Li, F. N. & Johnston, M. Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. EMBO J. 16, 5629–5638 ( 1997). (10.1093/emboj/16.18.5629) / EMBO J. by FN Li (1997)
  15. Zhou, P. & Howley, P. M. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mol. Cell 2, 571–580 ( 1998). (10.1016/S1097-2765(00)80156-2) / Mol. Cell by P Zhou (1998)
  16. Connelly, C. & Hieter, P. Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell 86, 275–285 ( 1996). (10.1016/S0092-8674(00)80099-9) / Cell by C Connelly (1996)
  17. Russell, I. D., Grancell, A. S. & Sorger, P. K. The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex. J. Cell Biol. 145, 933–950 (1999). (10.1083/jcb.145.5.933) / J. Cell Biol. by ID Russell (1999)
  18. Lisztwan, J. et al. Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. EMBO J. 17, 368–383 (1998). (10.1093/emboj/17.2.368) / EMBO J. by J Lisztwan (1998)
  19. Costanzo, M. C. et al. The yeast proteome database (YPD) and Caenorhabditis elegans proteome database (WormPD): comprehensive resources for the organization and comparison of model organism protein information. Nucleic Acids Res. 28, 73–76 ( 2000). (10.1093/nar/28.1.73) / Nucleic Acids Res. by MC Costanzo (2000)
  20. Rubin, G. M. et al. Comparative genomics of the eukaryotes. Science 287, 2204–2215 ( 2000). (10.1126/science.287.5461.2204) / Science by GM Rubin (2000)
  21. Lonergan, K. M. et al. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol. Cell. Biol. 18, 732– 41 (1998). (10.1128/MCB.18.2.732) / Mol. Cell. Biol. by KM Lonergan (1998)
  22. Kamura, T. et al. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 284, 657– 661 (1999). (10.1126/science.284.5414.657) / Science by T Kamura (1999)
  23. Stebbins, C. E., Kaelin, W. G. Jr & Pavletich, N. P. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science 284, 455–461 ( 1999). (10.1126/science.284.5413.455) / Science by CE Stebbins (1999)
  24. Shirane, M. et al. Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing. J. Biol. Chem. 274, 13886–13893 (1999). (10.1074/jbc.274.20.13886) / J. Biol. Chem. by M Shirane (1999)
  25. Spencer, E., Jiang, J. & Chen, Z. J. Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP. Genes Dev. 13, 284–294 (1999). (10.1101/gad.13.3.284) / Genes Dev. by E Spencer (1999)
  26. Kobe, B. & Deisenhofer, J. A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature 374, 183–186 (1995). (10.1038/374183a0) / Nature by B Kobe (1995)
  27. Price, S. R., Evans, P. R. & Nagai, K. Crystal structure of the spliceosomal U2B′′–U2A′ protein complex bound to a fragment of U2 small nuclear RNA. Nature 394, 645–650 ( 1998). (10.1038/29234) / Nature by SR Price (1998)
  28. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 176, 307–326 ( 1997). (10.1016/S0076-6879(97)76066-X) / Methods Enzymol. by Z Otwinowski (1997)
  29. Collaborative Computational Project B. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760–763 ( 1994). (10.1107/S0907444994003112) / Acta Crystallogr. D by Collaborative Computational Project B (1994)
  30. Brünger, A. T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905–921 (1998). (10.1107/S0907444998003254) / Acta Crystallogr. D by AT Brünger (1998)
Dates
Type When
Created 23 years ago (July 26, 2002, 4:46 a.m.)
Deposited 2 years, 3 months ago (May 16, 2023, 10:14 p.m.)
Indexed 2 days, 11 hours ago (Aug. 21, 2025, 2:17 p.m.)
Issued 24 years, 9 months ago (Nov. 1, 2000)
Published 24 years, 9 months ago (Nov. 1, 2000)
Published Print 24 years, 9 months ago (Nov. 1, 2000)
Funders 0

None

@article{Schulman_2000, title={Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex}, volume={408}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35042620}, DOI={10.1038/35042620}, number={6810}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Schulman, Brenda A. and Carrano, Andrea C. and Jeffrey, Philip D. and Bowen, Zachary and Kinnucan, Elspeth R. E. and Finnin, Michael S. and Elledge, Stephen J. and Harper, J. Wade and Pagano, Michele and Pavletich, Nikola P.}, year={2000}, month=nov, pages={381–386} }