DOI: 10.1038/35039551. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

10.1038/35039551

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Pellegrini, L., Burke, D. F., von Delft, F., Mulloy, B., & Blundell, T. L. (2000). Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature, 407(6807), 1029â1034.

Authors 5

Luca Pellegrini (first)
David F. Burke (additional)
Frank von Delft (additional)
Barbara Mulloy (additional)
Tom L. Blundell (additional)

References 30 Referenced 597

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Johnson, D. E. & Williams, L. T. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 60, 1–41 (1993). / Adv. Cancer Res. by DE Johnson (1993)
Rapraeger, A. C., Krufka, A. & Olwin, B. B. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 252, 1705–1708 (1991). (10.1126/science.1646484) / Science by AC Rapraeger (1991)
Spivak-Kroizman, T. et al. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation and cell proliferation. Cell 79, 1015–1024 ( 1994). (10.1016/0092-8674(94)90032-9) / Cell by T Spivak-Kroizman (1994)
Lin, X., Buff, E. M., Perrimon, N. & Michelson, A. M. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Development 126 , 3715–3723 (1999). (10.1242/dev.126.17.3715) / Development by X Lin (1999)
Faham, S., Hileman, R. E., Fromm, J. R., Linhardt, R. J. & Rees, D. C. Heparin structure and interactions with basic fibroblast growth factor. Science 271, 1116–1120 (1996). (10.1126/science.271.5252.1116) / Science by S Faham (1996)
DiGabriele, A. et al. Structure of a heparin-linked biologically active dimer of fibroblast growth factor. Nature 393, 812 –817 (1998). (10.1038/31741) / Nature by A DiGabriele (1998)
Plotnikov, A. N., Schlessinger, J., Hubbard, S. R. & Mohammadi, M. Structural basis for FGF receptor dimerization and activation. Cell 98, 641–650 ( 1999). (10.1016/S0092-8674(00)80051-3) / Cell by AN Plotnikov (1999)
Stauber, D., DiGabriele, A. & Hendrickson, W. Structural Interactions of fibroblast growth factor receptor with its ligands. Proc. Natl Acad. Sci. USA 97, 49–54 (2000). (10.1073/pnas.97.1.49) / Proc. Natl Acad. Sci. USA by D Stauber (2000)
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Thompson, L. D., Pantoliano, M. W. & Springer, B. A. Energetic characterization of the basic fibroblast growth factor-heparin interaction: identification of the heparin binding domain. Biochemistry 33, 3831– 3840 (1994). (10.1021/bi00179a006) / Biochemistry by LD Thompson (1994)
Springer, B. A. et al. Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis. J. Biol. Chem. 269, 26879–26884 (1994). (10.1016/S0021-9258(18)47101-3) / J. Biol. Chem. by BA Springer (1994)
Kan, M. et al. An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science 259, 1918– 1921 (1993). (10.1126/science.8456318) / Science by M Kan (1993)
Guimond, S., Maccarana, M., Olwin, B. B., Lindahl, U. & Rapraeger, A. C. Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4. J. Biol. Chem. 268, 23906– 23914 (1993). (10.1016/S0021-9258(20)80471-2) / J. Biol. Chem. by S Guimond (1993)
Ornitz, D. M. et al. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol. Cell. Biol. 12, 240–247 (1992). (10.1128/MCB.12.1.240) / Mol. Cell. Biol. by DM Ornitz (1992)
Sudhalter, J., Folkman, J., Svahn, C. M., Bergendal, K. & D'Amore, P. A. Importance of size, sulfation, and anticoagulant activity in the potentiation of acidic fibroblast growth factor by heparin. J. Biol. Chem. 264, 6892 –6897 (1989). (10.1016/S0021-9258(18)83515-3) / J. Biol. Chem. by J Sudhalter (1989)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:46 a.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10:12 p.m.)
Indexed	1 week, 3 days ago (Aug. 26, 2025, 2:47 a.m.)
Issued	24 years, 11 months ago (Oct. 1, 2000)
Published	24 years, 11 months ago (Oct. 1, 2000)
Published Print	24 years, 11 months ago (Oct. 1, 2000)

Funders 0

None

BibTeX

@article{Pellegrini_2000, title={Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin}, volume={407}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35039551}, DOI={10.1038/35039551}, number={6807}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Pellegrini, Luca and Burke, David F. and von Delft, Frank and Mulloy, Barbara and Blundell, Tom L.}, year={2000}, month=oct, pages={1029–1034} }

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