DOI: 10.1038/31159. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

10.1038/31159

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., â¦ Barrell, B. G. (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature, 393(6685), 537â544.

Authors 42

S. T. Cole (first)
R. Brosch (additional)
J. Parkhill (additional)
T. Garnier (additional)
C. Churcher (additional)
D. Harris (additional)
S. V. Gordon (additional)
K. Eiglmeier (additional)
S. Gas (additional)
C. E. Barry (additional)
F. Tekaia (additional)
K. Badcock (additional)
D. Basham (additional)
D. Brown (additional)
T. Chillingworth (additional)
R. Connor (additional)
R. Davies (additional)
K. Devlin (additional)
T. Feltwell (additional)
S. Gentles (additional)
N. Hamlin (additional)
S. Holroyd (additional)
T. Hornsby (additional)
K. Jagels (additional)
A. Krogh (additional)
J. McLean (additional)
S. Moule (additional)
L. Murphy (additional)
K. Oliver (additional)
J. Osborne (additional)
M. A. Quail (additional)
M.-A. Rajandream (additional)
J. Rogers (additional)
S. Rutter (additional)
K. Seeger (additional)
J. Skelton (additional)
R. Squares (additional)
S. Squares (additional)
J. E. Sulston (additional)
K. Taylor (additional)
S. Whitehead (additional)
B. G. Barrell (additional)

References 50 Referenced 6,355

Snider, D. E. J, Raviglione, M. & Kochi, A. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 2–11 (Am. Soc. Microbiol., Washington DC, (1994). / Tuberculosis: Pathogenesis, Protection, and Control by DEJ Snider (1994)
Wheeler, P. R. & Ratledge, C. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 353–385 (Am. Soc. Microbiol., Washington DC, (1994). (10.1128/9781555818357.ch23) / Tuberculosis: Pathogenesis, Protection, and Control by PR Wheeler (1994)
Chan, J. & Kaufmann, S. H. E. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 271– 284 (Am. Soc. Microbiol., Washington DC, (1994). / Tuberculosis: Pathogenesis, Protection, and Control by J Chan (1994)
Brennan, P. J. & Draper, P. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 271–284 (Am. Soc. Microbiol., Washington DC, (1994). (10.1128/9781555818357.ch19) / Tuberculosis: Pathogenesis, Protection, and Control by PJ Brennan (1994)
Kolattukudy, P. E., Fernandes, N. D., Azad, A. K., Fitzmaurice, A. M. & Sirakova, T. D. Biochemistry and molecular genetics of cell-wall lipid biosynthesis in mycobacteria. Mol. Microbiol. 24, 263–270 (1997). (10.1046/j.1365-2958.1997.3361705.x) / Mol. Microbiol. by PE Kolattukudy (1997)
Sreevatsan, S.et al. Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination. Proc. Natl Acad. Sci. USA 94, 9869– 9874 (1997). (10.1073/pnas.94.18.9869) / Proc. Natl Acad. Sci. USA by S Sreevatsan (1997)
Brosch, R.et al. Use of a Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing and comparative genomics. Infect. Immun. 66, 2221– 2229 (1998). (10.1128/IAI.66.5.2221-2229.1998) / Infect. Immun. by R Brosch (1998)
Philipp, W. J.et al. An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae. Proc. Natl Acad. Sci. USA 93, 3132–3137 (1996). (10.1073/pnas.93.7.3132) / Proc. Natl Acad. Sci. USA by WJ Philipp (1996)
Blattner, F. R.et al . The complete genome sequence of Escherichia coli K-12. Science 277, 1453– 1462 (1997). (10.1126/science.277.5331.1453) / Science by FR Blattner (1997)
Cole, S. T. & Saint-Girons, I. Bacterial genomics. FEMS Microbiol. Rev. 14, 139–160 (1994). (10.1111/j.1574-6976.1994.tb00084.x) / FEMS Microbiol. Rev. by ST Cole (1994)
Freiberg, C.et al. Molecular basis of symbiosis between Rhizobium and legumes. Nature 387, 394–401 (1997). (10.1038/387394a0) / Nature by C Freiberg (1997)
Bardarov, S.et al. Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 94, 10961–10966 (1997). (10.1073/pnas.94.20.10961) / Proc. Natl Acad. Sci. USA by S Bardarov (1997)
Mahairas, G. G., Sabo, P. J., Hickey, M. J., Singh, D. C. & Stover, C. K. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis . J. Bacteriol. 178, 1274– 1282 (1996). (10.1128/jb.178.5.1274-1282.1996) / J. Bacteriol. by GG Mahairas (1996)
Kunst, F.et al. The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature 390, 249– 256 (1997). (10.1038/36786) / Nature by F Kunst (1997)
Smith, D. R.et al. Multiplex sequencing of 1.5 Mb of the Mycobacterium leprae genome. Genome Res. 7, 802– 819 (1997). (10.1101/gr.7.8.802) / Genome Res. by DR Smith (1997)
Greenacre, M. Theory and Application of Correspondence Analysis (Academic, London, (1984). / Theory and Application of Correspondence Analysis by M Greenacre (1984)
Ratledge, C. R. in The Biology of the Mycobacteria (eds Ratledge, C. & Stanford, J.) 53–94 (Academic, San Diego, (1982). / The Biology of the Mycobacteria by CR Ratledge (1982)
Av-Gay, Y. & Davies, J. Components of eukaryotic-like protein signaling pathways in Mycobacterium tuberculosis. Microb. Comp. Genomics 2, 63–73 (1997). (10.1089/omi.1.1997.2.63) / Microb. Comp. Genomics by Y Av-Gay (1997)
Cole, S. T. & Telenti, A. Drug resistance in Mycobacterium tuberculosis. Eur. Resp. Rev. 8, 701 S–713S (1995). (10.1183/09031936.95.08050701) / Eur. Resp. Rev. by ST Cole (1995)
Riley, M. & Labedan, B. in Escherichia coli and Salmonella (ed. Neidhardt, F. C.) 2118–2202 (ASM, Washington, (1996). / Escherichia coli and Salmonella by M Riley (1996)
Mdluli, K.et al. Inhibition of a Mycobacterium tuberculosis β-ketoacyl ACP synthase by isoniazid. Science 280, 1607–1610 (1998). (10.1126/science.280.5369.1607) / Science by K Mdluli (1998)
Banerjee, A.et al. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263, 227–230 (1994). (10.1126/science.8284673) / Science by A Banerjee (1994)
Hopwood, D. A. Genetic contributions to understanding polyketide synthases. Chem. Rev. 97, 2465–2497 ( 1997). (10.1021/cr960034i) / Chem. Rev. by DA Hopwood (1997)
Minnikin, D. E. in The Biology of the Mycobacteria (eds Ratledge, C. & Stanford, J.) 95–184 (Academic, London, (1982). / The Biology of the Mycobacteria by DE Minnikin (1982)
Barry, C. E. IIet al . Mycolic acids: structure, biosynthesis, and phsyiological functions. Prog. Lipid Res.(in the press).
Belisle, J. T.et al . Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 276, 1420–1422 (1997). (10.1126/science.276.5317.1420) / Science by JT Belisle (1997)
Marahiel, M. A., Stachelhaus, T. & Mootz, H. D. Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem. Rev. 97, 2651– 2673 (1997). (10.1021/cr960029e) / Chem. Rev. by MA Marahiel (1997)
Gobin, J.et al. Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl Acad. Sci. USA 92, 5189–5193 (1995). (10.1073/pnas.92.11.5189) / Proc. Natl Acad. Sci. USA by J Gobin (1995)
Young, D. B. & Fruth, U. in New Generation Vaccines (eds Levine, M., Woodrow, G., Kaper, J. & Cobon, G. S.) 631– 645 (Marcel Dekker, New York, (1997). / New Generation Vaccines by DB Young (1997)
Sorensen, A. L., Nagai, S., Houen, G., Andersen, P. & Anderson, A. B. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect. Immun. 63, 1710–1717 (1995). (10.1128/IAI.63.5.1710-1717.1995) / Infect. Immun. by AL Sorensen (1995)
Hermans, P. W. M., van Soolingen, D. & van Embden, J. D. A. Characterization of a major polymorphic tandem repeat in Mycobacterium tuberculosis and its potential use in the epidemiology of Mycobacterium kansasii and Mycobacterium gordonae. J. Bacteriol. 174, 4157–4165 (1992). (10.1128/jb.174.12.4157-4165.1992) / J. Bacteriol. by PWM Hermans (1992)
Poulet, S. & Cole, S. T. Characterisation of the polymorphic GC-rich repetitive sequence (PGRS) present in Mycobacterium tuberculosis . Arch. Microbiol. 163, 87– 95 (1995). (10.1007/BF00381781) / Arch. Microbiol. by S Poulet (1995)
Cole, S. T. & Barrell, B. G. in Genetics and Tuberculosis (eds Chadwick, D. J. & Cardew, G., Novartis Foundation Symp. 217 ) 160–172 (Wiley, Chichester, ( 1998). (10.1002/0470846526.ch12) / Genetics and Tuberculosis by ST Cole (1998)
Vega-Lopez, F.et al . Sequence and immunological characterization of a serine-rich antigen from Mycobacterium leprae. Infect. Immun. 61, 2145–2153 (1993). (10.1128/IAI.61.5.2145-2153.1993) / Infect. Immun. by F Vega-Lopez (1993)
Abou-Zeid, C.et al. Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding proteins. Infect. Immun. 59 , 2712–2718 (1991). (10.1128/IAI.59.8.2712-2718.1991) / Infect. Immun. by C Abou-Zeid (1991)
Robertson, B. D. & Meyer, T. F. Genetic variation in pathogenic bacteria. Trends Genet. 8, 422–427 (1992). (10.1016/0168-9525(92)90325-X) / Trends Genet. by BD Robertson (1992)
Levitskaya, J.et al . Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 375, 685–688 (1995). (10.1038/375685a0) / Nature by J Levitskaya (1995)
Levitskaya, J., Sharipo, A., Leonchiks, A., Ciechanover, A. & Masucci, M. G. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc. Natl Acad. Sci. USA 94, 12616–12621 (1997). (10.1073/pnas.94.23.12616) / Proc. Natl Acad. Sci. USA by J Levitskaya (1997)
Flynn, J. L., Goldstein, M. A., Treibold, K. J., Koller, B. & Bloom, B. R. Major histocompatability complex class-I restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl Acad. Sci. USA 89, 12013–12017 (1992). (10.1073/pnas.89.24.12013) / Proc. Natl Acad. Sci. USA by JL Flynn (1992)
Bloom, B. R. & Fine, P. E. M. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 531– 557 (Am. Soc. Microbiol., Washington DC, (1994). (10.1128/9781555818357.ch31) / Tuberculosis: Pathogenesis, Protection, and Control by BR Bloom (1994)
Collins, D. M. In search of tuberculosis virulence genes. Trends Microbiol. 4, 426–430 (1996). (10.1016/0966-842X(96)10066-4) / Trends Microbiol. by DM Collins (1996)
Arruda, S., Bomfim, G., Knights, R., Huima-Byron, T. & Riley, L. W. Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells. Science 261, 1454–1457 (1993). (10.1126/science.8367727) / Science by S Arruda (1993)
Baumler, A. J., Kusters, J. G., Stojikovic, I. & Heffron, F. Salmonella typhimurium loci involved in survival within macrophages. Infect. Immun. 62, 1623–1630 (1994). (10.1128/IAI.62.5.1623-1630.1994) / Infect. Immun. by AJ Baumler (1994)
McMurray, A. A., Sulston, J. E. & Quail, M. A. Short-insert libraries as a method of problem solving in genome sequencing. Genome Res. 8, 562 –566 (1998). (10.1101/gr.8.5.562) / Genome Res. by AA McMurray (1998)
Bonfield, J. K., Smith, K. F. & Staden, R. Anew DNA sequence assembly program. Nucleic Acids Res. 24, 4992–4999 (1995). (10.1093/nar/23.24.4992) / Nucleic Acids Res. by JK Bonfield (1995)
Krogh, A., Mian, I. S. & Haussler, D. Ahidden Markov model that finds genes in E. coli DNA. Nucleic Acids Res. 22, 4768– 4778 (1994). (10.1093/nar/22.22.4768) / Nucleic Acids Res. by A Krogh (1994)
Bairoch, A., Bucher, P. & Hofmann, K. The PROSITE database, its status in 1997. Nucleic Acids Res. 25, 217–221 (1997). (10.1093/nar/25.1.217) / Nucleic Acids Res. by A Bairoch (1997)
Altschul, S., Gish, W., Miller, W., Myers, E. & Lipman, D. Abasic local alignment search tool. J. Mol. Biol. 215, 403–410 ( 1990). (10.1016/S0022-2836(05)80360-2) / J. Mol. Biol. by S Altschul (1990)
Pearson, W. & Lipman, D. Improved tools for biological sequence comparisons. Proc. Natl Acad. USA 85, 2444 –2448 (1988). (10.1073/pnas.85.8.2444) / Proc. Natl Acad. USA by W Pearson (1988)
Lowe, T. M. & Eddy, S. R. tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic DNA. Nucleic Acids Res. 25, 955–964 ( 1997). (10.1093/nar/25.5.955) / Nucleic Acids Res. by TM Lowe (1997)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:33 a.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 8:59 p.m.)
Indexed	3 hours, 42 minutes ago (Sept. 3, 2025, 6:50 a.m.)
Issued	27 years, 3 months ago (June 1, 1998)
Published	27 years, 3 months ago (June 1, 1998)
Published Print	27 years, 3 months ago (June 1, 1998)

Funders 0

None

BibTeX

@article{Cole_1998, title={Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence}, volume={393}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/31159}, DOI={10.1038/31159}, number={6685}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Cole, S. T. and Brosch, R. and Parkhill, J. and Garnier, T. and Churcher, C. and Harris, D. and Gordon, S. V. and Eiglmeier, K. and Gas, S. and Barry, C. E. and Tekaia, F. and Badcock, K. and Basham, D. and Brown, D. and Chillingworth, T. and Connor, R. and Davies, R. and Devlin, K. and Feltwell, T. and Gentles, S. and Hamlin, N. and Holroyd, S. and Hornsby, T. and Jagels, K. and Krogh, A. and McLean, J. and Moule, S. and Murphy, L. and Oliver, K. and Osborne, J. and Quail, M. A. and Rajandream, M.-A. and Rogers, J. and Rutter, S. and Seeger, K. and Skelton, J. and Squares, R. and Squares, S. and Sulston, J. E. and Taylor, K. and Whitehead, S. and Barrell, B. G.}, year={1998}, month=jun, pages={537–544} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:50:21Z",
    "timestamp": 1756896621182
  },
  "reference-count": 50,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6685",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1998,
            6,
            1
          ]
        ],
        "date-time": "1998-06-01T00:00:00Z",
        "timestamp": 896659200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    },
    {
      "start": {
        "date-parts": [
          [
            1998,
            6,
            1
          ]
        ],
        "date-time": "1998-06-01T00:00:00Z",
        "timestamp": 896659200000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [
      "link.springer.com"
    ],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  },
  "DOI": "10.1038/31159",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T08:33:27Z",
    "timestamp": 1027672407000
  },
  "page": "537-544",
  "update-policy": "http://dx.doi.org/10.1007/springer_crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 6355,
  "title": "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence",
  "prefix": "10.1038",
  "volume": "393",
  "author": [
    {
      "given": "S. T.",
      "family": "Cole",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "R.",
      "family": "Brosch",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.",
      "family": "Parkhill",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "T.",
      "family": "Garnier",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C.",
      "family": "Churcher",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "D.",
      "family": "Harris",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S. V.",
      "family": "Gordon",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K.",
      "family": "Eiglmeier",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Gas",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "suffix": "III",
      "given": "C. E.",
      "family": "Barry",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "F.",
      "family": "Tekaia",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K.",
      "family": "Badcock",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "D.",
      "family": "Basham",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "D.",
      "family": "Brown",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "T.",
      "family": "Chillingworth",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "R.",
      "family": "Connor",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "R.",
      "family": "Davies",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K.",
      "family": "Devlin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "T.",
      "family": "Feltwell",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Gentles",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "N.",
      "family": "Hamlin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Holroyd",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "T.",
      "family": "Hornsby",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K.",
      "family": "Jagels",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.",
      "family": "Krogh",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.",
      "family": "McLean",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Moule",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "L.",
      "family": "Murphy",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K.",
      "family": "Oliver",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.",
      "family": "Osborne",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M. A.",
      "family": "Quail",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M.-A.",
      "family": "Rajandream",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.",
      "family": "Rogers",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Rutter",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K.",
      "family": "Seeger",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.",
      "family": "Skelton",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "R.",
      "family": "Squares",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Squares",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J. E.",
      "family": "Sulston",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K.",
      "family": "Taylor",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S.",
      "family": "Whitehead",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "B. G.",
      "family": "Barrell",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF31159_CR1",
      "first-page": "2",
      "volume-title": "Tuberculosis: Pathogenesis, Protection, and Control",
      "author": "DEJ Snider",
      "year": "1994",
      "unstructured": "Snider, D. E. J, Raviglione, M. & Kochi, A. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 2\u201311 (Am. Soc. Microbiol., Washington DC, (1994)."
    },
    {
      "key": "BF31159_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "353",
      "DOI": "10.1128/9781555818357.ch23",
      "volume-title": "Tuberculosis: Pathogenesis, Protection, and Control",
      "author": "PR Wheeler",
      "year": "1994",
      "unstructured": "Wheeler, P. R. & Ratledge, C. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 353\u2013385 (Am. Soc. Microbiol., Washington DC, (1994)."
    },
    {
      "key": "BF31159_CR3",
      "first-page": "271",
      "volume-title": "Tuberculosis: Pathogenesis, Protection, and Control",
      "author": "J Chan",
      "year": "1994",
      "unstructured": "Chan, J. & Kaufmann, S. H. E. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 271\u2013 284 (Am. Soc. Microbiol., Washington DC, (1994)."
    },
    {
      "key": "BF31159_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "271",
      "DOI": "10.1128/9781555818357.ch19",
      "volume-title": "Tuberculosis: Pathogenesis, Protection, and Control",
      "author": "PJ Brennan",
      "year": "1994",
      "unstructured": "Brennan, P. J. & Draper, P. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 271\u2013284 (Am. Soc. Microbiol., Washington DC, (1994)."
    },
    {
      "key": "BF31159_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "263",
      "DOI": "10.1046/j.1365-2958.1997.3361705.x",
      "volume": "24",
      "author": "PE Kolattukudy",
      "year": "1997",
      "unstructured": "Kolattukudy, P. E., Fernandes, N. D., Azad, A. K., Fitzmaurice, A. M. & Sirakova, T. D. Biochemistry and molecular genetics of cell-wall lipid biosynthesis in mycobacteria. Mol. Microbiol. 24, 263\u2013270 (1997).",
      "journal-title": "Mol. Microbiol."
    },
    {
      "key": "BF31159_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "9869",
      "DOI": "10.1073/pnas.94.18.9869",
      "volume": "94",
      "author": "S Sreevatsan",
      "year": "1997",
      "unstructured": "Sreevatsan, S.et al. Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination. Proc. Natl Acad. Sci. USA 94, 9869\u2013 9874 (1997).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF31159_CR7",
      "doi-asserted-by": "crossref",
      "first-page": "2221",
      "DOI": "10.1128/IAI.66.5.2221-2229.1998",
      "volume": "66",
      "author": "R Brosch",
      "year": "1998",
      "unstructured": "Brosch, R.et al. Use of a Mycobacterium tuberculosis H37Rv bacterial artificial chromosome library for genome mapping, sequencing and comparative genomics. Infect. Immun. 66, 2221\u2013 2229 (1998).",
      "journal-title": "Infect. Immun."
    },
    {
      "key": "BF31159_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "3132",
      "DOI": "10.1073/pnas.93.7.3132",
      "volume": "93",
      "author": "WJ Philipp",
      "year": "1996",
      "unstructured": "Philipp, W. J.et al. An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae. Proc. Natl Acad. Sci. USA 93, 3132\u20133137 (1996).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF31159_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "1453",
      "DOI": "10.1126/science.277.5331.1453",
      "volume": "277",
      "author": "FR Blattner",
      "year": "1997",
      "unstructured": "Blattner, F. R.et al . The complete genome sequence of Escherichia coli K-12. Science 277, 1453\u2013 1462 (1997).",
      "journal-title": "Science"
    },
    {
      "key": "BF31159_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "139",
      "DOI": "10.1111/j.1574-6976.1994.tb00084.x",
      "volume": "14",
      "author": "ST Cole",
      "year": "1994",
      "unstructured": "Cole, S. T. & Saint-Girons, I. Bacterial genomics. FEMS Microbiol. Rev. 14, 139\u2013160 (1994).",
      "journal-title": "FEMS Microbiol. Rev."
    },
    {
      "key": "BF31159_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "394",
      "DOI": "10.1038/387394a0",
      "volume": "387",
      "author": "C Freiberg",
      "year": "1997",
      "unstructured": "Freiberg, C.et al. Molecular basis of symbiosis between Rhizobium and legumes. Nature 387, 394\u2013401 (1997).",
      "journal-title": "Nature"
    },
    {
      "key": "BF31159_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "10961",
      "DOI": "10.1073/pnas.94.20.10961",
      "volume": "94",
      "author": "S Bardarov",
      "year": "1997",
      "unstructured": "Bardarov, S.et al. Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 94, 10961\u201310966 (1997).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF31159_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "1274",
      "DOI": "10.1128/jb.178.5.1274-1282.1996",
      "volume": "178",
      "author": "GG Mahairas",
      "year": "1996",
      "unstructured": "Mahairas, G. G., Sabo, P. J., Hickey, M. J., Singh, D. C. & Stover, C. K. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis . J. Bacteriol. 178, 1274\u2013 1282 (1996).",
      "journal-title": "J. Bacteriol."
    },
    {
      "key": "BF31159_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "249",
      "DOI": "10.1038/36786",
      "volume": "390",
      "author": "F Kunst",
      "year": "1997",
      "unstructured": "Kunst, F.et al. The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature 390, 249\u2013 256 (1997).",
      "journal-title": "Nature"
    },
    {
      "key": "BF31159_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "802",
      "DOI": "10.1101/gr.7.8.802",
      "volume": "7",
      "author": "DR Smith",
      "year": "1997",
      "unstructured": "Smith, D. R.et al. Multiplex sequencing of 1.5\u2009Mb of the Mycobacterium leprae genome. Genome Res. 7, 802\u2013 819 (1997).",
      "journal-title": "Genome Res."
    },
    {
      "key": "BF31159_CR16",
      "volume-title": "Theory and Application of Correspondence Analysis",
      "author": "M Greenacre",
      "year": "1984",
      "unstructured": "Greenacre, M. Theory and Application of Correspondence Analysis (Academic, London, (1984)."
    },
    {
      "key": "BF31159_CR17",
      "first-page": "53",
      "volume-title": "The Biology of the Mycobacteria",
      "author": "CR Ratledge",
      "year": "1982",
      "unstructured": "Ratledge, C. R. in The Biology of the Mycobacteria (eds Ratledge, C. & Stanford, J.) 53\u201394 (Academic, San Diego, (1982)."
    },
    {
      "key": "BF31159_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "63",
      "DOI": "10.1089/omi.1.1997.2.63",
      "volume": "2",
      "author": "Y Av-Gay",
      "year": "1997",
      "unstructured": "Av-Gay, Y. & Davies, J. Components of eukaryotic-like protein signaling pathways in Mycobacterium tuberculosis. Microb. Comp. Genomics 2, 63\u201373 (1997).",
      "journal-title": "Microb. Comp. Genomics"
    },
    {
      "key": "BF31159_CR19",
      "doi-asserted-by": "crossref",
      "first-page": "701",
      "DOI": "10.1183/09031936.95.08050701",
      "volume": "8",
      "author": "ST Cole",
      "year": "1995",
      "unstructured": "Cole, S. T. & Telenti, A. Drug resistance in Mycobacterium tuberculosis. Eur. Resp. Rev. 8, 701 S\u2013713S (1995).",
      "journal-title": "Eur. Resp. Rev."
    },
    {
      "key": "BF31159_CR20",
      "first-page": "2118",
      "volume-title": "Escherichia coli and Salmonella",
      "author": "M Riley",
      "year": "1996",
      "unstructured": "Riley, M. & Labedan, B. in Escherichia coli and Salmonella (ed. Neidhardt, F. C.) 2118\u20132202 (ASM, Washington, (1996)."
    },
    {
      "key": "BF31159_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "1607",
      "DOI": "10.1126/science.280.5369.1607",
      "volume": "280",
      "author": "K Mdluli",
      "year": "1998",
      "unstructured": "Mdluli, K.et al. Inhibition of a Mycobacterium tuberculosis \u03b2-ketoacyl ACP synthase by isoniazid. Science 280, 1607\u20131610 (1998).",
      "journal-title": "Science"
    },
    {
      "key": "BF31159_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "227",
      "DOI": "10.1126/science.8284673",
      "volume": "263",
      "author": "A Banerjee",
      "year": "1994",
      "unstructured": "Banerjee, A.et al. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263, 227\u2013230 (1994).",
      "journal-title": "Science"
    },
    {
      "key": "BF31159_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "2465",
      "DOI": "10.1021/cr960034i",
      "volume": "97",
      "author": "DA Hopwood",
      "year": "1997",
      "unstructured": "Hopwood, D. A. Genetic contributions to understanding polyketide synthases. Chem. Rev. 97, 2465\u20132497 ( 1997).",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "BF31159_CR24",
      "first-page": "95",
      "volume-title": "The Biology of the Mycobacteria",
      "author": "DE Minnikin",
      "year": "1982",
      "unstructured": "Minnikin, D. E. in The Biology of the Mycobacteria (eds Ratledge, C. & Stanford, J.) 95\u2013184 (Academic, London, (1982)."
    },
    {
      "key": "BF31159_CR25",
      "unstructured": "Barry, C. E. IIet al . Mycolic acids: structure, biosynthesis, and phsyiological functions. Prog. Lipid Res.(in the press)."
    },
    {
      "key": "BF31159_CR26",
      "doi-asserted-by": "publisher",
      "first-page": "1420",
      "DOI": "10.1126/science.276.5317.1420",
      "volume": "276",
      "author": "JT Belisle",
      "year": "1997",
      "unstructured": "Belisle, J. T.et al . Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 276, 1420\u20131422 (1997).",
      "journal-title": "Science"
    },
    {
      "key": "BF31159_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "2651",
      "DOI": "10.1021/cr960029e",
      "volume": "97",
      "author": "MA Marahiel",
      "year": "1997",
      "unstructured": "Marahiel, M. A., Stachelhaus, T. & Mootz, H. D. Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem. Rev. 97, 2651\u2013 2673 (1997).",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "BF31159_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "5189",
      "DOI": "10.1073/pnas.92.11.5189",
      "volume": "92",
      "author": "J Gobin",
      "year": "1995",
      "unstructured": "Gobin, J.et al. Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl Acad. Sci. USA 92, 5189\u20135193 (1995).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF31159_CR29",
      "first-page": "631",
      "volume-title": "New Generation Vaccines",
      "author": "DB Young",
      "year": "1997",
      "unstructured": "Young, D. B. & Fruth, U. in New Generation Vaccines (eds Levine, M., Woodrow, G., Kaper, J. & Cobon, G. S.) 631\u2013 645 (Marcel Dekker, New York, (1997)."
    },
    {
      "key": "BF31159_CR30",
      "doi-asserted-by": "crossref",
      "first-page": "1710",
      "DOI": "10.1128/IAI.63.5.1710-1717.1995",
      "volume": "63",
      "author": "AL Sorensen",
      "year": "1995",
      "unstructured": "Sorensen, A. L., Nagai, S., Houen, G., Andersen, P. & Anderson, A. B. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect. Immun. 63, 1710\u20131717 (1995).",
      "journal-title": "Infect. Immun."
    },
    {
      "key": "BF31159_CR31",
      "doi-asserted-by": "publisher",
      "first-page": "4157",
      "DOI": "10.1128/jb.174.12.4157-4165.1992",
      "volume": "174",
      "author": "PWM Hermans",
      "year": "1992",
      "unstructured": "Hermans, P. W. M., van Soolingen, D. & van Embden, J. D. A. Characterization of a major polymorphic tandem repeat in Mycobacterium tuberculosis and its potential use in the epidemiology of Mycobacterium kansasii and Mycobacterium gordonae. J. Bacteriol. 174, 4157\u20134165 (1992).",
      "journal-title": "J. Bacteriol."
    },
    {
      "key": "BF31159_CR32",
      "doi-asserted-by": "publisher",
      "first-page": "87",
      "DOI": "10.1007/BF00381781",
      "volume": "163",
      "author": "S Poulet",
      "year": "1995",
      "unstructured": "Poulet, S. & Cole, S. T. Characterisation of the polymorphic GC-rich repetitive sequence (PGRS) present in Mycobacterium tuberculosis . Arch. Microbiol. 163, 87\u2013 95 (1995).",
      "journal-title": "Arch. Microbiol."
    },
    {
      "key": "BF31159_CR33",
      "doi-asserted-by": "publisher",
      "first-page": "160",
      "DOI": "10.1002/0470846526.ch12",
      "volume-title": "Genetics and Tuberculosis",
      "author": "ST Cole",
      "year": "1998",
      "unstructured": "Cole, S. T. & Barrell, B. G. in Genetics and Tuberculosis (eds Chadwick, D. J. & Cardew, G., Novartis Foundation Symp. 217 ) 160\u2013172 (Wiley, Chichester, ( 1998)."
    },
    {
      "key": "BF31159_CR34",
      "doi-asserted-by": "crossref",
      "first-page": "2145",
      "DOI": "10.1128/IAI.61.5.2145-2153.1993",
      "volume": "61",
      "author": "F Vega-Lopez",
      "year": "1993",
      "unstructured": "Vega-Lopez, F.et al . Sequence and immunological characterization of a serine-rich antigen from Mycobacterium leprae. Infect. Immun. 61, 2145\u20132153 (1993).",
      "journal-title": "Infect. Immun."
    },
    {
      "key": "BF31159_CR35",
      "doi-asserted-by": "crossref",
      "first-page": "2712",
      "DOI": "10.1128/IAI.59.8.2712-2718.1991",
      "volume": "59",
      "author": "C Abou-Zeid",
      "year": "1991",
      "unstructured": "Abou-Zeid, C.et al. Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding proteins. Infect. Immun. 59 , 2712\u20132718 (1991).",
      "journal-title": "Infect. Immun."
    },
    {
      "key": "BF31159_CR36",
      "doi-asserted-by": "publisher",
      "first-page": "422",
      "DOI": "10.1016/0168-9525(92)90325-X",
      "volume": "8",
      "author": "BD Robertson",
      "year": "1992",
      "unstructured": "Robertson, B. D. & Meyer, T. F. Genetic variation in pathogenic bacteria. Trends Genet. 8, 422\u2013427 (1992).",
      "journal-title": "Trends Genet."
    },
    {
      "key": "BF31159_CR37",
      "doi-asserted-by": "publisher",
      "first-page": "685",
      "DOI": "10.1038/375685a0",
      "volume": "375",
      "author": "J Levitskaya",
      "year": "1995",
      "unstructured": "Levitskaya, J.et al . Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 375, 685\u2013688 (1995).",
      "journal-title": "Nature"
    },
    {
      "key": "BF31159_CR38",
      "doi-asserted-by": "publisher",
      "first-page": "12616",
      "DOI": "10.1073/pnas.94.23.12616",
      "volume": "94",
      "author": "J Levitskaya",
      "year": "1997",
      "unstructured": "Levitskaya, J., Sharipo, A., Leonchiks, A., Ciechanover, A. & Masucci, M. G. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc. Natl Acad. Sci. USA 94, 12616\u201312621 (1997).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF31159_CR39",
      "doi-asserted-by": "publisher",
      "first-page": "12013",
      "DOI": "10.1073/pnas.89.24.12013",
      "volume": "89",
      "author": "JL Flynn",
      "year": "1992",
      "unstructured": "Flynn, J. L., Goldstein, M. A., Treibold, K. J., Koller, B. & Bloom, B. R. Major histocompatability complex class-I restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl Acad. Sci. USA 89, 12013\u201312017 (1992).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF31159_CR40",
      "doi-asserted-by": "publisher",
      "first-page": "531",
      "DOI": "10.1128/9781555818357.ch31",
      "volume-title": "Tuberculosis: Pathogenesis, Protection, and Control",
      "author": "BR Bloom",
      "year": "1994",
      "unstructured": "Bloom, B. R. & Fine, P. E. M. in Tuberculosis: Pathogenesis, Protection, and Control (ed. Bloom, B. R.) 531\u2013 557 (Am. Soc. Microbiol., Washington DC, (1994)."
    },
    {
      "key": "BF31159_CR41",
      "doi-asserted-by": "publisher",
      "first-page": "426",
      "DOI": "10.1016/0966-842X(96)10066-4",
      "volume": "4",
      "author": "DM Collins",
      "year": "1996",
      "unstructured": "Collins, D. M. In search of tuberculosis virulence genes. Trends Microbiol. 4, 426\u2013430 (1996).",
      "journal-title": "Trends Microbiol."
    },
    {
      "key": "BF31159_CR42",
      "doi-asserted-by": "publisher",
      "first-page": "1454",
      "DOI": "10.1126/science.8367727",
      "volume": "261",
      "author": "S Arruda",
      "year": "1993",
      "unstructured": "Arruda, S., Bomfim, G., Knights, R., Huima-Byron, T. & Riley, L. W. Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells. Science 261, 1454\u20131457 (1993).",
      "journal-title": "Science"
    },
    {
      "key": "BF31159_CR43",
      "doi-asserted-by": "crossref",
      "first-page": "1623",
      "DOI": "10.1128/IAI.62.5.1623-1630.1994",
      "volume": "62",
      "author": "AJ Baumler",
      "year": "1994",
      "unstructured": "Baumler, A. J., Kusters, J. G., Stojikovic, I. & Heffron, F. Salmonella typhimurium loci involved in survival within macrophages. Infect. Immun. 62, 1623\u20131630 (1994).",
      "journal-title": "Infect. Immun."
    },
    {
      "key": "BF31159_CR44",
      "doi-asserted-by": "publisher",
      "first-page": "562",
      "DOI": "10.1101/gr.8.5.562",
      "volume": "8",
      "author": "AA McMurray",
      "year": "1998",
      "unstructured": "McMurray, A. A., Sulston, J. E. & Quail, M. A. Short-insert libraries as a method of problem solving in genome sequencing. Genome Res. 8, 562 \u2013566 (1998).",
      "journal-title": "Genome Res."
    },
    {
      "key": "BF31159_CR45",
      "doi-asserted-by": "publisher",
      "first-page": "4992",
      "DOI": "10.1093/nar/23.24.4992",
      "volume": "24",
      "author": "JK Bonfield",
      "year": "1995",
      "unstructured": "Bonfield, J. K., Smith, K. F. & Staden, R. Anew DNA sequence assembly program. Nucleic Acids Res. 24, 4992\u20134999 (1995).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF31159_CR46",
      "doi-asserted-by": "publisher",
      "first-page": "4768",
      "DOI": "10.1093/nar/22.22.4768",
      "volume": "22",
      "author": "A Krogh",
      "year": "1994",
      "unstructured": "Krogh, A., Mian, I. S. & Haussler, D. Ahidden Markov model that finds genes in E. coli DNA. Nucleic Acids Res. 22, 4768\u2013 4778 (1994).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF31159_CR47",
      "doi-asserted-by": "publisher",
      "first-page": "217",
      "DOI": "10.1093/nar/25.1.217",
      "volume": "25",
      "author": "A Bairoch",
      "year": "1997",
      "unstructured": "Bairoch, A., Bucher, P. & Hofmann, K. The PROSITE database, its status in 1997. Nucleic Acids Res. 25, 217\u2013221 (1997).",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "BF31159_CR48",
      "doi-asserted-by": "publisher",
      "first-page": "403",
      "DOI": "10.1016/S0022-2836(05)80360-2",
      "volume": "215",
      "author": "S Altschul",
      "year": "1990",
      "unstructured": "Altschul, S., Gish, W., Miller, W., Myers, E. & Lipman, D. Abasic local alignment search tool. J. Mol. Biol. 215, 403\u2013410 ( 1990).",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "BF31159_CR49",
      "doi-asserted-by": "publisher",
      "first-page": "2444",
      "DOI": "10.1073/pnas.85.8.2444",
      "volume": "85",
      "author": "W Pearson",
      "year": "1988",
      "unstructured": "Pearson, W. & Lipman, D. Improved tools for biological sequence comparisons. Proc. Natl Acad. USA 85, 2444 \u20132448 (1988).",
      "journal-title": "Proc. Natl Acad. USA"
    },
    {
      "key": "BF31159_CR50",
      "doi-asserted-by": "publisher",
      "first-page": "955",
      "DOI": "10.1093/nar/25.5.955",
      "volume": "25",
      "author": "TM Lowe",
      "year": "1997",
      "unstructured": "Lowe, T. M. & Eddy, S. R. tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic DNA. Nucleic Acids Res. 25, 955\u2013964 ( 1997).",
      "journal-title": "Nucleic Acids Res."
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/31159.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/31159",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/31159.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T00:59:29Z",
    "timestamp": 1684285169000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/31159"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  },
  "references-count": 50,
  "journal-issue": {
    "issue": "6685",
    "published-print": {
      "date-parts": [
        [
          1998,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "BF31159"
  ],
  "URL": "http://dx.doi.org/10.1038/31159",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  },
  "assertion": [
    {
      "value": "15 April 1998",
      "order": 1,
      "name": "received",
      "label": "Received",
      "group": {
        "name": "ArticleHistory",
        "label": "Article History"
      }
    },
    {
      "value": "8 May 1998",
      "order": 2,
      "name": "accepted",
      "label": "Accepted",
      "group": {
        "name": "ArticleHistory",
        "label": "Article History"
      }
    },
    {
      "value": "This content has been made available to all.",
      "name": "free",
      "label": "Free to read"
    }
  ]
}