DOI: 10.1038/335070a0. Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

10.1038/335070a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Hughes, S. M., Lillien, L. E., Raff, M. C., Rohrer, H., & Sendtner, M. (1988). Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture. Nature, 335(6185), 70â73.

Authors 5

Simon M. Hughes (first)
Laura E. Lillien (additional)
Martin C. Raff (additional)
Hermann Rohrer (additional)
Michael Sendtner (additional)

References 31 Referenced 280

Raff, M. C., Miller, R. & Noble, M. Nature 303, 390–396 (1983). (10.1038/303390a0) / Nature by MC Raff (1983)
ffrench-Constant, C. & Raff, M. C. Nature 323, 335–338 (1986). (10.1038/323335a0) / Nature by C ffrench-Constant (1986)
Miller, R. H., ffrench-Constant, C. & Raff, M. C. A. Rev. Neurosci. (in the press).
Raff, M. C., Abney, E. R. & Fok-Seang, J. Cell 42, 61–69 (1985). (10.1016/S0092-8674(85)80101-X) / Cell by MC Raff (1985)
Temple, S. & Raff, M. C. Nature 313, 223–225 (1985). (10.1038/313223a0) / Nature by S Temple (1985)
Hughes, S. M. & Raff, M. C. Development 101, 157–167 (1987). (10.1242/dev.101.1.157) / Development by SM Hughes (1987)
Bignami, A., Eng, L. F., Dahl, D. & Uyeda, C. T. Brain Res. 43, 429–435 (1972). (10.1016/0006-8993(72)90398-8) / Brain Res. by A Bignami (1972)
Barbin, G., Manthorpe, M. & Varon, S. J. Neurochem. 43, 1468–1478 (1984). (10.1111/j.1471-4159.1984.tb05410.x) / J. Neurochem. by G Barbin (1984)
Manthorpe, M., Skaper, S. D., Williams, L. R. & Varon, S. Brain Res. 367, 282–286 (1986). (10.1016/0006-8993(86)91603-3) / Brain Res. by M Manthorpe (1986)
Helfand, S., Smith, G. A. & Wessells, N. K. Devl Biol. 50, 541–547 (1976). (10.1016/0012-1606(76)90174-3) / Devl Biol. by S Helfand (1976)
Greene, L. A. & Shooter, E. M. A. Rev. Neurosci. 3, 353–402 (1980). (10.1146/annurev.ne.03.030180.002033) / A. Rev. Neurosci. by LA Greene (1980)
Levi-Montalcini, R. Science 237, 1154–1162 (1987). (10.1126/science.3306916) / Science by R Levi-Montalcini (1987)
Barde, Y.-A., Edgar, D. & Thoenen, H. EMBO J. 1, 549–553 (1982). (10.1002/j.1460-2075.1982.tb01207.x) / EMBO J. by Y-A Barde (1982)
Rudge, J. S., Davis, G. E., Manthorpe, M. & Varon, S. Devi Brain Res. 32, 103–110 (1987). (10.1016/0165-3806(87)90143-X) / Devi Brain Res. by JS Rudge (1987)
Richardson, W. D., Pringle, N., Mosley, M., Westermark, B. & Dubois-Dalcq, M. Cell 53, 309–319 (1988). (10.1016/0092-8674(88)90392-3) / Cell by WD Richardson (1988)
Miller, R. H., David, S., Patel, R., Abney, E. R. & Raff, M. C. Devl Biol. 111, 35–41 (1985). (10.1016/0012-1606(85)90432-4) / Devl Biol. by RH Miller (1985)
Lillien, L. E., Sendtner, M., Rohrer, H., Hughes, S. M. & Raff, M. C. Neuron (in the press).
Noble, M. & Murray, K. EMBO J. 3, 2243–2247 (1984). (10.1002/j.1460-2075.1984.tb02122.x) / EMBO J. by M Noble (1984)
Noble, M., Murray, K., Stroobant, P., Waterfield, M. & Riddle, P. Nature 333, 559–561 (1988). (10.1038/333560a0) / Nature by M Noble (1988)
Raff, M. C., Lillien, L. E., Richardson, W., Burnes, J. & Noble, M. Nature 333, 562–565 (1988). (10.1038/333562a0) / Nature by MC Raff (1988)
Rudge, J. S., Manthorpe, M. & Varon, S. Devl Brain Res. 19, 161–172 (1985). (10.1016/0165-3806(85)90188-9) / Devl Brain Res. by JS Rudge (1985)
Williams, B. P., Abney, E. R. & Raff, M. C. Devl Biol. 112, 126–134 (1985). (10.1016/0012-1606(85)90126-5) / Devl Biol. by BP Williams (1985)
Rohrer, H., Sendtner, M. & Ernsberger, U. Biol. Chem. Hoppe Seyler 368, 1290–1291 (1987). / Biol. Chem. Hoppe Seyler by H Rohrer (1987)
Bottenstein, J. E. & Sato, G. H. Proc. natn. Acad. Sci. U.S.A. 76, 514–517 (1979). (10.1073/pnas.76.1.514) / Proc. natn. Acad. Sci. U.S.A. by JE Bottenstein (1979)
Eisenbarth, G. S., Walsh, F. S. & Nirenberg, M. Proc. natn. Acad. Sci. U.S.A. 76, 4913–4917 (1979). (10.1073/pnas.76.10.4913) / Proc. natn. Acad. Sci. U.S.A. by GS Eisenbarth (1979)
Pruss, R. Nature 280, 688–690 (1979). (10.1038/280688a0) / Nature by R Pruss (1979)
Temple, S. & Raff, M. C. Cell 44, 773–779 (1986). (10.1016/0092-8674(86)90843-3) / Cell by S Temple (1986)
Harper, G. P. et al. Neuroscience 8, 375–387 (1983). (10.1016/0306-4522(83)90073-8) / Neuroscience by GP Harper (1983)
Laemmli, U. K. & Favre, M. J. molec. Biol. 80, 577–599 (1974). / J. molec. Biol. by UK Laemmli (1974)
Oakley, B. R., Kirsch, D. R. & Morris, N. R. Analyt. Biochem. 105, 361–363 (1980). (10.1016/0003-2697(80)90470-4) / Analyt. Biochem. by BR Oakley (1980)
Lemke, G. E. & Brockes, J. P. J. Neurosci. 4, 75–83 (1984). (10.1523/JNEUROSCI.04-01-00075.1984) / J. Neurosci. by GE Lemke (1984)

Dates

Type	When
Created	22 years, 2 months ago (June 12, 2003, 6:07 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 9:46 p.m.)
Indexed	1 day, 20 hours ago (Aug. 28, 2025, 8:37 a.m.)
Issued	36 years, 11 months ago (Sept. 1, 1988)
Published	36 years, 11 months ago (Sept. 1, 1988)
Published Online	36 years, 11 months ago (Sept. 1, 1988)
Published Print	36 years, 11 months ago (Sept. 1, 1988)

Funders 0

None

BibTeX

@article{Hughes_1988, title={Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture}, volume={335}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/335070a0}, DOI={10.1038/335070a0}, number={6185}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Hughes, Simon M. and Lillien, Laura E. and Raff, Martin C. and Rohrer, Hermann and Sendtner, Michael}, year={1988}, month=sep, pages={70–73} }

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