DOI: 10.1038/326347a0. Knowledge-based prediction of protein structures and the design of novel molecules

Knowledge-based prediction of protein structures and the design of novel molecules

10.1038/326347a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Blundell, T. L., Sibanda, B. L., Sternberg, M. J. E., & Thornton, J. M. (1987). Knowledge-based prediction of protein structures and the design of novel molecules. Nature, 326(6111), 347â352.

Authors 4

T. L. Blundell (first)
B. L. Sibanda (additional)
M. J. E. Sternberg (additional)
J. M. Thornton (additional)

References 74 Referenced 526

Blundell, T. L. et al. Phil. Trans. R. Soc. A 317, 333–344 (1986). (10.1098/rsta.1986.0043) / Phil. Trans. R. Soc. by TL Blundell (1986)
Porter, R. & Whelan, J. (eds) Synthetic Peptides as Antigens, CIBA Foundation Symposium 119 (Wiley, Avon, 1986).
Haddon, R. C. & Lamola, A. A. Proc. natn. Acad. Sci. U.S.A. 82, 1874–1878 (1985). (10.1073/pnas.82.7.1874) / Proc. natn. Acad. Sci. U.S.A. by RC Haddon (1985)
Wagner, G. & Wuthrich, K. J. molec. Biol. 155, 347–366 (1982). (10.1016/0022-2836(82)90009-2) / J. molec. Biol. by G Wagner (1982)
Winter, G. & Fersht, A. R. Trends Biotechnol. 2, 115–119 (1984). (10.1016/0167-7799(84)90019-2) / Trends Biotechnol. by G Winter (1984)
Richards, W. G. (ed.) J. molec. Graphics 4, 1–73 (1986). (10.1016/0263-7855(86)80036-4)
Brooks, B. & Karplus, M. Proc. natn. Acad. Sci. U.S.A. 80, 6571–6575 (1983). (10.1073/pnas.80.21.6571) / Proc. natn. Acad. Sci. U.S.A. by B Brooks (1983)
Kneale, G. G. & Bishop, M. J. Cabios Rev. 1, 11–17 (1985). / Cabios Rev. by GG Kneale (1985)
Needleman, S. B. & Wunsch, C. D. J. molec. Biol. 48, 443–453 (1970). (10.1016/0022-2836(70)90057-4) / J. molec. Biol. by SB Needleman (1970)
Sellers, P. J. appl. Math. 26, 787–793 (1974). / J. appl. Math. by P Sellers (1974)
Waterman, M. S., Smith, T. F. & Beyer, W. A. Adv. Math. 20, 367–387 (1976). (10.1016/0001-8708(76)90202-4) / Adv. Math. by MS Waterman (1976)
Fitch, W. M. & Smith, T. F. Proc. natn. Acad. Sci. U.S.A. 80, 1382–2386 (1983). (10.1073/pnas.80.5.1382) / Proc. natn. Acad. Sci. U.S.A. by WM Fitch (1983)
Barton, G. & Sternberg, M. J. E. Protein Engng (in the press).
Lesk, A., Levitt, M. & Chothia, C. Protein Engng 1, 77–78 (1987). (10.1093/protein/1.1.77) / Protein Engng by A Lesk (1987)
Gooad, W. B. & Kanehisa, M. I. Nucleic Acids Res. 10, 247–263 (1982). (10.1093/nar/10.1.247) / Nucleic Acids Res. by WB Gooad (1982)
Sellers, P. Proc. natn. Acad. Sci. U.S.A. 76, 3041–3044 (1979). (10.1073/pnas.76.7.3041) / Proc. natn. Acad. Sci. U.S.A. by P Sellers (1979)
Boswell, D. R. & McLachlan, A. D. Nucleic Acids Res. 12, 457–464 (1984). (10.1093/nar/12.1Part2.457) / Nucleic Acids Res. by DR Boswell (1984)
Taylor, W. R. J. molec. Biol. 188, 233–258 (1986). (10.1016/0022-2836(86)90308-6) / J. molec. Biol. by WR Taylor (1986)
Bajaj, M. & Blundell, T. L. A. Rev. Biophys. Bioengng 13, 453–492 (1984). (10.1146/annurev.bb.13.060184.002321) / A. Rev. Biophys. Bioengng by M Bajaj (1984)
Greer, J. J. molec. Biol. 153, 1027–1042 (1981). (10.1016/0022-2836(81)90465-4) / J. molec. Biol. by J Greer (1981)
Richardson, J. S., Getzoff, E. D. & Richardson, D. C. Proc. natn. Acad. Sci. U.S.A. 75, 2574–2578 (1978). (10.1073/pnas.75.6.2574) / Proc. natn. Acad. Sci. U.S.A. by JS Richardson (1978)
Cutfield, J. F. et al. in Structural Studies on Molecules of Biological Interest (ed. Dodson, G. C.) 501–508 (Clarendon Press, Oxford, 1981). / Structural Studies on Molecules of Biological Interest by JF Cutfield (1981)
Lesk, A. M. & Chothia, C. J. molec. Biol. 136, 225–270 (1980). (10.1016/0022-2836(80)90373-3) / J. molec. Biol. by AM Lesk (1980)
Lesk, A. M. & Chothia, C. J. molec. Biol. 160, 325–342 (1982). (10.1016/0022-2836(82)90179-6) / J. molec. Biol. by AM Lesk (1982)
Chothia, C. & Lesk, A. M. J. molec. Biol. 160, 309–323 (1982). (10.1016/0022-2836(82)90178-4) / J. molec. Biol. by C Chothia (1982)
Chothia, C. & Lesk, A. M. EMBO J. 5, 823–826 (1986). (10.1002/j.1460-2075.1986.tb04288.x) / EMBO J. by C Chothia (1986)
Hubbard, T. & Blundell, T. L. Prot. Engng (submitted).
Browne, W. J. et al. J. molec. Biol. 120, 97–120 (1969). / J. molec. Biol. by WJ Browne (1969)
Jones, A. T. J. appl. Cryst. 11, 268–272 (1978). (10.1107/S0021889878013308) / J. appl. Cryst. by AT Jones (1978)
Palmer, K. A., Scheraga, H. A., Riordan, J. F. & Vallee, R. Z. Proc. natn. Acad. Sci. U.S.A. 83, 1965–1969 (1986). (10.1073/pnas.83.7.1965) / Proc. natn. Acad. Sci. U.S.A. by KA Palmer (1986)
Isaacs, N. et al. Nature 271, 278–281 (1978). (10.1038/271278a0) / Nature by N Isaacs (1978)
Bedarkar, S. et al. Nature 270, 449–451 (1977). (10.1038/270449a0) / Nature by S Bedarkar (1977)
Blundell, T. L., Bedarkar, S. & Humbel, R. E. Proc. natn. Acad. Sci. U.S.A. 75, 180–184 (1978). (10.1073/pnas.75.1.180) / Proc. natn. Acad. Sci. U.S.A. by TL Blundell (1978)
Travers, P. et al. Nature 310, 235–278 (1984). (10.1038/310235a0) / Nature by P Travers (1984)
Blundell, T. L., Sibanda, B. L. & Pearl, L. H. Nature 304, 273–275 (1983). (10.1038/304273a0) / Nature by TL Blundell (1983)
Sibanda, B. L. et al. FEBS Lett. 174, 103–111 (1984). (10.1016/0014-5793(84)81086-8) / FEBS Lett. by BL Sibanda (1984)
Carlson, W., Karplus, M. & Haber, E. Hypertension 7, 13–26 (1985). (10.1161/01.HYP.7.1.13) / Hypertension by W Carlson (1985)
Akahone, P. et al. Hypertension 7, 3–12 (1985). (10.1161/01.HYP.7.1.3) / Hypertension by P Akahone (1985)
Chothia, C. et al. Science 233, 755–758 (1986). (10.1126/science.3090684) / Science by C Chothia (1986)
La Paz, P., Sutton, B. R., Darsley, M. J. & Rees, A. R. EMBO J. 5, 415–425 (1986). (10.1002/j.1460-2075.1986.tb04227.x) / EMBO J. by P La Paz (1986)
Ripka, W. C. Nature 321, 93–94 (1986). (10.1038/321093a0) / Nature by WC Ripka (1986)
O'Neil, K. & De Grado, W. F. Proc. natn. Acad. Sci. U.S.A. 82, 4954–4958 (1985). (10.1073/pnas.82.15.4954) / Proc. natn. Acad. Sci. U.S.A. by K O'Neil (1985)
Sutcliffe, M. & Haneef, I. Inf. Q. Prot. Cryst. 18, 11–18 (1986). / Inf. Q. Prot. Cryst. by M Sutcliffe (1986)
Read, R. J., Fujinaga, M., Sielecki, A. R. & James, M. N. G. Biochemistry 22, 4420–4433 (1983). (10.1021/bi00288a012) / Biochemistry by RJ Read (1983)
Read, R. J., Brayer, G. D., Jarasek, L. & James, M. N. G. Biochemistry 23, 6570–6575 (1984). (10.1021/bi00321a045) / Biochemistry by RJ Read (1984)
Sibanda, B. L. & Thornton, J. M. Nature 316, 170–174 (1985). (10.1038/316170a0) / Nature by BL Sibanda (1985)
Edwards, M., Sternberg, M. J. E. & Thornton, J. M. Prot. Engng (in the press).
Moult, J. & James, M. N. Proteins 2, 146–163 (1986). (10.1002/prot.340010207) / Proteins by J Moult (1986)
Milner-White, J. & Poet, R. Biochem. J. 240, 289–292 (1986). (10.1042/bj2400289) / Biochem. J. by J Milner-White (1986)
Sibanda, B. L. thesis, Univ. London (1986).
Jones, T. A. & Sirup, T. EMBO J. 5, 819–822 (1986). (10.1002/j.1460-2075.1986.tb04287.x) / EMBO J. by TA Jones (1986)
Crippen, G. M. in Chemometric Research Studies Series Vol. 1 (ed. Bandan, D.) 1–58 (Wiley, New York, 1981). / Chemometric Research Studies Series by GM Crippen (1981)
Weiner, S. J. et al. J. Am. chem. Soc. 106, 765–784 (1984). (10.1021/ja00315a051) / J. Am. chem. Soc. by SJ Weiner (1984)
Brooks, B. R. J. Computation Chem. 4, 187–217 (1983). (10.1002/jcc.540040211) / J. Computation Chem. by BR Brooks (1983)
Shih, H. L., Brady, J. & Karplus, M. Proc. natn. Acad. Sci. U.S.A. 82, 1697–1700 (1985). (10.1073/pnas.82.6.1697) / Proc. natn. Acad. Sci. U.S.A. by HL Shih (1985)
Hagler, A. T. & Moult, J. Nature 272, 222–227 (1979). (10.1038/272222a0) / Nature by AT Hagler (1979)
Wodak, S. J., Alard, P., Delhouse, P. & Renneboog-Squilbin, C., J. molec. Biol. 181, 317–322 (1984). (10.1016/0022-2836(85)90095-6) / J. molec. Biol. by SJ Wodak (1984)
Robson, B. & Platt, E. J. molec. Biol. 188, 259–281. (10.1016/0022-2836(86)90309-8)
Summers, L. D. et al. Expl Eye Res. 43, 77–92 (1986). (10.1016/S0014-4835(86)80047-1) / Expl Eye Res. by LD Summers (1986)
Driessen, H. P. C. & White, H. in Molecular Replacement (ed. Machin, P. A.) 27–32 (Daresbury Laboratory, Daresbury, 1985). / Molecular Replacement by HPC Driessen (1985)
Amit, A. G. et al. Science 233, 747–753 (1986). (10.1126/science.2426778) / Science by AG Amit (1986)
Novotny, J., Bruccoleri, R. & Karplus, M. J. molec. Biol. 177, 787–818 (1984). (10.1016/0022-2836(84)90049-4) / J. molec. Biol. by J Novotny (1984)
Banner et al. Nature 255, 609–614 (1975). (10.1038/255609a0) / Nature by Banner (1975)
Abad-Zapatero, C. et al. Nature 286, 33–39 (1980). (10.1038/286033a0) / Nature by C Abad-Zapatero (1980)
Wistow, G., Summers, L. J. & Blundell, T. L. Nature 315, 771–773 (1985). (10.1038/315771a0) / Nature by G Wistow (1985)
Wieranga, R. K. & Hol, W. G. Nature 302, 842–844 (1983). (10.1038/302842a0) / Nature by RK Wieranga (1983)
Sternberg, M. J. E. & Taylor, W. R. FEBS Lett. 175, 387–392 (1984). (10.1016/0014-5793(84)80774-7) / FEBS Lett. by MJE Sternberg (1984)
Neuberger, M. S., Williams, G. T. & Fox, R. O. Nature 312, 604–608 (1984). (10.1038/312604a0) / Nature by MS Neuberger (1984)
Hemmings, A., Foundling, S., Sibanda, B. L., Wood, S. P. & Blundell, T. L. Trans. Biochem. Soc. 13, 1036–1041 (1985). (10.1042/bst0131036) / Trans. Biochem. Soc. by A Hemmings (1985)
Thomas, K. A., Smith, G. M., Thomas, T. J. & Feldmann, R. J., Proc. natn. Acad. Sci. 79, 4843–4847 (1982). (10.1073/pnas.79.16.4843) / Proc. natn. Acad. Sci. by KA Thomas (1982)
Reid, K. S. C., Lindley, P. F. & Thornton, J. M. FEBS Lett. 190, 209–213 (1985). (10.1016/0014-5793(85)81285-0) / FEBS Lett. by KSC Reid (1985)
Singh, J. & Thornton, J. M. FEBS Lett. 191, 1–6 (1985). (10.1016/0014-5793(85)80982-0) / FEBS Lett. by J Singh (1985)
Nussenzweig, V. & Nussenzweig, R. in Ciba Foundation Symposium 119 (eds Porter, R. & Whelan, J.) 150–163 (Wiley, Avon, 1986). / Ciba Foundation Symposium by V Nussenzweig (1986)
Geysen, H. M., Rodda, S. J. & Mason, T. J. in Ciba Foundation Symposium 119 (eds Porter, R. & Whelan, J.) 130–149 (Wiley, Avon, 1986). / Ciba Foundation Symposium by HM Geysen (1986)

Dates

Type	When
Created	22 years, 2 months ago (June 12, 2003, 5:17 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 9:05 p.m.)
Indexed	3 weeks, 1 day ago (Aug. 2, 2025, 12:50 a.m.)
Issued	38 years, 5 months ago (March 1, 1987)
Published	38 years, 5 months ago (March 1, 1987)
Published Print	38 years, 5 months ago (March 1, 1987)

Funders 0

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BibTeX

@article{Blundell_1987, title={Knowledge-based prediction of protein structures and the design of novel molecules}, volume={326}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/326347a0}, DOI={10.1038/326347a0}, number={6111}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Blundell, T. L. and Sibanda, B. L. and Sternberg, M. J. E. and Thornton, J. M.}, year={1987}, month=mar, pages={347–352} }

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      "year": "1986",
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    },
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      "author": "TA Jones",
      "year": "1986",
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      "first-page": "1",
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      "volume": "106",
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      "year": "1984",
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    },
    {
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      "doi-asserted-by": "publisher",
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      "DOI": "10.1002/jcc.540040211",
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    {
      "key": "BF326347a0_CR55",
      "doi-asserted-by": "publisher",
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      "author": "HL Shih",
      "year": "1985",
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      "volume": "272",
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      "year": "1979",
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    },
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    {
      "key": "BF326347a0_CR59",
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      "author": "LD Summers",
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      "DOI": "10.1126/science.2426778",
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      "author": "J Novotny",
      "year": "1984",
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      "year": "1983",
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      "year": "1984",
      "unstructured": "Sternberg, M. J. E. & Taylor, W. R. FEBS Lett. 175, 387\u2013392 (1984).",
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    },
    {
      "key": "BF326347a0_CR68",
      "doi-asserted-by": "publisher",
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    },
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