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Garrett, T. P. J., McKern, N. M., Lou, M., Frenkel, M. J., Bentley, J. D., Lovrecz, G. O., Elleman, T. C., Cosgrove, L. J., & Ward, C. W. (1998). Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. Nature, 394(6691), 395–399.

Authors 9
  1. Thomas P. J. Garrett (first)
  2. Neil M. McKern (additional)
  3. Meizhen Lou (additional)
  4. Maurice J. Frenkel (additional)
  5. John D. Bentley (additional)
  6. George O. Lovrecz (additional)
  7. Thomas C. Elleman (additional)
  8. Leah J. Cosgrove (additional)
  9. Colin W. Ward (additional)
References 30 Referenced 195
  1. Ullrich, A. et al. Insulin-like growth factor 1 receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5, 2503–2512 (1986). (10.1002/j.1460-2075.1986.tb04528.x) / EMBO J. by A Ullrich (1986)
  2. De Meyts, P. The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia 37, 135–148 (1994). (10.1007/BF00400837) / Diabetologia by P De Meyts (1994)
  3. Baserga, R. Controlling IGF-receptor function: a possible strategy for tumor therapy. Trends Biotechnol. 14, 150–152 (1996). (10.1016/0167-7799(96)10023-8) / Trends Biotechnol. by R Baserga (1996)
  4. Steele, R. E., Lieu, P., Mai, N. H., Shenk, M. A. & Sarras, M. P. J Response to insulin and the expression pattern of a gene encoding an insulin receptor homologue suggest a role for an insulin-like molecule in regulating growth and patterning in Hydra. Dev. Genes. Evol. 206, 247–259 (1996). (10.1007/s004270050050) / Dev. Genes. Evol. by RE Steele (1996)
  5. Torres, A. M. et al. Solution structure of human insulin-like growth factor II—relationship to receptor and binding protein interactions. J. Mol. Biol. 248, 385–401 (1995). / J. Mol. Biol. by AM Torres (1995)
  6. Schaefer, E. M., Siddle, K. & Ellis, L. Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric α-subunit. J.Biol. Chem. 265, 13248–13253 (1990). (10.1016/S0021-9258(19)38291-2) / J.Biol. Chem. by EM Schaefer (1990)
  7. Mynarcik, D. C., Yu, G. Q. & Whittaker, J. Alanine-scanning mutagenesis of a C-terminal ligand binding domain of the insulin receptor alpha subunit. J. Biol. Chem. 271, 2439–2442 (1996). (10.1074/jbc.271.5.2439) / J. Biol. Chem. by DC Mynarcik (1996)
  8. McKern, N. M. et al. Crystallization of the first three domains of insulin-like growth factor I receptor. Protein Sci. 6, 2663–2666 (1997). (10.1002/pro.5560061223) / Protein Sci. by NM McKern (1997)
  9. Taylor, S. I. et al. Mutations in the insulin receptor gene: update 1994. Endocr. Rev. 2, 58–65 (1994). / Endocr. Rev. by SI Taylor (1994)
  10. Bajaj, M., Waterfield, M. D., Schlessinger, J., Taylor, W. R. & Blundell, T. On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. Biochim. Biophys. Acta 916, 220–226 (1987). (10.1016/0167-4838(87)90112-9) / Biochim. Biophys. Acta by M Bajaj (1987)
  11. Ward, C. W., Hoyne, P. A. & Flegg, R. H. Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumour necrosis factor receptor. Proteins Struct. Funct. Genet. 22, 141–153 (1995). (10.1002/prot.340220207) / Proteins Struct. Funct. Genet. by CW Ward (1995)
  12. Holm, L. & Sander, S. Protein structure comparison by alignment of distance matrices. J. Mol. Biol. 233, 123–138 (1993). (10.1006/jmbi.1993.1489) / J. Mol. Biol. by L Holm (1993)
  13. Kobe, B. & Deisenhofer, J. Proteins with leucine-rich repeats. Curr. Opin. Struct. Biol. 5, 409–416 (1995). (10.1016/0959-440X(95)80105-7) / Curr. Opin. Struct. Biol. by B Kobe (1995)
  14. Yoder, M. D., Lietzke, S. E. & Jurnak, F. Unusual structural features in the parallel β-helix in pectate lyases. Structure 1, 241–251 (1993). (10.1016/0969-2126(93)90013-7) / Structure by MD Yoder (1993)
  15. Stetefeld, J., Mayer, U., Timpl, R. & Huber, R. Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma-1 chain harboring the nidogen binding site. J. Mol. Biol. 257, 644–657 (1996). (10.1006/jmbi.1996.0191) / J. Mol. Biol. by J Stetefeld (1996)
  16. Taylor, S. I. Lilly lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin receptor gene. Diabetes 41, 1473–1490 (1992). (10.2337/diab.41.11.1473) / Diabetes by SI Taylor (1992)
  17. Williams, P. F., Mynarcik, D. C., Yu, G. Q. & Whittaker, J. Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis. J. Biol. Chem. 270, 3012–3016 (1995). (10.1074/jbc.270.7.3012) / J. Biol. Chem. by PF Williams (1995)
  18. Kjeldsen, T. et al. Ligand specificities of insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. Proc. Natl Acad. Sci. USA 88, 4404–4408 (1991). (10.1073/pnas.88.10.4404) / Proc. Natl Acad. Sci. USA by T Kjeldsen (1991)
  19. Schäffer, L. et al. Interactions of a hybrid insulin-like growth factor-I analog with chimeric insulin/Type I insulin-like growth factor receptors. J. Biol. Chem. 268, 3044–3047 (1993). (10.1016/S0021-9258(18)53656-5) / J. Biol. Chem. by L Schäffer (1993)
  20. Gustafson, T. A. & Rutter, W. J. The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. J. Biol. Chem. 265, 18663–18667 (1990). (10.1016/S0021-9258(17)44803-4) / J. Biol. Chem. by TA Gustafson (1990)
  21. 1. Kurose, T. et al. Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxy-terminal regional of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor. J. Biol. Chem. 269, 29190–29197 (1994). (10.1016/S0021-9258(19)62029-6) / J. Biol. Chem. by T Kurose (1994)
  22. Bayne, M. L. et al. The C-region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type I IGF receptor. J. Biol. Chem. 264, 11004–11008 (1988). (10.1016/S0021-9258(18)60418-1) / J. Biol. Chem. by ML Bayne (1988)
  23. Roach, P. et al. Anovel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing. Diabetes 43, 1096–1102 (1994). (10.2337/diab.43.9.1096) / Diabetes by P Roach (1994)
  24. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307–326 (1996). (10.1016/S0076-6879(97)76066-X) / Methods Enzymol. by Z Otwinowski (1996)
  25. Steigeman, W. Dissertation, Technical Univ. Munich (1974).
  26. Cowtan, K. DM: an automated procedure for phase improvement by density modification. Joint CCP4 and ESF-EACBM newslett. Protein Crystallogr. 31, 34–38 (1994). / Protein Crystallogr. by K Cowtan (1994)
  27. Jones, T. A., Cowan, S., Zou, J.-Y. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110–119 (1991). (10.1107/S0108767390010224) / Acta Crystallogr. A by TA Jones (1991)
  28. Brunger, A. T. X-PLOR reference manual 3.851 (Yale Univ., New Haven, CT, 1996). / X-PLOR reference manual 3.851 by AT Brunger (1996)
  29. Murshudov, G. N., Vagin, A. A. & Dodson, E. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D 53, 240–255 (1997). (10.1107/S0907444996012255) / Acta Crystallogr. D by GN Murshudov (1997)
  30. Nakae, J., Morioka, H., Ohtsuka, E. & Fujieda, K. Replacements of leucine 87 in human insulin receptor alter affinity for insulin. J. Biol. Chem. 270, 22017–22022 (1995). (10.1074/jbc.270.37.22017) / J. Biol. Chem. by J Nakae (1995)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:39 a.m.)
Deposited 2 years, 3 months ago (May 16, 2023, 8:43 p.m.)
Indexed 1 month ago (July 25, 2025, 6:20 a.m.)
Issued 27 years, 1 month ago (July 1, 1998)
Published 27 years, 1 month ago (July 1, 1998)
Published Print 27 years, 1 month ago (July 1, 1998)
Funders 0

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@article{Garrett_1998, title={Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor}, volume={394}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/28668}, DOI={10.1038/28668}, number={6691}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Garrett, Thomas P. J. and McKern, Neil M. and Lou, Meizhen and Frenkel, Maurice J. and Bentley, John D. and Lovrecz, George O. and Elleman, Thomas C. and Cosgrove, Leah J. and Ward, Colin W.}, year={1998}, month=jul, pages={395–399} }