DOI: 10.1021/tx950109y. Evidence That Nitric Oxide Enhances Cadmium Toxicity by Displacing the Metal from Metallothionein

Evidence That Nitric Oxide Enhances Cadmium Toxicity by Displacing the Metal from Metallothionein

10.1021/tx950109y

Crossref journal-article

American Chemical Society (ACS)

Chemical Research in Toxicology (316)

Authors 6

R. Rita Misra (first)
James F. Hochadel (additional)
George T. Smith (additional)
John C. Cook (additional)
Michael P. Waalkes (additional)
David A. Wink (additional)

References 44 Referenced 118

{'key': 'tx950109yb00001/tx950109yb00001_1', 'first-page': '237', 'volume': '58', 'author': 'IARC', 'year': '1993', 'journal-title': 'Eval. Carcinog. Risks Hum.'} / Eval. Carcinog. Risks Hum. by IARC (1993)
{'key': 'tx950109yb00002/tx950109yb00002_1', 'volume-title': 'The scientific fallacy of route specificity of carcinogenesis with particular reference to cadmium. Regu. Toxicol. Pharmacol. 20, 119−121', 'author': 'Waalkes M. P.', 'year': '1994'} / The scientific fallacy of route specificity of carcinogenesis with particular reference to cadmium. Regu. Toxicol. Pharmacol. 20, 119−121 by Waalkes M. P. (1994)
10.1006/taap.1994.1083 / Toxicol. Appl. Pharmacol. by Cherian M. G. (1994)
{'key': 'tx950109yb00004/tx950109yb00004_1', 'volume': '257', 'author': 'Winge D. R.', 'year': '1981', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Winge D. R. (1981)
10.1016/0167-4838(85)90098-6 / Biochim. Biophys. Acta by Thornalley P. J. (1985)
{'key': 'tx950109yb00006/tx950109yb00006_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 91', 'author': 'Palmiter R. D.', 'year': '1994'} / Proc. Natl. Acad. Sci. U.S.A. 91 by Palmiter R. D. (1994)
10.1146/annurev.pa.30.040190.002535 / Annu. Rev. Pharmacol. Toxicol. by Ignarro L. J. (1990)
{'key': 'tx950109yb00008/tx950109yb00008_1', 'volume': '43', 'author': 'Moncada S.', 'year': '1991', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. by Moncada S. (1991)
{'key': 'tx950109yb00009/tx950109yb00009_1', 'volume-title': 'in Trace Atmospheric Constituents. Properties, Transformation and Fates', 'author': 'Schwartz S. E.', 'year': '1983'} / in Trace Atmospheric Constituents. Properties, Transformation and Fates by Schwartz S. E. (1983)
Wink, D. A., Nims, R. W., Darbyshire, J. F., Christodoulou, D., Hanbauer, I., Cox, G. W., Laval, F., Laval, J., Cook, J. A., Krishna, M. C., DeGraff, W., and Mitchell, J. B. (1994) Reaction kinetics for nitrosation of cysteine and glutathione in aerobic nitric oxide solutions at neutral pH. Insights into the fate and physiological effects of intermediates generated in the NO/O2reaction.Chem. Res. Toxicol.7, 519−525. (10.1021/tx00040a007)
{'key': 'tx950109yb00011/tx950109yb00011_1', 'volume-title': 'Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Arch. Biochem. Biophys. 300, 115−123', 'author': 'Wink D. A.', 'year': '1993'} / Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Arch. Biochem. Biophys. 300, 115−123 by Wink D. A. (1993)
{'key': 'tx950109yb00012/tx950109yb00012_1', 'volume': '267', 'author': 'Molina', 'year': '1992', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Molina (1992)
{'key': 'tx950109yb00013/tx950109yb00013_1', 'volume-title': 'Inhibition by nitric oxide of the repair protein O6, methylguanine-DNA-methyltransferase. Carcinogenesis 15, 2125−2129', 'author': 'Wink D. A.', 'year': '1994'} / Inhibition by nitric oxide of the repair protein O6, methylguanine-DNA-methyltransferase. Carcinogenesis 15, 2125−2129 by Wink D. A. (1994)
{'key': 'tx950109yb00014/tx950109yb00014_1', 'volume-title': 'The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo. Carcinogenesis 15, 443−447', 'author': 'Laval F.', 'year': '1994'} / The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo. Carcinogenesis 15, 443−447 by Laval F. (1994)
{'key': 'tx950109yb00015/tx950109yb00015_1', 'volume-title': 'DNA deaminatingability and genotoxicity of nitric oxide and its progenitors. Science 254, 1001−1003', 'author': 'Wink D. A.', 'year': '1991'} / DNA deaminatingability and genotoxicity of nitric oxide and its progenitors. Science 254, 1001−1003 by Wink D. A. (1991)
{'key': 'tx950109yb00016/tx950109yb00016_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 89', 'author': 'Nguyen T.', 'year': '1992'} / Proc. Natl. Acad. Sci. U.S.A. 89 by Nguyen T. (1992)
Kroncke, K.D., Fechsel, K., Schmidt, T., Zenke, F. T., Dasting, I., Wesener, J. R., Bettermann, H., Breunig, K. D., and Kolb-Bachofen, V. (1994) Nitric oxide destroys zinc finger clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9.Biochem. Biophys. Res. Commun.200, 1105−1110. (10.1006/bbrc.1994.1564)
10.1021/jm00115a013 / J. Med. Chem. by Maragos C. M. (1991)
10.1097/00005344-199304000-00023 / J. Cardiovasc. Pharmacol. by Morley D. (1993)
{'key': 'tx950109yb00020/tx950109yb00020_1', 'volume-title': 'in DNA Repair:\u2009 A Laboratory Manual of Research Procedures', 'volume': '521', 'author': 'McCormick J. J.', 'year': '1981'} / in DNA Repair: A Laboratory Manual of Research Procedures by McCormick J. J. (1981)
10.1016/0022-1759(89)90397-9 / J. Immunol. Methods by Hansen M. B. (1989)
10.1248/jhs1956.24.128 / Eisei Kagaku by Onosaka S. (1978)
{'key': 'tx950109yb00023/tx950109yb00023_1', 'volume': '234', 'author': 'Sobocinski P. Z.', 'year': '1978', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Sobocinski P. Z. (1978)
{'key': 'tx950109yb00024/tx950109yb00024_1', 'volume-title': 'Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66, 134−142', 'author': 'Eaton D. L.', 'year': '1982'} / Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66, 134−142 by Eaton D. L. (1982)
{'key': 'tx950109yb00025/tx950109yb00025_1', 'volume-title': 'Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature 303, 401−406', 'author': 'Stanton L. W.', 'year': '1983'} / Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature 303, 401−406 by Stanton L. W. (1983)
10.1002/kin.550261208 / Int. J. Chem. Kinet. by Pires M. (1994)
{'key': 'tx950109yb00027/tx950109yb00027_1', 'volume-title': 'Nitric oxide-induced cytotoxicity:\u2009 Involvement of cellular resistance to oxidative stress and the role of glutathione in protection. Pediat. Res. (in press)', 'author': 'Walker M. W.', 'year': '1995'} / Nitric oxide-induced cytotoxicity: Involvement of cellular resistance to oxidative stress and the role of glutathione in protection. Pediat. Res. (in press) by Walker M. W. (1995)
{'key': 'tx950109yb00028/tx950109yb00028_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 92', 'author': 'Schwarz M. A.', 'year': '1995'} / Proc. Natl. Acad. Sci. U.S.A. 92 by Schwarz M. A. (1995)
10.1016/S0021-9258(17)44080-4 / J. Biol. Chem. by Nielson K. B. (1983)
{'key': 'tx950109yb00030/tx950109yb00030_1', 'volume-title': 'Nitric oxide protects against alkyl peroxide mediated cytotoxicity. Insights into the role nitric oxide plays in lipid peroxidation mediated cell death. Arch Biochem. Biophys. (in press)', 'author': 'Wink D. A.', 'year': '1995'} / Nitric oxide protects against alkyl peroxide mediated cytotoxicity. Insights into the role nitric oxide plays in lipid peroxidation mediated cell death. Arch Biochem. Biophys. (in press) by Wink D. A. (1995)
10.1016/0014-5793(93)81747-N / FEBS Lett. by Ford P. C. (1993)
{'key': 'tx950109yb00032/tx950109yb00032_1', 'volume': '1243', 'author': 'Clarkson R. B.', 'year': '1995', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta by Clarkson R. B. (1995)
{'key': 'tx950109yb00033/tx950109yb00033_1', 'volume-title': 'Mammalian synthesis of nitite, nitrate, nitric oxide and N-nitrosating agents. Chem. Res. Toxicol. 1, 249−257', 'author': 'Marletta M. A.', 'year': '1988'} / Mammalian synthesis of nitite, nitrate, nitric oxide and N-nitrosating agents. Chem. Res. Toxicol. 1, 249−257 by Marletta M. A. (1988)
{'key': 'tx950109yb00034/tx950109yb00034_1', 'volume-title': 'Elevated formation of nitrate and N-nitrosodimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection. Cancer Res. 51, 3925−3929', 'author': 'Liu R. H.', 'year': '1991'} / Elevated formation of nitrate and N-nitrosodimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection. Cancer Res. 51, 3925−3929 by Liu R. H. (1991)
{'key': 'tx950109yb00035/tx950109yb00035_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 90', 'author': 'Gaston B.', 'year': '1993'} / Proc. Natl. Acad. Sci. U.S.A. 90 by Gaston B. (1993)
{'key': 'tx950109yb00036/tx950109yb00036_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 89', 'author': 'Stamler J. S.', 'year': '1992'} / Proc. Natl. Acad. Sci. U.S.A. 89 by Stamler J. S. (1992)
{'key': 'tx950109yb00037/tx950109yb00037_1', 'first-page': '10', 'volume': '52', 'author': 'Luethy J. D.', 'year': '1992', 'journal-title': 'Cancer Res.'} / Cancer Res. by Luethy J. D. (1992)
{'key': 'tx950109yb00038/tx950109yb00038_1', 'volume': '265', 'author': 'Jin P.', 'year': '1990', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Jin P. (1990)
{'key': 'tx950109yb00039/tx950109yb00039_1', 'first-page': '306', 'volume': '14', 'author': 'Abshire M. K.', 'year': '1994', 'journal-title': 'Toxicologist'} / Toxicologist by Abshire M. K. (1994)
{'key': 'tx950109yb00040/tx950109yb00040_1', 'volume-title': 'Response to adversity:\u2009 Molecular control of gene activation following genotoxic stress. New Biol. 3, 825−833', 'author': 'Holbrook N. J.', 'year': '1991'} / Response to adversity: Molecular control of gene activation following genotoxic stress. New Biol. 3, 825−833 by Holbrook N. J. (1991)
{'key': 'tx950109yb00041/tx950109yb00041_1', 'first-page': '49', 'volume': '3', 'author': 'Evan G. I.', 'year': '1993', 'journal-title': 'Curr. Opin. Genet. Devel.'} / Curr. Opin. Genet. Devel. by Evan G. I. (1993)
{'key': 'tx950109yb00042/tx950109yb00042_1', 'first-page': '104', 'volume': '4', 'author': 'Shichiri M.', 'year': '1993', 'journal-title': 'Cell Growth Diff.'} / Cell Growth Diff. by Shichiri M. (1993)
Fornari, F. A., Jarvis, W. D., Grant, S., Orr, M. S., Randolph, J. K., White, F. K. H., Mumaw, R. H., Lovings, E. T., Freeman, R. H., and Gewirtz, D. A. (1994) Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reducedc-mycexpression in MCF-7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin.Cell Growth Differ.5, 723−733.
{'key': 'tx950109yn00001/tx950109yn00001_1', 'volume-title': 'cadmium', 'author': 'Abbreviations'} / cadmium by Abbreviations

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 1:30 a.m.)
Deposited	2 years, 5 months ago (March 13, 2023, 7:14 p.m.)
Indexed	2 months, 2 weeks ago (June 10, 2025, 1:26 p.m.)
Issued	29 years, 7 months ago (Jan. 1, 1996)
Published	29 years, 7 months ago (Jan. 1, 1996)
Published Online	29 years, 7 months ago (Jan. 15, 1996)
Published Print	29 years, 7 months ago (Jan. 1, 1996)

Funders 0

None

BibTeX

@article{Misra_1996, title={Evidence That Nitric Oxide Enhances Cadmium Toxicity by Displacing the Metal from Metallothionein}, volume={9}, ISSN={1520-5010}, url={http://dx.doi.org/10.1021/tx950109y}, DOI={10.1021/tx950109y}, number={1}, journal={Chemical Research in Toxicology}, publisher={American Chemical Society (ACS)}, author={Misra, R. Rita and Hochadel, James F. and Smith, George T. and Cook, John C. and Waalkes, Michael P. and Wink, David A.}, year={1996}, month=jan, pages={326–332} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        10
      ]
    ],
    "date-time": "2025-06-10T17:26:58Z",
    "timestamp": 1749576418761
  },
  "reference-count": 44,
  "publisher": "American Chemical Society (ACS)",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  },
  "DOI": "10.1021/tx950109y",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T05:30:15Z",
    "timestamp": 1027661415000
  },
  "page": "326-332",
  "source": "Crossref",
  "is-referenced-by-count": 118,
  "title": "Evidence That Nitric Oxide Enhances Cadmium Toxicity by Displacing the Metal from Metallothionein",
  "prefix": "10.1021",
  "volume": "9",
  "author": [
    {
      "given": "R. Rita",
      "family": "Misra",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Inorganic Carcinogenesis and Chemistry Sections, Laboratory of Comparative Carcinogenesis, Division of Cancer Etiology, and BCDP, SAIC Frederick, National Cancer Institute\u2212Frederick Cancer Research and Development Center, Frederick, Maryland 21702, and Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "James F.",
      "family": "Hochadel",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Inorganic Carcinogenesis and Chemistry Sections, Laboratory of Comparative Carcinogenesis, Division of Cancer Etiology, and BCDP, SAIC Frederick, National Cancer Institute\u2212Frederick Cancer Research and Development Center, Frederick, Maryland 21702, and Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "George T.",
      "family": "Smith",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Inorganic Carcinogenesis and Chemistry Sections, Laboratory of Comparative Carcinogenesis, Division of Cancer Etiology, and BCDP, SAIC Frederick, National Cancer Institute\u2212Frederick Cancer Research and Development Center, Frederick, Maryland 21702, and Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "John C.",
      "family": "Cook",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Inorganic Carcinogenesis and Chemistry Sections, Laboratory of Comparative Carcinogenesis, Division of Cancer Etiology, and BCDP, SAIC Frederick, National Cancer Institute\u2212Frederick Cancer Research and Development Center, Frederick, Maryland 21702, and Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "Michael P.",
      "family": "Waalkes",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Inorganic Carcinogenesis and Chemistry Sections, Laboratory of Comparative Carcinogenesis, Division of Cancer Etiology, and BCDP, SAIC Frederick, National Cancer Institute\u2212Frederick Cancer Research and Development Center, Frederick, Maryland 21702, and Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892"
        }
      ]
    },
    {
      "given": "David A.",
      "family": "Wink",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Inorganic Carcinogenesis and Chemistry Sections, Laboratory of Comparative Carcinogenesis, Division of Cancer Etiology, and BCDP, SAIC Frederick, National Cancer Institute\u2212Frederick Cancer Research and Development Center, Frederick, Maryland 21702, and Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        1996,
        1,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "tx950109yb00001/tx950109yb00001_1",
      "first-page": "237",
      "volume": "58",
      "author": "IARC",
      "year": "1993",
      "journal-title": "Eval. Carcinog. Risks Hum."
    },
    {
      "key": "tx950109yb00002/tx950109yb00002_1",
      "volume-title": "The scientific fallacy of route specificity of carcinogenesis with particular reference to cadmium. Regu. Toxicol. Pharmacol. 20, 119\u2212121",
      "author": "Waalkes M. P.",
      "year": "1994"
    },
    {
      "key": "tx950109yb00003/tx950109yb00003_1",
      "doi-asserted-by": "crossref",
      "first-page": "5",
      "DOI": "10.1006/taap.1994.1083",
      "volume": "126",
      "author": "Cherian M. G.",
      "year": "1994",
      "journal-title": "Toxicol. Appl. Pharmacol."
    },
    {
      "key": "tx950109yb00004/tx950109yb00004_1",
      "volume": "257",
      "author": "Winge D. R.",
      "year": "1981",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "tx950109yb00005/tx950109yb00005_1",
      "doi-asserted-by": "crossref",
      "first-page": "44",
      "DOI": "10.1016/0167-4838(85)90098-6",
      "volume": "827",
      "author": "Thornalley P. J.",
      "year": "1985",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "tx950109yb00006/tx950109yb00006_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 91",
      "author": "Palmiter R. D.",
      "year": "1994"
    },
    {
      "key": "tx950109yb00007/tx950109yb00007_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1146/annurev.pa.30.040190.002535",
      "volume": "30",
      "author": "Ignarro L. J.",
      "year": "1990",
      "journal-title": "Annu. Rev. Pharmacol. Toxicol."
    },
    {
      "key": "tx950109yb00008/tx950109yb00008_1",
      "volume": "43",
      "author": "Moncada S.",
      "year": "1991",
      "journal-title": "Pharmacol. Rev."
    },
    {
      "key": "tx950109yb00009/tx950109yb00009_1",
      "volume-title": "in Trace Atmospheric Constituents. Properties, Transformation and Fates",
      "author": "Schwartz S. E.",
      "year": "1983"
    },
    {
      "key": "tx950109yb00010/tx950109yb00010_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Wink, D. A., Nims, R. W., Darbyshire, J. F., Christodoulou, D., Hanbauer, I., Cox, G. W., Laval, F., Laval, J., Cook, J. A., Krishna, M. C., DeGraff, W., and Mitchell, J. B. (1994) Reaction kinetics for nitrosation of cysteine and glutathione in aerobic nitric oxide solutions at neutral pH. Insights into the fate and physiological effects of intermediates generated in the NO/O2reaction.Chem. Res. Toxicol.7, 519\u2212525.",
      "DOI": "10.1021/tx00040a007"
    },
    {
      "key": "tx950109yb00011/tx950109yb00011_1",
      "volume-title": "Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Arch. Biochem. Biophys. 300, 115\u2212123",
      "author": "Wink D. A.",
      "year": "1993"
    },
    {
      "key": "tx950109yb00012/tx950109yb00012_1",
      "volume": "267",
      "author": "Molina",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "tx950109yb00013/tx950109yb00013_1",
      "volume-title": "Inhibition by nitric oxide of the repair protein O6, methylguanine-DNA-methyltransferase. Carcinogenesis 15, 2125\u22122129",
      "author": "Wink D. A.",
      "year": "1994"
    },
    {
      "key": "tx950109yb00014/tx950109yb00014_1",
      "volume-title": "The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo. Carcinogenesis 15, 443\u2212447",
      "author": "Laval F.",
      "year": "1994"
    },
    {
      "key": "tx950109yb00015/tx950109yb00015_1",
      "volume-title": "DNA deaminatingability and genotoxicity of nitric oxide and its progenitors. Science 254, 1001\u22121003",
      "author": "Wink D. A.",
      "year": "1991"
    },
    {
      "key": "tx950109yb00016/tx950109yb00016_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 89",
      "author": "Nguyen T.",
      "year": "1992"
    },
    {
      "key": "tx950109yb00017/tx950109yb00017_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Kroncke, K.D., Fechsel, K., Schmidt, T., Zenke, F. T., Dasting, I., Wesener, J. R., Bettermann, H., Breunig, K. D., and Kolb-Bachofen, V. (1994) Nitric oxide destroys zinc finger clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9.Biochem. Biophys. Res. Commun.200, 1105\u22121110.",
      "DOI": "10.1006/bbrc.1994.1564"
    },
    {
      "key": "tx950109yb00018/tx950109yb00018_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1021/jm00115a013",
      "volume": "34",
      "author": "Maragos C. M.",
      "year": "1991",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "tx950109yb00019/tx950109yb00019_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1097/00005344-199304000-00023",
      "volume": "21",
      "author": "Morley D.",
      "year": "1993",
      "journal-title": "J. Cardiovasc. Pharmacol."
    },
    {
      "key": "tx950109yb00020/tx950109yb00020_1",
      "volume-title": "in DNA Repair:\u2009 A Laboratory Manual of Research Procedures",
      "volume": "521",
      "author": "McCormick J. J.",
      "year": "1981"
    },
    {
      "key": "tx950109yb00021/tx950109yb00021_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/0022-1759(89)90397-9",
      "volume": "119",
      "author": "Hansen M. B.",
      "year": "1989",
      "journal-title": "J. Immunol. Methods"
    },
    {
      "key": "tx950109yb00022/tx950109yb00022_1",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1248/jhs1956.24.128",
      "volume": "24",
      "author": "Onosaka S.",
      "year": "1978",
      "journal-title": "Eisei Kagaku"
    },
    {
      "key": "tx950109yb00023/tx950109yb00023_1",
      "volume": "234",
      "author": "Sobocinski P. Z.",
      "year": "1978",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "tx950109yb00024/tx950109yb00024_1",
      "volume-title": "Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66, 134\u2212142",
      "author": "Eaton D. L.",
      "year": "1982"
    },
    {
      "key": "tx950109yb00025/tx950109yb00025_1",
      "volume-title": "Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature 303, 401\u2212406",
      "author": "Stanton L. W.",
      "year": "1983"
    },
    {
      "key": "tx950109yb00026/tx950109yb00026_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1002/kin.550261208",
      "volume": "26",
      "author": "Pires M.",
      "year": "1994",
      "journal-title": "Int. J. Chem. Kinet."
    },
    {
      "key": "tx950109yb00027/tx950109yb00027_1",
      "volume-title": "Nitric oxide-induced cytotoxicity:\u2009 Involvement of cellular resistance to oxidative stress and the role of glutathione in protection. Pediat. Res. (in press)",
      "author": "Walker M. W.",
      "year": "1995"
    },
    {
      "key": "tx950109yb00028/tx950109yb00028_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 92",
      "author": "Schwarz M. A.",
      "year": "1995"
    },
    {
      "key": "tx950109yb00029/tx950109yb00029_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/S0021-9258(17)44080-4",
      "volume": "258",
      "author": "Nielson K. B.",
      "year": "1983",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "tx950109yb00030/tx950109yb00030_1",
      "volume-title": "Nitric oxide protects against alkyl peroxide mediated cytotoxicity. Insights into the role nitric oxide plays in lipid peroxidation mediated cell death. Arch Biochem. Biophys. (in press)",
      "author": "Wink D. A.",
      "year": "1995"
    },
    {
      "key": "tx950109yb00031/tx950109yb00031_1",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1016/0014-5793(93)81747-N",
      "volume": "326",
      "author": "Ford P. C.",
      "year": "1993",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "tx950109yb00032/tx950109yb00032_1",
      "volume": "1243",
      "author": "Clarkson R. B.",
      "year": "1995",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "tx950109yb00033/tx950109yb00033_1",
      "volume-title": "Mammalian synthesis of nitite, nitrate, nitric oxide and N-nitrosating agents. Chem. Res. Toxicol. 1, 249\u2212257",
      "author": "Marletta M. A.",
      "year": "1988"
    },
    {
      "key": "tx950109yb00034/tx950109yb00034_1",
      "volume-title": "Elevated formation of nitrate and N-nitrosodimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection. Cancer Res. 51, 3925\u22123929",
      "author": "Liu R. H.",
      "year": "1991"
    },
    {
      "key": "tx950109yb00035/tx950109yb00035_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 90",
      "author": "Gaston B.",
      "year": "1993"
    },
    {
      "key": "tx950109yb00036/tx950109yb00036_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 89",
      "author": "Stamler J. S.",
      "year": "1992"
    },
    {
      "key": "tx950109yb00037/tx950109yb00037_1",
      "first-page": "10",
      "volume": "52",
      "author": "Luethy J. D.",
      "year": "1992",
      "journal-title": "Cancer Res."
    },
    {
      "key": "tx950109yb00038/tx950109yb00038_1",
      "volume": "265",
      "author": "Jin P.",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "tx950109yb00039/tx950109yb00039_1",
      "first-page": "306",
      "volume": "14",
      "author": "Abshire M. K.",
      "year": "1994",
      "journal-title": "Toxicologist"
    },
    {
      "key": "tx950109yb00040/tx950109yb00040_1",
      "volume-title": "Response to adversity:\u2009 Molecular control of gene activation following genotoxic stress. New Biol. 3, 825\u2212833",
      "author": "Holbrook N. J.",
      "year": "1991"
    },
    {
      "key": "tx950109yb00041/tx950109yb00041_1",
      "first-page": "49",
      "volume": "3",
      "author": "Evan G. I.",
      "year": "1993",
      "journal-title": "Curr. Opin. Genet. Devel."
    },
    {
      "key": "tx950109yb00042/tx950109yb00042_1",
      "first-page": "104",
      "volume": "4",
      "author": "Shichiri M.",
      "year": "1993",
      "journal-title": "Cell Growth Diff."
    },
    {
      "key": "tx950109yb00043/tx950109yb00043_1",
      "unstructured": "Fornari, F. A., Jarvis, W. D., Grant, S., Orr, M. S., Randolph, J. K., White, F. K. H., Mumaw, R. H., Lovings, E. T., Freeman, R. H., and Gewirtz, D. A. (1994) Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reducedc-mycexpression in MCF-7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin.Cell Growth Differ.5, 723\u2212733."
    },
    {
      "key": "tx950109yn00001/tx950109yn00001_1",
      "volume-title": "cadmium",
      "author": "Abbreviations"
    }
  ],
  "container-title": "Chemical Research in Toxicology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/tx950109y",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        3,
        13
      ]
    ],
    "date-time": "2023-03-13T23:14:35Z",
    "timestamp": 1678749275000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/tx950109y"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  },
  "references-count": 44,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1996,
          1,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/tx950109y"
  ],
  "URL": "http://dx.doi.org/10.1021/tx950109y",
  "relation": {},
  "ISSN": [
    "0893-228X",
    "1520-5010"
  ],
  "subject": [],
  "container-title-short": "Chem. Res. Toxicol.",
  "published": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  }
}