DOI: 10.1034/j.1600-065x.2003.00031.x. The Wiskott–Aldrich syndrome protein: forging the link between actin and cell activation

The Wiskott–Aldrich syndrome protein: forging the link between actin and cell activation

10.1034/j.1600-065x.2003.00031.x

Crossref journal-article

Wiley

Immunological Reviews (311)

Abstract

Summary:The Wiskott–Aldrich syndrome protein (WASp) has emerged as a central player in the regulation of actin remodeling in T cells. The unique domain structure of WASp and other WASp family members enables these proteins to associate with a myriad of signaling effectors and to thereby regulate the coupling of T cell antigen receptor (TCR) engagement to both cytoskeletal rearrangement and transcriptional activation. This review focuses on these biochemical properties of WASp and also on the mechanisms whereby WASp interactions with its cognate ligands influence T cell activation. Because of its capacity to shift intracellular location and thereby dictate both the timing and the spatial distribution of actin polymerization following cell stimulation, WASp is well positioned to play major regulatory roles in directing a wide range of cellular processes and signaling pathways. Further dissection of the functional and biochemical properties of WASp therefore represents a promising avenue towards defining the molecular mechanisms that convey TCR stimulatory signals to the actin cytoskeleton and integrate cytoskeletal and other signaling systems so as to evoke a biological response.

Bibliography

Badour, K., Zhang, J., & Siminovitch, K. A. (2003). The WiskottâAldrich syndrome protein: forging the link between actin and cell activation. Immunological Reviews, 192(1), 98â112. Portico.

Authors 3

Karen Badour (first)
Jinyi Zhang (additional)
Katherine A. Siminovitch (additional)

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Dates

Type	When
Created	21 years, 7 months ago (Jan. 12, 2004, 6:43 a.m.)
Deposited	1 year, 10 months ago (Oct. 13, 2023, 4:06 p.m.)
Indexed	5 months ago (March 30, 2025, 1:04 a.m.)
Issued	22 years, 4 months ago (April 1, 2003)
Published	22 years, 4 months ago (April 1, 2003)
Published Online	22 years, 4 months ago (April 2, 2003)
Published Print	22 years, 4 months ago (April 1, 2003)

Funders 0

None

BibTeX

@article{Badour_2003, title={The Wiskott–Aldrich syndrome protein: forging the link between actin and cell activation}, volume={192}, ISSN={1600-065X}, url={http://dx.doi.org/10.1034/j.1600-065x.2003.00031.x}, DOI={10.1034/j.1600-065x.2003.00031.x}, number={1}, journal={Immunological Reviews}, publisher={Wiley}, author={Badour, Karen and Zhang, Jinyi and Siminovitch, Katherine A.}, year={2003}, month=apr, pages={98–112} }

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  }
}