DOI: 10.1038/234466a0. Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions

Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions

10.1038/234466a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

LITWACK, G., KETTERER, B., & ARIAS, I. M. (1971). Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions. Nature, 234(5330), 466â467.

Authors 3

GERALD LITWACK (first)
BRIAN KETTERER (additional)
IRWIN M. ARIAS (additional)

References 23 Referenced 420

Ketterer, B., and Whitehead, J. K., FEBS Abstracts, 57 (1965). (10.2307/3756752)
Ketterer, B., Ross-Mansell, P., and Whitehead, J. K., Biochem. J., 103, 316 (1967). (10.1042/bj1030316) / Biochem. J. by B Ketterer (1967)
Morey, K. S., and Litwack, G., Biochemistry, 8, 4813 (1969). (10.1021/bi00840a024) / Biochemistry by KS Morey (1969)
Singer, S., Morey, K. S., and Litwack, G., Physiol. Chem. Physics, 2, 117 (1970). / Physiol. Chem. Physics by S Singer (1970)
Levi, A. J., Gatmaitan, Z., and Arias, I. M., J. Clin. Invest., 48, 2156 (1969). (10.1172/JCI106182) / J. Clin. Invest. by AJ Levi (1969)
Ketterer, B., and Beale, D., Biochem. J., 122, 53p (1971). (10.1042/bj1220053Pb) / Biochem. J. by B Ketterer (1971)
Litwack, G., and Morey, K. S., Biochem. Biophys. Res. Commun., 38, 1141 (1970). (10.1016/0006-291X(70)90358-X) / Biochem. Biophys. Res. Commun. by G Litwack (1970)
Fleischner, G., Mishkin, S., Reyes, H., Robbins, J., Levi, A. J., Gatmaitan, Z., and Arias, I. M., J. Clin. Invest., 50, 31a (1971). / J. Clin. Invest. by G Fleischner (1971)
Litwack, G., Morey, K. S., and Ketterer, B., in Drugs and Cellular Control Mechanisms (edit. by Rabin, B. R.) (Macmillan, London, in the press).
Levi, A. J., Gatmaitan, Z., and Arias, I. M., Lancet, ii, 139 (1969). (10.1016/S0140-6736(69)92444-1)
Fleischner, G., and Arias, I. M., Amer. J. Med., 48, 576 (1970). (10.1016/S0002-9343(70)80126-7) / Amer. J. Med. by G Fleischner (1970)
Levi, A. J., Gatmaitan, Z., and Arias, I. M., New Engl. J. Med., 283, 1136 (1970). (10.1056/NEJM197011192832104) / New Engl. J. Med. by AJ Levi (1970)
Singer, S., and Litwack, G., Endocrinology, 88, 1448 (1971) (10.1210/endo-88-6-1448) / Endocrinology by S Singer (1971)
Levine, R., Reyes, H., Levi, A. J., Gatmaitan, Z., and Arias, I. M., Nature New Biology, 231, 277 (1971). (10.1038/newbio231277a0) / Nature New Biology by R Levine (1971)
Baldwin, R. W., Barker, C. R., and Moore, M., Brit. J. Cancer, 22, 776 (1968). (10.1038/bjc.1968.92) / Brit. J. Cancer by RW Baldwin (1968)
Singer, S., and Litwack, G., Cancer Res., 31, 1364 (1971). / Cancer Res. by S Singer (1971)
Ketterer, B., and Christodoulides, L., Chem.-Biol. Interact., 1, 173 (1969). (10.1016/0009-2797(69)90005-2) / Chem.-Biol. Interact. by B Ketterer (1969)
Reyes, H., Levi, A. J., Gatmaitan, Z., and Arias, I. M., Proc. US Nat. Acad. Sci., 64, 168 (1969). (10.1073/pnas.64.1.168) / Proc. US Nat. Acad. Sci. by H Reyes (1969)
Reyes, H., Levi, A. J., Levine, R., Gatmaitan, Z., and Arias, I. M., Proc. New York Acad. Sci. (in the press).
Reyes, H., Levi, A. J., Gatmaitan, Z., and Arias, I. M., J. Clin. Invest. (in the press).
Bakay, B., and Sorof, S., Cancer Res., 24, 1814 (1964). / Cancer Res. by B Bakay (1964)
Ketterer, B., Beale, D., Litwack, G., and Hackney, J. F., Chem.-Biol. Interact., 3, 285 (1971). (10.1016/0009-2797(71)90062-7) / Chem.-Biol. Interact. by B Ketterer (1971)
Litwack, G., and Singer, S., in Biochemical Actions of Hormones (edit. by Litwack, G.), 2 (Academic Press, New York) (in the press).

Dates

Type	When
Created	20 years ago (Aug. 2, 2005, 3:41 a.m.)
Deposited	3 years, 8 months ago (Dec. 1, 2021, 7:29 p.m.)
Indexed	2 weeks, 6 days ago (Aug. 5, 2025, 8:51 a.m.)
Issued	53 years, 8 months ago (Dec. 1, 1971)
Published	53 years, 8 months ago (Dec. 1, 1971)
Published Print	53 years, 8 months ago (Dec. 1, 1971)

Funders 0

None

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        5
      ]
    ],
    "date-time": "2025-08-05T12:51:48Z",
    "timestamp": 1754398308517
  },
  "reference-count": 23,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "5330",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1971,
            12,
            1
          ]
        ],
        "date-time": "1971-12-01T00:00:00Z",
        "timestamp": 60393600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1971,
        12
      ]
    ]
  },
  "DOI": "10.1038/234466a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        8,
        2
      ]
    ],
    "date-time": "2005-08-02T07:41:47Z",
    "timestamp": 1122968507000
  },
  "page": "466-467",
  "source": "Crossref",
  "is-referenced-by-count": 420,
  "title": "Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions",
  "prefix": "10.1038",
  "volume": "234",
  "author": [
    {
      "given": "GERALD",
      "family": "LITWACK",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "BRIAN",
      "family": "KETTERER",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "IRWIN M.",
      "family": "ARIAS",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF234466a0_CR1",
      "doi-asserted-by": "crossref",
      "unstructured": "Ketterer, B., and Whitehead, J. K., FEBS Abstracts, 57 (1965).",
      "DOI": "10.2307/3756752"
    },
    {
      "key": "BF234466a0_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "316",
      "DOI": "10.1042/bj1030316",
      "volume": "103",
      "author": "B Ketterer",
      "year": "1967",
      "unstructured": "Ketterer, B., Ross-Mansell, P., and Whitehead, J. K., Biochem. J., 103, 316 (1967).",
      "journal-title": "Biochem. J."
    },
    {
      "key": "BF234466a0_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "4813",
      "DOI": "10.1021/bi00840a024",
      "volume": "8",
      "author": "KS Morey",
      "year": "1969",
      "unstructured": "Morey, K. S., and Litwack, G., Biochemistry, 8, 4813 (1969).",
      "journal-title": "Biochemistry"
    },
    {
      "key": "BF234466a0_CR4",
      "first-page": "117",
      "volume": "2",
      "author": "S Singer",
      "year": "1970",
      "unstructured": "Singer, S., Morey, K. S., and Litwack, G., Physiol. Chem. Physics, 2, 117 (1970).",
      "journal-title": "Physiol. Chem. Physics"
    },
    {
      "key": "BF234466a0_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "2156",
      "DOI": "10.1172/JCI106182",
      "volume": "48",
      "author": "AJ Levi",
      "year": "1969",
      "unstructured": "Levi, A. J., Gatmaitan, Z., and Arias, I. M., J. Clin. Invest., 48, 2156 (1969).",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "BF234466a0_CR6",
      "doi-asserted-by": "crossref",
      "first-page": "53p",
      "DOI": "10.1042/bj1220053Pb",
      "volume": "122",
      "author": "B Ketterer",
      "year": "1971",
      "unstructured": "Ketterer, B., and Beale, D., Biochem. J., 122, 53p (1971).",
      "journal-title": "Biochem. J."
    },
    {
      "key": "BF234466a0_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "1141",
      "DOI": "10.1016/0006-291X(70)90358-X",
      "volume": "38",
      "author": "G Litwack",
      "year": "1970",
      "unstructured": "Litwack, G., and Morey, K. S., Biochem. Biophys. Res. Commun., 38, 1141 (1970).",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "BF234466a0_CR8",
      "first-page": "31a",
      "volume": "50",
      "author": "G Fleischner",
      "year": "1971",
      "unstructured": "Fleischner, G., Mishkin, S., Reyes, H., Robbins, J., Levi, A. J., Gatmaitan, Z., and Arias, I. M., J. Clin. Invest., 50, 31a (1971).",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "BF234466a0_CR9",
      "unstructured": "Litwack, G., Morey, K. S., and Ketterer, B., in Drugs and Cellular Control Mechanisms (edit. by Rabin, B. R.) (Macmillan, London, in the press)."
    },
    {
      "key": "BF234466a0_CR10",
      "doi-asserted-by": "crossref",
      "unstructured": "Levi, A. J., Gatmaitan, Z., and Arias, I. M., Lancet, ii, 139 (1969).",
      "DOI": "10.1016/S0140-6736(69)92444-1"
    },
    {
      "key": "BF234466a0_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "576",
      "DOI": "10.1016/S0002-9343(70)80126-7",
      "volume": "48",
      "author": "G Fleischner",
      "year": "1970",
      "unstructured": "Fleischner, G., and Arias, I. M., Amer. J. Med., 48, 576 (1970).",
      "journal-title": "Amer. J. Med."
    },
    {
      "key": "BF234466a0_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "1136",
      "DOI": "10.1056/NEJM197011192832104",
      "volume": "283",
      "author": "AJ Levi",
      "year": "1970",
      "unstructured": "Levi, A. J., Gatmaitan, Z., and Arias, I. M., New Engl. J. Med., 283, 1136 (1970).",
      "journal-title": "New Engl. J. Med."
    },
    {
      "key": "BF234466a0_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "1448",
      "DOI": "10.1210/endo-88-6-1448",
      "volume": "88",
      "author": "S Singer",
      "year": "1971",
      "unstructured": "Singer, S., and Litwack, G., Endocrinology, 88, 1448 (1971)",
      "journal-title": "Endocrinology"
    },
    {
      "key": "BF234466a0_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "277",
      "DOI": "10.1038/newbio231277a0",
      "volume": "231",
      "author": "R Levine",
      "year": "1971",
      "unstructured": "Levine, R., Reyes, H., Levi, A. J., Gatmaitan, Z., and Arias, I. M., Nature New Biology, 231, 277 (1971).",
      "journal-title": "Nature New Biology"
    },
    {
      "key": "BF234466a0_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "776",
      "DOI": "10.1038/bjc.1968.92",
      "volume": "22",
      "author": "RW Baldwin",
      "year": "1968",
      "unstructured": "Baldwin, R. W., Barker, C. R., and Moore, M., Brit. J. Cancer, 22, 776 (1968).",
      "journal-title": "Brit. J. Cancer"
    },
    {
      "key": "BF234466a0_CR16",
      "first-page": "1364",
      "volume": "31",
      "author": "S Singer",
      "year": "1971",
      "unstructured": "Singer, S., and Litwack, G., Cancer Res., 31, 1364 (1971).",
      "journal-title": "Cancer Res."
    },
    {
      "key": "BF234466a0_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "173",
      "DOI": "10.1016/0009-2797(69)90005-2",
      "volume": "1",
      "author": "B Ketterer",
      "year": "1969",
      "unstructured": "Ketterer, B., and Christodoulides, L., Chem.-Biol. Interact., 1, 173 (1969).",
      "journal-title": "Chem.-Biol. Interact."
    },
    {
      "key": "BF234466a0_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "168",
      "DOI": "10.1073/pnas.64.1.168",
      "volume": "64",
      "author": "H Reyes",
      "year": "1969",
      "unstructured": "Reyes, H., Levi, A. J., Gatmaitan, Z., and Arias, I. M., Proc. US Nat. Acad. Sci., 64, 168 (1969).",
      "journal-title": "Proc. US Nat. Acad. Sci."
    },
    {
      "key": "BF234466a0_CR19",
      "unstructured": "Reyes, H., Levi, A. J., Levine, R., Gatmaitan, Z., and Arias, I. M., Proc. New York Acad. Sci. (in the press)."
    },
    {
      "key": "BF234466a0_CR20",
      "unstructured": "Reyes, H., Levi, A. J., Gatmaitan, Z., and Arias, I. M., J. Clin. Invest. (in the press)."
    },
    {
      "key": "BF234466a0_CR21",
      "first-page": "1814",
      "volume": "24",
      "author": "B Bakay",
      "year": "1964",
      "unstructured": "Bakay, B., and Sorof, S., Cancer Res., 24, 1814 (1964).",
      "journal-title": "Cancer Res."
    },
    {
      "key": "BF234466a0_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "285",
      "DOI": "10.1016/0009-2797(71)90062-7",
      "volume": "3",
      "author": "B Ketterer",
      "year": "1971",
      "unstructured": "Ketterer, B., Beale, D., Litwack, G., and Hackney, J. F., Chem.-Biol. Interact., 3, 285 (1971).",
      "journal-title": "Chem.-Biol. Interact."
    },
    {
      "key": "BF234466a0_CR23",
      "unstructured": "Litwack, G., and Singer, S., in Biochemical Actions of Hormones (edit. by Litwack, G.), 2 (Academic Press, New York) (in the press)."
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/234466a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/234466a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/234466a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        12,
        2
      ]
    ],
    "date-time": "2021-12-02T00:29:58Z",
    "timestamp": 1638404998000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/234466a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1971,
        12
      ]
    ]
  },
  "references-count": 23,
  "journal-issue": {
    "issue": "5330",
    "published-print": {
      "date-parts": [
        [
          1971,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "BF234466a0"
  ],
  "URL": "http://dx.doi.org/10.1038/234466a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1971,
        12
      ]
    ]
  }
}