G-protein-coupled receptor heterodimerization modulates receptor function
10.1038/21441
Crossref journal-article
Springer Science and Business Media LLC
Nature (297)
Bibliography

Jordan, B. A., & Devi, L. A. (1999). G-protein-coupled receptor heterodimerization modulates receptor function. Nature, 399(6737), 697–700.

Authors 2
  1. Bryen A. Jordan (first)
  2. Lakshmi A. Devi (additional)
References 30 Referenced 918
  1. Herz, A. Opioids Vol. 1(Springer, Berlin, 1993). / Opioids by A Herz (1993)
  2. Miotto, K., Magendzo, K. & Evans, C. J. in The Pharmacology of Opioid Peptides(ed. Tseng, L.) 57–71 (Harwood, Singapore, 1995). / The Pharmacology of Opioid Peptides by K Miotto (1995)
  3. Kieffer, B. L. Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides. Cell. Mol. Neurobiol. 15, 615–635 ( 1995). (10.1007/BF02071128) / Cell. Mol. Neurobiol. by BL Kieffer (1995)
  4. Hebert, T. E. & Bouvier, M. Structural and functional aspects of G protein-coupled receptor oligomerization. Biochem. Cell Biol. 76, 1–11 (1998 ). (10.1139/o98-012) / Biochem. Cell Biol. by TE Hebert (1998)
  5. Gouldson, P. R., Snell, C. R., Bywater, R. P., Higgs, C. & Reynolds, C. A. Domain swapping in G-protein coupled receptor dimers. Protein Eng. 11, 1181–1193 (1998). (10.1093/protein/11.12.1181) / Protein Eng. by PR Gouldson (1998)
  6. Maggio, R., Vogel, Z. & Wess, J. Co-expression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular cross-talk between G-protein-linked receptors. Proc. Natl Acad. Sci. USA 90, 3103– 3107 (1993). (10.1073/pnas.90.7.3103) / Proc. Natl Acad. Sci. USA by R Maggio (1993)
  7. Monnot, C. et al . Polar residues in the transmembrane domains of the type I angiotensin II receptor are required for binding and coupling: Reconstitution of the binding site by co-expression of two deficient mutants. J. Biol. Chem. 271, 1507–1513 ( 1996). (10.1074/jbc.271.3.1507) / J. Biol. Chem. by C Monnot (1996)
  8. Jones, K. A. et al . GABAB receptors function as a heteromeric assembly fo the subunits GABABR1 and GABABR2. Nature 396, 674–679 ( 1998). (10.1038/25348) / Nature by KA Jones (1998)
  9. Kaupmann, K. et al . GABAB-receptor subtypes assemble into functional heteromeric complexes. Nature 396, 683– 687 (1998). (10.1038/25360) / Nature by K Kaupmann (1998)
  10. White, J. H. et al . Heterodimerization is required for the formation of a functional GABAB receptor. Nature 396, 679 –682 (1998). (10.1038/25354) / Nature by JH White (1998)
  11. Kuner, R. et al . Role of heteromer formation in GABAB receptor function. Science 283, 74–77 (1999). (10.1126/science.283.5398.74) / Science by R Kuner (1999)
  12. Cvejic, S. & Devi, L. Dimerization of the delta opioid receptor; implications for a function in receptor internalization. J. Biol. Chem. 272, 26959–26964 ( 1997). (10.1074/jbc.272.43.26959) / J. Biol. Chem. by S Cvejic (1997)
  13. Romano, C., Yang, W. & O'Malley, K. Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J. Biol. Chem. 271, 28612– 28616 (1996). (10.1074/jbc.271.45.28612) / J. Biol. Chem. by C Romano (1996)
  14. Bai, M., Trivedi, S. & Brown, E. M. Dimerization of the extracellular calcium-sensing receptor on the cell surface of CaR-transfected HEK-293 cells. J. Biol. Chem. 273, 23605–23610 (1998). (10.1074/jbc.273.36.23605) / J. Biol. Chem. by M Bai (1998)
  15. Trapaidze, N., Keith, D. E., Cvejic, S., Evans, C. J. & Devi, L. A. Sequestration of the delta opioid receptor: Role of the C terminus in agonist-mediated internalization. J. Biol. Chem. 271, 29279–29285 ( 1996). (10.1074/jbc.271.46.29279) / J. Biol. Chem. by N Trapaidze (1996)
  16. Keith, D. E. et al . Morphine activates opioid receptors without causing their rapid internalization. J. Biol. Chem. 271, 19021–19024 (1996). (10.1074/jbc.271.32.19021) / J. Biol. Chem. by DE Keith (1996)
  17. Chu, P., Murray, S., Lissin, D. & von Zastrow, M. Delta and kappa opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J. Biol. Chem. 272, 27124–27130 (1997). (10.1074/jbc.272.43.27124) / J. Biol. Chem. by P Chu (1997)
  18. Lahti, R. A., Mickelson, M. M., McCall, J. M. & Von Voigtlander, P. [3H]U-69593, a highly selective ligand for the opioid κ receptor. Eur. J. Pharmacol. 109, 281– 284 (1985). (10.1016/0014-2999(85)90431-5) / Eur. J. Pharmacol. by RA Lahti (1985)
  19. Roth, G. et al . [D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for δ opioid receptors. J. Med. Chem. 258, 299–303 (1990). / J. Med. Chem. by G Roth (1990)
  20. Portoghese, P. S., Lipkowski, A. W. & Takemori, A. E. Binaltrophimine and norbinaltrophimine, potent and selective κ-opioid receptor antagonists. Life Sci. 40, 1287–1292 (1987). (10.1016/0024-3205(87)90585-6) / Life Sci. by PS Portoghese (1987)
  21. Schiller, P. et al . TIPPΨ: A highly potent and stable pseudopeptide δ opioid receptor antagonist with extraordinary δ selectivity. J. Med. Chem. 36, 3182–3187 (1993). (10.1021/jm00073a020) / J. Med. Chem. by P Schiller (1993)
  22. Zukin, R. S., Echbali, M., Olive, D., Unterwald, E. M. & Tempel, A. Characterization and visualization of rat and guinea pig brain κ opioid receptors: Evidence for κ1 and κ 2 opioid receptors. Proc. Natl Acad. Sci. USA 4061–4065 (1988). (10.1073/pnas.85.11.4061)
  23. Nock, B. in The Pharmacology of Opioid Peptides(ed. Tseng, L.) 29– 56 (Harwood, Singapore, 1995). / The Pharmacology of Opioid Peptides by B Nock (1995)
  24. Traynor, J. R. & Elliott, J. Delta opioid receptor subtypes and cross talk with mu receptors. Trends Pharmacol. Sci. 14, 84–86 ( 1993). (10.1016/0165-6147(93)90068-U) / Trends Pharmacol. Sci. by JR Traynor (1993)
  25. Zaki, P. A. et al . Opioid receptor types and subtypes: the delta receptor as a model. Annu. Rev. Pharmacol. Toxicol. 36, 379–401 (1996). (10.1146/annurev.pa.36.040196.002115) / Annu. Rev. Pharmacol. Toxicol. by PA Zaki (1996)
  26. Jordan, B. & Devi, L. A. Molecular mechanisms of opiate receptor signal transduction. Br. J. Anaesth. 81, 12–19 (1998). (10.1093/bja/81.1.12) / Br. J. Anaesth. by B Jordan (1998)
  27. Lord, J. A. H., Waterfield, A. A., Hughes, J. & Kosterlitz, H. W. Endogenous opioid peptides: Multiple agonists and receptors. Nature 267, 495–499 ( 1977). (10.1038/267495a0) / Nature by JAH Lord (1977)
  28. Cvejic, S., Trapaidze, N., Cyr, C. & Devi, L. A. Thr353, located within the COOH-terminal tail of the delta opiate receptor, is involved in receptor down-regulation. J. Biol. Chem. 271, 4073–4076 (1996). (10.1074/jbc.271.8.4073) / J. Biol. Chem. by S Cvejic (1996)
  29. Cheng, Y. C. & Prusoff, W. H. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzyme reaction. Biochem. Pharmacol. 22, 3099–3102 ( 1973). (10.1016/0006-2952(73)90196-2) / Biochem. Pharmacol. by YC Cheng (1973)
  30. Polakiewicz, R., Schieferl, S. M., Dorner, L. F., Kansra, V. & Comb, M. J. Amitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization. J. Biol. Chem. 273, 12402–12406 (1998). (10.1074/jbc.273.20.12402) / J. Biol. Chem. by R Polakiewicz (1998)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:39 a.m.)
Deposited 3 years, 8 months ago (Dec. 1, 2021, 2:19 p.m.)
Indexed 1 week, 2 days ago (Aug. 22, 2025, 12:45 a.m.)
Issued 26 years, 2 months ago (June 1, 1999)
Published 26 years, 2 months ago (June 1, 1999)
Published Print 26 years, 2 months ago (June 1, 1999)
Funders 0

None

@article{Jordan_1999, title={G-protein-coupled receptor heterodimerization modulates receptor function}, volume={399}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/21441}, DOI={10.1038/21441}, number={6737}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Jordan, Bryen A. and Devi, Lakshmi A.}, year={1999}, month=jun, pages={697–700} }