DOI: 10.1038/2221243a0. Inhibition of CO2 Combination and Reduction of the Bohr Effect in Haemoglobin chemically modified at its α-Amino Groups

Inhibition of CO2 Combination and Reduction of the Bohr Effect in Haemoglobin chemically modified at its α-Amino Groups

10.1038/2221243a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

KILMARTIN, J. V., & ROSSI-BERNARDI, L. (1969). Inhibition of CO2 Combination and Reduction of the Bohr Effect in Haemoglobin chemically modified at its Î±-Amino Groups. Nature, 222(5200), 1243â1246.

Authors 2

J. V. KILMARTIN (first)
L. ROSSI-BERNARDI (additional)

References 25 Referenced 206

Ferguson, J. K. W., and Roughton, F. J. W., J. Physiol., 83, 68 (1934). (10.1113/jphysiol.1934.sp003212) / J. Physiol. by JKW Ferguson (1934)
Ferguson, J. K. W., and Roughton, F. J. W., J. Physiol., 83, 87 (1934). (10.1113/jphysiol.1934.sp003213) / J. Physiol. by JKW Ferguson (1934)
Ferguson, J. K. W., J. Physiol., 88, 40 (1936). (10.1113/jphysiol.1936.sp003421) / J. Physiol. by JKW Ferguson (1936)
Rossi-Bernardi, L., and Roughton, F. J. W., J. Physiol., 189, 1 (1967). (10.1113/jphysiol.1967.sp008152) / J. Physiol. by L Rossi-Bernardi (1967)
Faurolt, C., J. Chim. Phys., 22, 1 (1925). Siegfried, H., Z. Physiol. Chem., 44, 85 (1905). / J. Chim. Phys. by C Faurolt (1925)
Tanford, C., Physical Chemistry of Macromolecules (Wiley, New York, 1962). / Physical Chemistry of Macromolecules by C Tanford (1962)
Tanford, C., and Nozaki, Y., J. Biol. Chem., 241, 2832 (1966). (10.1016/S0021-9258(18)96539-7) / J. Biol. Chem. by C Tanford (1966)
Rossi-Bernardi, L., and Roughton, F. J. W., J. Biol. Chem., 242, 784 (1967). (10.1016/S0021-9258(18)96194-6) / J. Biol. Chem. by L Rossi-Bernardi (1967)
Hill, R. J., and Davis, R. W., J. Biol. Chem., 242, 2005 (1967). (10.1016/S0021-9258(18)96009-6) / J. Biol. Chem. by RJ Hill (1967)
Stark, G. R., and Smyth, D. G., J. Biol. Chem., 238, 214 (1963). (10.1016/S0021-9258(19)83983-2) / J. Biol. Chem. by GR Stark (1963)
Stark, G. R., Biochemistry, 4, 1030 (1965). (10.1021/bi00882a008) / Biochemistry by GR Stark (1965)
Smyth, D. G., J. Biol. Chem., 242, 1579 (1967). (10.1016/S0021-9258(18)96131-4) / J. Biol. Chem. by DG Smyth (1967)
Perutz, M. F., Muirhead, H., Cox, J. M., and Goaman, L. C. G., Nature, 219, 131 (1968). (10.1038/219131a0) / Nature by MF Perutz (1968)
Bolton, W., Cox, J. M., and Perutz, M. F., J. Mol. Biol., 33, 283 (1968). (10.1016/0022-2836(68)90294-5) / J. Mol. Biol. by W Bolton (1968)
Bangham, A. D., and Lehmann, H., Nature, 181, 267 (1958). (10.1038/181267a0) / Nature by AD Bangham (1958)
Kilmartin, J. V., and Clegg, J. B., Nature, 213, 269 (1967). (10.1038/213269a0) / Nature by JV Kilmartin (1967)
Clegg, M. D., and Schroeder, W. A., J. Amer. Chem. Soc., 81, 6065 (1959). (10.1021/ja01531a051) / J. Amer. Chem. Soc. by MD Clegg (1959)
Taylor, J. F., Antonini, E., Brunori, M., and Wyman, J., J. Biol. Chem., 241, 241 (1966). (10.1016/S0021-9258(18)96985-1) / J. Biol. Chem. by JF Taylor (1966)
Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Mol. Biol., 19, 91 (1966). (10.1016/S0022-2836(66)80052-9) / J. Mol. Biol. by JB Clegg (1966)
Kilmartin, J. V., and Rossi-Bernardi, L., Symposium on CO2 (International Union of Physiological Sciences, 1968, in the press). / Symposium on CO2 by JV Kilmartin (1968)
Riggs, A. F., J. Gen. Physiol., 35, 23 (1951). (10.1085/jgp.35.1.23) / J. Gen. Physiol. by AF Riggs (1951)
Margaria, R., and Green, A. A., J. Biol. Chem., 102, 611 (1933). (10.1016/S0021-9258(18)50194-0) / J. Biol. Chem. by R Margaria (1933)
Kernohan, J. C., Kreuzer, F., Rossi-Bernardi, L., and Roughton, F. J. W., Biochem. J., 100, 49P (1966). / Biochem. J. by JC Kernohan (1966)
Stadie, W. C., and O'Brien, H., J. Biol. Chem., 117, 439 (1937). (10.1016/S0021-9258(18)74545-6) / J. Biol. Chem. by WC Stadie (1937)
Perutz, M. F., Muirhead, H., Mazzarella, L., Crowther, R. G. A., Greer, J., and Kilmartin, J. V., preceding paper, Nature, 222, 1240 (1969). (10.1038/2221240a0) / Nature by MF Perutz (1969)

Dates

Type	When
Created	19 years, 2 months ago (July 6, 2006, 10:54 a.m.)
Deposited	3 years, 9 months ago (Dec. 1, 2021, 3:42 p.m.)
Indexed	2 days, 3 hours ago (Sept. 4, 2025, 9:57 a.m.)
Issued	56 years, 3 months ago (June 1, 1969)
Published	56 years, 3 months ago (June 1, 1969)
Published Print	56 years, 3 months ago (June 1, 1969)

Funders 0

None

BibTeX

@article{KILMARTIN_1969, title={Inhibition of CO2 Combination and Reduction of the Bohr Effect in Haemoglobin chemically modified at its α-Amino Groups}, volume={222}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/2221243a0}, DOI={10.1038/2221243a0}, number={5200}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={KILMARTIN, J. V. and ROSSI-BERNARDI, L.}, year={1969}, month=jun, pages={1243–1246} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T13:57:18Z",
    "timestamp": 1756994238853
  },
  "reference-count": 25,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "5200",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1969,
            6,
            1
          ]
        ],
        "date-time": "1969-06-01T00:00:00Z",
        "timestamp": -18489600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1969,
        6
      ]
    ]
  },
  "DOI": "10.1038/2221243a0",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        7,
        6
      ]
    ],
    "date-time": "2006-07-06T14:54:30Z",
    "timestamp": 1152197670000
  },
  "page": "1243-1246",
  "source": "Crossref",
  "is-referenced-by-count": 206,
  "title": "Inhibition of CO2 Combination and Reduction of the Bohr Effect in Haemoglobin chemically modified at its \u03b1-Amino Groups",
  "prefix": "10.1038",
  "volume": "222",
  "author": [
    {
      "given": "J. V.",
      "family": "KILMARTIN",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "L.",
      "family": "ROSSI-BERNARDI",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF2221243a0_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "68",
      "DOI": "10.1113/jphysiol.1934.sp003212",
      "volume": "83",
      "author": "JKW Ferguson",
      "year": "1934",
      "unstructured": "Ferguson, J. K. W., and Roughton, F. J. W., J. Physiol., 83, 68 (1934).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF2221243a0_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "87",
      "DOI": "10.1113/jphysiol.1934.sp003213",
      "volume": "83",
      "author": "JKW Ferguson",
      "year": "1934",
      "unstructured": "Ferguson, J. K. W., and Roughton, F. J. W., J. Physiol., 83, 87 (1934).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF2221243a0_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "40",
      "DOI": "10.1113/jphysiol.1936.sp003421",
      "volume": "88",
      "author": "JKW Ferguson",
      "year": "1936",
      "unstructured": "Ferguson, J. K. W., J. Physiol., 88, 40 (1936).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF2221243a0_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "1",
      "DOI": "10.1113/jphysiol.1967.sp008152",
      "volume": "189",
      "author": "L Rossi-Bernardi",
      "year": "1967",
      "unstructured": "Rossi-Bernardi, L., and Roughton, F. J. W., J. Physiol., 189, 1 (1967).",
      "journal-title": "J. Physiol."
    },
    {
      "key": "BF2221243a0_CR5",
      "first-page": "1",
      "volume": "22",
      "author": "C Faurolt",
      "year": "1925",
      "unstructured": "Faurolt, C., J. Chim. Phys., 22, 1 (1925). Siegfried, H., Z. Physiol. Chem., 44, 85 (1905).",
      "journal-title": "J. Chim. Phys."
    },
    {
      "key": "BF2221243a0_CR6",
      "volume-title": "Physical Chemistry of Macromolecules",
      "author": "C Tanford",
      "year": "1962",
      "unstructured": "Tanford, C., Physical Chemistry of Macromolecules (Wiley, New York, 1962)."
    },
    {
      "key": "BF2221243a0_CR7",
      "doi-asserted-by": "crossref",
      "first-page": "2832",
      "DOI": "10.1016/S0021-9258(18)96539-7",
      "volume": "241",
      "author": "C Tanford",
      "year": "1966",
      "unstructured": "Tanford, C., and Nozaki, Y., J. Biol. Chem., 241, 2832 (1966).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF2221243a0_CR8",
      "doi-asserted-by": "crossref",
      "first-page": "784",
      "DOI": "10.1016/S0021-9258(18)96194-6",
      "volume": "242",
      "author": "L Rossi-Bernardi",
      "year": "1967",
      "unstructured": "Rossi-Bernardi, L., and Roughton, F. J. W., J. Biol. Chem., 242, 784 (1967).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF2221243a0_CR9",
      "doi-asserted-by": "crossref",
      "first-page": "2005",
      "DOI": "10.1016/S0021-9258(18)96009-6",
      "volume": "242",
      "author": "RJ Hill",
      "year": "1967",
      "unstructured": "Hill, R. J., and Davis, R. W., J. Biol. Chem., 242, 2005 (1967).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF2221243a0_CR10",
      "doi-asserted-by": "crossref",
      "first-page": "214",
      "DOI": "10.1016/S0021-9258(19)83983-2",
      "volume": "238",
      "author": "GR Stark",
      "year": "1963",
      "unstructured": "Stark, G. R., and Smyth, D. G., J. Biol. Chem., 238, 214 (1963).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF2221243a0_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "1030",
      "DOI": "10.1021/bi00882a008",
      "volume": "4",
      "author": "GR Stark",
      "year": "1965",
      "unstructured": "Stark, G. R., Biochemistry, 4, 1030 (1965).",
      "journal-title": "Biochemistry"
    },
    {
      "key": "BF2221243a0_CR12",
      "doi-asserted-by": "crossref",
      "first-page": "1579",
      "DOI": "10.1016/S0021-9258(18)96131-4",
      "volume": "242",
      "author": "DG Smyth",
      "year": "1967",
      "unstructured": "Smyth, D. G., J. Biol. Chem., 242, 1579 (1967).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF2221243a0_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "131",
      "DOI": "10.1038/219131a0",
      "volume": "219",
      "author": "MF Perutz",
      "year": "1968",
      "unstructured": "Perutz, M. F., Muirhead, H., Cox, J. M., and Goaman, L. C. G., Nature, 219, 131 (1968).",
      "journal-title": "Nature"
    },
    {
      "key": "BF2221243a0_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "283",
      "DOI": "10.1016/0022-2836(68)90294-5",
      "volume": "33",
      "author": "W Bolton",
      "year": "1968",
      "unstructured": "Bolton, W., Cox, J. M., and Perutz, M. F., J. Mol. Biol., 33, 283 (1968).",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "BF2221243a0_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "267",
      "DOI": "10.1038/181267a0",
      "volume": "181",
      "author": "AD Bangham",
      "year": "1958",
      "unstructured": "Bangham, A. D., and Lehmann, H., Nature, 181, 267 (1958).",
      "journal-title": "Nature"
    },
    {
      "key": "BF2221243a0_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "269",
      "DOI": "10.1038/213269a0",
      "volume": "213",
      "author": "JV Kilmartin",
      "year": "1967",
      "unstructured": "Kilmartin, J. V., and Clegg, J. B., Nature, 213, 269 (1967).",
      "journal-title": "Nature"
    },
    {
      "key": "BF2221243a0_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "6065",
      "DOI": "10.1021/ja01531a051",
      "volume": "81",
      "author": "MD Clegg",
      "year": "1959",
      "unstructured": "Clegg, M. D., and Schroeder, W. A., J. Amer. Chem. Soc., 81, 6065 (1959).",
      "journal-title": "J. Amer. Chem. Soc."
    },
    {
      "key": "BF2221243a0_CR18",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1016/S0021-9258(18)96985-1",
      "volume": "241",
      "author": "JF Taylor",
      "year": "1966",
      "unstructured": "Taylor, J. F., Antonini, E., Brunori, M., and Wyman, J., J. Biol. Chem., 241, 241 (1966).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF2221243a0_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "91",
      "DOI": "10.1016/S0022-2836(66)80052-9",
      "volume": "19",
      "author": "JB Clegg",
      "year": "1966",
      "unstructured": "Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Mol. Biol., 19, 91 (1966).",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "BF2221243a0_CR20",
      "volume-title": "Symposium on CO2",
      "author": "JV Kilmartin",
      "year": "1968",
      "unstructured": "Kilmartin, J. V., and Rossi-Bernardi, L., Symposium on CO2 (International Union of Physiological Sciences, 1968, in the press)."
    },
    {
      "key": "BF2221243a0_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "23",
      "DOI": "10.1085/jgp.35.1.23",
      "volume": "35",
      "author": "AF Riggs",
      "year": "1951",
      "unstructured": "Riggs, A. F., J. Gen. Physiol., 35, 23 (1951).",
      "journal-title": "J. Gen. Physiol."
    },
    {
      "key": "BF2221243a0_CR22",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1016/S0021-9258(18)50194-0",
      "volume": "102",
      "author": "R Margaria",
      "year": "1933",
      "unstructured": "Margaria, R., and Green, A. A., J. Biol. Chem., 102, 611 (1933).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF2221243a0_CR23",
      "first-page": "49P",
      "volume": "100",
      "author": "JC Kernohan",
      "year": "1966",
      "unstructured": "Kernohan, J. C., Kreuzer, F., Rossi-Bernardi, L., and Roughton, F. J. W., Biochem. J., 100, 49P (1966).",
      "journal-title": "Biochem. J."
    },
    {
      "key": "BF2221243a0_CR24",
      "doi-asserted-by": "crossref",
      "first-page": "439",
      "DOI": "10.1016/S0021-9258(18)74545-6",
      "volume": "117",
      "author": "WC Stadie",
      "year": "1937",
      "unstructured": "Stadie, W. C., and O'Brien, H., J. Biol. Chem., 117, 439 (1937).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF2221243a0_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "1240",
      "DOI": "10.1038/2221240a0",
      "volume": "222",
      "author": "MF Perutz",
      "year": "1969",
      "unstructured": "Perutz, M. F., Muirhead, H., Mazzarella, L., Crowther, R. G. A., Greer, J., and Kilmartin, J. V., preceding paper, Nature, 222, 1240 (1969).",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/2221243a0",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/2221243a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/2221243a0.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        12,
        1
      ]
    ],
    "date-time": "2021-12-01T20:42:36Z",
    "timestamp": 1638391356000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/2221243a0"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1969,
        6
      ]
    ]
  },
  "references-count": 25,
  "journal-issue": {
    "issue": "5200",
    "published-print": {
      "date-parts": [
        [
          1969,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "BF2221243a0"
  ],
  "URL": "http://dx.doi.org/10.1038/2221243a0",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1969,
        6
      ]
    ]
  }
}