DOI: 10.1021/jp9033936. Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

10.1021/jp9033936

Crossref journal-article

American Chemical Society (ACS)

The Journal of Physical Chemistry B (316)

Bibliography

Chen, J., Hessler, J. A., Putchakayala, K., Panama, B. K., Khan, D. P., Hong, S., Mullen, D. G., DiMaggio, S. C., Som, A., Tew, G. N., Lopatin, A. N., Baker, J. R., Holl, M. M. B., & Orr, B. G. (2009). Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes. The Journal of Physical Chemistry B, 113(32), 11179â11185.

Authors 14

Jiumei Chen (first)
Jessica A. Hessler (additional)
Krishna Putchakayala (additional)
Brian K. Panama (additional)
Damian P. Khan (additional)
Seungpyo Hong (additional)
Douglas G. Mullen (additional)
Stassi C. DiMaggio (additional)
Abhigyan Som (additional)
Gregory N. Tew (additional)
Anatoli N. Lopatin (additional)
James R. Baker (additional)
Mark M. Banaszak Holl (additional)
Bradford G. Orr (additional)

References 27 Referenced 206

10.1021/bc049962b / Bioconjugate Chem. by Hong S. (2004)
10.1021/bc060077y / Bioconjugate Chem. by Hong S. (2006)
10.1021/nl0722929 / Nano Lett. by Leroueil P. R. (2008)
10.1021/ar600012y / Acc. Chem. Res. by Leroueil P. R. (2007)
10.1016/S0142-9612(02)00445-3 / Biomaterials by Fischer D. (2003)
10.1038/nmat2202 / Nat. Mater. by Verma A. (2008)
10.1021/bc000018z / Bioconjugate Chem. by Zhang Z.-Y. (2000)
10.1021/la050629l / Langmuir by Mecke A. (2005)
10.1016/j.chemphyslip.2004.09.001 / Chem. Phys. Lipids by Mecke A. (2004)
10.1021/nl072053l / Nano Lett. by Ginzburg V. V. (2007)
10.1021/jp054339p / J. Phys. Chem B by Arnt L. (2006)
10.1073/pnas.0806456105 / Proc. Natl. Acad. Sci. U. S. A. by Yang L. H. (2008)
10.1021/ja072310o / J. Am. Chem. Soc. by Yang L. H. (2007)
10.1128/IAI.68.8.4578-4584.2000 / Infect. Immun. by Noronha F. S. M. (2000)
{'key': 'ref15/cit15', 'volume-title': 'Ionic channels of excitable membranes', 'author': 'Hille R.', 'year': '1992'} / Ionic channels of excitable membranes by Hille R. (1992)
10.1021/jp802606y / J. Phys. Chem B by Lee H. (2008)
10.1021/jp0630830 / J. Phys. Chem. B by Lee H. (2006)
10.3390/molecules14010423 / Molecules by Lee H. (2009)
10.1021/jp805026m / J. Phys. Chem B by Lee H. (2008)
10.1021/jp801377a / J. Phys. Chem B by Kelly C. V. (2008)
10.1021/jp8013783 / J. Phys. Chem B by Kelly C. V. (2008)
10.1289/ehp.7339 / Environ. Health Perspect. by Oberdorster G. (2005)
10.1023/B:PHAM.0000019302.26097.cc / Pharm. Res. by Nigavekar S. S. (2004)
10.1093/toxsci/kfj027 / Toxicol. Sci. by Kim J. S. (2006)
10.1289/ehp.8006 / Environ. Health Perspect. by Geiser M. (2005)
10.1016/j.addr.2005.09.019 / Adv. Drug Delivery Rev. by Duncan R. (2005)
10.1038/nmat2442 / Nat. Mater. by Nel A. E. (2009)

Dates

Type	When
Created	16 years, 1 month ago (July 16, 2009, 12:49 p.m.)
Deposited	2 years, 5 months ago (March 5, 2023, 11:44 p.m.)
Indexed	4 days, 10 hours ago (Aug. 31, 2025, 6:37 a.m.)
Issued	16 years, 1 month ago (July 16, 2009)
Published	16 years, 1 month ago (July 16, 2009)
Published Online	16 years, 1 month ago (July 16, 2009)
Published Print	16 years ago (Aug. 13, 2009)

Funders 0

None

BibTeX

@article{Chen_2009, title={Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes}, volume={113}, ISSN={1520-5207}, url={http://dx.doi.org/10.1021/jp9033936}, DOI={10.1021/jp9033936}, number={32}, journal={The Journal of Physical Chemistry B}, publisher={American Chemical Society (ACS)}, author={Chen, Jiumei and Hessler, Jessica A. and Putchakayala, Krishna and Panama, Brian K. and Khan, Damian P. and Hong, Seungpyo and Mullen, Douglas G. and DiMaggio, Stassi C. and Som, Abhigyan and Tew, Gregory N. and Lopatin, Anatoli N. and Baker, James R. and Holl, Mark M. Banaszak and Orr, Bradford G.}, year={2009}, month=jul, pages={11179–11185} }

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      "DOI": "10.1021/ar600012y",
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      "author": "Leroueil P. R.",
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    },
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      "first-page": "1121",
      "DOI": "10.1016/S0142-9612(02)00445-3",
      "volume": "24",
      "author": "Fischer D.",
      "year": "2003",
      "journal-title": "Biomaterials"
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      "first-page": "588",
      "DOI": "10.1038/nmat2202",
      "volume": "7",
      "author": "Verma A.",
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      "journal-title": "Nat. Mater."
    },
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      "key": "ref7/cit7",
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      "first-page": "805",
      "DOI": "10.1021/bc000018z",
      "volume": "11",
      "author": "Zhang Z.-Y.",
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    },
    {
      "key": "ref8/cit8",
      "doi-asserted-by": "crossref",
      "first-page": "10348",
      "DOI": "10.1021/la050629l",
      "volume": "21",
      "author": "Mecke A.",
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      "journal-title": "Langmuir"
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      "key": "ref9/cit9",
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      "first-page": "3",
      "DOI": "10.1016/j.chemphyslip.2004.09.001",
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      "author": "Mecke A.",
      "year": "2004",
      "journal-title": "Chem. Phys. Lipids"
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      "doi-asserted-by": "crossref",
      "first-page": "3716",
      "DOI": "10.1021/nl072053l",
      "volume": "7",
      "author": "Ginzburg V. V.",
      "year": "2007",
      "journal-title": "Nano Lett."
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      "key": "ref11/cit11",
      "doi-asserted-by": "crossref",
      "first-page": "3527",
      "DOI": "10.1021/jp054339p",
      "volume": "110",
      "author": "Arnt L.",
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      "journal-title": "J. Phys. Chem B"
    },
    {
      "key": "ref12/cit12",
      "doi-asserted-by": "crossref",
      "first-page": "20595",
      "DOI": "10.1073/pnas.0806456105",
      "volume": "105",
      "author": "Yang L. H.",
      "year": "2008",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "ref13/cit13",
      "doi-asserted-by": "crossref",
      "first-page": "12141",
      "DOI": "10.1021/ja072310o",
      "volume": "129",
      "author": "Yang L. H.",
      "year": "2007",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ref14/cit14",
      "doi-asserted-by": "crossref",
      "first-page": "4578",
      "DOI": "10.1128/IAI.68.8.4578-4584.2000",
      "volume": "68",
      "author": "Noronha F. S. M.",
      "year": "2000",
      "journal-title": "Infect. Immun."
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      "DOI": "10.1021/jp802606y",
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      "key": "ref17/cit17",
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      "DOI": "10.1021/jp0630830",
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      "author": "Lee H.",
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      "journal-title": "J. Phys. Chem. B"
    },
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      "key": "ref18/cit18",
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      "first-page": "423",
      "DOI": "10.3390/molecules14010423",
      "volume": "14",
      "author": "Lee H.",
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      "journal-title": "Molecules"
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      "DOI": "10.1021/jp805026m",
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      "DOI": "10.1021/jp8013783",
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      "author": "Oberdorster G.",
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