DOI: 10.1038/267808a0. Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin

Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin

10.1038/267808a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

James, M. N. G., Hsu, I.-N., & Delbaere, L. T. J. (1977). Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin. Nature, 267(5614), 808â813.

Authors 3

Michael N. G. James (first)
I-Nan Hsu (additional)
Louis T. J. Delbaere (additional)

References 26 Referenced 87

Hsu, I.-N., Delbaere, L. T. J., James, M. N. G. & Hofmann, T., Nature 266, 140–145 (1977). (10.1038/266140a0) / Nature by I-N Hsu (1977)
Subramanian, E. et al. Proc. natn. Acad. Sci. U.S.A. 74, 556–559 (1977). (10.1073/pnas.74.2.556) / Proc. natn. Acad. Sci. U.S.A. by E Subramanian (1977)
Fruton, J. S., Adv. Enzym. 44, 1–36 (1976). / Adv. Enzym. by JS Fruton (1976)
Hsu, I.-N., Hofmann, T., Nyburg, S. C. & James, M. N. G., Biochem. biophys. Res. Commun. 72, 363–368 (1976). (10.1016/0006-291X(76)91002-0) / Biochem. biophys. Res. Commun. by I-N Hsu (1976)
Codding, P. W., Delbaere, L. T. J., Hayakawa, K., Hutcheon, W. L. B., James, M. N. G. & Jurasek, L., Can. J. Biochem. 52, 208–220 (1974). (10.1139/o74-034) / Can. J. Biochem. by PW Codding (1974)
Delbaere, L. T. J., Hutcheon, W. L. B., James, M. N. G. & Thiessen, W. E., Nature 257, 758–763 (1975). (10.1038/257758a0) / Nature by LTJ Delbaere (1975)
Blow, D. M. & Crick, F. H. C., Acta Crystallogr. 12, 794–802 (1959). (10.1107/S0365110X59002274) / Acta Crystallogr. by DM Blow (1959)
Cunningham, A. et al. Can. J. Biochem. 54, 902–914 (1976). (10.1139/o76-128) / Can. J. Biochem. by A Cunningham (1976)
Hartsuck, J. A. & Tang, J., J. biol. Chem. 247, 2575–2580 (1972). (10.1016/S0021-9258(19)45464-1) / J. biol. Chem. by JA Hartsuck (1972)
Chen, K. C. S. & Tang, J., J. biol. Chem. 247, 2566–2574 (1972). (10.1016/S0021-9258(19)45463-X) / J. biol. Chem. by KCS Chen (1972)
Lipscomb, W. N. et al. Brookhaven Symp. Biol. 21, 24–90 (1968). / Brookhaven Symp. Biol. by WN Lipscomb (1968)
Quiocho, F. A. & Lipscomb, W. N., Adv. Protein Chem. 25, 1–78 (1971). (10.1016/S0065-3233(08)60278-8) / Adv. Protein Chem. by FA Quiocho (1971)
Wang, T. T., Dorrington, K. J. & Hofmann, T., Biochem. biophys. Res. Commun. 57, 865–869 (1974). (10.1016/0006-291X(74)90626-3) / Biochem. biophys. Res. Commun. by TT Wang (1974)
Parker, R. E. & Isaacs, N. S., Chem. Rev. 59, 737–799 (1959). (10.1021/cr50028a006) / Chem. Rev. by RE Parker (1959)
Blow, D. M., Acc. Chem. Res. 9, 145–152 (1976). (10.1021/ar50100a004) / Acc. Chem. Res. by DM Blow (1976)
Takahashi, M. & Hofmann, T., Biochem. J. 147, 549–563 (1975). (10.1042/bj1470549) / Biochem. J. by M Takahashi (1975)
Sepulveda, P., Marciniszyn, J., Liu, D. & Tang, J., J. biol. Chem. 250, 5082–5088(1975). (10.1016/S0021-9258(19)41281-7) / J. biol. Chem. by P Sepulveda (1975)
Knowles, J. R., Phil. Trans. R. Soc. B 257, 135–146 (1970). / Phil. Trans. R. Soc. by JR Knowles (1970)
Kitson, T. M. & Knowles, J. R., FEBS Lett. 16, 337–338 (1971). (10.1016/0014-5793(71)80384-8) / FEBS Lett. by TM Kitson (1971)
Huang, W.-Y. & Tang, J., Fedn Proc. 30, 759 (1971). / Fedn Proc. by W-Y Huang (1971)
Rühlmann, A., Kukla, D., Schwager, P., Bartels, K. & Huber, R., J. molec. Biol. 77, 417–426(1973). (10.1016/0022-2836(73)90448-8) / J. molec. Biol. by A Rühlmann (1973)
Sweet, R. M., Wright, H. T., Janin, J., Chothia, C. H. & Blow, D. M., Biochemistry 13, 4212–4228 (1974). (10.1021/bi00717a024) / Biochemistry by RM Sweet (1974)
Dreath, J., Jansonius, J. N., Koekoek, R. & Wolthers, B. G., Adv. Protein Chem. 25, 79–115 (1971). (10.1016/S0065-3233(08)60279-X) / Adv. Protein Chem. by J Dreath (1971)
Newmark, A. K. & Knowles, J. R., J. Am. chem. Soc. 97, 3557–3559 (1975). (10.1021/ja00845a068) / J. Am. chem. Soc. by AK Newmark (1975)
Kaiser, E. T. & Kaiser, B. L., Accts Chem. Res. 5, 219–224 (1972). (10.1021/ar50054a005) / Accts Chem. Res. by ET Kaiser (1972)
Fruton, J. S., Accts Chem. Res. 7, 241–246 (1974). (10.1021/ar50080a001) / Accts Chem. Res. by JS Fruton (1974)

Dates

Type	When
Created	20 years ago (Aug. 3, 2005, 1:11 a.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 8:30 p.m.)
Indexed	2 months ago (June 20, 2025, 1:26 p.m.)
Issued	48 years, 2 months ago (June 1, 1977)
Published	48 years, 2 months ago (June 1, 1977)
Published Online	48 years, 2 months ago (June 1, 1977)
Published Print	48 years, 2 months ago (June 1, 1977)

Funders 0

None

BibTeX

@article{James_1977, title={Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin}, volume={267}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/267808a0}, DOI={10.1038/267808a0}, number={5614}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={James, Michael N. G. and Hsu, I-Nan and Delbaere, Louis T. J.}, year={1977}, month=jun, pages={808–813} }

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