Identification of the receptor component of the IκBα–ubiquitin ligase
10.1038/25159
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Yaron, A., Hatzubai, A., Davis, M., Lavon, I., Amit, S., Manning, A. M., Andersen, J. S., Mann, M., Mercurio, F., & Ben-Neriah, Y. (1998). Identification of the receptor component of the IκBα–ubiquitin ligase. Nature, 396(6711), 590–594.

Authors 10
  1. Avraham Yaron (first)
  2. Ada Hatzubai (additional)
  3. Matti Davis (additional)
  4. Iris Lavon (additional)
  5. Sharon Amit (additional)
  6. Anthony M. Manning (additional)
  7. Jens S. Andersen (additional)
  8. Matthias Mann (additional)
  9. Frank Mercurio (additional)
  10. Yinon Ben-Neriah (additional)
References 27 Referenced 574
  1. Baldwin, A. S. J The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649–683 (1996). (10.1146/annurev.immunol.14.1.649) / Annu. Rev. Immunol. by ASJ Baldwin (1996)
  2. May, M. J. & Ghosh, S. Signal transduction through NF-κB. Immunol. Today 19, 80–88 (1998). (10.1016/S0167-5699(97)01197-3) / Immunol. Today by MJ May (1998)
  3. Baeuerle, P. A. & Baltimore, D. NF-κB: ten years after. Cell 87, 13–20 (1996). (10.1016/S0092-8674(00)81318-5) / Cell by PA Baeuerle (1996)
  4. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. & Karin, M. Acytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548–554 (1997). (10.1038/41493) / Nature by JA DiDonato (1997)
  5. Regnier, C. H. et al. Identification and characterization of an IκB kinase. Cell 90, 373–383 (1997). (10.1016/S0092-8674(00)80344-X) / Cell by CH Regnier (1997)
  6. Mercurio, F. et al. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278, 860–866 (1997). (10.1126/science.278.5339.860) / Science by F Mercurio (1997)
  7. Woronicz, J. D., Gao, X., Cao, Z., Rothe, M. & Goeddel, D. V. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278, 866–869 (1997). (10.1126/science.278.5339.866) / Science by JD Woronicz (1997)
  8. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M. & Karin, M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91, 243–252 (1997). (10.1016/S0092-8674(00)80406-7) / Cell by E Zandi (1997)
  9. Yamaoka, S. et al. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93, 1231–1240 (1998). (10.1016/S0092-8674(00)81466-X) / Cell by S Yamaoka (1998)
  10. Rothwarf, D. M., Zandi, E., Natoli, G. & Karin, M. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395, 297–300 (1998). (10.1038/26261) / Nature by DM Rothwarf (1998)
  11. Cohen, L., Henzel, W. J. & Baeuerle, P. A. IKAP is a scaffold protein of the IκB kinase complex. Nature 395, 292–296 (1998). (10.1038/26254) / Nature by L Cohen (1998)
  12. Chen, Z. et al. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 9, 1586–1597 (1995). (10.1101/gad.9.13.1586) / Genes Dev. by Z Chen (1995)
  13. Alkalay, I. et al. Stimulation-dependent IκBα phosphorylation marks the NF-κB inhibitor for degradation via the ubiquitin-proteasome pathway. Proc. Natl Acad. Sci. USA 92, 10599–10603 (1995). (10.1073/pnas.92.23.10599) / Proc. Natl Acad. Sci. USA by I Alkalay (1995)
  14. Yaron, A. et al. Inhibition of NF-κB cellular function via specific targeting of the IκB-ubiquitin ligase. EMBO J. 16, 6486–6494 (1997). (10.1093/emboj/16.21.6486) / EMBO J. by A Yaron (1997)
  15. Wilm, M. et al. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature 379, 466–469 (1996). (10.1038/379466a0) / Nature by M Wilm (1996)
  16. Margottin, F. et al. Anovel human WD protein, h-βTrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol. Cell 1, 565–574 (1998). (10.1016/S1097-2765(00)80056-8) / Mol. Cell by F Margottin (1998)
  17. Shevchenko, A. et al. Rapid de novo peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 11, 1015–1024 (1997). (10.1002/(SICI)1097-0231(19970615)11:9<1015::AID-RCM958>3.0.CO;2-H) / Rapid Commun. Mass Spectrom. by A Shevchenko (1997)
  18. Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425–479 (1998). (10.1146/annurev.biochem.67.1.425) / Annu. Rev. Biochem. by A Hershko (1998)
  19. Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405–439 (1996). (10.1146/annurev.genet.30.1.405) / Annu. Rev. Genet. by M Hochstrasser (1996)
  20. Varshavsky, A. The ubiquitin system. Trends Biochem. Sci. 22, 383–387 (1997). (10.1016/S0968-0004(97)01122-5) / Trends Biochem. Sci. by A Varshavsky (1997)
  21. Paul, M. & Jabbar, M. A. Phosphorylation of both phosphoacceptor sites in the HIV-1 Vpu cytoplasmic domain is essential for Vpu-mediated ER degradation of CD4. Virology 232, 207–216 (1997). (10.1006/viro.1997.8541) / Virology by M Paul (1997)
  22. Jiang, J. & Struhl, G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493–496 (1998). (10.1038/35154) / Nature by J Jiang (1998)
  23. Skowyra, D., Craig, K. L., Tyers, M., Elledge, S. J. & Harper, J. W. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209–219 (1997). (10.1016/S0092-8674(00)80403-1) / Cell by D Skowyra (1997)
  24. Feldman, R. M., Correll, C. C., Kaplan, K. B. & Deshaies, R. J. Acomplex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221–230 (1997). (10.1016/S0092-8674(00)80404-3) / Cell by RM Feldman (1997)
  25. Patton, E. E. et al. Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12, 692–705 (1998). (10.1101/gad.12.5.692) / Genes Dev. by EE Patton (1998)
  26. Elledge, S. J. & Harper, J. W. The role of protein stability in the cell cycle and cancer. Biochim. Biophys. Acta 1377, M61–M70 (1998). / Biochim. Biophys. Acta by SJ Elledge (1998)
  27. Jensen, J. P., Bates, P. W., Yang, M., Vierstra, R. D. & Weissman, A. M. Identification of a family of closely related human ubiquitin conjugating enzymes. J. Biol. Chem. 270, 30408–30414 (1995). (10.1074/jbc.270.51.30408) / J. Biol. Chem. by JP Jensen (1995)
Dates
Type When
Created 23 years ago (July 26, 2002, 4:39 a.m.)
Deposited 2 years, 3 months ago (May 16, 2023, 3:18 a.m.)
Indexed 1 month, 1 week ago (July 14, 2025, 11:15 p.m.)
Issued 26 years, 8 months ago (Dec. 1, 1998)
Published 26 years, 8 months ago (Dec. 1, 1998)
Published Print 26 years, 8 months ago (Dec. 1, 1998)
Funders 0

None

@article{Yaron_1998, title={Identification of the receptor component of the IκBα–ubiquitin ligase}, volume={396}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/25159}, DOI={10.1038/25159}, number={6711}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Yaron, Avraham and Hatzubai, Ada and Davis, Matti and Lavon, Iris and Amit, Sharon and Manning, Anthony M. and Andersen, Jens S. and Mann, Matthias and Mercurio, Frank and Ben-Neriah, Yinon}, year={1998}, month=dec, pages={590–594} }