DOI: 10.1021/mp8000556. Nanoemulsion Preparations of the Anticancer Drug Dacarbazine Significantly Increase Its Efficacy in a Xenograft Mouse Melanoma Model

Nanoemulsion Preparations of the Anticancer Drug Dacarbazine Significantly Increase Its Efficacy in a Xenograft Mouse Melanoma Model

10.1021/mp8000556

Crossref journal-article

American Chemical Society (ACS)

Molecular Pharmaceutics (316)

Bibliography

Tagne, J.-B., Kakumanu, S., & Nicolosi, R. J. (2008). Nanoemulsion Preparations of the Anticancer Drug Dacarbazine Significantly Increase Its Efficacy in a Xenograft Mouse Melanoma Model. Molecular Pharmaceutics, 5(6), 1055â1063.

Authors 3

Jean-Bosco Tagne (first)
Srikanth Kakumanu (additional)
Robert J. Nicolosi (additional)

References 35 Referenced 85

{'issue': '1', 'key': 'ref1/cit1', 'first-page': '61', 'volume': '54', 'author': 'Little J. W.', 'year': '2006', 'journal-title': 'Gen. Dent.'} / Gen. Dent. by Little J. W. (2006)
{'issue': '3', 'key': 'ref2/cit2', 'first-page': '211', 'volume': '110', 'author': 'Murayama K.', 'year': '2006', 'journal-title': 'Nippon Ganka Gakkai Zasshi'} / Nippon Ganka Gakkai Zasshi by Murayama K. (2006)
{'issue': '1', 'key': 'ref3/cit3', 'first-page': '85', 'volume': '47', 'author': 'Lim C. C.', 'year': '2006', 'journal-title': 'Can. Vet. J.'} / Can. Vet. J. by Lim C. C. (2006)
10.1016/j.cdp.2004.09.003 / Cancer Detect. Prev. by Pasco S. (2005)
10.1055/s-2007-1008230 / Laryngol. Rhinol. Otol. by Scherer H. (1984)
{'issue': '11', 'key': 'ref6/cit6', 'first-page': '1844', 'volume': '28', 'author': 'Niederkorn J. Y.', 'year': '1987', 'journal-title': 'Invest. Ophthalmol. Visual Sci.'} / Invest. Ophthalmol. Visual Sci. by Niederkorn J. Y. (1987)
10.1016/j.mrgentox.2006.04.019 / Mutat. Res. by Kumar S. G. (2006)
{'issue': '5', 'key': 'ref8/cit8', 'first-page': '37', 'volume': '12', 'author': 'Ancheva M. N.', 'year': '1990', 'journal-title': 'Eksp. Onkol.'} / Eksp. Onkol. by Ancheva M. N. (1990)
10.1016/S0151-9638(06)70868-7 / Ann. Dermatol. Venereol. by Levy A. (2006)
{'issue': '10', 'key': 'ref10/cit10', 'first-page': '2790', 'volume': '35', 'author': 'Povlsen C. O.', 'year': '1975', 'journal-title': 'Cancer Res.'} / Cancer Res. by Povlsen C. O. (1975)
10.1016/j.ejps.2005.08.001 / Eur. J. Pharm. Sci. by Sadurni N. (2005)
10.1016/j.cis.2003.10.023 / Adv. Colloid Interface Sci. by Tadros T. (2004)
10.1016/j.addr.2003.12.005 / Adv. Drug Delivery Rev. by Constantinides P. P. (2004)
10.1023/A:1024474609667 / Pharm. Res. by Thanos C. G. (2003)
{'issue': '2', 'key': 'ref15/cit15', 'first-page': '129', 'volume': '6', 'author': 'Kuo F.', 'year': '2007', 'journal-title': 'J. Exp. Ther. Oncol.'} / J. Exp. Ther. Oncol. by Kuo F. (2007)
10.1016/j.ijpharm.2006.07.027 / Int. J. Pharm. by Zhao X. (2006)
10.1016/j.jconrel.2006.03.001 / J. Controlled Release by Koziara J. M. (2006)
10.1038/nrd1494 / Nat. Rev. Drug Discovery by Rabinow B. E. (2004)
10.1021/ja039651w / J. Am. Chem. Soc. by Kumar R. (2004)
10.1016/S0378-5173(99)00066-6 / Int. J. Pharm. by Cavalli R. (1999)
10.1081/DDC-200047802 / Drug Dev. Ind. Pharm. by Attivi D. (2005)
10.1023/B:PHAM.0000041446.14569.e2 / Pharm. Res. by Merisko-Liversidge E. (2004)
{'issue': '11', 'key': 'ref23/cit23', 'first-page': '1051', 'volume': '23', 'author': 'Pan Y.', 'year': '2002', 'journal-title': 'Acta Pharmacol. Sin.'} / Acta Pharmacol. Sin. by Pan Y. (2002)
10.1016/j.ijpharm.2004.09.002 / Int. J. Pharm. by Vila A. (2005)
10.1016/j.jcis.2005.04.091 / J. Colloid Interface Sci. by Singh B. P. (2005)
10.1016/j.jhazmat.2004.12.023 / J. Hazard. Mater. by Kaya A. (2005)
10.1166/jnn.2005.091 / J. Nanosci. Nanotechnol. by Peng J. (2005)
10.1006/jcis.2002.8409 / J. Colloid Interface Sci. by Grosse C. (2002)
10.1016/j.addr.2004.12.005 / Adv. Drug Delivery Rev. by Mahato R. I. (2005)
10.1021/la034780b / Langmuir by Matos C. (2004)
10.1080/10611860400015936 / J. Drug Targeting by Lockman P. R. (2004)
10.1081/DDC-120001481 / Drug Dev. Ind. Pharm. by Lockman P. R. (2002)
10.1021/mp700091j / Mol. Pharmaceutics by Tagne J. B. (2008)
10.1002/jps.10471 / J. Pharm. Sci. by Lee J. (2003)
{'issue': '8', 'key': 'ref35/cit35', 'first-page': '2192', 'volume': '5', 'author': 'Reid J. M.', 'year': '1999', 'journal-title': 'Clin. Cancer Res.'} / Clin. Cancer Res. by Reid J. M. (1999)

Dates

Type	When
Created	16 years, 10 months ago (Oct. 1, 2008, 6:01 a.m.)
Deposited	2 years, 5 months ago (March 21, 2023, 9:29 p.m.)
Indexed	1 month ago (July 25, 2025, 6:33 a.m.)
Issued	16 years, 10 months ago (Oct. 1, 2008)
Published	16 years, 10 months ago (Oct. 1, 2008)
Published Online	16 years, 10 months ago (Oct. 1, 2008)
Published Print	16 years, 8 months ago (Dec. 1, 2008)

Funders 0

None

BibTeX

@article{Tagne_2008, title={Nanoemulsion Preparations of the Anticancer Drug Dacarbazine Significantly Increase Its Efficacy in a Xenograft Mouse Melanoma Model}, volume={5}, ISSN={1543-8392}, url={http://dx.doi.org/10.1021/mp8000556}, DOI={10.1021/mp8000556}, number={6}, journal={Molecular Pharmaceutics}, publisher={American Chemical Society (ACS)}, author={Tagne, Jean-Bosco and Kakumanu, Srikanth and Nicolosi, Robert J.}, year={2008}, month=oct, pages={1055–1063} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        25
      ]
    ],
    "date-time": "2025-07-25T10:33:26Z",
    "timestamp": 1753439606459
  },
  "reference-count": 35,
  "publisher": "American Chemical Society (ACS)",
  "issue": "6",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2008,
        12,
        1
      ]
    ]
  },
  "DOI": "10.1021/mp8000556",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2008,
        10,
        1
      ]
    ],
    "date-time": "2008-10-01T10:01:05Z",
    "timestamp": 1222855265000
  },
  "page": "1055-1063",
  "source": "Crossref",
  "is-referenced-by-count": 85,
  "title": "Nanoemulsion Preparations of the Anticancer Drug Dacarbazine Significantly Increase Its Efficacy in a Xenograft Mouse Melanoma Model",
  "prefix": "10.1021",
  "volume": "5",
  "author": [
    {
      "given": "Jean-Bosco",
      "family": "Tagne",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Center for Health and Disease Research and the Biomedical Engineering/Biotechnology Program, University of Massachusetts Lowell, Lowell, Massachusetts 01854"
        }
      ]
    },
    {
      "given": "Srikanth",
      "family": "Kakumanu",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Health and Disease Research and the Biomedical Engineering/Biotechnology Program, University of Massachusetts Lowell, Lowell, Massachusetts 01854"
        }
      ]
    },
    {
      "given": "Robert J.",
      "family": "Nicolosi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Center for Health and Disease Research and the Biomedical Engineering/Biotechnology Program, University of Massachusetts Lowell, Lowell, Massachusetts 01854"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2008,
        10,
        1
      ]
    ]
  },
  "reference": [
    {
      "issue": "1",
      "key": "ref1/cit1",
      "first-page": "61",
      "volume": "54",
      "author": "Little J. W.",
      "year": "2006",
      "journal-title": "Gen. Dent."
    },
    {
      "issue": "3",
      "key": "ref2/cit2",
      "first-page": "211",
      "volume": "110",
      "author": "Murayama K.",
      "year": "2006",
      "journal-title": "Nippon Ganka Gakkai Zasshi"
    },
    {
      "issue": "1",
      "key": "ref3/cit3",
      "first-page": "85",
      "volume": "47",
      "author": "Lim C. C.",
      "year": "2006",
      "journal-title": "Can. Vet. J."
    },
    {
      "issue": "3",
      "key": "ref4/cit4",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1016/j.cdp.2004.09.003",
      "volume": "29",
      "author": "Pasco S.",
      "year": "2005",
      "journal-title": "Cancer Detect. Prev."
    },
    {
      "issue": "1",
      "key": "ref5/cit5",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1055/s-2007-1008230",
      "volume": "63",
      "author": "Scherer H.",
      "year": "1984",
      "journal-title": "Laryngol. Rhinol. Otol."
    },
    {
      "issue": "11",
      "key": "ref6/cit6",
      "first-page": "1844",
      "volume": "28",
      "author": "Niederkorn J. Y.",
      "year": "1987",
      "journal-title": "Invest. Ophthalmol. Visual Sci."
    },
    {
      "issue": "2",
      "key": "ref7/cit7",
      "doi-asserted-by": "crossref",
      "first-page": "240",
      "DOI": "10.1016/j.mrgentox.2006.04.019",
      "volume": "607",
      "author": "Kumar S. G.",
      "year": "2006",
      "journal-title": "Mutat. Res."
    },
    {
      "issue": "5",
      "key": "ref8/cit8",
      "first-page": "37",
      "volume": "12",
      "author": "Ancheva M. N.",
      "year": "1990",
      "journal-title": "Eksp. Onkol."
    },
    {
      "issue": "2",
      "key": "ref9/cit9",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/S0151-9638(06)70868-7",
      "volume": "133",
      "author": "Levy A.",
      "year": "2006",
      "journal-title": "Ann. Dermatol. Venereol."
    },
    {
      "issue": "10",
      "key": "ref10/cit10",
      "first-page": "2790",
      "volume": "35",
      "author": "Povlsen C. O.",
      "year": "1975",
      "journal-title": "Cancer Res."
    },
    {
      "issue": "5",
      "key": "ref11/cit11",
      "doi-asserted-by": "crossref",
      "first-page": "438",
      "DOI": "10.1016/j.ejps.2005.08.001",
      "volume": "26",
      "author": "Sadurni N.",
      "year": "2005",
      "journal-title": "Eur. J. Pharm. Sci."
    },
    {
      "key": "ref12/cit12",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1016/j.cis.2003.10.023",
      "volume": "108",
      "author": "Tadros T.",
      "year": "2004",
      "journal-title": "Adv. Colloid Interface Sci."
    },
    {
      "issue": "9",
      "key": "ref13/cit13",
      "doi-asserted-by": "crossref",
      "first-page": "1243",
      "DOI": "10.1016/j.addr.2003.12.005",
      "volume": "56",
      "author": "Constantinides P. P.",
      "year": "2004",
      "journal-title": "Adv. Drug Delivery Rev."
    },
    {
      "issue": "7",
      "key": "ref14/cit14",
      "doi-asserted-by": "crossref",
      "first-page": "1093",
      "DOI": "10.1023/A:1024474609667",
      "volume": "20",
      "author": "Thanos C. G.",
      "year": "2003",
      "journal-title": "Pharm. Res."
    },
    {
      "issue": "2",
      "key": "ref15/cit15",
      "first-page": "129",
      "volume": "6",
      "author": "Kuo F.",
      "year": "2007",
      "journal-title": "J. Exp. Ther. Oncol."
    },
    {
      "issue": "1",
      "key": "ref16/cit16",
      "doi-asserted-by": "crossref",
      "first-page": "58",
      "DOI": "10.1016/j.ijpharm.2006.07.027",
      "volume": "327",
      "author": "Zhao X.",
      "year": "2006",
      "journal-title": "Int. J. Pharm."
    },
    {
      "issue": "3",
      "key": "ref17/cit17",
      "doi-asserted-by": "crossref",
      "first-page": "312",
      "DOI": "10.1016/j.jconrel.2006.03.001",
      "volume": "112",
      "author": "Koziara J. M.",
      "year": "2006",
      "journal-title": "J. Controlled Release"
    },
    {
      "issue": "9",
      "key": "ref18/cit18",
      "doi-asserted-by": "crossref",
      "first-page": "785",
      "DOI": "10.1038/nrd1494",
      "volume": "3",
      "author": "Rabinow B. E.",
      "year": "2004",
      "journal-title": "Nat. Rev. Drug Discovery"
    },
    {
      "issue": "34",
      "key": "ref19/cit19",
      "doi-asserted-by": "crossref",
      "first-page": "10640",
      "DOI": "10.1021/ja039651w",
      "volume": "126",
      "author": "Kumar R.",
      "year": "2004",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "issue": "1",
      "key": "ref20/cit20",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1016/S0378-5173(99)00066-6",
      "volume": "182",
      "author": "Cavalli R.",
      "year": "1999",
      "journal-title": "Int. J. Pharm."
    },
    {
      "issue": "2",
      "key": "ref21/cit21",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1081/DDC-200047802",
      "volume": "31",
      "author": "Attivi D.",
      "year": "2005",
      "journal-title": "Drug Dev. Ind. Pharm."
    },
    {
      "issue": "9",
      "key": "ref22/cit22",
      "doi-asserted-by": "crossref",
      "first-page": "1545",
      "DOI": "10.1023/B:PHAM.0000041446.14569.e2",
      "volume": "21",
      "author": "Merisko-Liversidge E.",
      "year": "2004",
      "journal-title": "Pharm. Res."
    },
    {
      "issue": "11",
      "key": "ref23/cit23",
      "first-page": "1051",
      "volume": "23",
      "author": "Pan Y.",
      "year": "2002",
      "journal-title": "Acta Pharmacol. Sin."
    },
    {
      "issue": "1",
      "key": "ref24/cit24",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1016/j.ijpharm.2004.09.002",
      "volume": "292",
      "author": "Vila A.",
      "year": "2005",
      "journal-title": "Int. J. Pharm."
    },
    {
      "issue": "1",
      "key": "ref25/cit25",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1016/j.jcis.2005.04.091",
      "volume": "291",
      "author": "Singh B. P.",
      "year": "2005",
      "journal-title": "J. Colloid Interface Sci."
    },
    {
      "issue": "1",
      "key": "ref26/cit26",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1016/j.jhazmat.2004.12.023",
      "volume": "120",
      "author": "Kaya A.",
      "year": "2005",
      "journal-title": "J. Hazard. Mater."
    },
    {
      "issue": "5",
      "key": "ref27/cit27",
      "doi-asserted-by": "crossref",
      "first-page": "713",
      "DOI": "10.1166/jnn.2005.091",
      "volume": "5",
      "author": "Peng J.",
      "year": "2005",
      "journal-title": "J. Nanosci. Nanotechnol."
    },
    {
      "issue": "2",
      "key": "ref28/cit28",
      "doi-asserted-by": "crossref",
      "first-page": "304",
      "DOI": "10.1006/jcis.2002.8409",
      "volume": "251",
      "author": "Grosse C.",
      "year": "2002",
      "journal-title": "J. Colloid Interface Sci."
    },
    {
      "issue": "5",
      "key": "ref29/cit29",
      "doi-asserted-by": "crossref",
      "first-page": "699",
      "DOI": "10.1016/j.addr.2004.12.005",
      "volume": "57",
      "author": "Mahato R. I.",
      "year": "2005",
      "journal-title": "Adv. Drug Delivery Rev."
    },
    {
      "issue": "2",
      "key": "ref30/cit30",
      "doi-asserted-by": "crossref",
      "first-page": "369",
      "DOI": "10.1021/la034780b",
      "volume": "20",
      "author": "Matos C.",
      "year": "2004",
      "journal-title": "Langmuir"
    },
    {
      "issue": "9",
      "key": "ref31/cit31",
      "doi-asserted-by": "crossref",
      "first-page": "635",
      "DOI": "10.1080/10611860400015936",
      "volume": "12",
      "author": "Lockman P. R.",
      "year": "2004",
      "journal-title": "J. Drug Targeting"
    },
    {
      "issue": "1",
      "key": "ref32/cit32",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1081/DDC-120001481",
      "volume": "28",
      "author": "Lockman P. R.",
      "year": "2002",
      "journal-title": "Drug Dev. Ind. Pharm."
    },
    {
      "issue": "2",
      "key": "ref33/cit33",
      "doi-asserted-by": "crossref",
      "first-page": "280",
      "DOI": "10.1021/mp700091j",
      "volume": "5",
      "author": "Tagne J. B.",
      "year": "2008",
      "journal-title": "Mol. Pharmaceutics"
    },
    {
      "issue": "10",
      "key": "ref34/cit34",
      "doi-asserted-by": "crossref",
      "first-page": "2057",
      "DOI": "10.1002/jps.10471",
      "volume": "92",
      "author": "Lee J.",
      "year": "2003",
      "journal-title": "J. Pharm. Sci."
    },
    {
      "issue": "8",
      "key": "ref35/cit35",
      "first-page": "2192",
      "volume": "5",
      "author": "Reid J. M.",
      "year": "1999",
      "journal-title": "Clin. Cancer Res."
    }
  ],
  "container-title": "Molecular Pharmaceutics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/mp8000556",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        3,
        22
      ]
    ],
    "date-time": "2023-03-22T01:29:13Z",
    "timestamp": 1679448553000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/mp8000556"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2008,
        10,
        1
      ]
    ]
  },
  "references-count": 35,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2008,
          12,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/mp8000556"
  ],
  "URL": "http://dx.doi.org/10.1021/mp8000556",
  "relation": {},
  "ISSN": [
    "1543-8384",
    "1543-8392"
  ],
  "subject": [],
  "container-title-short": "Mol. Pharmaceutics",
  "published": {
    "date-parts": [
      [
        2008,
        10,
        1
      ]
    ]
  }
}