DOI: 10.1038/17533. A mammalian protein with specific demethylase activity for mCpG DNA

A mammalian protein with specific demethylase activity for mCpG DNA

10.1038/17533

Crossref journal-article

Springer Science and Business Media LLC

Nature (297)

Bibliography

Bhattacharya, S. K., Ramchandani, S., Cervoni, N., & Szyf, M. (1999). A mammalian protein with specific demethylase activity for mCpG DNA. Nature, 397(6720), 579â583.

Authors 4

Sanjoy K. Bhattacharya (first)
Shyam Ramchandani (additional)
Nadia Cervoni (additional)
Moshe Szyf (additional)

References 28 Referenced 477

Siegfried, Z. & Cedar, H. DNA methylation: a molecular lock. Curr. Biol. 7, 305–307 (1997). (10.1016/S0960-9822(06)00144-8) / Curr. Biol. by Z Siegfried (1997)
Nan, X., Campoy, F. J. & Bird, A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 88, 471–481 (1997). (10.1016/S0092-8674(00)81887-5) / Cell by X Nan (1997)
Nan, X. S. et al. Transcriptional repression by the methyl-CpG-binding protein MECP2 involves a histone deacetylase complex. Nature 393, 386–389 (1998). (10.1038/30764) / Nature by XS Nan (1998)
Jones, P. L. et al. Methylated DNA and MECP2 recruit histone deacetylase to repress transcription. Nature Genet. 19, 187–191 (1998). (10.1038/561) / Nature Genet. by PL Jones (1998)
Li, E., Bestor, T. H. & Jaenish, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926 (1992). (10.1016/0092-8674(92)90611-F) / Cell by E Li (1992)
Razin, A. & Riggs, A. D. DNA methylation and gene function. Science 210, 604–610 (1980). (10.1126/science.6254144) / Science by A Razin (1980)
Brandeis, M., Ariel, M. & Cedar, H. Dynamics of DNA methylation during development. Bioassays 15, 709–713 (1993). (10.1002/bies.950151103) / Bioassays by M Brandeis (1993)
Kafri, T., Gao, X. & Razin, A. Methanistic aspects of genome-wide demethylation in the preimplantation mouse embryo. Proc. Natl Acad. Sci. USA 90, 10558–10562 (1993). (10.1073/pnas.90.22.10558) / Proc. Natl Acad. Sci. USA by T Kafri (1993)
Monk, M., Boubelik, M. & Lehnert, S. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99, 371–382 (1987). (10.1242/dev.99.3.371) / Development by M Monk (1987)
Bestor, T., Laudano, A., Mattaliano, R. & Ingram, V. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J. Mol. Biol. 203, 971–983 (1988). (10.1016/0022-2836(88)90122-2) / J. Mol. Biol. by T Bestor (1988)
Bestor, T. H. & Verdine, G. L. DNA methyltransferases. Curr. Opin. Cell Biol. 6, 380–389 (1994). (10.1016/0955-0674(94)90030-2) / Curr. Opin. Cell Biol. by TH Bestor (1994)
Razin, A. et al. Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation. Proc. Natl Acad. Sci. USA 83, 2827–2831 (1986). (10.1073/pnas.83.9.2827) / Proc. Natl Acad. Sci. USA by A Razin (1986)
Vairapandi, M. & Duker, N. J. Enzymic removal of 5-methylcytosine from DNA by a human glycosylase. Nucleic Acids Res. 21, 5323–5327 (1993). (10.1093/nar/21.23.5323) / Nucleic Acids Res. by M Vairapandi (1993)
Jost, J. P., Siegmann, M., Sun, L. J. & Leung, R. Mechanisms of demethylation in chicken embryos—purification and properties of a 5-methylcytosine-DNA glycosylase. J. Biol. Chem. 270, 9734–9739 (1995). (10.1074/jbc.270.17.9734) / J. Biol. Chem. by JP Jost (1995)
Weiss, A., Keshet, I., Razin, A. & Cedar, H. DNA demethylation in vitro: involvement of RNA. Cell 86, 709–718 (1996). (10.1016/S0092-8674(00)80146-4) / Cell by A Weiss (1996)
Cross, S. H., Meehan, R. R., Nan, X. & Bird, A. Acomponent of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nature Genet. 16, 256–259 (1997). (10.1038/ng0797-256) / Nature Genet. by SH Cross (1997)
Boguski, M. S., Lowe, T. M. & Tolstoshev, C. M. dbEST-database for expressed sequence tags. Nature Genet. 4, 332–373 (1995). (10.1038/ng0893-332) / Nature Genet. by MS Boguski (1995)
Henrich, B. & Bird, A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell. Biol. 18, 6538–6547 (1998). (10.1128/MCB.18.11.6538) / Mol. Cell. Biol. by B Henrich (1998)
Corpet, F., Gouzy, J. & Kahn, D. The ProDom database of protein domain families. Nucleic Acids Res. 26, 323–326 (1998). (10.1093/nar/26.1.323) / Nucleic Acids Res. by F Corpet (1998)
Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403–410 (1990). (10.1016/S0022-2836(05)80360-2) / J. Mol. Biol. by SF Altschul (1990)
Bairoch, A., Bucher, P. & Hofman, K. The PROSITE database, its status in 1997. Nucleic Acids Res. 25, 217–221 (1997). (10.1093/nar/25.1.217) / Nucleic Acids Res. by A Bairoch (1997)
Rost, B. PHD: predicting one-dimensional protein structure by profile based neural networks. Methods Enzymol. 266, 525–539 (1996). (10.1016/S0076-6879(96)66033-9) / Methods Enzymol. by B Rost (1996)
Lupas, A., Van Dyke, M. & Stock, J. Predicting coiled coils from protein sequences. Science 252, 1162–1164 (1991). (10.1126/science.252.5009.1162) / Science by A Lupas (1991)
O'Shea, E. K., Rutkowski, R. & Kim, P. S. Evidence that the leucine zipper is a coiled coil. Science 243, 538–542 (1989). (10.1126/science.2911757) / Science by EK O'Shea (1989)
Nur, I. et al. Prokayotic and eukaryotic traits of DNA methylation in spiroplasmas (mycoplasmas). J. Bacteriol. 164, 19–24 (1985). (10.1128/JB.164.1.19-24.1985) / J. Bacteriol. by I Nur (1985)
Szyf, M., Theberge, J. & Bozovic, V. Ras induces a general DNA demethylation activity in mouse embryonal P19 cells. J. Biol. Chem. 270, 12690–12696 (1995). (10.1074/jbc.270.21.12690) / J. Biol. Chem. by M Szyf (1995)
Szyf, M. DNA methylation properties: consequences for pharmacoloty. Trends Pharmacol. Sci. 7, 233–238 (1994). (10.1016/0165-6147(94)90317-4) / Trends Pharmacol. Sci. by M Szyf (1994)
Swisher, J. A., Rand, E., Cedar, H. & Pyle, A. M. Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts. Nucleic Acids Res. 26, 5573–5580 (1998). (10.1093/nar/26.24.5573) / Nucleic Acids Res. by JA Swisher (1998)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:39 a.m.)
Deposited	3 years, 9 months ago (Dec. 1, 2021, 4:04 p.m.)
Indexed	2 days, 15 hours ago (Aug. 31, 2025, 6:21 a.m.)
Issued	26 years, 7 months ago (Feb. 1, 1999)
Published	26 years, 7 months ago (Feb. 1, 1999)
Published Print	26 years, 7 months ago (Feb. 1, 1999)

Funders 0

None

BibTeX

@article{Bhattacharya_1999, title={A mammalian protein with specific demethylase activity for mCpG DNA}, volume={397}, ISSN={1476-4687}, url={http://dx.doi.org/10.1038/17533}, DOI={10.1038/17533}, number={6720}, journal={Nature}, publisher={Springer Science and Business Media LLC}, author={Bhattacharya, Sanjoy K. and Ramchandani, Shyam and Cervoni, Nadia and Szyf, Moshe}, year={1999}, month=feb, pages={579–583} }

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