DOI: 10.1038/300650a0. A circulating inhibitor of (Na+ + K+) ATPase associated with essential hypertension

A circulating inhibitor of (Na+ + K+) ATPase associated with essential hypertension

10.1038/300650a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Hamlyn, J. M., Ringel, R., Schaeffer, J., Levinson, P. D., Hamilton, B. P., Kowarski, A. A., & Blaustein, M. P. (1982). A circulating inhibitor of (Na+ + K+) ATPase associated with essential hypertension. Nature, 300(5893), 650â652.

Authors 7

John M. Hamlyn (first)
Richard Ringel (additional)
Juergen Schaeffer (additional)
Paul D. Levinson (additional)
Bruce P. Hamilton (additional)
A. Avinoam Kowarski (additional)
Mordecai P. Blaustein (additional)

References 26 Referenced 402

Blaustein, M. P. Am. J. Physiol. 232, C165–C173 (1977). (10.1152/ajpcell.1977.232.5.C165) / Am. J. Physiol. by MP Blaustein (1977)
MacGregor, G. A. et al. Br. med. J. 283, 1335–1357 (1981). / Br. med. J. by GA MacGregor (1981)
Poston, L. et al. Br. med. J. 282, 847–849 (1981). (10.1136/bmj.282.6267.847) / Br. med. J. by L Poston (1981)
Pamnani, M. B., Huot, S., Buggy, J., Clough, D. & Haddy, F. Hypertension 3, Suppl. Ii, II-96–Ii-101 (1981). (10.1161/01.HYP.3.6_Pt_2.II-96) / Hypertension by MB Pamnani (1981)
Akera, T., Choi, Y. R. & Yamamoto, S. in Na, K-ATPase, Structure and Kinetics (eds Skou, J. C. & Norby, J. G.) 405–420 (Academic, New York, 1979). / Na, K-ATPase, Structure and Kinetics by T Akera (1979)
Fagan, J. B. & Racker, E. Biochemistry 16, 152–158 (1977). (10.1021/bi00620a026) / Biochemistry by JB Fagan (1977)
Quist, E. E. & Hokin, L. E. Biochim. biophys. Acta 511, 202–212 (1978). (10.1016/0005-2736(78)90314-0) / Biochim. biophys. Acta by EE Quist (1978)
Cantley, L. C. et al. J. biol Chem. 252, 7421–7423 (1977). (10.1016/S0021-9258(17)40978-1) / J. biol Chem. by LC Cantley (1977)
Jorgensen, P. L. Biochim. biophys. Acta 356, 36–52 (1974). (10.1016/0005-2736(74)90292-2) / Biochim. biophys. Acta by PL Jorgensen (1974)
Gruber, K. A., Whitaker, J. M. & Buckalew, V. M. Nature 287, 743–745 (1980). (10.1038/287743a0) / Nature by KA Gruber (1980)
Gruber, K. A., Rudel, L. L. & Bullock, B. C. Hypertension 4, 348–354 (1982). (10.1161/01.HYP.4.3.348) / Hypertension by KA Gruber (1982)
Losse, H., Wehmeyer, H. & Wessels, F. Klin. Wschr. 38, 393–395 (1960). (10.1007/BF01483466) / Klin. Wschr. by H Losse (1960)
Edmondson, R. P. S., Thomas, R. D., Hilton, P. J., Patrick, J. & Jones, N. F. Lancet i, 1003–1005 (1975). (10.1016/S0140-6736(75)91947-9) / Lancet by RPS Edmondson (1975)
Blaustein, M. P. Clin. exp. Hypertension 3, 173–178 (1981). (10.3109/10641968109037175) / Clin. exp. Hypertension by MP Blaustein (1981)
Blaustein, M. P. in Recent Advances in Hypertension Mechanisms (eds Villareal, H. & Sambhi, M.) (in the press).
Lang, S. & Blaustein, M. P. Circulation Res. 46, 463–470 (1980). (10.1161/01.RES.46.4.463) / Circulation Res. by S Lang (1980)
Filo, R. S., Bohr, D. F. & Rüegg, J. C. Science 147, 1581–1583 (1972). (10.1126/science.147.3665.1581) / Science by RS Filo (1972)
Folkow, B. & Neil, E. Circulation, 560–583 (Oxford University Press, 1971). / Circulation by B Folkow (1971)
Nakazato, Y., Ohga, A. & Onoda, Y. J. Physiol., Land. 278, 45–54 (1978). (10.1113/jphysiol.1978.sp012291) / J. Physiol., Land. by Y Nakazato (1978)
Leitz, F. H. & Stefano, F. J. E. Eur. J. Pharmac. 11, 278–285 (1970). (10.1016/0014-2999(70)90002-6) / Eur. J. Pharmac. by FH Leitz (1970)
de Wardener, H. E. & MacGregor, G. A. Kidney Int. 18, 1–9 (1980). (10.1038/ki.1980.104) / Kidney Int. by HE de Wardener (1980)
de Wardener, H. E. Am. J. Physiol. 235, F163–F173 (1978). / Am. J. Physiol. by HE de Wardener (1978)
Zadik, Z., Hamilton, B. P. & Kowarski, A. A. J. clin Endocr. Metab. 50, 842–845 (1980). (10.1210/jcem-50-5-842) / J. clin Endocr. Metab. by Z Zadik (1980)
Kowarski, A. A., Edwin, C. J., Akesode, A. P., Pitrowski, L. S. & Hamilton, B. P. Johns Hopkins med. J. 142, 35–38 (1978). / Johns Hopkins med. J. by AA Kowarski (1978)
King, E. J. Biochem. J. 26, 292–297 (1932). (10.1042/bj0260292) / Biochem. J. by EJ King (1932)
Bradford, M. M. Analyt. Biochem. 72, 248–254 (1976). (10.1016/0003-2697(76)90527-3) / Analyt. Biochem. by MM Bradford (1976)

Dates

Type	When
Created	20 years, 9 months ago (Nov. 17, 2004, 6:30 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 9:19 p.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 1:45 a.m.)
Issued	42 years, 8 months ago (Dec. 1, 1982)
Published	42 years, 8 months ago (Dec. 1, 1982)
Published Print	42 years, 8 months ago (Dec. 1, 1982)

Funders 0

None

BibTeX

@article{Hamlyn_1982, title={A circulating inhibitor of (Na+ + K+) ATPase associated with essential hypertension}, volume={300}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/300650a0}, DOI={10.1038/300650a0}, number={5893}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Hamlyn, John M. and Ringel, Richard and Schaeffer, Juergen and Levinson, Paul D. and Hamilton, Bruce P. and Kowarski, A. Avinoam and Blaustein, Mordecai P.}, year={1982}, month=dec, pages={650–652} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        7
      ]
    ],
    "date-time": "2025-07-07T05:45:23Z",
    "timestamp": 1751867123352
  },
  "reference-count": 26,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "5893",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1982,
            12,
            1
          ]
        ],
        "date-time": "1982-12-01T00:00:00Z",
        "timestamp": 407548800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1982,
        12
      ]
    ]
  },
  "DOI": "10.1038/300650a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        11,
        17
      ]
    ],
    "date-time": "2004-11-17T23:30:49Z",
    "timestamp": 1100734249000
  },
  "page": "650-652",
  "source": "Crossref",
  "is-referenced-by-count": 402,
  "title": "A circulating inhibitor of (Na+ + K+) ATPase associated with essential hypertension",
  "prefix": "10.1038",
  "volume": "300",
  "author": [
    {
      "given": "John M.",
      "family": "Hamlyn",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Richard",
      "family": "Ringel",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Juergen",
      "family": "Schaeffer",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Paul D.",
      "family": "Levinson",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Bruce P.",
      "family": "Hamilton",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A. Avinoam",
      "family": "Kowarski",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mordecai P.",
      "family": "Blaustein",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF300650a0_CR1",
      "doi-asserted-by": "crossref",
      "first-page": "C165",
      "DOI": "10.1152/ajpcell.1977.232.5.C165",
      "volume": "232",
      "author": "MP Blaustein",
      "year": "1977",
      "unstructured": "Blaustein, M. P. Am. J. Physiol. 232, C165\u2013C173 (1977).",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "BF300650a0_CR2",
      "first-page": "1335",
      "volume": "283",
      "author": "GA MacGregor",
      "year": "1981",
      "unstructured": "MacGregor, G. A. et al. Br. med. J. 283, 1335\u20131357 (1981).",
      "journal-title": "Br. med. J."
    },
    {
      "key": "BF300650a0_CR3",
      "doi-asserted-by": "crossref",
      "first-page": "847",
      "DOI": "10.1136/bmj.282.6267.847",
      "volume": "282",
      "author": "L Poston",
      "year": "1981",
      "unstructured": "Poston, L. et al. Br. med. J. 282, 847\u2013849 (1981).",
      "journal-title": "Br. med. J."
    },
    {
      "key": "BF300650a0_CR4",
      "doi-asserted-by": "crossref",
      "first-page": "II-96",
      "DOI": "10.1161/01.HYP.3.6_Pt_2.II-96",
      "volume": "3",
      "author": "MB Pamnani",
      "year": "1981",
      "unstructured": "Pamnani, M. B., Huot, S., Buggy, J., Clough, D. & Haddy, F. Hypertension 3, Suppl. Ii, II-96\u2013Ii-101 (1981).",
      "journal-title": "Hypertension"
    },
    {
      "key": "BF300650a0_CR5",
      "first-page": "405",
      "volume-title": "Na, K-ATPase, Structure and Kinetics",
      "author": "T Akera",
      "year": "1979",
      "unstructured": "Akera, T., Choi, Y. R. & Yamamoto, S. in Na, K-ATPase, Structure and Kinetics (eds Skou, J. C. & Norby, J. G.) 405\u2013420 (Academic, New York, 1979)."
    },
    {
      "key": "BF300650a0_CR6",
      "doi-asserted-by": "crossref",
      "first-page": "152",
      "DOI": "10.1021/bi00620a026",
      "volume": "16",
      "author": "JB Fagan",
      "year": "1977",
      "unstructured": "Fagan, J. B. & Racker, E. Biochemistry 16, 152\u2013158 (1977).",
      "journal-title": "Biochemistry"
    },
    {
      "key": "BF300650a0_CR7",
      "doi-asserted-by": "crossref",
      "first-page": "202",
      "DOI": "10.1016/0005-2736(78)90314-0",
      "volume": "511",
      "author": "EE Quist",
      "year": "1978",
      "unstructured": "Quist, E. E. & Hokin, L. E. Biochim. biophys. Acta 511, 202\u2013212 (1978).",
      "journal-title": "Biochim. biophys. Acta"
    },
    {
      "key": "BF300650a0_CR8",
      "doi-asserted-by": "crossref",
      "first-page": "7421",
      "DOI": "10.1016/S0021-9258(17)40978-1",
      "volume": "252",
      "author": "LC Cantley",
      "year": "1977",
      "unstructured": "Cantley, L. C. et al. J. biol Chem. 252, 7421\u20137423 (1977).",
      "journal-title": "J. biol Chem."
    },
    {
      "key": "BF300650a0_CR9",
      "doi-asserted-by": "crossref",
      "first-page": "36",
      "DOI": "10.1016/0005-2736(74)90292-2",
      "volume": "356",
      "author": "PL Jorgensen",
      "year": "1974",
      "unstructured": "Jorgensen, P. L. Biochim. biophys. Acta 356, 36\u201352 (1974).",
      "journal-title": "Biochim. biophys. Acta"
    },
    {
      "key": "BF300650a0_CR10",
      "doi-asserted-by": "crossref",
      "first-page": "743",
      "DOI": "10.1038/287743a0",
      "volume": "287",
      "author": "KA Gruber",
      "year": "1980",
      "unstructured": "Gruber, K. A., Whitaker, J. M. & Buckalew, V. M. Nature 287, 743\u2013745 (1980).",
      "journal-title": "Nature"
    },
    {
      "key": "BF300650a0_CR11",
      "doi-asserted-by": "crossref",
      "first-page": "348",
      "DOI": "10.1161/01.HYP.4.3.348",
      "volume": "4",
      "author": "KA Gruber",
      "year": "1982",
      "unstructured": "Gruber, K. A., Rudel, L. L. & Bullock, B. C. Hypertension 4, 348\u2013354 (1982).",
      "journal-title": "Hypertension"
    },
    {
      "key": "BF300650a0_CR12",
      "doi-asserted-by": "crossref",
      "first-page": "393",
      "DOI": "10.1007/BF01483466",
      "volume": "38",
      "author": "H Losse",
      "year": "1960",
      "unstructured": "Losse, H., Wehmeyer, H. & Wessels, F. Klin. Wschr. 38, 393\u2013395 (1960).",
      "journal-title": "Klin. Wschr."
    },
    {
      "key": "BF300650a0_CR13",
      "doi-asserted-by": "crossref",
      "first-page": "1003",
      "DOI": "10.1016/S0140-6736(75)91947-9",
      "volume": "i",
      "author": "RPS Edmondson",
      "year": "1975",
      "unstructured": "Edmondson, R. P. S., Thomas, R. D., Hilton, P. J., Patrick, J. & Jones, N. F. Lancet i, 1003\u20131005 (1975).",
      "journal-title": "Lancet"
    },
    {
      "key": "BF300650a0_CR14",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.3109/10641968109037175",
      "volume": "3",
      "author": "MP Blaustein",
      "year": "1981",
      "unstructured": "Blaustein, M. P. Clin. exp. Hypertension 3, 173\u2013178 (1981).",
      "journal-title": "Clin. exp. Hypertension"
    },
    {
      "key": "BF300650a0_CR15",
      "unstructured": "Blaustein, M. P. in Recent Advances in Hypertension Mechanisms (eds Villareal, H. & Sambhi, M.) (in the press)."
    },
    {
      "key": "BF300650a0_CR16",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1161/01.RES.46.4.463",
      "volume": "46",
      "author": "S Lang",
      "year": "1980",
      "unstructured": "Lang, S. & Blaustein, M. P. Circulation Res. 46, 463\u2013470 (1980).",
      "journal-title": "Circulation Res."
    },
    {
      "key": "BF300650a0_CR17",
      "doi-asserted-by": "crossref",
      "first-page": "1581",
      "DOI": "10.1126/science.147.3665.1581",
      "volume": "147",
      "author": "RS Filo",
      "year": "1972",
      "unstructured": "Filo, R. S., Bohr, D. F. & R\u00fcegg, J. C. Science 147, 1581\u20131583 (1972).",
      "journal-title": "Science"
    },
    {
      "key": "BF300650a0_CR18",
      "first-page": "560",
      "volume-title": "Circulation",
      "author": "B Folkow",
      "year": "1971",
      "unstructured": "Folkow, B. & Neil, E. Circulation, 560\u2013583 (Oxford University Press, 1971)."
    },
    {
      "key": "BF300650a0_CR19",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1113/jphysiol.1978.sp012291",
      "volume": "278",
      "author": "Y Nakazato",
      "year": "1978",
      "unstructured": "Nakazato, Y., Ohga, A. & Onoda, Y. J. Physiol., Land. 278, 45\u201354 (1978).",
      "journal-title": "J. Physiol., Land."
    },
    {
      "key": "BF300650a0_CR20",
      "doi-asserted-by": "crossref",
      "first-page": "278",
      "DOI": "10.1016/0014-2999(70)90002-6",
      "volume": "11",
      "author": "FH Leitz",
      "year": "1970",
      "unstructured": "Leitz, F. H. & Stefano, F. J. E. Eur. J. Pharmac. 11, 278\u2013285 (1970).",
      "journal-title": "Eur. J. Pharmac."
    },
    {
      "key": "BF300650a0_CR21",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1038/ki.1980.104",
      "volume": "18",
      "author": "HE de Wardener",
      "year": "1980",
      "unstructured": "de Wardener, H. E. & MacGregor, G. A. Kidney Int. 18, 1\u20139 (1980).",
      "journal-title": "Kidney Int."
    },
    {
      "key": "BF300650a0_CR22",
      "first-page": "F163",
      "volume": "235",
      "author": "HE de Wardener",
      "year": "1978",
      "unstructured": "de Wardener, H. E. Am. J. Physiol. 235, F163\u2013F173 (1978).",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "BF300650a0_CR23",
      "doi-asserted-by": "crossref",
      "first-page": "842",
      "DOI": "10.1210/jcem-50-5-842",
      "volume": "50",
      "author": "Z Zadik",
      "year": "1980",
      "unstructured": "Zadik, Z., Hamilton, B. P. & Kowarski, A. A. J. clin Endocr. Metab. 50, 842\u2013845 (1980).",
      "journal-title": "J. clin Endocr. Metab."
    },
    {
      "key": "BF300650a0_CR24",
      "first-page": "35",
      "volume": "142",
      "author": "AA Kowarski",
      "year": "1978",
      "unstructured": "Kowarski, A. A., Edwin, C. J., Akesode, A. P., Pitrowski, L. S. & Hamilton, B. P. Johns Hopkins med. J. 142, 35\u201338 (1978).",
      "journal-title": "Johns Hopkins med. J."
    },
    {
      "key": "BF300650a0_CR25",
      "doi-asserted-by": "crossref",
      "first-page": "292",
      "DOI": "10.1042/bj0260292",
      "volume": "26",
      "author": "EJ King",
      "year": "1932",
      "unstructured": "King, E. J. Biochem. J. 26, 292\u2013297 (1932).",
      "journal-title": "Biochem. J."
    },
    {
      "key": "BF300650a0_CR26",
      "doi-asserted-by": "crossref",
      "first-page": "248",
      "DOI": "10.1016/0003-2697(76)90527-3",
      "volume": "72",
      "author": "MM Bradford",
      "year": "1976",
      "unstructured": "Bradford, M. M. Analyt. Biochem. 72, 248\u2013254 (1976).",
      "journal-title": "Analyt. Biochem."
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/300650a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/300650a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/300650a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        17
      ]
    ],
    "date-time": "2023-05-17T01:19:44Z",
    "timestamp": 1684286384000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/300650a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1982,
        12
      ]
    ]
  },
  "references-count": 26,
  "journal-issue": {
    "issue": "5893",
    "published-print": {
      "date-parts": [
        [
          1982,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "BF300650a0"
  ],
  "URL": "http://dx.doi.org/10.1038/300650a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1982,
        12
      ]
    ]
  }
}