DOI: 10.1038/20459. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

10.1038/20459

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature, 399(6733), 271â275.

Authors 10

Patrick H. Maxwell (first)
Michael S. Wiesener (additional)
Gin-Wen Chang (additional)
Steven C. Clifford (additional)
Emma C. Vaux (additional)
Matthew E. Cockman (additional)
Charles C. Wykoff (additional)
Christopher W. Pugh (additional)
Eamonn R. Maher (additional)
Peter J. Ratcliffe (additional)

References 30 Referenced 4,165

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Bunn, H. F. & Poyton, R. O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76, 839– 885 (1996). (10.1152/physrev.1996.76.3.839) / Physiol. Rev. by HF Bunn (1996)
Carmeliet, P. et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485 –90 (1998). (10.1038/28867) / Nature by P Carmeliet (1998)
An, W. G. et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1α. Nature 392, 405–408 (1998). (10.1038/32925) / Nature by WG An (1998)
Huang, L. E., Gu, J., Schau, M. & Bunn, H. F. Regulation of hypoxia-inducible factor 1α is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway. Proc. Natl Acad. Sci. USA 95, 7987–7992 ( 1998). (10.1073/pnas.95.14.7987) / Proc. Natl Acad. Sci. USA by LE Huang (1998)
Goldberg, M. A., Dunning, S. P. & Bunn, H. F. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242, 1412–1415 (1988). (10.1126/science.2849206) / Science by MA Goldberg (1988)
Wang, G. L. & Semenza, G. L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82 , 3610–3615 (1993). (10.1182/blood.V82.12.3610.3610) / Blood by GL Wang (1993)
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Kaelin, W. G. & Maher, E. R. The VHL tumour-suppressor gene paradigm. Trends Genet. 14, 423– 426 (1998). (10.1016/S0168-9525(98)01558-3) / Trends Genet. by WG Kaelin (1998)
Gnarra, J. R. et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc. Natl Acad. Sci. USA 93, 10589– 10594 (1996). (10.1073/pnas.93.20.10589) / Proc. Natl Acad. Sci. USA by JR Gnarra (1996)
Iliopoulos, O., Levy, A. P., Jiang, C., Kaelin, W. G. J & Goldberg, M. A. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl Acad. Sci. USA 93, 10595–10599 (1996). (10.1073/pnas.93.20.10595) / Proc. Natl Acad. Sci. USA by O Iliopoulos (1996)
Dang, C. V. & Semenza, G. L. Oncogenic alterations of metabolism. Trends Biochem. Sci. 24, 68– 72 (1999). (10.1016/S0968-0004(98)01344-9) / Trends Biochem. Sci. by CV Dang (1999)
Huang, L. E., Arany, Z., Livingston, D. M. & Bunn, H. F. Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its α subunit. J. Biol. Chem. 271, 32253–32259 ( 1996). (10.1074/jbc.271.50.32253) / J. Biol. Chem. by LE Huang (1996)
Wiesener, M. S. et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α. Blood 92, 2260–2268 ( 1998). (10.1182/blood.V92.7.2260) / Blood by MS Wiesener (1998)
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Maxwell, P. H. et al. Hypoxia inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA 94, 8104–8109 (1997). (10.1073/pnas.94.15.8104) / Proc. Natl Acad. Sci. USA by PH Maxwell (1997)
Zelzer, E. et al. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J. 17, 5083 –5094 (1998). (10.1093/emboj/17.17.5085) / EMBO J. by E Zelzer (1998)
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Dates

Type	When
Created	23 years ago (July 26, 2002, 4:39 a.m.)
Deposited	3 years, 8 months ago (Dec. 1, 2021, 7:12 p.m.)
Indexed	3 hours, 6 minutes ago (Aug. 21, 2025, 1:14 p.m.)
Issued	26 years, 3 months ago (May 1, 1999)
Published	26 years, 3 months ago (May 1, 1999)
Published Print	26 years, 3 months ago (May 1, 1999)

Funders 0

None

BibTeX

@article{Maxwell_1999, title={The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis}, volume={399}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/20459}, DOI={10.1038/20459}, number={6733}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Maxwell, Patrick H. and Wiesener, Michael S. and Chang, Gin-Wen and Clifford, Steven C. and Vaux, Emma C. and Cockman, Matthew E. and Wykoff, Charles C. and Pugh, Christopher W. and Maher, Eamonn R. and Ratcliffe, Peter J.}, year={1999}, month=may, pages={271–275} }

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