Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
10.1038/35016111
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Huppert, S. S., Le, A., Schroeter, E. H., Mumm, J. S., Saxena, M. T., Milner, L. A., & Kopan, R. (2000). Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature, 405(6789), 966–970.

Authors 7
  1. Stacey S. Huppert (first)
  2. Anh Le (additional)
  3. Eric H. Schroeter (additional)
  4. Jeffrey S. Mumm (additional)
  5. Meera T. Saxena (additional)
  6. Laurie A. Milner (additional)
  7. Raphael Kopan (additional)
References 28 Referenced 281
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  4. Swiatek, P. J., Lindsell, C. E., Amo, F. F. d., Weinmaster, G. & Gridley, T. Notch1 is essential for postimplantation development in mice. Genes Dev. 8, 707– 719 (1994). (10.1101/gad.8.6.707) / Genes Dev. by PJ Swiatek (1994)
  5. Kidd, S., Lieber, T. & Young, M. W. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev. 12, 3728–3740 ( 1998). (10.1101/gad.12.23.3728) / Genes Dev. by S Kidd (1998)
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  7. De Strooper, B. et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518–521 (1999). (10.1038/19083) / Nature by B De Strooper (1999)
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  11. Herreman, A. et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl Acad. Sci. USA 96, 11872–11877 ( 1999). (10.1073/pnas.96.21.11872) / Proc. Natl Acad. Sci. USA by A Herreman (1999)
  12. Li, X. & Greenwald, I. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Natl Acad. Sci. USA 94, 12204–12209 (1997). (10.1073/pnas.94.22.12204) / Proc. Natl Acad. Sci. USA by X Li (1997)
  13. Westlund, B., Parry, D., Clover, R., Basson, M. & Johnson, C. D. Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. Proc. Natl Acad. Sci. USA 96, 2497–2502 (1999). (10.1073/pnas.96.5.2497) / Proc. Natl Acad. Sci. USA by B Westlund (1999)
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  16. Berechid, B. E., Thinakaran, G., Wong, P. C., Sisodia, S. S. & Nye, J. S. Lack of requirement for Presenilin1 in Notch1 signaling. Curr. Biol. 9, 1493 –1496 (1999). (10.1016/S0960-9822(00)80121-9) / Curr. Biol. by BE Berechid (1999)
  17. Kopan, R., Schroeter, E. H., Weintraub, H. & Nye, J. S. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl Acad. Sci. USA 93, 1683–1688 ( 1996). (10.1073/pnas.93.4.1683) / Proc. Natl Acad. Sci. USA by R Kopan (1996)
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Dates
Type When
Created 23 years ago (July 26, 2002, 4:45 a.m.)
Deposited 2 years, 3 months ago (May 16, 2023, 9:59 p.m.)
Indexed 2 hours, 38 minutes ago (Aug. 22, 2025, 12:45 a.m.)
Issued 25 years, 2 months ago (June 22, 2000)
Published 25 years, 2 months ago (June 22, 2000)
Published Print 25 years, 2 months ago (June 22, 2000)
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@article{Huppert_2000, title={Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1}, volume={405}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35016111}, DOI={10.1038/35016111}, number={6789}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Huppert, Stacey S. and Le, Anh and Schroeter, Eric H. and Mumm, Jeffrey S. and Saxena, Meera T. and Milner, Laurie A. and Kopan, Raphael}, year={2000}, month=jun, pages={966–970} }