Molecular portraits of human breast tumours
10.1038/35021093
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Perou, C. M., Sørlie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Rees, C. A., Pollack, J. R., Ross, D. T., Johnsen, H., Akslen, L. A., Fluge, Ø., Pergamenschikov, A., Williams, C., Zhu, S. X., Lønning, P. E., Børresen-Dale, A.-L., Brown, P. O., & Botstein, D. (2000). Molecular portraits of human breast tumours. Nature, 406(6797), 747–752.

Authors 18
  1. Charles M. Perou (first)
  2. Therese Sørlie (additional)
  3. Michael B. Eisen (additional)
  4. Matt van de Rijn (additional)
  5. Stefanie S. Jeffrey (additional)
  6. Christian A. Rees (additional)
  7. Jonathan R. Pollack (additional)
  8. Douglas T. Ross (additional)
  9. Hilde Johnsen (additional)
  10. Lars A. Akslen (additional)
  11. Øystein Fluge (additional)
  12. Alexander Pergamenschikov (additional)
  13. Cheryl Williams (additional)
  14. Shirley X. Zhu (additional)
  15. Per E. Lønning (additional)
  16. Anne-Lise Børresen-Dale (additional)
  17. Patrick O. Brown (additional)
  18. David Botstein (additional)
References 23 Referenced 12,203
  1. Tavassoli, F. A. & Schnitt, S. J. Pathology of the Breast (Elsevier, New York, 1992). / Pathology of the Breast by FA Tavassoli (1992)
  2. Eisen, M. B. & Brown, P. O. DNA arrays for analysis of gene expression. Methods Enzymol. 303, 179– 205 (1999). (10.1016/S0076-6879(99)03014-1) / Methods Enzymol. by MB Eisen (1999)
  3. Ross, D. T. et al. Systematic variation in gene expression patterns in human cancer cell lines. Nature Genet. 24, 227 –235 (2000). (10.1038/73432) / Nature Genet. by DT Ross (2000)
  4. Aas, T. et al. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nature Med. 2, 811–814 (1996). (10.1038/nm0796-811) / Nature Med. by T Aas (1996)
  5. Eisen, M. B., Spellman, P. T., Brown, P. O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl Acad. Sci. USA 95, 14863– 14868 (1998). (10.1073/pnas.95.25.14863) / Proc. Natl Acad. Sci. USA by MB Eisen (1998)
  6. Perou, C. M. et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc. Natl Acad. Sci. USA 96, 9212–9217 (1999). (10.1073/pnas.96.16.9212) / Proc. Natl Acad. Sci. USA by CM Perou (1999)
  7. Yang, G. P., Ross, D. T., Kuang, W. W., Brown, P. O. & Weigel, R. J. Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res. 27, 1517–1523 (1999). (10.1093/nar/27.6.1517) / Nucleic Acids Res. by GP Yang (1999)
  8. Hoch, R. V., Thompson, D. A., Baker, R. J. & Weigel, R. J. GATA-3 is expressed in association with estrogen receptor in breast cancer. Int. J. Cancer 84, 122– 128 (1999). (10.1002/(SICI)1097-0215(19990420)84:2<122::AID-IJC5>3.0.CO;2-S) / Int. J. Cancer by RV Hoch (1999)
  9. Pauletti, G., Godolphin, W., Press, M. F. & Slamon, D. J. Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization. Oncogene 13, 63–72 ( 1996). / Oncogene by G Pauletti (1996)
  10. Pollack, J. R. et al. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nature Genet. 23, 41– 46 (1999). (10.1038/12640) / Nature Genet. by JR Pollack (1999)
  11. Ronnov-Jessen, L., Petersen, O. W. & Bissell, M. J. Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol. Rev. 76, 69–125 ( 1996). (10.1152/physrev.1996.76.1.69) / Physiol. Rev. by L Ronnov-Jessen (1996)
  12. Taylor-Papadimitriou, J. et al. Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium. J. Cell Sci. 94, 403– 413 (1989). (10.1242/jcs.94.3.403) / J. Cell Sci. by J Taylor-Papadimitriou (1989)
  13. Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286 , 531–537 (1999). (10.1126/science.286.5439.531) / Science by TR Golub (1999)
  14. Dairkee, S. H., Mayall, B. H., Smith, H. S. & Hackett, A. J. Monoclonal marker that predicts early recurrence of breast cancer. Lancet 1, 514 (1987). (10.1016/S0140-6736(87)92129-5) / Lancet by SH Dairkee (1987)
  15. Dairkee, S. H., Puett, L. & Hackett, A. J. Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue. J. Natl Cancer Inst. 80, 691–695 (1988). (10.1093/jnci/80.9.691) / J. Natl Cancer Inst. by SH Dairkee (1988)
  16. Malzahn, K., Mitze, M., Thoenes, M. & Moll, R. Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas. Virchows Arch. 433, 119 –129 (1998). (10.1007/s004280050226) / Virchows Arch. by K Malzahn (1998)
  17. Guelstein, V. I. et al. Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. Int. J. Cancer 42, 147– 153 (1988). (10.1002/ijc.2910420202) / Int. J. Cancer by VI Guelstein (1988)
  18. Gusterson, B. A. et al. Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases. Cancer Res. 42, 4763–4770 (1982). / Cancer Res. by BA Gusterson (1982)
  19. Nagle, R. B. et al. Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. J. Histochem. Cytochem. 34, 869–881 (1986). (10.1177/34.7.2423579) / J. Histochem. Cytochem. by RB Nagle (1986)
  20. Berns, E. M. et al. Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumors: correlation with steroid receptors. Eur. J. Cancer 28, 697– 700 (1992). (10.1016/S0959-8049(05)80129-7) / Eur. J. Cancer by EM Berns (1992)
  21. Heintz, N. H., Leslie, K. O., Rogers, L. A. & Howard, P. L. Amplification of the c-erb B-2 oncogene and prognosis of breast adenocarcinoma. Arch. Pathol. Lab. Med. 114, 160– 163 (1990). / Arch. Pathol. Lab. Med. by NH Heintz (1990)
  22. DeRisi, J. L., Iyer, V. R. & Brown, P. O. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278, 680–686 (1997). (10.1126/science.278.5338.680) / Science by JL DeRisi (1997)
  23. Alizadeh, A. A. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503–511 (2000). (10.1038/35000501)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:45 a.m.)
Deposited 2 years, 11 months ago (Sept. 19, 2022, 5:11 a.m.)
Indexed 26 minutes ago (Aug. 31, 2025, 5:36 a.m.)
Issued 25 years ago (Aug. 17, 2000)
Published 25 years ago (Aug. 17, 2000)
Published Online 25 years ago (Aug. 17, 2000)
Published Print 25 years ago (Aug. 17, 2000)
Funders 0

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@article{Perou_2000, title={Molecular portraits of human breast tumours}, volume={406}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35021093}, DOI={10.1038/35021093}, number={6797}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Perou, Charles M. and Sørlie, Therese and Eisen, Michael B. and van de Rijn, Matt and Jeffrey, Stefanie S. and Rees, Christian A. and Pollack, Jonathan R. and Ross, Douglas T. and Johnsen, Hilde and Akslen, Lars A. and Fluge, Øystein and Pergamenschikov, Alexander and Williams, Cheryl and Zhu, Shirley X. and Lønning, Per E. and Børresen-Dale, Anne-Lise and Brown, Patrick O. and Botstein, David}, year={2000}, month=aug, pages={747–752} }