DOI: 10.1038/343559a0. Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

10.1038/343559a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

MacLennan, D. H., Duff, C., Zorzato, F., Fujii, J., Phillips, M., Korneluk, R. G., Frodis, W., Britt, B. A., & Wortont, R. G. (1990). Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia. Nature, 343(6258), 559â561.

Authors 9

David H. MacLennan (first)
Catherine Duff (additional)
Francesco Zorzato (additional)
Junichi Fujii (additional)
Michael Phillips (additional)
Robert G. Korneluk (additional)
Wanda Frodis (additional)
Beverley A. Britt (additional)
Ronald G. Wortont (additional)

References 24 Referenced 386

Britt, B. A. in Malignant Hyperthermia (ed. Britt, B. A.) 11–42 (Martinus Nijhoff, Boston, 1987). (10.1007/978-1-4613-2079-1_2) / Malignant Hyperthermia by BA Britt (1987)
Kalow, W. in Malignant Hyperthermia (ed. Britt, B. A.) 155–180 (Martinus Nijhoff, Boston, 1987). (10.1007/978-1-4613-2079-1_7) / Malignant Hyperthermia by W Kalow (1987)
Harrison, G. G. in Malignant Hyperthermia (ed. Britt, B. A.) 103–136 (Martinus Nijhoff, Boston, 1987). (10.1007/978-1-4613-2079-1_5) / Malignant Hyperthermia by GG Harrison (1987)
Kalow, W., Britt, B. A., Terreau, M. E. & Haist, C. Lancet ii, 895–898 (1970). (10.1016/S0140-6736(70)92069-6) / Lancet by W Kalow (1970)
Britt, B. A. in Malignant Hyperthermia Current Concepts (eds Nalda Felipe, M. A., Gottman, S. & Khambatta, H. J.) 53–96 (Norman, Bad Homburg, 1989). / Malignant Hyperthermia Current Concepts by BA Britt (1989)
Iaizzo, P. A., Klein, W. & Lehmann-Horn, F. Pflugers Arch. 411, 648–653 (1988). (10.1007/BF00580861) / Pflugers Arch. by PA Iaizzo (1988)
Endo, M. et al. Biomed Res. 4, 83–92 (1983). (10.2220/biomedres.4.83) / Biomed Res. by M Endo (1983)
Ohnishi, S. T., Taylor, S. & Gronert, G. A. FEBS Lett. 161, 103–107 (1983). (10.1016/0014-5793(83)80739-X) / FEBS Lett. by ST Ohnishi (1983)
Nelson, T. E. J. clin. Invest. 72, 862–873 (1983). (10.1172/JCI111057) / J. clin. Invest. by TE Nelson (1983)
Kim, D. H. et al. Biochim. biophys. Acta 775, 320–327 (1984). (10.1016/0005-2736(84)90187-1) / Biochim. biophys. Acta by DH Kim (1984)
Mickelson, J. R. et al. J. biol. Chem. 263, 9310–9315 (1988). (10.1016/S0021-9258(19)76541-7) / J. biol. Chem. by JR Mickelson (1988)
O'Brien, P. J. Can. J. vet Res. 50, 318–328 (1986). / Can. J. vet Res. by PJ O'Brien (1986)
Zorzato, F. et al. J. biol. Chem. 265, 2244–2256 (1989). (10.1016/S0021-9258(19)39968-5) / J. biol. Chem. by F Zorzato (1989)
MacKenzie, A. E. et al. Am. J. hum. Genet. (submitted).
McCarthy, T. V. et al. Nature 343, 562–564 (1990). (10.1038/343562a0) / Nature by TV McCarthy (1990)
Davies, W., Harbitz, I., Fries, R., Stranzinger, G. & Hauge, J. G. An. Genet. 19, 203–212 (1988). (10.1111/j.1365-2052.1988.tb00809.x) / An. Genet. by W Davies (1988)
Smeets, H. et al. Nucleic Acids Res. 17, 3324 (1989). (10.1093/nar/17.8.3324) / Nucleic Acids Res. by H Smeets (1989)
Hulsebos, T., Westphal, H., Peek, R., Coerwinkel, M. & Wieringa, B. Nucleic Acids Res. 14, 7137 (1986). (10.1093/nar/14.17.7137) / Nucleic Acids Res. by T Hulsebos (1986)
Smeets, H. et al. Nucleic Acids Res. 17, 3325 (1989). (10.1093/nar/17.8.3325) / Nucleic Acids Res. by H Smeets (1989)
Smeets, H. et al. Nucleic Acids Res. 15, 8120 (1987). (10.1093/nar/15.19.8120) / Nucleic Acids Res. by H Smeets (1987)
Schepens, J. et al. Nucleic Acids Res. 15, 3193 (1987). (10.1093/nar/15.7.3193) / Nucleic Acids Res. by J Schepens (1987)
Schepens, J., Smeets, H., Hulsebos, T., Brunner, H. & Wieringa, B. Nucleic Acids Res. 15, 3192 (1987). (10.1093/nar/15.7.3192) / Nucleic Acids Res. by J Schepens (1987)
Humphries, S. E. et al. Molec. Biol. Med. 1, 463–471 (1983). / Molec. Biol. Med. by SE Humphries (1983)
Schonk, D. et al. Genomics 4, 384–396 (1989). (10.1016/0888-7543(89)90346-7) / Genomics by D Schonk (1989)

Dates

Type	When
Created	22 years ago (Aug. 11, 2003, 6:33 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 9:54 p.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 6:27 a.m.)
Issued	35 years, 6 months ago (Feb. 1, 1990)
Published	35 years, 6 months ago (Feb. 1, 1990)
Published Print	35 years, 6 months ago (Feb. 1, 1990)

Funders 0

None

BibTeX

@article{MacLennan_1990, title={Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia}, volume={343}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/343559a0}, DOI={10.1038/343559a0}, number={6258}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={MacLennan, David H. and Duff, Catherine and Zorzato, Francesco and Fujii, Junichi and Phillips, Michael and Korneluk, Robert G. and Frodis, Wanda and Britt, Beverley A. and Wortont, Ronald G.}, year={1990}, month=feb, pages={559–561} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        11
      ]
    ],
    "date-time": "2025-07-11T10:27:55Z",
    "timestamp": 1752229675578
  },
  "reference-count": 24,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6258",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1990,
            2,
            1
          ]
        ],
        "date-time": "1990-02-01T00:00:00Z",
        "timestamp": 633830400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1990,
        2
      ]
    ]
  },
  "DOI": "10.1038/343559a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        8,
        11
      ]
    ],
    "date-time": "2003-08-11T22:33:05Z",
    "timestamp": 1060641185000
  },
  "page": "559-561",
  "source": "Crossref",
  "is-referenced-by-count": 386,
  "title": "Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia",
  "prefix": "10.1038",
  "volume": "343",
  "author": [
    {
      "given": "David H.",
      "family": "MacLennan",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Catherine",
      "family": "Duff",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Francesco",
      "family": "Zorzato",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Junichi",
      "family": "Fujii",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Michael",
      "family": "Phillips",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Robert G.",
      "family": "Korneluk",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Wanda",
      "family": "Frodis",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Beverley A.",
      "family": "Britt",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ronald G.",
      "family": "Wortont",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF343559a0_CR1",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1007/978-1-4613-2079-1_2",
      "volume-title": "Malignant Hyperthermia",
      "author": "BA Britt",
      "year": "1987",
      "unstructured": "Britt, B. A. in Malignant Hyperthermia (ed. Britt, B. A.) 11\u201342 (Martinus Nijhoff, Boston, 1987)."
    },
    {
      "key": "BF343559a0_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "155",
      "DOI": "10.1007/978-1-4613-2079-1_7",
      "volume-title": "Malignant Hyperthermia",
      "author": "W Kalow",
      "year": "1987",
      "unstructured": "Kalow, W. in Malignant Hyperthermia (ed. Britt, B. A.) 155\u2013180 (Martinus Nijhoff, Boston, 1987)."
    },
    {
      "key": "BF343559a0_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "103",
      "DOI": "10.1007/978-1-4613-2079-1_5",
      "volume-title": "Malignant Hyperthermia",
      "author": "GG Harrison",
      "year": "1987",
      "unstructured": "Harrison, G. G. in Malignant Hyperthermia (ed. Britt, B. A.) 103\u2013136 (Martinus Nijhoff, Boston, 1987)."
    },
    {
      "key": "BF343559a0_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "895",
      "DOI": "10.1016/S0140-6736(70)92069-6",
      "volume": "ii",
      "author": "W Kalow",
      "year": "1970",
      "unstructured": "Kalow, W., Britt, B. A., Terreau, M. E. & Haist, C. Lancet ii, 895\u2013898 (1970).",
      "journal-title": "Lancet"
    },
    {
      "key": "BF343559a0_CR5",
      "first-page": "53",
      "volume-title": "Malignant Hyperthermia Current Concepts",
      "author": "BA Britt",
      "year": "1989",
      "unstructured": "Britt, B. A. in Malignant Hyperthermia Current Concepts (eds Nalda Felipe, M. A., Gottman, S. & Khambatta, H. J.) 53\u201396 (Norman, Bad Homburg, 1989)."
    },
    {
      "key": "BF343559a0_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "648",
      "DOI": "10.1007/BF00580861",
      "volume": "411",
      "author": "PA Iaizzo",
      "year": "1988",
      "unstructured": "Iaizzo, P. A., Klein, W. & Lehmann-Horn, F. Pflugers Arch. 411, 648\u2013653 (1988).",
      "journal-title": "Pflugers Arch."
    },
    {
      "key": "BF343559a0_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "83",
      "DOI": "10.2220/biomedres.4.83",
      "volume": "4",
      "author": "M Endo",
      "year": "1983",
      "unstructured": "Endo, M. et al. Biomed Res. 4, 83\u201392 (1983).",
      "journal-title": "Biomed Res."
    },
    {
      "key": "BF343559a0_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "103",
      "DOI": "10.1016/0014-5793(83)80739-X",
      "volume": "161",
      "author": "ST Ohnishi",
      "year": "1983",
      "unstructured": "Ohnishi, S. T., Taylor, S. & Gronert, G. A. FEBS Lett. 161, 103\u2013107 (1983).",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "BF343559a0_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "862",
      "DOI": "10.1172/JCI111057",
      "volume": "72",
      "author": "TE Nelson",
      "year": "1983",
      "unstructured": "Nelson, T. E. J. clin. Invest. 72, 862\u2013873 (1983).",
      "journal-title": "J. clin. Invest."
    },
    {
      "key": "BF343559a0_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "320",
      "DOI": "10.1016/0005-2736(84)90187-1",
      "volume": "775",
      "author": "DH Kim",
      "year": "1984",
      "unstructured": "Kim, D. H. et al. Biochim. biophys. Acta 775, 320\u2013327 (1984).",
      "journal-title": "Biochim. biophys. Acta"
    },
    {
      "key": "BF343559a0_CR11",
      "doi-asserted-by": "crossref",
      "first-page": "9310",
      "DOI": "10.1016/S0021-9258(19)76541-7",
      "volume": "263",
      "author": "JR Mickelson",
      "year": "1988",
      "unstructured": "Mickelson, J. R. et al. J. biol. Chem. 263, 9310\u20139315 (1988).",
      "journal-title": "J. biol. Chem."
    },
    {
      "key": "BF343559a0_CR12",
      "first-page": "318",
      "volume": "50",
      "author": "PJ O'Brien",
      "year": "1986",
      "unstructured": "O'Brien, P. J. Can. J. vet Res. 50, 318\u2013328 (1986).",
      "journal-title": "Can. J. vet Res."
    },
    {
      "key": "BF343559a0_CR13",
      "doi-asserted-by": "crossref",
      "first-page": "2244",
      "DOI": "10.1016/S0021-9258(19)39968-5",
      "volume": "265",
      "author": "F Zorzato",
      "year": "1989",
      "unstructured": "Zorzato, F. et al. J. biol. Chem. 265, 2244\u20132256 (1989).",
      "journal-title": "J. biol. Chem."
    },
    {
      "key": "BF343559a0_CR14",
      "unstructured": "MacKenzie, A. E. et al. Am. J. hum. Genet. (submitted)."
    },
    {
      "key": "BF343559a0_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "562",
      "DOI": "10.1038/343562a0",
      "volume": "343",
      "author": "TV McCarthy",
      "year": "1990",
      "unstructured": "McCarthy, T. V. et al. Nature 343, 562\u2013564 (1990).",
      "journal-title": "Nature"
    },
    {
      "key": "BF343559a0_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "203",
      "DOI": "10.1111/j.1365-2052.1988.tb00809.x",
      "volume": "19",
      "author": "W Davies",
      "year": "1988",
      "unstructured": "Davies, W., Harbitz, I., Fries, R., Stranzinger, G. & Hauge, J. G. An. Genet. 19, 203\u2013212 (1988).",
      "journal-title": "An. Genet."
    },
    {
      "key": "BF343559a0_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "3324",
      "DOI": "10.1093/nar/17.8.3324",
      "volume": "17",
      "author": "H Smeets",
      "year": "1989",
      "unstructured": "Smeets, H. et al. Nucleic Acids Res. 17, 3324 (1989).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF343559a0_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "7137",
      "DOI": "10.1093/nar/14.17.7137",
      "volume": "14",
      "author": "T Hulsebos",
      "year": "1986",
      "unstructured": "Hulsebos, T., Westphal, H., Peek, R., Coerwinkel, M. & Wieringa, B. Nucleic Acids Res. 14, 7137 (1986).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF343559a0_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "3325",
      "DOI": "10.1093/nar/17.8.3325",
      "volume": "17",
      "author": "H Smeets",
      "year": "1989",
      "unstructured": "Smeets, H. et al. Nucleic Acids Res. 17, 3325 (1989).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF343559a0_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "8120",
      "DOI": "10.1093/nar/15.19.8120",
      "volume": "15",
      "author": "H Smeets",
      "year": "1987",
      "unstructured": "Smeets, H. et al. Nucleic Acids Res. 15, 8120 (1987).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF343559a0_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "3193",
      "DOI": "10.1093/nar/15.7.3193",
      "volume": "15",
      "author": "J Schepens",
      "year": "1987",
      "unstructured": "Schepens, J. et al. Nucleic Acids Res. 15, 3193 (1987).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF343559a0_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "3192",
      "DOI": "10.1093/nar/15.7.3192",
      "volume": "15",
      "author": "J Schepens",
      "year": "1987",
      "unstructured": "Schepens, J., Smeets, H., Hulsebos, T., Brunner, H. & Wieringa, B. Nucleic Acids Res. 15, 3192 (1987).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF343559a0_CR23",
      "first-page": "463",
      "volume": "1",
      "author": "SE Humphries",
      "year": "1983",
      "unstructured": "Humphries, S. E. et al. Molec. Biol. Med. 1, 463\u2013471 (1983).",
      "journal-title": "Molec. Biol. Med."
    },
    {
      "key": "BF343559a0_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "384",
      "DOI": "10.1016/0888-7543(89)90346-7",
      "volume": "4",
      "author": "D Schonk",
      "year": "1989",
      "unstructured": "Schonk, D. et al. Genomics 4, 384\u2013396 (1989).",
      "journal-title": "Genomics"
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/343559a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/343559a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/343559a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T01:54:46Z",
    "timestamp": 1684288486000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/343559a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1990,
        2
      ]
    ]
  },
  "references-count": 24,
  "journal-issue": {
    "issue": "6258",
    "published-print": {
      "date-parts": [
        [
          1990,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "BF343559a0"
  ],
  "URL": "http://dx.doi.org/10.1038/343559a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1990,
        2
      ]
    ]
  }
}