Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
10.1038/22572
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Huang, J. T., Welch, J. S., Ricote, M., Binder, C. J., Willson, T. M., Kelly, C., Witztum, J. L., Funk, C. D., Conrad, D., & Glass, C. K. (1999). Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase. Nature, 400(6742), 378–382.

Authors 10
  1. Jannet T. Huang (first)
  2. John S. Welch (additional)
  3. Mercedes Ricote (additional)
  4. Christoph J. Binder (additional)
  5. Timothy M. Willson (additional)
  6. Carolyn Kelly (additional)
  7. Joseph L. Witztum (additional)
  8. Colin D. Funk (additional)
  9. Douglas Conrad (additional)
  10. Christopher K. Glass (additional)
References 30 Referenced 728
  1. Tontonoz, P., Hu, E. & Spiegelman, B. M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147–1156 (1994). (10.1016/0092-8674(94)90006-X) / Cell by P Tontonoz (1994)
  2. Lehmann, J. M.et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor-γ (PPARγ). J. Biol. Chem. 270, 12953–12956 (1995). (10.1074/jbc.270.22.12953) / J. Biol. Chem. by JM Lehmann (1995)
  3. Willson, T. M.et al. The structure–activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem. 39, 665–668 (1996). (10.1021/jm950395a) / J. Med. Chem. by TM Willson (1996)
  4. Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomazy, V. A. & Evans, R. M. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93, 241–252 (1998). (10.1016/S0092-8674(00)81575-5) / Cell by P Tontonoz (1998)
  5. Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J. & Glass, C. K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391, 79–82 (1998). (10.1038/34178) / Nature by M Ricote (1998)
  6. Jiang, C., Ting, A. T. & Seed, B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82–86 (1998). (10.1038/34184) / Nature by C Jiang (1998)
  7. Kliewer, S. A.et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc. Natl Acad. Sci. USA 94, 4318–4323 (1997). (10.1073/pnas.94.9.4318) / Proc. Natl Acad. Sci. USA by SA Kliewer (1997)
  8. Kliewer, S. A.et al. Aprostaglandin J2metabolite binds peroxisome prolifator-activated receptorγ and promotes adipocyte differentiation. Cell 83, 813–819 (1995). (10.1016/0092-8674(95)90194-9) / Cell by SA Kliewer (1995)
  9. Forman, B. M.et al. 15-Deoxy-Δ12,14-prostaglandin J2is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803–812 (1995). (10.1016/0092-8674(95)90193-0) / Cell by BM Forman (1995)
  10. Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H. & Evans, R. M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-γ. Cell 93, 229–240 (1998). (10.1016/S0092-8674(00)81574-3) / Cell by L Nagy (1998)
  11. Conrad, D. J., Kuhn, H., Mulkins, M., Highland, E. & Sigal, E. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc. Natl Acad. Sci. USA 89, 217–221 (1992). (10.1073/pnas.89.1.217) / Proc. Natl Acad. Sci. USA by DJ Conrad (1992)
  12. Ricote, M.et al. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc. Natl Acad. Sci. USA 95, 7614–7619 (1998). (10.1073/pnas.95.13.7614) / Proc. Natl Acad. Sci. USA by M Ricote (1998)
  13. Zhu, Y.et al. Structural organization of mouse peroxisome proliferator-activated receptor γ (mPPAR γ) gene: alternative promoter use and different splicing yield two mPPAR γ isoforms. Proc. Natl Acad. Sci. USA 92, 7921–7925 (1995). (10.1073/pnas.92.17.7921) / Proc. Natl Acad. Sci. USA by Y Zhu (1995)
  14. Fajas, L., Fruchart, J. C. & Auwerx, J. PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter. FEBS Lett. 438, 55–60 (1998). (10.1016/S0014-5793(98)01273-3) / FEBS Lett. by L Fajas (1998)
  15. Yamamoto, S. Mammalian lipoxygenases: molecular structure and functions. Biochem. Biophys. Res. Commun. 1128, 117–131 (1992). / Biochem. Biophys. Res. Commun. by S Yamamoto (1992)
  16. van Leyen, K., Duvoisin, R. M., Engelhardt, H. & Wiedmann, M. Afunction for lipoxygenase in programmed organelle degradation. Nature 395, 392–395 (1998). (10.1038/26500) / Nature by K van Leyen (1998)
  17. Rankin, S. M., Parthasarathy, S. & Steinberg, D. Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. J. Lipid Res. 32, 449–456 (1991). (10.1016/S0022-2275(20)42068-1) / J. Lipid Res. by SM Rankin (1991)
  18. Benz, D. J.et al. Enhanced levels of lipoperoxides in low density lipoproteins incubated with murine fibroblasts expressing high levels of human 15-lipoxygenase. J. Biol. Chem. 270, 5191–5197 (1995). (10.1074/jbc.270.10.5191) / J. Biol. Chem. by DJ Benz (1995)
  19. Funk, C. D. The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice. Biochim. Biophys. Acta 1304, 65–84 (1996). (10.1016/S0005-2760(96)00107-5) / Biochim. Biophys. Acta by CD Funk (1996)
  20. Kuhn, H. Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)xy-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)xy-9Z,11E-octadecadienoic acid. Prog. Lipid Res. 35, 203–226 (1996). (10.1016/S0163-7827(96)00008-2) / Prog. Lipid Res. by H Kuhn (1996)
  21. Heydeck, D.et al. Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6. Blood 92, 2503–2510 (1998). (10.1182/blood.V92.7.2503) / Blood by D Heydeck (1998)
  22. Scheidegger, K. J., Butler, S. & Witztum, J. L. Angiotensin II increases macrophage-mediated modification of low density lipoprotein via a lipoxygenase-dependent pathway. J. Biol. Chem. 272, 21609–21615 (1997). (10.1074/jbc.272.34.21609) / J. Biol. Chem. by KJ Scheidegger (1997)
  23. Bogdan, C., Vodovotz, Y., Paik, J., Xie, Q.-W. & Nathan, C. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. J. Leukocyte Biol. 55, 227–233 (1994). (10.1002/jlb.55.2.227) / J. Leukocyte Biol. by C Bogdan (1994)
  24. Yesner, L. M., Huh, H. Y., Pearce, S. F. & Silverstein, R. L. Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators. Arterioscler. Thromb. Vasc. Biol. 16, 1019–1025 (1996). (10.1161/01.ATV.16.8.1019) / Arterioscler. Thromb. Vasc. Biol. by LM Yesner (1996)
  25. Yamada, Y., Doi, T., Hamakubo, T. & Kodama, T. Scavenger receptor family proteins: roles for atherosclerosis, host defence and disorders of the central nervous system. Cell. Mol. Life Sci. 54, 628–640 (1998). (10.1007/s000180050191) / Cell. Mol. Life Sci. by Y Yamada (1998)
  26. Endemann, G.et al. CD36 is a receptor for oxidized low density lipoprotein. J. Biol. Chem. 268, 11811–11816 (1993). (10.1016/S0021-9258(19)50272-1) / J. Biol. Chem. by G Endemann (1993)
  27. Savill, J. S., Hogg, N., Ren, Y. & Haslett, C. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J. Clin. Invest. 90, 1513–1522 (1992). (10.1172/JCI116019) / J. Clin. Invest. by JS Savill (1992)
  28. Sun, D. & Funk, C. D. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. J. Biol. Chem. 271, 24055–24062 (1996). (10.1074/jbc.271.39.24055) / J. Biol. Chem. by D Sun (1996)
  29. Nolte, R. T.et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ. Nature 395, 137–143 (1998). (10.1038/25931) / Nature by RT Nolte (1998)
  30. Sigal, E. C., Craik, C. S. & Highland, E. Molecular cloning and primary structure of human 15-lipoxygenase. Biochem. Biophys. Res. Commun. 157, 457–464 (1988). (10.1016/S0006-291X(88)80271-7) / Biochem. Biophys. Res. Commun. by EC Sigal (1988)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:41 a.m.)
Deposited 3 years, 8 months ago (Dec. 1, 2021, 2:17 p.m.)
Indexed 1 day, 20 hours ago (Aug. 28, 2025, 8:14 a.m.)
Issued 26 years, 1 month ago (July 1, 1999)
Published 26 years, 1 month ago (July 1, 1999)
Published Print 26 years, 1 month ago (July 1, 1999)
Funders 0

None

@article{Huang_1999, title={Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase}, volume={400}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/22572}, DOI={10.1038/22572}, number={6742}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Huang, Jannet T. and Welch, John S. and Ricote, Mercedes and Binder, Christoph J. and Willson, Timothy M. and Kelly, Carolyn and Witztum, Joseph L. and Funk, Colin D. and Conrad, Douglas and Glass, Christopher K.}, year={1999}, month=jul, pages={378–382} }