DOI: 10.1038/221235a0. Structure of Subtilisin BPN′ at 2.5 Å Resolution

Structure of Subtilisin BPN′ at 2.5 Å Resolution

10.1038/221235a0

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

WRIGHT, C. S., ALDEN, R. A., & KRAUT, J. (1969). Structure of Subtilisin BPNâ² at 2.5 Ã Resolution. Nature, 221(5177), 235â242.

Authors 3

CHRISTINE SCHUBERT WRIGHT (first)
RICHARD A. ALDEN (additional)
JOSEPH KRAUT (additional)

References 54 Referenced 439

Welker, N. E., and Campbell, L. L., J. Bact., 94, 1124 (1967). (10.1128/JB.94.4.1124-1130.1967) / J. Bact. by NE Welker (1967)
Drenth, J., and Hol, W. G. J., J. Mol. Biol., 28, 543 (1967). (10.1016/S0022-2836(67)80104-9) / J. Mol. Biol. by J Drenth (1967)
Hunt, J. A., and Ottesen, M., Biochim. Biophys. Acta, 48, 411 (1961). (10.1016/0006-3002(61)90498-X) / Biochim. Biophys. Acta by JA Hunt (1961)
Johansen, G., and Ottesen, M., CR Lab. Carlsberg, Sér. Chim., 34, 199 (1964). / CR Lab. Carlsberg, Sér. Chim. by G Johansen (1964)
Smith, E. L., Abstr. Seventh Intern. Cong. Biochem., Tokyo, I-1, 5, p. 9 (1967). / Abstr. Seventh Intern. Cong. Biochem. by EL Smith (1967)
Smith, E. L., Markland, F. S., Kasper, C. B., DeLange, R. J., Landon, M., and Evans, W. H., J. Biol. Chem., 241, 5974 (1966). (10.1016/S0021-9258(18)96365-9) / J. Biol. Chem. by EL Smith (1966)
Gounaris, A., and Ottesen, M., CR Lab. Carlsberg, Sér. Chim., 35, 37 (1965). / CR Lab. Carlsberg, Sér. Chim. by A Gounaris (1965)
Markland, F. S., and Smith, E. L., J. Biol. Chem., 242, 5198 (1967). (10.1016/S0021-9258(18)99412-3) / J. Biol. Chem. by FS Markland (1967)
Smith, E. L., DeLange, R. J., Evans, W. H., Landon, M., and Markland, F. S., J. Biol. Chem., 243, 2184 (1968). (10.1016/S0021-9258(18)93461-7) / J. Biol. Chem. by EL Smith (1968)
Markland, F. S., Ribadeau-Dumas, B., and Smith, E. L., J. Biol. Chem., 242, 5174 (1967). (10.1016/S0021-9258(18)99411-1) / J. Biol. Chem. by FS Markland (1967)
Barel, A. O., and Glazer, A. N., J. Biol. Chem., 243, 1344 (1968). (10.1016/S0021-9258(18)93552-0) / J. Biol. Chem. by AO Barel (1968)
Johansen, J. T., Ottesen, M., and Svendsen, I., Biochim. Biophys. Acta, 139, 211 (1967). (10.1016/0005-2744(67)90138-6) / Biochim. Biophys. Acta by JT Johansen (1967)
Ottesen, M., and Wollenberger, A., Nature, 170, 801 (1952). (10.1038/170801a0) / Nature by M Ottesen (1952)
Ottesen, M., and Spector, A., CR Lab. Carlsberg, Sér. Chim., 32, 63 (1960). / CR Lab. Carlsberg, Sér. Chim. by M Ottesen (1960)
Tuppy, H., Monats. Chem., 84, 996 (1953). (10.1007/BF00899307) / Monats. Chem. by H Tuppy (1953)
Ottesen, M., Johansen, J., Svendsen, I., and Wybrandt, G., Abstr. Seventh Intern. Cong. Biochem., Tokyo, F-211, 801 (1967). / Abstr. Seventh Intern. Cong. Biochem. by M Ottesen (1967)
Richards, F. M., and Vithayathil, P. J., J. Biol. Chem., 234, 1459 (1959). (10.1016/S0021-9258(18)70031-8) / J. Biol. Chem. by FM Richards (1959)
Gordillo, G., Vithayathil, P. J., and Richards, F. M., Yale J. Biol. and Med., 34, 582 (1962). / Yale J. Biol. and Med. by G Gordillo (1962)
Doscher, M. S., and Hirs, C. H. W., Biochemistry, 6, 304 (1967). (10.1021/bi00853a047) / Biochemistry by MS Doscher (1967)
Gross, E., and Witkop, B., Biochemistry, 6, 745 (1967). (10.1021/bi00855a014) / Biochemistry by E Gross (1967)
Polgar, L., and Bender, M. L., Biochemistry, 6, 610 (1967). (10.1021/bi00854a032) / Biochemistry by L Polgar (1967)
Neet, K. E., and Koshland, D. E., Proc. US Nat. Acad. Sci., 56, 1606 (1966). (10.1073/pnas.56.5.1606) / Proc. US Nat. Acad. Sci. by KE Neet (1966)
Farney, D. E., and Gold, A. M., J. Amer. Chem. Soc., 85, 997 (1963). (10.1021/ja00890a037) / J. Amer. Chem. Soc. by DE Farney (1963)
Ottesen, M., and Schellmann, C. G., CR Lab. Carlsberg, Sér. Chim., 30, 157 (1957). / CR Lab. Carlsberg, Sér. Chim. by M Ottesen (1957)
Matsubara, H., and Nishimura, S., J. Biochem., 45, 503 (1958). (10.1093/oxfordjournals.jbchem.a126894) / J. Biochem. by H Matsubara (1958)
Jansen, E. F., Nutting, D., Jang, R., and Balls, A. K., J. Biol. Chem., 179, 189 (1949). (10.1016/S0021-9258(18)56827-7) / J. Biol. Chem. by EF Jansen (1949)
Schonbaum, G. R., Zerner, B., and Bender, M. L., J. Biol. Chem., 236, 2930 (1961). (10.1016/S0021-9258(19)76404-7) / J. Biol. Chem. by GR Schonbaum (1961)
Bernhard, S. A., Lau, S. J., and Noller, H., Biochemistry, 4, 1108 (1965). (10.1021/bi00882a020) / Biochemistry by SA Bernhard (1965)
Keizer, J., and Bernhard, S. A., Biochemistry, 5, 4127 (1966). (10.1021/bi00876a049) / Biochemistry by J Keizer (1966)
Zerner, B., and Bender, M. L., J. Amer. Chem. Soc., 86, 3669 (1964). (10.1021/ja01072a015) / J. Amer. Chem. Soc. by B Zerner (1964)
Kaufmann, S., Schwert, G. W., and Neurath, H., Arch. Biochem. Biophys., 17, 203 (1948). / Arch. Biochem. Biophys. by S Kaufmann (1948)
Glazer, A. N., J. Biol. Chem., 242, 433 (1967). (10.1016/S0021-9258(18)96290-3) / J. Biol. Chem. by AN Glazer (1967)
Green, N. M., and Neurath, H., The Proteins, 2, 1057 (Academic Press, New York, 1954). (10.1016/B978-0-12-395721-4.50011-1) / The Proteins by NM Green (1954)
Schoellmann, G., and Shaw, E., Biochemistry, 2, 252 (1963). (10.1021/bi00902a008) / Biochemistry by G Schoellmann (1963)
Shaw, E., Mares-Guia, M., and Cohen, W., Biochemistry, 4, 2219 (1965). (10.1021/bi00886a039) / Biochemistry by E Shaw (1965)
Sigler, P. B., Blow, D. M., Mathews, B. W., and Henderson, R., J. Mol. Biol., 35, 143 (1968). (10.1016/S0022-2836(68)80043-9) / J. Mol. Biol. by PB Sigler (1968)
Svendsen, I., CR Lab. Carlsberg, Sér. Chim., 36, 235 (1967). / CR Lab. Carlsberg, Sér. Chim. by I Svendsen (1967)
Hartley, B., Nature, 201, 1284 (1964). (10.1038/2011284a0) / Nature by B Hartley (1964)
Walsh, K. A., and Neurath, H., Proc. US Nat. Acad. Sci., 52, 884 (1964). (10.1073/pnas.52.4.884) / Proc. US Nat. Acad. Sci. by KA Walsh (1964)
Structure and Activity of Enzymes (edit. by Goodwin, T. W., Harris, J. I., and Hartley, B. S.) (Academic Press, London, 1964).
Sanger, F., and Shaw, D. C., Nature, 187, 872 (1960). (10.1038/187872a0) / Nature by F Sanger (1960)
Wang, J. H., Science, 161, 328 (1968). (10.1126/science.161.3839.328) / Science by JH Wang (1968)
Wyckoff, H. W., Doscher, M., Tsernoglou, D., Inagami, T., Johnson, L. N., Hardman, K. D., Allewell, N. M., Kelly, D. M., and Richards, F. M., J. Mol. Biol., 27, 563 (1967). (10.1016/0022-2836(67)90059-9) / J. Mol. Biol. by HW Wyckoff (1967)
Furnas, T. C., Single Crystal Orienter Instruction Manual (General Electric Company, Milwaukee, 1967). / Single Crystal Orienter Instruction Manual by TC Furnas (1967)
Wright, C. G., thesis, University Calif., San Diego (1969).
Blow, D. M., and Crick, F. H. C., Acta Cryst., 12, 794 (1959). (10.1107/S0365110X59002274) / Acta Cryst. by DM Blow (1959)
Kraut, J., J. Mol. Biol., 35, 511 (1968). / J. Mol. Biol. by J Kraut (1968)
Weber, B. H., and Kraut, J., Biophys. Biochem. Res. Commun., 33, 280 (1968). (10.1016/0006-291X(68)90781-X) / Biophys. Biochem. Res. Commun. by BH Weber (1968)
Némethy, G., Phillips, D. C., Leach, S. J., and Scheraga, H. A., Nature, 214, 363 (1967). (10.1038/214363a0) / Nature by G Némethy (1967)
Pauling, L., and Corey, R. B., Proc. US Nat. Acad. Sci., 39, 253 (1953). (10.1073/pnas.39.4.253) / Proc. US Nat. Acad. Sci. by L Pauling (1953)
Johnson, C. K., A Fortran Thermal-Ellipsoid Plot Program ORNL-3794 (Oak Ridge National Laboratory, Tennessee, 1965). / A Fortran Thermal-Ellipsoid Plot Program ORNL-3794 by CK Johnson (1965)
Wyckoff, H. W., Hardman, K. D., Allewell, N. M., Inagami, T., Johnson, L. N., and Richards, F. M., J. Biol. Chem., 242, 3984 (1967). (10.1016/S0021-9258(18)95844-8) / J. Biol. Chem. by HW Wyckoff (1967)
Kretsinger, R. H., J. Mol. Biol., 31, 315 (1968). (10.1016/0022-2836(68)90447-6) / J. Mol. Biol. by RH Kretsinger (1968)
Perutz, M. F., Kendrew, J. C., and Watson, H. C., J. Mol. Biol., 13, 669 (1965). (10.1016/S0022-2836(65)80134-6) / J. Mol. Biol. by MF Perutz (1965)

Dates

Type	When
Created	19 years, 1 month ago (July 6, 2006, 7:11 a.m.)
Deposited	3 years, 8 months ago (Dec. 1, 2021, 3:32 p.m.)
Indexed	1 day, 12 hours ago (Aug. 23, 2025, 1:02 a.m.)
Issued	56 years, 7 months ago (Jan. 1, 1969)
Published	56 years, 7 months ago (Jan. 1, 1969)
Published Print	56 years, 7 months ago (Jan. 1, 1969)

Funders 0

None

BibTeX

@article{WRIGHT_1969, title={Structure of Subtilisin BPN′ at 2.5 Å Resolution}, volume={221}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/221235a0}, DOI={10.1038/221235a0}, number={5177}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={WRIGHT, CHRISTINE SCHUBERT and ALDEN, RICHARD A. and KRAUT, JOSEPH}, year={1969}, month=jan, pages={235–242} }

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