DOI: 10.1038/337283a0. Mutation rates differ among regions of the mammalian genome

Mutation rates differ among regions of the mammalian genome

10.1038/337283a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Wolfe, K. H., Sharp, P. M., & Li, W.-H. (1989). Mutation rates differ among regions of the mammalian genome. Nature, 337(6204), 283â285.

Authors 3

Kenneth H. Wolfe (first)
Paul M. Sharp (additional)
Wen-Hsiung Li (additional)

References 30 Referenced 427

Kimura, M. The Neutral Theory of Molecular Evolution (Cambridge University Press, 1983). (10.1017/CBO9780511623486) / The Neutral Theory of Molecular Evolution by M Kimura (1983)
Sharp, P. M. & Li, W.-H. Molec. biol. Evol. 4, 222–230 (1987). / Molec. biol. Evol. by PM Sharp (1987)
Aota, S. & Ikemura, T. Nucleic Acids Res. 14, 6345–6355 (1986). (10.1093/nar/14.16.6345) / Nucleic Acids Res. by S Aota (1986)
Bernardi, G. et al. Science 228, 953–958 (1985). (10.1126/science.4001930) / Science by G Bernardi (1985)
Li, W.-H., Tanimura, M. & Sharp, P. M. J. molec. Evol. 25, 330–342 (1987). (10.1007/BF02603118) / J. molec. Evol. by W-H Li (1987)
Li, W.-H., Gojobori, T. & Nei, M. Nature 292, 237–239 (1981). (10.1038/292237a0) / Nature by W-H Li (1981)
Miyata, T. & Hayashida, H. Proc. natn. Acad. Sci. U.S.A. 78, 5739–5743 (1981). (10.1073/pnas.78.9.5739) / Proc. natn. Acad. Sci. U.S.A. by T Miyata (1981)
Fukasawa, K. M. et al. Genetics 115, 177–184 (1987). (10.1093/genetics/115.1.177) / Genetics by KM Fukasawa (1987)
Miyata, T. et al. J. molec. Evol. 19, 28–35 (1982). (10.1007/BF02100221) / J. molec. Evol. by T Miyata (1982)
Filipski, J. J. theor. Biol. 134, 159–164 (1988). (10.1016/S0022-5193(88)80199-1) / J. theor. Biol. by J Filipski (1988)
Smithies, O., Engels, W. R., Devereux, J. R., Slightom, J. L. & Shen, S-h. Cell 26, 345–353 (1981). (10.1016/0092-8674(81)90203-8) / Cell by O Smithies (1981)
Mouchiroud, D. & Gautier, C. Molec. biol. Evol. 5, 192–194 (1988). / Molec. biol. Evol. by D Mouchiroud (1988)
Nadeau, J. H. & Taylor, B. A. Proc. natn. Acad. Sci. U.S.A. 81, 814–818 (1984). (10.1073/pnas.81.3.814) / Proc. natn. Acad. Sci. U.S.A. by JH Nadeau (1984)
Friedberg, E. C. DNA Repair (Freeman, New York, 1985). / DNA Repair by EC Friedberg (1985)
Topal, M. D. & Fresco, J. R. Nature 263, 285–289 (1976). (10.1038/263285a0) / Nature by MD Topal (1976)
Holmquist, G. P. Am. J. hum. Genet. 40, 151–173 (1987). / Am. J. hum. Genet. by GP Holmquist (1987)
Leeds, J. M., Slabaugh, M. B. & Mathews, C. K. Molec. cell Biol. 5, 3443–3450 (1985). (10.1128/MCB.5.12.3443) / Molec. cell Biol. by JM Leeds (1985)
Kelly, T. & Stillman, B. (eds) Cancer Cells 6: Eukaryotic DNA Replication (Cold Spring Harbor Laboratory, New York, 1988).
Fersht, A. R. & Knill-Jones, J. W. Proc. natn. Acad. Sci. U.S.A. 78, 4251–4255 (1981). (10.1073/pnas.78.7.4251) / Proc. natn. Acad. Sci. U.S.A. by AR Fersht (1981)
Holmquist, G., Gray, M., Porter, T. & Jordan, J. Cell 31, 121–129 (1982). (10.1016/0092-8674(82)90411-1) / Cell by G Holmquist (1982)
Brown, E. H. et al. Molec cell. Biol. 7, 450–457 (1987). (10.1128/MCB.7.1.450) / Molec cell. Biol. by EH Brown (1987)
Filipski, J. FEBS Lett. 217, 184–186 (1987). (10.1016/0014-5793(87)80660-9) / FEBS Lett. by J Filipski (1987)
Bohr, V. A., Phillips, D. H. & Hanawalt, P. C. Cancer Res. 47, 6426–6436 (1987). / Cancer Res. by VA Bohr (1987)
Prelich, G. & Stillman, B. Cell 53, 117–126 (1988). (10.1016/0092-8674(88)90493-X) / Cell by G Prelich (1988)
Bernardi, G. & Bernardi, G. J. molec. Evol. 24, 1–11 (1986). (10.1007/BF02099946) / J. molec. Evol. by G Bernardi (1986)
Gillespie, J. H. Genetics 113, 1077–1091 (1986). (10.1093/genetics/113.4.1077) / Genetics by JH Gillespie (1986)
Ikemura, T. Molec. biol Evol. 2, 13–34 (1985). / Molec. biol Evol. by T Ikemura (1985)
Hanai, R. & Wada, A. J. molec Evol. 27, 321–325 (1988). (10.1007/BF02101194) / J. molec Evol. by R Hanai (1988)
Nei, M. & Graur, D. Evol. Biol. 17, 73–118 (1984). (10.1007/978-1-4615-6974-9_3) / Evol. Biol. by M Nei (1984)
Tajima, F. & Nei, M. Molec. biol. Evol. 1, 269–285 (1984). / Molec. biol. Evol. by F Tajima (1984)

Dates

Type	When
Created	22 years, 2 months ago (June 12, 2003, 6:19 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 10 p.m.)
Indexed	2 days, 1 hour ago (Sept. 3, 2025, 6:10 a.m.)
Issued	36 years, 8 months ago (Jan. 1, 1989)
Published	36 years, 8 months ago (Jan. 1, 1989)
Published Print	36 years, 8 months ago (Jan. 1, 1989)

Funders 0

None

BibTeX

@article{Wolfe_1989, title={Mutation rates differ among regions of the mammalian genome}, volume={337}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/337283a0}, DOI={10.1038/337283a0}, number={6204}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Wolfe, Kenneth H. and Sharp, Paul M. and Li, Wen-Hsiung}, year={1989}, month=jan, pages={283–285} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:10:51Z",
    "timestamp": 1756894251218
  },
  "reference-count": 30,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6204",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1989,
            1,
            1
          ]
        ],
        "date-time": "1989-01-01T00:00:00Z",
        "timestamp": 599616000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1989,
        1
      ]
    ]
  },
  "DOI": "10.1038/337283a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        6,
        12
      ]
    ],
    "date-time": "2003-06-12T22:19:15Z",
    "timestamp": 1055456355000
  },
  "page": "283-285",
  "source": "Crossref",
  "is-referenced-by-count": 427,
  "title": "Mutation rates differ among regions of the mammalian genome",
  "prefix": "10.1038",
  "volume": "337",
  "author": [
    {
      "given": "Kenneth H.",
      "family": "Wolfe",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Paul M.",
      "family": "Sharp",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Wen-Hsiung",
      "family": "Li",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF337283a0_CR1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1017/CBO9780511623486",
      "volume-title": "The Neutral Theory of Molecular Evolution",
      "author": "M Kimura",
      "year": "1983",
      "unstructured": "Kimura, M. The Neutral Theory of Molecular Evolution (Cambridge University Press, 1983)."
    },
    {
      "key": "BF337283a0_CR2",
      "first-page": "222",
      "volume": "4",
      "author": "PM Sharp",
      "year": "1987",
      "unstructured": "Sharp, P. M. & Li, W.-H. Molec. biol. Evol. 4, 222\u2013230 (1987).",
      "journal-title": "Molec. biol. Evol."
    },
    {
      "key": "BF337283a0_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "6345",
      "DOI": "10.1093/nar/14.16.6345",
      "volume": "14",
      "author": "S Aota",
      "year": "1986",
      "unstructured": "Aota, S. & Ikemura, T. Nucleic Acids Res. 14, 6345\u20136355 (1986).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF337283a0_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "953",
      "DOI": "10.1126/science.4001930",
      "volume": "228",
      "author": "G Bernardi",
      "year": "1985",
      "unstructured": "Bernardi, G. et al. Science 228, 953\u2013958 (1985).",
      "journal-title": "Science"
    },
    {
      "key": "BF337283a0_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "330",
      "DOI": "10.1007/BF02603118",
      "volume": "25",
      "author": "W-H Li",
      "year": "1987",
      "unstructured": "Li, W.-H., Tanimura, M. & Sharp, P. M. J. molec. Evol. 25, 330\u2013342 (1987).",
      "journal-title": "J. molec. Evol."
    },
    {
      "key": "BF337283a0_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "237",
      "DOI": "10.1038/292237a0",
      "volume": "292",
      "author": "W-H Li",
      "year": "1981",
      "unstructured": "Li, W.-H., Gojobori, T. & Nei, M. Nature 292, 237\u2013239 (1981).",
      "journal-title": "Nature"
    },
    {
      "key": "BF337283a0_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "5739",
      "DOI": "10.1073/pnas.78.9.5739",
      "volume": "78",
      "author": "T Miyata",
      "year": "1981",
      "unstructured": "Miyata, T. & Hayashida, H. Proc. natn. Acad. Sci. U.S.A. 78, 5739\u20135743 (1981).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF337283a0_CR8",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1093/genetics/115.1.177",
      "volume": "115",
      "author": "KM Fukasawa",
      "year": "1987",
      "unstructured": "Fukasawa, K. M. et al. Genetics 115, 177\u2013184 (1987).",
      "journal-title": "Genetics"
    },
    {
      "key": "BF337283a0_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "28",
      "DOI": "10.1007/BF02100221",
      "volume": "19",
      "author": "T Miyata",
      "year": "1982",
      "unstructured": "Miyata, T. et al. J. molec. Evol. 19, 28\u201335 (1982).",
      "journal-title": "J. molec. Evol."
    },
    {
      "key": "BF337283a0_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "159",
      "DOI": "10.1016/S0022-5193(88)80199-1",
      "volume": "134",
      "author": "J Filipski",
      "year": "1988",
      "unstructured": "Filipski, J. J. theor. Biol. 134, 159\u2013164 (1988).",
      "journal-title": "J. theor. Biol."
    },
    {
      "key": "BF337283a0_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "345",
      "DOI": "10.1016/0092-8674(81)90203-8",
      "volume": "26",
      "author": "O Smithies",
      "year": "1981",
      "unstructured": "Smithies, O., Engels, W. R., Devereux, J. R., Slightom, J. L. & Shen, S-h. Cell 26, 345\u2013353 (1981).",
      "journal-title": "Cell"
    },
    {
      "key": "BF337283a0_CR12",
      "first-page": "192",
      "volume": "5",
      "author": "D Mouchiroud",
      "year": "1988",
      "unstructured": "Mouchiroud, D. & Gautier, C. Molec. biol. Evol. 5, 192\u2013194 (1988).",
      "journal-title": "Molec. biol. Evol."
    },
    {
      "key": "BF337283a0_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "814",
      "DOI": "10.1073/pnas.81.3.814",
      "volume": "81",
      "author": "JH Nadeau",
      "year": "1984",
      "unstructured": "Nadeau, J. H. & Taylor, B. A. Proc. natn. Acad. Sci. U.S.A. 81, 814\u2013818 (1984).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF337283a0_CR14",
      "volume-title": "DNA Repair",
      "author": "EC Friedberg",
      "year": "1985",
      "unstructured": "Friedberg, E. C. DNA Repair (Freeman, New York, 1985)."
    },
    {
      "key": "BF337283a0_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "285",
      "DOI": "10.1038/263285a0",
      "volume": "263",
      "author": "MD Topal",
      "year": "1976",
      "unstructured": "Topal, M. D. & Fresco, J. R. Nature 263, 285\u2013289 (1976).",
      "journal-title": "Nature"
    },
    {
      "key": "BF337283a0_CR16",
      "first-page": "151",
      "volume": "40",
      "author": "GP Holmquist",
      "year": "1987",
      "unstructured": "Holmquist, G. P. Am. J. hum. Genet. 40, 151\u2013173 (1987).",
      "journal-title": "Am. J. hum. Genet."
    },
    {
      "key": "BF337283a0_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "3443",
      "DOI": "10.1128/MCB.5.12.3443",
      "volume": "5",
      "author": "JM Leeds",
      "year": "1985",
      "unstructured": "Leeds, J. M., Slabaugh, M. B. & Mathews, C. K. Molec. cell Biol. 5, 3443\u20133450 (1985).",
      "journal-title": "Molec. cell Biol."
    },
    {
      "key": "BF337283a0_CR18",
      "unstructured": "Kelly, T. & Stillman, B. (eds) Cancer Cells 6: Eukaryotic DNA Replication (Cold Spring Harbor Laboratory, New York, 1988)."
    },
    {
      "key": "BF337283a0_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "4251",
      "DOI": "10.1073/pnas.78.7.4251",
      "volume": "78",
      "author": "AR Fersht",
      "year": "1981",
      "unstructured": "Fersht, A. R. & Knill-Jones, J. W. Proc. natn. Acad. Sci. U.S.A. 78, 4251\u20134255 (1981).",
      "journal-title": "Proc. natn. Acad. Sci. U.S.A."
    },
    {
      "key": "BF337283a0_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "121",
      "DOI": "10.1016/0092-8674(82)90411-1",
      "volume": "31",
      "author": "G Holmquist",
      "year": "1982",
      "unstructured": "Holmquist, G., Gray, M., Porter, T. & Jordan, J. Cell 31, 121\u2013129 (1982).",
      "journal-title": "Cell"
    },
    {
      "key": "BF337283a0_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "450",
      "DOI": "10.1128/MCB.7.1.450",
      "volume": "7",
      "author": "EH Brown",
      "year": "1987",
      "unstructured": "Brown, E. H. et al. Molec cell. Biol. 7, 450\u2013457 (1987).",
      "journal-title": "Molec cell. Biol."
    },
    {
      "key": "BF337283a0_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "184",
      "DOI": "10.1016/0014-5793(87)80660-9",
      "volume": "217",
      "author": "J Filipski",
      "year": "1987",
      "unstructured": "Filipski, J. FEBS Lett. 217, 184\u2013186 (1987).",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "BF337283a0_CR23",
      "first-page": "6426",
      "volume": "47",
      "author": "VA Bohr",
      "year": "1987",
      "unstructured": "Bohr, V. A., Phillips, D. H. & Hanawalt, P. C. Cancer Res. 47, 6426\u20136436 (1987).",
      "journal-title": "Cancer Res."
    },
    {
      "key": "BF337283a0_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "117",
      "DOI": "10.1016/0092-8674(88)90493-X",
      "volume": "53",
      "author": "G Prelich",
      "year": "1988",
      "unstructured": "Prelich, G. & Stillman, B. Cell 53, 117\u2013126 (1988).",
      "journal-title": "Cell"
    },
    {
      "key": "BF337283a0_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "1",
      "DOI": "10.1007/BF02099946",
      "volume": "24",
      "author": "G Bernardi",
      "year": "1986",
      "unstructured": "Bernardi, G. & Bernardi, G. J. molec. Evol. 24, 1\u201311 (1986).",
      "journal-title": "J. molec. Evol."
    },
    {
      "key": "BF337283a0_CR26",
      "doi-asserted-by": "crossref",
      "first-page": "1077",
      "DOI": "10.1093/genetics/113.4.1077",
      "volume": "113",
      "author": "JH Gillespie",
      "year": "1986",
      "unstructured": "Gillespie, J. H. Genetics 113, 1077\u20131091 (1986).",
      "journal-title": "Genetics"
    },
    {
      "key": "BF337283a0_CR27",
      "first-page": "13",
      "volume": "2",
      "author": "T Ikemura",
      "year": "1985",
      "unstructured": "Ikemura, T. Molec. biol Evol. 2, 13\u201334 (1985).",
      "journal-title": "Molec. biol Evol."
    },
    {
      "key": "BF337283a0_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "321",
      "DOI": "10.1007/BF02101194",
      "volume": "27",
      "author": "R Hanai",
      "year": "1988",
      "unstructured": "Hanai, R. & Wada, A. J. molec Evol. 27, 321\u2013325 (1988).",
      "journal-title": "J. molec Evol."
    },
    {
      "key": "BF337283a0_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "73",
      "DOI": "10.1007/978-1-4615-6974-9_3",
      "volume": "17",
      "author": "M Nei",
      "year": "1984",
      "unstructured": "Nei, M. & Graur, D. Evol. Biol. 17, 73\u2013118 (1984).",
      "journal-title": "Evol. Biol."
    },
    {
      "key": "BF337283a0_CR30",
      "first-page": "269",
      "volume": "1",
      "author": "F Tajima",
      "year": "1984",
      "unstructured": "Tajima, F. & Nei, M. Molec. biol. Evol. 1, 269\u2013285 (1984).",
      "journal-title": "Molec. biol. Evol."
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/337283a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/337283a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/337283a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T02:00:44Z",
    "timestamp": 1684288844000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/337283a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1989,
        1
      ]
    ]
  },
  "references-count": 30,
  "journal-issue": {
    "issue": "6204",
    "published-print": {
      "date-parts": [
        [
          1989,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "BF337283a0"
  ],
  "URL": "http://dx.doi.org/10.1038/337283a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1989,
        1
      ]
    ]
  }
}