DOI: 10.1038/18465. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

10.1038/18465

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Ninomiya-Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z., & Matsumoto, K. (1999). The kinase TAK1 can activate the NIK-IÎºB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature, 398(6724), 252â256.

Authors 6

Jun Ninomiya-Tsuji (first)
Kazuya Kishimoto (additional)
Atsushi Hiyama (additional)
Jun-ichiro Inoue (additional)
Zhaodan Cao (additional)
Kunihiro Matsumoto (additional)

References 25 Referenced 1,002

Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. & Goeddel, D. V. TRAF6 is a signal transducer for interleukin-1. Nature 383, 443–446 (1996). (10.1038/383443a0) / Nature by Z Cao (1996)
Malinin, N. L., Boldin, M. P., Kovalenko, A. V. & Wallach, D. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385, 540–544 (1997). (10.1038/385540a0) / Nature by NL Malinin (1997)
Regnier, C. H. et al. Identification and characterization of an IκB kinase. Cell 90, 373–383 (1997). (10.1016/S0092-8674(00)80344-X) / Cell by CH Regnier (1997)
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. & Karin, M. Acytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548–554 (1997). (10.1038/41493) / Nature by JA DiDonato (1997)
Mercurio, F. et al. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278, 860–866 (1997). (10.1126/science.278.5339.860) / Science by F Mercurio (1997)
Woronicz, J. D., Gao, X., Cao, Z., Rothe, M. & Goeddel, D. V. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278, 866–869 (1997). (10.1126/science.278.5339.866) / Science by JD Woronicz (1997)
Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M. & Karin, M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91, 243–252 (1997). (10.1016/S0092-8674(00)80406-7) / Cell by E Zandi (1997)
Yamaguchi, K. et al. Identification of a member of the MAPKKK family as a potential mediataor of TGF-β signal transduction. Science 270, 2008–2011 (1995). (10.1126/science.270.5244.2008) / Science by K Yamaguchi (1995)
Dinarello, C. A. Biologic basis for interleukin-1 in disease. Blood 87, 2095–2147 (1996). (10.1182/blood.V87.6.2095.bloodjournal8762095) / Blood by CA Dinarello (1996)
Thanos, D. & Maniatis, T. NF-κB: a lesson in family values. Cell 80, 529–532 (1995). (10.1016/0092-8674(95)90506-5) / Cell by D Thanos (1995)
Verma, I. M., Stevenson, J. K., Schwarz, E. M., van Antwerp D. & Miyamoto, S. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9, 2723–2735 (1995). (10.1101/gad.9.22.2723) / Genes Dev. by IM Verma (1995)
Baeuerle, P. A. & Baltimore, D. NF-κB: ten years after. Cell 87, 13–20 (1996). (10.1016/S0092-8674(00)81318-5) / Cell by PA Baeuerle (1996)
Cao, Z., Henzel, W. J. & Gao, X. IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128–1131 (1996). (10.1126/science.271.5252.1128) / Science by Z Cao (1996)
Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837–847 (1997). (10.1016/S1074-7613(00)80402-1) / Immunity by H Wesche (1997)
Song, H. Y., Regnier, C. H., Kirschning, C. J., Goeddel, D. V. & Rothe, M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc. Natl Acad. Sci. USA 94, 9792–9796 (1997). (10.1073/pnas.94.18.9792) / Proc. Natl Acad. Sci. USA by HY Song (1997)
Karin, M. & Delhase, M. JNK or IKK, AP-1 or NF-κB: which are the targets for MEK kinase 1 action? Proc. Natl Acad. Sci. USA 95, 9067–9069 (1998). (10.1073/pnas.95.16.9067) / Proc. Natl Acad. Sci. USA by M Karin (1998)
Shirakabe, K. et al. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J. Biol. Chem. 272, 8141–8144 (1997). (10.1074/jbc.272.13.8141) / J. Biol. Chem. by K Shirakabe (1997)
Moriguchi, T. et al. Anovel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J. Biol. Chem. 271, 13675–13679 (1996). (10.1074/jbc.271.23.13675) / J. Biol. Chem. by T Moriguchi (1996)
Shibuya, H. et al. TAB1: an activator of the TAK1 MAPKKK in TGF-β signal transduction. Science 272, 1179–1182 (1996). (10.1126/science.272.5265.1179) / Science by H Shibuya (1996)
Takekawa, M., Posas, F. & Saito, H. Ahuman homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 16, 4973–4982 (1997). (10.1093/emboj/16.16.4973) / EMBO J. by M Takekawa (1997)
Sakurai, H., Shigemori, N., Hasegawa, K. & Sugita, T. TGF-β-activating kinase 1 stimulates NF-κB activation by an NF-κB-inducing kinase-independent mechanism. Biochem. Biophys. Res. Commun. 243, 545–549 (1998). (10.1006/bbrc.1998.8124) / Biochem. Biophys. Res. Commun. by H Sakurai (1998)
Johnson, L. N., Noble, M. E. M. & Owen, D. J. Active and inactive protein kinases: structural basis for regulation. Cell 85, 149–158 (1996). (10.1016/S0092-8674(00)81092-2) / Cell by LN Johnson (1996)
Lin, X. et al. Molecular determinants of NF-κB-inducing kinase action. Mol. Cell. Biol. 18, 5899–5907 (1998). (10.1128/MCB.18.10.5899) / Mol. Cell. Biol. by X Lin (1998)
Cohen, L., Henzel, W. J. & Baeuerle, P. A. IKAP is a scaffold protein of the IκB kinase ocmplex. Nature 395, 292–296 (1998). (10.1038/26254) / Nature by L Cohen (1998)
Ling, L., Cao, Z. & Goeddel, D. V. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl Acad. Sci. USA 95, 3792–3797 (1998). (10.1073/pnas.95.7.3792) / Proc. Natl Acad. Sci. USA by L Ling (1998)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:39 a.m.)
Deposited	3 years, 8 months ago (Dec. 1, 2021, 5 p.m.)
Indexed	4 days, 10 hours ago (Aug. 23, 2025, 12:58 a.m.)
Issued	26 years, 5 months ago (March 1, 1999)
Published	26 years, 5 months ago (March 1, 1999)
Published Print	26 years, 5 months ago (March 1, 1999)

Funders 0

None

BibTeX

@article{Ninomiya_Tsuji_1999, title={The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway}, volume={398}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/18465}, DOI={10.1038/18465}, number={6724}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Ninomiya-Tsuji, Jun and Kishimoto, Kazuya and Hiyama, Atsushi and Inoue, Jun-ichiro and Cao, Zhaodan and Matsumoto, Kunihiro}, year={1999}, month=mar, pages={252–256} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        23
      ]
    ],
    "date-time": "2025-08-23T04:58:51Z",
    "timestamp": 1755925131446
  },
  "reference-count": 25,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6724",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            3,
            1
          ]
        ],
        "date-time": "1999-03-01T00:00:00Z",
        "timestamp": 920246400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        3
      ]
    ]
  },
  "DOI": "10.1038/18465",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T08:39:24Z",
    "timestamp": 1027672764000
  },
  "page": "252-256",
  "source": "Crossref",
  "is-referenced-by-count": 1002,
  "title": "The kinase TAK1 can activate the NIK-I\u03baB as well as the MAP kinase cascade in the IL-1 signalling pathway",
  "prefix": "10.1038",
  "volume": "398",
  "author": [
    {
      "given": "Jun",
      "family": "Ninomiya-Tsuji",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Kazuya",
      "family": "Kishimoto",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Atsushi",
      "family": "Hiyama",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jun-ichiro",
      "family": "Inoue",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Zhaodan",
      "family": "Cao",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Kunihiro",
      "family": "Matsumoto",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "BF18465_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "443",
      "DOI": "10.1038/383443a0",
      "volume": "383",
      "author": "Z Cao",
      "year": "1996",
      "unstructured": "Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. & Goeddel, D. V. TRAF6 is a signal transducer for interleukin-1. Nature 383, 443\u2013446 (1996).",
      "journal-title": "Nature"
    },
    {
      "key": "BF18465_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "540",
      "DOI": "10.1038/385540a0",
      "volume": "385",
      "author": "NL Malinin",
      "year": "1997",
      "unstructured": "Malinin, N. L., Boldin, M. P., Kovalenko, A. V. & Wallach, D. MAP3K-related kinase involved in NF-\u03baB induction by TNF, CD95 and IL-1. Nature 385, 540\u2013544 (1997).",
      "journal-title": "Nature"
    },
    {
      "key": "BF18465_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "373",
      "DOI": "10.1016/S0092-8674(00)80344-X",
      "volume": "90",
      "author": "CH Regnier",
      "year": "1997",
      "unstructured": "Regnier, C. H. et al. Identification and characterization of an I\u03baB kinase. Cell 90, 373\u2013383 (1997).",
      "journal-title": "Cell"
    },
    {
      "key": "BF18465_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "548",
      "DOI": "10.1038/41493",
      "volume": "388",
      "author": "JA DiDonato",
      "year": "1997",
      "unstructured": "DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. & Karin, M. Acytokine-responsive I\u03baB kinase that activates the transcription factor NF-\u03baB. Nature 388, 548\u2013554 (1997).",
      "journal-title": "Nature"
    },
    {
      "key": "BF18465_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "860",
      "DOI": "10.1126/science.278.5339.860",
      "volume": "278",
      "author": "F Mercurio",
      "year": "1997",
      "unstructured": "Mercurio, F. et al. IKK-1 and IKK-2: cytokine-activated I\u03baB kinases essential for NF-\u03baB activation. Science 278, 860\u2013866 (1997).",
      "journal-title": "Science"
    },
    {
      "key": "BF18465_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "866",
      "DOI": "10.1126/science.278.5339.866",
      "volume": "278",
      "author": "JD Woronicz",
      "year": "1997",
      "unstructured": "Woronicz, J. D., Gao, X., Cao, Z., Rothe, M. & Goeddel, D. V. I\u03baB kinase-\u03b2: NF-\u03baB activation and complex formation with I\u03baB kinase-\u03b1 and NIK. Science 278, 866\u2013869 (1997).",
      "journal-title": "Science"
    },
    {
      "key": "BF18465_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "243",
      "DOI": "10.1016/S0092-8674(00)80406-7",
      "volume": "91",
      "author": "E Zandi",
      "year": "1997",
      "unstructured": "Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M. & Karin, M. The I\u03baB kinase complex (IKK) contains two kinase subunits, IKK\u03b1 and IKK\u03b2, necessary for I\u03baB phosphorylation and NF-\u03baB activation. Cell 91, 243\u2013252 (1997).",
      "journal-title": "Cell"
    },
    {
      "key": "BF18465_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "2008",
      "DOI": "10.1126/science.270.5244.2008",
      "volume": "270",
      "author": "K Yamaguchi",
      "year": "1995",
      "unstructured": "Yamaguchi, K. et al. Identification of a member of the MAPKKK family as a potential mediataor of TGF-\u03b2 signal transduction. Science 270, 2008\u20132011 (1995).",
      "journal-title": "Science"
    },
    {
      "key": "BF18465_CR9",
      "doi-asserted-by": "crossref",
      "first-page": "2095",
      "DOI": "10.1182/blood.V87.6.2095.bloodjournal8762095",
      "volume": "87",
      "author": "CA Dinarello",
      "year": "1996",
      "unstructured": "Dinarello, C. A. Biologic basis for interleukin-1 in disease. Blood 87, 2095\u20132147 (1996).",
      "journal-title": "Blood"
    },
    {
      "key": "BF18465_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "529",
      "DOI": "10.1016/0092-8674(95)90506-5",
      "volume": "80",
      "author": "D Thanos",
      "year": "1995",
      "unstructured": "Thanos, D. & Maniatis, T. NF-\u03baB: a lesson in family values. Cell 80, 529\u2013532 (1995).",
      "journal-title": "Cell"
    },
    {
      "key": "BF18465_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "2723",
      "DOI": "10.1101/gad.9.22.2723",
      "volume": "9",
      "author": "IM Verma",
      "year": "1995",
      "unstructured": "Verma, I. M., Stevenson, J. K., Schwarz, E. M., van Antwerp D. & Miyamoto, S. Rel/NF-\u03baB/I\u03baB family: intimate tales of association and dissociation. Genes Dev. 9, 2723\u20132735 (1995).",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BF18465_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "13",
      "DOI": "10.1016/S0092-8674(00)81318-5",
      "volume": "87",
      "author": "PA Baeuerle",
      "year": "1996",
      "unstructured": "Baeuerle, P. A. & Baltimore, D. NF-\u03baB: ten years after. Cell 87, 13\u201320 (1996).",
      "journal-title": "Cell"
    },
    {
      "key": "BF18465_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "1128",
      "DOI": "10.1126/science.271.5252.1128",
      "volume": "271",
      "author": "Z Cao",
      "year": "1996",
      "unstructured": "Cao, Z., Henzel, W. J. & Gao, X. IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128\u20131131 (1996).",
      "journal-title": "Science"
    },
    {
      "key": "BF18465_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "837",
      "DOI": "10.1016/S1074-7613(00)80402-1",
      "volume": "7",
      "author": "H Wesche",
      "year": "1997",
      "unstructured": "Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837\u2013847 (1997).",
      "journal-title": "Immunity"
    },
    {
      "key": "BF18465_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "9792",
      "DOI": "10.1073/pnas.94.18.9792",
      "volume": "94",
      "author": "HY Song",
      "year": "1997",
      "unstructured": "Song, H. Y., Regnier, C. H., Kirschning, C. J., Goeddel, D. V. & Rothe, M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-\u03baB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc. Natl Acad. Sci. USA 94, 9792\u20139796 (1997).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF18465_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "9067",
      "DOI": "10.1073/pnas.95.16.9067",
      "volume": "95",
      "author": "M Karin",
      "year": "1998",
      "unstructured": "Karin, M. & Delhase, M. JNK or IKK, AP-1 or NF-\u03baB: which are the targets for MEK kinase 1 action? Proc. Natl Acad. Sci. USA 95, 9067\u20139069 (1998).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "BF18465_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "8141",
      "DOI": "10.1074/jbc.272.13.8141",
      "volume": "272",
      "author": "K Shirakabe",
      "year": "1997",
      "unstructured": "Shirakabe, K. et al. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J. Biol. Chem. 272, 8141\u20138144 (1997).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF18465_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "13675",
      "DOI": "10.1074/jbc.271.23.13675",
      "volume": "271",
      "author": "T Moriguchi",
      "year": "1996",
      "unstructured": "Moriguchi, T. et al. Anovel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J. Biol. Chem. 271, 13675\u201313679 (1996).",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "BF18465_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "1179",
      "DOI": "10.1126/science.272.5265.1179",
      "volume": "272",
      "author": "H Shibuya",
      "year": "1996",
      "unstructured": "Shibuya, H. et al. TAB1: an activator of the TAK1 MAPKKK in TGF-\u03b2 signal transduction. Science 272, 1179\u20131182 (1996).",
      "journal-title": "Science"
    },
    {
      "key": "BF18465_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "4973",
      "DOI": "10.1093/emboj/16.16.4973",
      "volume": "16",
      "author": "M Takekawa",
      "year": "1997",
      "unstructured": "Takekawa, M., Posas, F. & Saito, H. Ahuman homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 16, 4973\u20134982 (1997).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BF18465_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "545",
      "DOI": "10.1006/bbrc.1998.8124",
      "volume": "243",
      "author": "H Sakurai",
      "year": "1998",
      "unstructured": "Sakurai, H., Shigemori, N., Hasegawa, K. & Sugita, T. TGF-\u03b2-activating kinase 1 stimulates NF-\u03baB activation by an NF-\u03baB-inducing kinase-independent mechanism. Biochem. Biophys. Res. Commun. 243, 545\u2013549 (1998).",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "BF18465_CR22",
      "doi-asserted-by": "publisher",
      "first-page": "149",
      "DOI": "10.1016/S0092-8674(00)81092-2",
      "volume": "85",
      "author": "LN Johnson",
      "year": "1996",
      "unstructured": "Johnson, L. N., Noble, M. E. M. & Owen, D. J. Active and inactive protein kinases: structural basis for regulation. Cell 85, 149\u2013158 (1996).",
      "journal-title": "Cell"
    },
    {
      "key": "BF18465_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "5899",
      "DOI": "10.1128/MCB.18.10.5899",
      "volume": "18",
      "author": "X Lin",
      "year": "1998",
      "unstructured": "Lin, X. et al. Molecular determinants of NF-\u03baB-inducing kinase action. Mol. Cell. Biol. 18, 5899\u20135907 (1998).",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "BF18465_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "292",
      "DOI": "10.1038/26254",
      "volume": "395",
      "author": "L Cohen",
      "year": "1998",
      "unstructured": "Cohen, L., Henzel, W. J. & Baeuerle, P. A. IKAP is a scaffold protein of the I\u03baB kinase ocmplex. Nature 395, 292\u2013296 (1998).",
      "journal-title": "Nature"
    },
    {
      "key": "BF18465_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "3792",
      "DOI": "10.1073/pnas.95.7.3792",
      "volume": "95",
      "author": "L Ling",
      "year": "1998",
      "unstructured": "Ling, L., Cao, Z. & Goeddel, D. V. NF-\u03baB-inducing kinase activates IKK-\u03b1 by phosphorylation of Ser-176. Proc. Natl Acad. Sci. USA 95, 3792\u20133797 (1998).",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    }
  ],
  "container-title": "Nature",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/18465.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/18465",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/doifinder/10.1038/18465",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    },
    {
      "URL": "http://www.nature.com/articles/18465.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        12,
        1
      ]
    ],
    "date-time": "2021-12-01T22:00:07Z",
    "timestamp": 1638396007000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/18465"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        3
      ]
    ]
  },
  "references-count": 25,
  "journal-issue": {
    "issue": "6724",
    "published-print": {
      "date-parts": [
        [
          1999,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "BF18465"
  ],
  "URL": "http://dx.doi.org/10.1038/18465",
  "relation": {},
  "ISSN": [
    "0028-0836",
    "1476-4687"
  ],
  "subject": [],
  "container-title-short": "Nature",
  "published": {
    "date-parts": [
      [
        1999,
        3
      ]
    ]
  }
}