Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
10.1038/10172
Crossref journal-article
Springer Science and Business Media LLC
Nature Neuroscience (297)
Bibliography

Takumi, Y., Ramírez-León, V., Laake, P., Rinvik, E., & Ottersen, O. P. (1999). Different modes of expression of AMPA and NMDA receptors in hippocampal synapses. Nature Neuroscience, 2(7), 618–624.

Authors 5
  1. Yutaka Takumi (first)
  2. Vania Ramírez-León (additional)
  3. Petter Laake (additional)
  4. Eric Rinvik (additional)
  5. Ole P. Ottersen (additional)
References 48 Referenced 569
  1. Seeburg, P. H. The TIPS/TINS lecture: the molecular biology of mammalian glutamate receptor channels. Trends Pharmacol. Sci. 14, 297 –303 (1993). (10.1016/0165-6147(93)90047-N) / Trends Pharmacol. Sci. by PH Seeburg (1993)
  2. Hollmann, M. & Heinemann, S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31–108 (1994). (10.1146/annurev.ne.17.030194.000335) / Annu. Rev. Neurosci. by M Hollmann (1994)
  3. Ottersen, O. P. & Landsend, A. S. Organization of glutamate receptors at the synapse. Eur. J. Neurosci. 9, 2219–2224 (1997). (10.1111/j.1460-9568.1997.tb01640.x) / Eur. J. Neurosci. by OP Ottersen (1997)
  4. Baude, A., Nusser, Z., Molnár, E., McIlhinney, R. A. & Somogyi, P. High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus. Neuroscience 69, 1031 –1055 (1995). (10.1016/0306-4522(95)00350-R) / Neuroscience by A Baude (1995)
  5. Matsubara, A., Laake, J. H., Davanger, S., Usami, S. & Ottersen, O. P. Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti. J. Neurosci. 16, 4457–4467 (1996). (10.1523/JNEUROSCI.16-14-04457.1996) / J. Neurosci. by A Matsubara (1996)
  6. Popratiloff, A., Weinberg, R. J. & Rustioni, A. AMPA receptor subunits underlying terminals of fine-caliber primary afferent fibers. J. Neurosci. 16, 3363–3372 (1996). (10.1523/JNEUROSCI.16-10-03363.1996) / J. Neurosci. by A Popratiloff (1996)
  7. Kharazia, V. N., Phend, K. D., Rustioni, A. & Weinberg, R. J. EM colocalization of AMPA and NMDA receptor subunits at synapses in rat cerebral cortex. Neurosci. Lett. 210, 37– 40 (1996). (10.1016/0304-3940(96)12658-6) / Neurosci. Lett. by VN Kharazia (1996)
  8. Nusser, Z. et al. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21 , 545–559 (1998). (10.1016/S0896-6273(00)80565-6) / Neuron by Z Nusser (1998)
  9. Wang, Y. X., Wenthold, R. J., Ottersen, O. P. & Petralia, R. S. Endbulb synapses in the anteroventral cochlear nucleus express a specific subset of AMPA-type glutamate receptor subunits. J. Neurosci. 18, 1148–1160 (1998). (10.1523/JNEUROSCI.18-03-01148.1998) / J. Neurosci. by YX Wang (1998)
  10. Kullmann, D. M. Amplitude fluctuations of dual-component EPSCs in hippocampal pyramidal cells: implications for long-term potentiation. Neuron 12, 1111–1120 (1994). (10.1016/0896-6273(94)90318-2) / Neuron by DM Kullmann (1994)
  11. Isaac, J. T., Nicoll, R. A. & Malenka, R. C. Evidence for silent synapses: implications for the expression of LTP. Neuron 15, 427– 434 (1995). (10.1016/0896-6273(95)90046-2) / Neuron by JT Isaac (1995)
  12. Liao, D., Hessler, N. A. & Malinow, R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 375, 400–404 ( 1995). (10.1038/375400a0) / Nature by D Liao (1995)
  13. Madison, D. V., Malenka, R. C. & Nicoll, R. A. Mechanisms underlying long-term potentiation of synaptic transmission. Annu. Rev. Neurosci. 14, 379 –397 (1991). (10.1146/annurev.ne.14.030191.002115) / Annu. Rev. Neurosci. by DV Madison (1991)
  14. Harris, K. M., Jensen, F. E. & Tsao, B. Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation. J. Neurosci. 12, 2685–2705 (1992). (10.1523/JNEUROSCI.12-07-02685.1992) / J. Neurosci. by KM Harris (1992)
  15. Schikorski, T. & Stevens, C. F. Quantitative ultrastructural analysis of hippocampal excitatory synapses. J. Neurosci. 17, 5858–5867 (1997). (10.1523/JNEUROSCI.17-15-05858.1997) / J. Neurosci. by T Schikorski (1997)
  16. Collingridge, G. L., Kehl, S. J. & McLennan, H. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J. Physiol. (Lond.) 334, 33–46 (1983). (10.1113/jphysiol.1983.sp014478) / J. Physiol. (Lond.) by GL Collingridge (1983)
  17. Benke, T. A., Luthi, A., Isaac, J. T. & Collingridge, G. L. Modulation of AMPA receptor unitary conductance by synaptic activity. Nature 393, 793–797 ( 1998). (10.1038/31709) / Nature by TA Benke (1998)
  18. He, Y., Janssen, W. G. & Morrison, J. H. Synaptic coexistence of AMPA and NMDA receptors in the rat hippocampus: a postembedding immunogold study. J. Neurosci. Res. 54, 444–449 ( 1998). (10.1002/(SICI)1097-4547(19981115)54:4<444::AID-JNR2>3.0.CO;2-3) / J. Neurosci. Res. by Y He (1998)
  19. Bramham, C. R., Torp, R., Zhang, N., Storm-Mathisen, J. & Ottersen, O. P. Distribution of glutamate-like immunoreactivity in excitatory hippocampal pathways: a semiquantitative electron microscopic study in rats. Neuroscience 39, 405– 417 (1990). (10.1016/0306-4522(90)90277-B) / Neuroscience by CR Bramham (1990)
  20. Bekkers, J. M. & Stevens, C. F. NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus. Nature 341, 230– 233 (1989). (10.1038/341230a0) / Nature by JM Bekkers (1989)
  21. Kauer, J. A., Malenka, R. C. & Nicoll, R. A. A persistent postsynaptic modification mediates long-term potentiation in the hippocampus. Neuron 1, 911–917 (1988). (10.1016/0896-6273(88)90148-1) / Neuron by JA Kauer (1988)
  22. Muller, D., Joly, M. & Lynch, G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242, 1694– 1697 (1988). (10.1126/science.2904701) / Science by D Muller (1988)
  23. Maren, S., Tocco, G., Standley, S., Baudry, M. & Thompson, R. F. Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo. Proc. Natl. Acad. Sci. USA 90, 9654–9658 (1993). (10.1073/pnas.90.20.9654) / Proc. Natl. Acad. Sci. USA by S Maren (1993)
  24. Shirke, A. M. & Malinow, R. Mechanisms of potentiation by calcium-calmodulin kinase II of postsynaptic sensitivity in rat hippocampal CA1 neurons. J. Neurophysiol. 78, 2682–2692 (1997). (10.1152/jn.1997.78.5.2682) / J. Neurophysiol. by AM Shirke (1997)
  25. Nayak, A., Zastrow, D. J., Lickteig, R., Zahniser, N. R. & Browning, M. D. Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis. Nature 394, 680–683 ( 1998). (10.1038/29305) / Nature by A Nayak (1998)
  26. Geinisman, Y. et al. Structural synaptic correlate of long-term potentiation: formation of axospinous synapses with multiple, completely partitioned transmission zones. Hippocampus 3, 435– 445 (1993). (10.1002/hipo.450030405) / Hippocampus by Y Geinisman (1993)
  27. Andersen, P. & Soleng, A. F. Long-term potentiation and spatial training are both associated with the generation of new excitatory synapses. Brain Res. Brain Res. Rev. 26, 353– 359 (1998). (10.1016/S0165-0173(97)00042-8) / Brain Res. Brain Res. Rev. by P Andersen (1998)
  28. Desmond, N. L. & Levy, W. B. Synaptic interface surface area increases with long-term potentiation in the hippocampal dentate gyrus. Brain Res. 453, 308– 314 (1988). (10.1016/0006-8993(88)90171-0) / Brain Res. by NL Desmond (1988)
  29. Kellenberger, E., Durrenberger, M., Villiger, W., Carlemalm, E. & Wurtz, M. The efficiency of immunolabel on Lowicryl sections compared to theoretical predictions. J. Histochem. Cytochem. 35, 959–969 ( 1987). (10.1177/35.9.3302020) / J. Histochem. Cytochem. by E Kellenberger (1987)
  30. Jonas, P., Major, G. & Sakmann, B. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. J. Physiol. (Lond.) 472, 615–663 ( 1993). (10.1113/jphysiol.1993.sp019965) / J. Physiol. (Lond.) by P Jonas (1993)
  31. Petralia, R. S. et al. Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nat. Neurosci. 2, 31–36 ( 1999). (10.1038/4532) / Nat. Neurosci. by RS Petralia (1999)
  32. Durand, G. M., Kovalchuk, Y. & Konnerth, A. Long-term potentiation and functional synapse induction in developing hippocampus. Nature 381, 71 –75 (1996). (10.1038/381071a0) / Nature by GM Durand (1996)
  33. Gomperts, S. N., Rao, A., Craig, A. M., Malenka, R. C. & Nicoll, R. A. Postsynaptically silent synapses in single neuron cultures. Neuron 21, 1443– 1451 (1998). (10.1016/S0896-6273(00)80662-5) / Neuron by SN Gomperts (1998)
  34. Kullmann, D. M. & Asztely, F. Extrasynaptic glutamate spillover in the hippocampus: evidence and implications. Trends Neurosci. 21, 8–14 (1998). (10.1016/S0166-2236(97)01150-8) / Trends Neurosci. by DM Kullmann (1998)
  35. Fritschy, J.-M., Weinmann, O., Wenzel, A. & Benke, D. Synapse-specific localization of NMDA and GABAA receptor subunits revealed by antigen-retrieval immunohistochemistry. J. Comp. Neurol. 390, 194–210 (1998). (10.1002/(SICI)1096-9861(19980112)390:2<194::AID-CNE3>3.0.CO;2-X) / J. Comp. Neurol. by J-M Fritschy (1998)
  36. Weisskopf, M. G. & Nicoll, R. A. Presynaptic changes during mossy fibre LTP revealed by NMDA receptor-mediated synaptic responses. Nature 376, 256– 259 (1995). (10.1038/376256a0) / Nature by MG Weisskopf (1995)
  37. Nicoll, R. A. & Malenka, R. C. Contrasting properties of two forms of long-term potentiation in the hippocampus. Nature 377, 115–118 (1995). (10.1038/377115a0) / Nature by RA Nicoll (1995)
  38. Castillo, P. E., Malenka, R. C. & Nicoll, R. A. Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature 388, 182–186 (1997). (10.1038/40645) / Nature by PE Castillo (1997)
  39. Vignes, M. & Collingridge, G. L. The synaptic activation of kainate receptors. Nature 388, 179– 182 (1997). (10.1038/40639) / Nature by M Vignes (1997)
  40. Kharazia, V. N. & Weinberg, R. J. Immunogold localization of AMPA and NMDA receptors in somatic sensory cortex of albino rat. J. Comp. Neurol. (in press). (10.1002/(SICI)1096-9861(19990920)412:2<292::AID-CNE8>3.0.CO;2-G)
  41. Ben-Ari, Y., Khazipov, R., Leinekugel, X., Caillard, O. & Gaiarsa, J.-L. GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'. Trends Neurosci. 20, 523–529 (1999). (10.1016/S0166-2236(97)01147-8) / Trends Neurosci. by Y Ben-Ari (1999)
  42. Nagelhus, E. A. et al. Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes. J. Neurosci. 18, 2506– 2519 (1998). (10.1523/JNEUROSCI.18-07-02506.1998) / J. Neurosci. by EA Nagelhus (1998)
  43. Hjelle, O. P., Chaudhry, F. A. & Ottersen, O. P. Antisera to glutathione: characterization and immunocytochemical application to the rat cerebellum. Eur. J. Neurosci. 6, 793–804 (1994). (10.1111/j.1460-9568.1994.tb00990.x) / Eur. J. Neurosci. by OP Hjelle (1994)
  44. Wenthold, R. J., Yokotani, N., Doi, K. & Wada, K. Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain. J. Biol. Chem. 267, 501–507 ( 1992). (10.1016/S0021-9258(18)48523-7) / J. Biol. Chem. by RJ Wenthold (1992)
  45. Petralia, R. S., Yokotani, N. & Wenthold, R. J. Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J. Neurosci. 14, 667– 696 (1994). (10.1523/JNEUROSCI.14-02-00667.1994) / J. Neurosci. by RS Petralia (1994)
  46. Petralia, R. S., Wang, Y. X. & Wenthold, R. J. The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1. J. Neurosci. 14, 6102–6120 (1994). (10.1523/JNEUROSCI.14-10-06102.1994) / J. Neurosci. by RS Petralia (1994)
  47. Ottersen, O. P., Zhang, N. & Walberg, F. Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum. Neuroscience 46, 519– 534 (1992). (10.1016/0306-4522(92)90141-N) / Neuroscience by OP Ottersen (1992)
  48. Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic, San Diego, 1986).
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:45 a.m.)
Deposited 3 years, 9 months ago (Dec. 1, 2021, 7:23 p.m.)
Indexed 3 weeks, 1 day ago (Aug. 12, 2025, 6:19 p.m.)
Issued 26 years, 2 months ago (July 1, 1999)
Published 26 years, 2 months ago (July 1, 1999)
Published Print 26 years, 2 months ago (July 1, 1999)
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@article{Takumi_1999, title={Different modes of expression of AMPA and NMDA receptors in hippocampal synapses}, volume={2}, ISSN={1546-1726}, url={http://dx.doi.org/10.1038/10172}, DOI={10.1038/10172}, number={7}, journal={Nature Neuroscience}, publisher={Springer Science and Business Media LLC}, author={Takumi, Yutaka and Ramírez-León, Vania and Laake, Petter and Rinvik, Eric and Ottersen, Ole P.}, year={1999}, month=jul, pages={618–624} }