Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
10.1038/35008096
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Schubert, U., Antón, L. C., Gibbs, J., Norbury, C. C., Yewdell, J. W., & Bennink, J. R. (2000). Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature, 404(6779), 770–774.

Authors 6
  1. Ulrich Schubert (first)
  2. Luis C. Antón (additional)
  3. James Gibbs (additional)
  4. Christopher C. Norbury (additional)
  5. Jonathan W. Yewdell (additional)
  6. Jack R. Bennink (additional)
References 18 Referenced 1,076
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  2. Pamer,E. & Cresswell,P. Mechanisms of MHC class I restricted antigen processing. Annu. Rev. Immunol. 16, 323–358 (1998). (10.1146/annurev.immunol.16.1.323) / Annu. Rev. Immunol. by E Pamer (1998)
  3. Yewdell,J. W., Antón,L. C. & Bennink, J. R. Defective ribosomal products (DRiPs). A major source of antigenic peptides for MHC class I molecules? J. Immunol. 157, 1823–1826 (1996). (10.4049/jimmunol.157.5.1823) / J. Immunol. by JW Yewdell (1996)
  4. Fenteany,G. et al. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268, 726–731 (1995). (10.1126/science.7732382) / Science by G Fenteany (1995)
  5. Rock,K. L. et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761–771 (1994). (10.1016/S0092-8674(94)90462-6) / Cell by KL Rock (1994)
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  13. Degen,E. & Williams,D. B. Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules. J. Cell Biol. 112, 1099– 1115 (1991). (10.1083/jcb.112.6.1099) / J. Cell Biol. by E Degen (1991)
  14. Reits,E. A. J., Vos,J. C., Grommé, M. & Neefjes,J. The major substrates for TAP in vivo are derived from newly synthesized proteins. Nature 404, 774–778 ( 2000). (10.1038/35008103) / Nature by EAJ Reits (2000)
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  16. Engelhard,V. H. Structures of peptides associated with class I and class II MHC molecules. Annu. Rev. Immunol. 12, 181– 207 (1994). (10.1146/annurev.iy.12.040194.001145) / Annu. Rev. Immunol. by VH Engelhard (1994)
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Dates
Type When
Created 23 years ago (July 26, 2002, 4:41 a.m.)
Deposited 2 years, 3 months ago (May 16, 2023, 9:53 p.m.)
Indexed 20 minutes ago (Aug. 24, 2025, 1:09 p.m.)
Issued 25 years, 4 months ago (April 1, 2000)
Published 25 years, 4 months ago (April 1, 2000)
Published Print 25 years, 4 months ago (April 1, 2000)
Funders 0

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@article{Schubert_2000, title={Rapid degradation of a large fraction of newly synthesized proteins by proteasomes}, volume={404}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/35008096}, DOI={10.1038/35008096}, number={6779}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Schubert, Ulrich and Antón, Luis C. and Gibbs, James and Norbury, Christopher C. and Yewdell, Jonathan W. and Bennink, Jack R.}, year={2000}, month=apr, pages={770–774} }