DOI: 10.1021/js9604117. A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres

A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres

10.1021/js9604117

Crossref journal-article

American Geophysical Union (AGU)

Journal of Pharmaceutical Sciences (13)

Bibliography

Batycky, R. P., Hanes, J., Langer, R., & Edwards, D. A. (1997). A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres. Journal of Pharmaceutical Sciences, 86(12), 1464â1477.

Authors 4

Richard P. Batycky (first)
Justin Hanes (additional)
Robert Langer (additional)
David A. Edwards (additional)

References 32 Referenced 306

10.1002/jps.2600521210 / J. Pharm. Sci / Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matricies by Higuchi (1963)
10.1016/S0376-7388(00)80472-X / J. Membr. Sci. / Diffusional release of a solute from a polymeric matrix—approximate analytical solutions by Lee (1980)
10.1016/0168-3659(91)90067-N / J. Controlled Release / Dynamics of controlled release from bioerodible matrices by Joshi (1991)
{'key': '10.1021/js9604117_bb0020', 'first-page': 'S21', 'article-title': 'Development of a single shot subunit vaccine for HIV-1', 'volume': '10', 'author': 'Cleland', 'year': '1994', 'journal-title': 'AIDS Res. Human Retrovirus'} / AIDS Res. Human Retrovirus / Development of a single shot subunit vaccine for HIV-1 by Cleland (1994)
10.1016/0168-3659(92)90171-M / J. Controlled Release / Poly(glycolic acid-co-dl-lactic acid): diffusion or degradation controlled drug delivery? by Shah (1992)
{'key': '10.1021/js9604117_bb0030', 'series-title': 'Biodegradable Polymers as Drug Delivery Systems', 'first-page': '1', 'article-title': 'Controlled release of bioactive agents from lactide/glycolide polymers', 'author': 'Lewis', 'year': '1990'} / Biodegradable Polymers as Drug Delivery Systems / Controlled release of bioactive agents from lactide/glycolide polymers by Lewis (1990)
{'key': '10.1021/js9604117_bb0035', 'first-page': '1', 'article-title': 'Biodegradable microspheres as controlled-release tetanus toxoid delivery systems', 'volume': '11', 'author': 'Alonso', 'year': '1993', 'journal-title': 'Vaccine'} / Vaccine / Biodegradable microspheres as controlled-release tetanus toxoid delivery systems by Alonso (1993)
Hanes, J.; Hildgen, P.; Edwards, D. A.; Batycky, R. P.; Coleman, S.; Cleland, J.; Langer, R. Poly(D, L-lactic-co-glycolic acid) microsphere degradation and pulsatile release of the globular protein gp 120. Submitted for publication in. J. Pharm. Sci.
{'key': '10.1021/js9604117_bb0045', 'series-title': 'Properties of Polymers—Correlations with Chemical Structure', 'author': 'Van Koevelen', 'year': '1972'} / Properties of Polymers—Correlations with Chemical Structure by Van Koevelen (1972)
10.1016/0168-3659(88)90082-X / J. Controlled Release / A one-week subdermal delivery system for l-methadone based on biodegradable microcapsules by Cha (1988)
As pointed out in the discussion section, the general analysis outlined herein applies to far more general circumstances than those of microparticles into which water tunnels via straight, regularly shaped ‘free molecular volume’ cylindrical pores.
10.1016/0168-3659(94)00100-9 / J. Controlled Release / Chain-end scission in acid catalyzed hydrolysis of poly-(D, L-lactide) in solution by Shih (1995)
10.1016/0168-3659(95)00104-2 / J. Controlled Release / Quantitative analysis of ester linkages in poly(D, L-lactide) and poly(D, L-lactide-co-gly- colide) by Shih (1996)
10.1039/tf9403500611 / Trans. Faraday Soc. / Degradation of long chain molecules by Mark (1940)
10.1063/1.1750807 / J. Chem. Phys. / Theory of depolymerization of long chain molecules by Montroll (1940)
10.1098/rsta.1966.0054 / Phil. Trans. R. Soc. Lond. / On the theory of reactions in continuous mixtures by Aris (1966)
10.1088/0305-4470/18/15/026 / J. Phys. A: Math. Gen. / The kinetics of cluster fragmentation and depolymerisation by Ziff (1985)
10.1021/ma00164a010 / Macromolecules / Kinetics of polymer degradation by Ziff (1986)
10.1016/0009-2509(88)87020-9 / Chem. Eng. Sci. / Continuous kinetics of first order degradation reactions in polydisperse mixtures by Kehlen (1988)
10.1002/aic.690410616 / AIChE J. / Continuous kinetics for thermal degradation of polymer in solution by Wang (1995)
10.1016/0141-3910(95)00067-V / Polymer Degradation Stability / Computer modelling of the degradation of linear polymers by Emsley (1995)
{'key': '10.1021/js9604117_bb0110', 'series-title': 'Handbook of Mathematical Functions', 'author': 'Abramowitz', 'year': '1965'} / Handbook of Mathematical Functions by Abramowitz (1965)
In effect, eqs 41–44 are an explicit method for inverting a triangular matrix.
{'key': '10.1021/js9604117_bb0120', 'series-title': 'Conduction of Heat in Solids', 'author': 'Carslaw', 'year': '1959'} / Conduction of Heat in Solids by Carslaw (1959)
This method of measurement is obviously approximate. Distinct mesopores become apparent by visual inspection of electron microscopic photos8 when mesopores reach a radius of approximately RM ≃ 1 μm. Measuring the rate of growth of pores in the domain RM ≥ 1 μm may or may not be equivalent to measuring the rate constant kcoal
10.1023/A:1016278902839 / Pharm. Res. / Adsorption of salmon calcitonin to PLGA microspheres by Calis (1995)
{'key': '10.1021/js9604117_bb0135', 'series-title': 'Controlled-Release Technology: Pharmaceutical Applications', 'first-page': '16', 'article-title': 'Microstructural models for diffusive transport in porous polymers', 'author': 'Saltzman', 'year': '1987'} / Controlled-Release Technology: Pharmaceutical Applications / Microstructural models for diffusive transport in porous polymers by Saltzman (1987)
10.1016/0168-3659(95)00102-6 / J. Controlled Release / Control of the biodegradation rate of poly(D, L-lactide) microparticles intended as chemoembolization materials by Grandfils (1996)
10.1126/science.8128245 / Science / Biodegradable long-circulating polymeric nanospheres by Gref (1994)
10.1023/A:1016256903322 / Pharm. Res. / Gamma Irradiation Effects on Molecular Weight and in Vitro Degradation of Poly(D, L-Lactide- CO-Glycolide) Microparticles by Hausberger (1995)
{'key': '10.1021/js9604117_bb0155', 'series-title': 'Macrotransport Processes', 'author': 'Brenner', 'year': '1993'} / Macrotransport Processes by Brenner (1993)
{'key': '10.1021/js9604117_bb0160', 'series-title': 'Diffusion in Polymers', 'first-page': '143', 'article-title': '1996 Free-volume theory', 'author': 'Duda', 'year': '1996'} / Diffusion in Polymers / 1996 Free-volume theory by Duda (1996)

Dates

Type	When
Created	23 years ago (Aug. 25, 2002, 5:40 a.m.)
Deposited	4 years, 1 month ago (July 20, 2021, 10:52 a.m.)
Indexed	4 weeks ago (Aug. 2, 2025, 12:09 a.m.)
Issued	27 years, 8 months ago (Dec. 1, 1997)
Published	27 years, 8 months ago (Dec. 1, 1997)
Published Print	27 years, 8 months ago (Dec. 1, 1997)

Funders 0

None

BibTeX

@article{Batycky_1997, title={A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres}, volume={86}, ISSN={0022-3549}, url={http://dx.doi.org/10.1021/js9604117}, DOI={10.1021/js9604117}, number={12}, journal={Journal of Pharmaceutical Sciences}, publisher={American Geophysical Union (AGU)}, author={Batycky, Richard P. and Hanes, Justin and Langer, Robert and Edwards, David A.}, year={1997}, month=dec, pages={1464–1477} }

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