DOI: 10.1038/21224. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

10.1038/21224

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999). Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature, 399(6736), 601â605.

Authors 6

Stefanie Dimmeler (first)
Ingrid Fleming (additional)
Beate Fisslthaler (additional)
Corinna Hermann (additional)
Rudi Busse (additional)
Andreas M. Zeiher (additional)

References 30 Referenced 2,893

Moncada, S. & Higgs, A. The L-arginine–nitric oxide pathway. N. Engl. J. Med. 329, 2002–2012 (1993). (10.1056/NEJM199312303292706) / N. Engl. J. Med. by S Moncada (1993)
Rudic, R. D. et al. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J. Clin. Invest. 101, 731–736 (1998). (10.1172/JCI1699) / J. Clin. Invest. by RD Rudic (1998)
Murohara, T. et al. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J. Clin. Invest. 101, 2567–2578 (1998). (10.1172/JCI1560) / J. Clin. Invest. by T Murohara (1998)
Rubanyi, G. M., Romero, J. C. & Vanhoutte, P. M. Flow-induced release of endothelium-derived relaxing factor. Am. J. Physiol. 250, H1145–H1149 (1986). (10.1152/ajpcell.1986.250.3.C406) / Am. J. Physiol. by GM Rubanyi (1986)
Kuchan, M. J. & Frangos, J. A. Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells. Am. J. Physiol. 266, C628–C636 (1994). (10.1152/ajpcell.1994.266.3.C628) / Am. J. Physiol. by MJ Kuchan (1994)
Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J. & Hintze, T. H. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74, 349–353 (1994). (10.1161/01.RES.74.2.349) / Circ. Res. by WC Sessa (1994)
Davies, P. F. Flow-mediated endothelial mechanotransduction. Physiol. Rev. 75, 519–560 (1995). (10.1152/physrev.1995.75.3.519) / Physiol. Rev. by PF Davies (1995)
Busse, R. & Fleming, I. Pulsatile stretch and shear: physiological stimuli determining the production of endothelial-derived relaxing factor. J. Vasc. Res. 35, 73–84 (1998). (10.1159/000025568) / J. Vasc. Res. by R Busse (1998)
Corson, M. A. et al. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ. Res. 79, 984–991 (1996). (10.1161/01.RES.79.5.984) / Circ. Res. by MA Corson (1996)
Fleming, I., Bauersachs, J., Fissthaler, B. & Busse, R. Ca2+-independent activation of the endothelial nitric oxide synthase in response to tryosine phosphatase inhibitors and fluid shear stress. Circ. Res. 79, 984–991 (1996). (10.1161/01.RES.79.5.984) / Circ. Res. by I Fleming (1996)
Franke, T. F. et al. The protein kinase encoded by the Akt proto-oncogen is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727–736 (1995). (10.1016/0092-8674(95)90534-0) / Cell by TF Franke (1995)
Burgering, B. M. T. & Coffer, P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376, 599–602 (1995). (10.1038/376599a0) / Nature by BMT Burgering (1995)
Downward, J. Lipid-regulating kinases: some common themes at last. Science 279, 673–674 (1998). (10.1126/science.279.5351.673) / Science by J Downward (1998)
Zeiher, A. M. Endothelial vasodilator dysfunction: pathogenetic link to myocardial ischaemia or epiphenomenon? Lancet 348, S10–S12 (1996). (10.1016/S0140-6736(96)98004-6) / Lancet by AM Zeiher (1996)
Moroi, M. et al. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular responses to injury in mice. J. Clin. Invest. 101, 1225–1232 (1998). (10.1172/JCI1293) / J. Clin. Invest. by M Moroi (1998)
Bredt, D. S. et al. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351, 714–718 (1991). (10.1038/351714a0) / Nature by DS Bredt (1991)
Busse, R. & Mülsch, A. Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin. FEBS Lett. 265, 133–136 (1990). (10.1016/0014-5793(90)80902-U) / FEBS Lett. by R Busse (1990)
Ayajiki, K., Kindermann, M., Hecker, M., Fleming, I. & Busse, R. Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells. Circ. Res. 78, 750–758 (1996). (10.1161/01.RES.78.5.750) / Circ. Res. by K Ayajiki (1996)
Dimmeler, S., Assmus, B., Hermann, C., Haendeler, J. & Zeiher, A. M. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ. Res. 83, 334–342 (1998). (10.1161/01.RES.83.3.334) / Circ. Res. by S Dimmeler (1998)
Alessi, D. R. et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541–6551 (1996). (10.1002/j.1460-2075.1996.tb01045.x) / EMBO J. by DR Alessi (1996)
van der Zee, R. et al. Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95, 1030–1037 (1997). (10.1161/01.CIR.95.4.1030) / Circulation by R van der Zee (1997)
Ziche, M. et al. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J. Clin. Invest. 99, 2625–2634 (1997). (10.1172/JCI119451) / J. Clin. Invest. by M Ziche (1997)
Gerber, H. P., Dixit, V. & Ferrara, N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem. 273, 13313–13316 (1998). (10.1074/jbc.273.21.13313) / J. Biol. Chem. by HP Gerber (1998)
Förstermann, U. et al. Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem. Pharmacol. 42, 1849–1857 (1991). (10.1016/0006-2952(91)90581-O) / Biochem. Pharmacol. by U Förstermann (1991)
Yano, S., Tokumitsu, H. & Soderling, T. R. Calcium promotes cell survival through CaM-K kinase activation of the protein kinase-B pathway. Nature 396, 584–587 (1998). (10.1038/25147) / Nature by S Yano (1998)
Zeiher, A. M., Fisslthaler, B., Schray-Utz, B. & Busse, R. Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells. Circ. Res. 76, 980–986 (1995). (10.1161/01.RES.76.6.980) / Circ. Res. by AM Zeiher (1995)
Khwaja, A., Rodriquez-Viciana, P., Wennström, S., Warne, P. H. & Downward, J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16, 2783–2793 (1997). (10.1093/emboj/16.10.2783) / EMBO J. by A Khwaja (1997)
Dimmeler, S., Haendeler, J., Nehls, M. & Zeiher, A. M. Suppression of apoptosis by nitric oxide via inhibition of ICE-like and CPP32-like proteases. J. Exp. Med. 185, 601–608 (1997). (10.1084/jem.185.4.601) / J. Exp. Med. by S Dimmeler (1997)
Kauffmann-Zeh, A. et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385, 544–548 (1997). (10.1038/385544a0) / Nature by A Kauffmann-Zeh (1997)
Copper, J. A., Sefton, B. M. & Hunter, T. Detection and quantification of phosphotyrosine in proteins. Methods Enzymol. 99, 387–402 (1983). (10.1016/0076-6879(83)99075-4) / Methods Enzymol. by JA Copper (1983)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:39 a.m.)
Deposited	3 years, 9 months ago (Dec. 1, 2021, 2:01 p.m.)
Indexed	3 days ago (Sept. 3, 2025, 7:03 a.m.)
Issued	26 years, 3 months ago (June 1, 1999)
Published	26 years, 3 months ago (June 1, 1999)
Published Print	26 years, 3 months ago (June 1, 1999)

Funders 0

None

BibTeX

@article{Dimmeler_1999, title={Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation}, volume={399}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/21224}, DOI={10.1038/21224}, number={6736}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Dimmeler, Stefanie and Fleming, Ingrid and Fisslthaler, Beate and Hermann, Corinna and Busse, Rudi and Zeiher, Andreas M.}, year={1999}, month=jun, pages={601–605} }

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