DOI: 10.1021/jm991172d. A Novel Approach for the Virtual Screening and Rational Design of Anticancer Compounds

A Novel Approach for the Virtual Screening and Rational Design of Anticancer Compounds

10.1021/jm991172d

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

Estrada, E., Uriarte, E., Montero, A., Teijeira, M., Santana, L., & De Clercq, E. (2000). A Novel Approach for the Virtual Screening and Rational Design of Anticancer Compounds. Journal of Medicinal Chemistry, 43(10), 1975â1985.

Authors 6

Ernesto Estrada (first)
Eugenio Uriarte (additional)
Alina Montero (additional)
Marta Teijeira (additional)
Lourdes Santana (additional)
Erik De Clercq (additional)

References 43 Referenced 144

10.3109/10799899909036635 / J. Recept. Signal Transduct. Res. by Kubinyi H (1999)
{'key': 'jm991172db00002/jm991172db00002_1', 'first-page': '256', 'volume': '50', 'author': 'Lien E. J.', 'year': '1998', 'journal-title': 'Chin. Pharm. J. (Taipei)'} / Chin. Pharm. J. (Taipei) by Lien E. J. (1998)
{'key': 'jm991172db00003/jm991172db00003_1', 'first-page': '361', 'volume': '8', 'author': 'Lunney E. A', 'year': '1998', 'journal-title': 'Med. Chem. Res.'} / Med. Chem. Res. by Lunney E. A (1998)
10.1016/S1359-6446(97)01163-X / Drug Discovery Today by Walters W. P. (1998)
{'key': 'jm991172db00005/jm991172db00005_1', 'first-page': '283', 'volume': '3', 'author': 'Drie J. H. V.', 'year': '1998', 'journal-title': 'Drug Discovery Today'} / Drug Discovery Today by Drie J. H. V. (1998)
{'key': 'jm991172db00006/jm991172db00006_1', 'first-page': '3314', 'volume': '42', 'author': 'Julián-Ortiz J. V.', 'year': '1999', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Julián-Ortiz J. V. (1999)
{'key': 'jm991172db00007/jm991172db00007_1', 'volume-title': 'The Search for Anticancer Drugs', 'author': 'Denny W. A.', 'year': '1992'} / The Search for Anticancer Drugs by Denny W. A. (1992)
10.1517/13543776.8.12.1627 / Expert Opin. Ther. Pat. by Menta E. (1998)
{'key': 'jm991172db00009/jm991172db00009_1', 'first-page': '162', 'volume': '33', 'author': 'Balasubramanian B. N.', 'year': '1998', 'journal-title': 'Annu. Rep. Med. Chem.'} / Annu. Rep. Med. Chem. by Balasubramanian B. N. (1998)
10.1007/s002800051100 / Cancer Chemother. Pharmacol. by Ferrante K. (1999)
{'key': 'jm991172db00011/jm991172db00011_1', 'first-page': '1945', 'volume': '53', 'author': 'Ishioka C.', 'year': '1998', 'journal-title': 'Saishin Igaku'} / Saishin Igaku by Ishioka C. (1998)
10.1016/S1367-5931(99)80073-8 / Curr. Opin. Chem. Biol. by Buolamwini J. K (1999)
{'key': 'jm991172db00013/jm991172db00013_1', 'first-page': '595', 'volume': '2', 'author': 'Estrada E.', 'year': '1998', 'journal-title': 'J. Comput.-Aided Mol. Des.'} / J. Comput.-Aided Mol. Des. by Estrada E. (1998)
{'key': 'jm991172db00014/jm991172db00014_1', 'first-page': '849', 'volume': '36', 'author': 'Estrada E', 'year': '1996', 'journal-title': 'J. Chem. Inf. Comput. Sci.'} / J. Chem. Inf. Comput. Sci. by Estrada E (1996)
10.1021/ci960113v / J. Chem. Inf. Comput. Sci. by Estrada E (1997)
{'key': 'jm991172db00016/jm991172db00016_1', 'first-page': '27', 'volume': '38', 'author': 'Estrada E', 'year': '1998', 'journal-title': 'J. Chem. Inf. Comput. Sci.'} / J. Chem. Inf. Comput. Sci. by Estrada E (1998)
10.1039/a709032c / J. Chem. Soc., Faraday Trans. by Estrada E (1998)
10.1016/S0021-9673(99)00808-0 / J. Chromatogr. A by Estrada E. (1999)
{'key': 'jm991172db00019/jm991172db00019_1', 'first-page': '33', 'volume': '35', 'author': 'Estrada E', 'year': '1995', 'journal-title': 'J. Chem. Inf. Comput. Sci.'} / J. Chem. Inf. Comput. Sci. by Estrada E (1995)
Ferguson, L. N.The Modern Structural Theory of Organic Chemstry; Prentice Hall: Englewood Cliffs, NJ, 1963; pp 200−203.
10.1080/10629360008033229 / SAR QSAR Environ. Res. by Estrada E (2000)
{'key': 'jm991172db00022/jm991172db00022_1', 'volume-title': 'The Physico-Chemical Basis of Therapy', 'author': 'Albert A.', 'year': '1984'} / The Physico-Chemical Basis of Therapy by Albert A. (1984)
{'key': 'jm991172db00023/jm991172db00023_1', 'first-page': '996', 'volume': '38', 'author': 'Willet P.', 'year': '1998', 'journal-title': 'J. Chem. Inf. Comput. Sci.'} / J. Chem. Inf. Comput. Sci. by Willet P. (1998)
10.1016/S0009-2614(00)00158-5 / Chem. Phys. Lett. by Estrada E (2000)
{'key': 'jm991172db00025/jm991172db00025_1', 'first-page': '95', 'volume': '39', 'author': 'Estrada E', 'year': '1999', 'journal-title': 'J. Chem. Inf. Comput. Sci.'} / J. Chem. Inf. Comput. Sci. by Estrada E (1999)
{'key': 'jm991172db00026/jm991172db00026_1', 'first-page': '687', 'volume': '37', 'author': 'Randic M', 'year': '1997', 'journal-title': 'J. Chem. Inf. Comput. Sci.'} / J. Chem. Inf. Comput. Sci. by Randic M (1997)
10.1515/9783112478622-001 / Organic-Chemical Drugs and their Synonyms by Negwer M. (1987)
{'key': 'jm991172db00028/jm991172db00028_1', 'volume-title': 'version 4.13', 'author': 'STATISTICA', 'year': '1993'} / version 4.13 by STATISTICA (1993)
{'key': 'jm991172db00029/jm991172db00029_1', 'first-page': '666', 'volume-title': 'Comprehensive Medicinal Chemistry. The Rational Design, Mechanistic Study & Therapeutic Application of Chemical Compounds.', 'volume': '4', 'author': 'Craig P. N.', 'year': '1990'} / Comprehensive Medicinal Chemistry. The Rational Design, Mechanistic Study & Therapeutic Application of Chemical Compounds. by Craig P. N. (1990)
{'key': 'jm991172db00030/jm991172db00030_1', 'first-page': '545', 'volume': '18', 'author': 'Chu K. C.', 'year': '1975', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Chu K. C. (1975)
{'key': 'jm991172db00031/jm991172db00031_1', 'first-page': '2990', 'volume': '40', 'author': 'Leonard D. M.', 'year': '1997', 'journal-title': 'A New Therapeutic Target. J. Med. Chem.'} / A New Therapeutic Target. J. Med. Chem. by Leonard D. M. (1997)
10.1016/S1367-5931(97)80010-5 / Curr. Opin. Biol. Chem. by Gibbs J. B. (1997)
10.1016/S0960-894X(98)00371-0 / Bioog. Med. Chem. Lett. by Singh S. B. (1998)
{'key': 'jm991172db00034/jm991172db00034_1', 'first-page': '4112', 'volume': '40', 'author': 'Kaminski J. J.', 'year': '1997', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Kaminski J. J. (1997)
Teijeira, M. Nucleosidos carbocíclicos 1,2-disubstituidos. Ph.D. Thesis, Universidad de Santiago de Compostela, Spain, 1996.
{'key': 'jm991172db00036/jm991172db00036_1', 'first-page': '1020', 'volume': '13', 'author': 'Shealy Y. F.', 'year': '1976', 'journal-title': 'J. Heterocycl. Chem.'} / J. Heterocycl. Chem. by Shealy Y. F. (1976)
{'key': 'jm991172db00037/jm991172db00037_1', 'first-page': '2797', 'volume': '63', 'author': 'Hronowski L. J. J.', 'year': '1985', 'journal-title': 'Can. J. Chem.'} / Can. J. Chem. by Hronowski L. J. J. (1985)
10.1021/jm50001a004 / J. Med. Chem. by Herdewijn P. (1985)
10.1021/jm00088a026 / J. Med. Chem. by Katagiri N. (1992)
10.1021/jm00163a004 / J. Med. Chem. by Vince R. (1990)
10.1002/jhet.5570360146 / J. Heterocycl. Chem. by Santana L. (1999)
10.1080/07328319608007386 / Nucleosides Nucleotides by Santana L. (1996)
{'key': 'jm991172db00043/jm991172db00043_1', 'first-page': '125', 'volume-title': 'vivo and ex vivo test systems to rationalize drug design and delivery', 'author': 'De Clercq', 'year': '1994'} / vivo and ex vivo test systems to rationalize drug design and delivery by De Clercq (1994)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 1:59 a.m.)
Deposited	2 years, 5 months ago (March 24, 2023, 2:36 a.m.)
Indexed	3 months, 1 week ago (May 22, 2025, 3:11 a.m.)
Issued	25 years, 4 months ago (April 22, 2000)
Published	25 years, 4 months ago (April 22, 2000)
Published Online	25 years, 4 months ago (April 22, 2000)
Published Print	25 years, 4 months ago (May 1, 2000)

Funders 0

None

BibTeX

@article{Estrada_2000, title={A Novel Approach for the Virtual Screening and Rational Design of Anticancer Compounds}, volume={43}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm991172d}, DOI={10.1021/jm991172d}, number={10}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={Estrada, Ernesto and Uriarte, Eugenio and Montero, Alina and Teijeira, Marta and Santana, Lourdes and De Clercq, Erik}, year={2000}, month=apr, pages={1975–1985} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        22
      ]
    ],
    "date-time": "2025-05-22T07:11:30Z",
    "timestamp": 1747897890107
  },
  "reference-count": 43,
  "publisher": "American Chemical Society (ACS)",
  "issue": "10",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        5,
        1
      ]
    ]
  },
  "DOI": "10.1021/jm991172d",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T05:59:58Z",
    "timestamp": 1027663198000
  },
  "page": "1975-1985",
  "source": "Crossref",
  "is-referenced-by-count": 144,
  "title": "A Novel Approach for the Virtual Screening and Rational Design of Anticancer Compounds",
  "prefix": "10.1021",
  "volume": "43",
  "author": [
    {
      "given": "Ernesto",
      "family": "Estrada",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Faculty of Pharmacy, Department of Organic Chemistry, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain, Centro de Bioactivos Qu\u00edmicos, Universidad Central de Las Villas, Santa Clara 54830, Villa Clara, Cuba, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"
        }
      ]
    },
    {
      "given": "Eugenio",
      "family": "Uriarte",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Faculty of Pharmacy, Department of Organic Chemistry, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain, Centro de Bioactivos Qu\u00edmicos, Universidad Central de Las Villas, Santa Clara 54830, Villa Clara, Cuba, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"
        }
      ]
    },
    {
      "given": "Alina",
      "family": "Montero",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Faculty of Pharmacy, Department of Organic Chemistry, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain, Centro de Bioactivos Qu\u00edmicos, Universidad Central de Las Villas, Santa Clara 54830, Villa Clara, Cuba, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"
        }
      ]
    },
    {
      "given": "Marta",
      "family": "Teijeira",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Faculty of Pharmacy, Department of Organic Chemistry, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain, Centro de Bioactivos Qu\u00edmicos, Universidad Central de Las Villas, Santa Clara 54830, Villa Clara, Cuba, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"
        }
      ]
    },
    {
      "given": "Lourdes",
      "family": "Santana",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Faculty of Pharmacy, Department of Organic Chemistry, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain, Centro de Bioactivos Qu\u00edmicos, Universidad Central de Las Villas, Santa Clara 54830, Villa Clara, Cuba, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"
        }
      ]
    },
    {
      "given": "Erik",
      "family": "De Clercq",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Faculty of Pharmacy, Department of Organic Chemistry, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain, Centro de Bioactivos Qu\u00edmicos, Universidad Central de Las Villas, Santa Clara 54830, Villa Clara, Cuba, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2000,
        4,
        22
      ]
    ]
  },
  "reference": [
    {
      "key": "jm991172db00001/jm991172db00001_1",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.3109/10799899909036635",
      "volume": "19",
      "author": "Kubinyi H",
      "year": "1999",
      "journal-title": "J. Recept. Signal Transduct. Res."
    },
    {
      "key": "jm991172db00002/jm991172db00002_1",
      "first-page": "256",
      "volume": "50",
      "author": "Lien E. J.",
      "year": "1998",
      "journal-title": "Chin. Pharm. J. (Taipei)"
    },
    {
      "key": "jm991172db00003/jm991172db00003_1",
      "first-page": "361",
      "volume": "8",
      "author": "Lunney E. A",
      "year": "1998",
      "journal-title": "Med. Chem. Res."
    },
    {
      "key": "jm991172db00004/jm991172db00004_1",
      "doi-asserted-by": "crossref",
      "first-page": "178",
      "DOI": "10.1016/S1359-6446(97)01163-X",
      "volume": "3",
      "author": "Walters W. P.",
      "year": "1998",
      "journal-title": "Drug Discovery Today"
    },
    {
      "key": "jm991172db00005/jm991172db00005_1",
      "first-page": "283",
      "volume": "3",
      "author": "Drie J. H. V.",
      "year": "1998",
      "journal-title": "Drug Discovery Today"
    },
    {
      "key": "jm991172db00006/jm991172db00006_1",
      "first-page": "3314",
      "volume": "42",
      "author": "Juli\u00e1n-Ortiz J. V.",
      "year": "1999",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm991172db00007/jm991172db00007_1",
      "volume-title": "The Search for Anticancer Drugs",
      "author": "Denny W. A.",
      "year": "1992"
    },
    {
      "key": "jm991172db00008/jm991172db00008_1",
      "doi-asserted-by": "crossref",
      "first-page": "1672",
      "DOI": "10.1517/13543776.8.12.1627",
      "volume": "8",
      "author": "Menta E.",
      "year": "1998",
      "journal-title": "Expert Opin. Ther. Pat."
    },
    {
      "key": "jm991172db00009/jm991172db00009_1",
      "first-page": "162",
      "volume": "33",
      "author": "Balasubramanian B. N.",
      "year": "1998",
      "journal-title": "Annu. Rep. Med. Chem."
    },
    {
      "key": "jm991172db00010/jm991172db00010_1",
      "doi-asserted-by": "crossref",
      "first-page": "S83",
      "DOI": "10.1007/s002800051100",
      "volume": "43",
      "author": "Ferrante K.",
      "year": "1999",
      "journal-title": "Cancer Chemother. Pharmacol."
    },
    {
      "key": "jm991172db00011/jm991172db00011_1",
      "first-page": "1945",
      "volume": "53",
      "author": "Ishioka C.",
      "year": "1998",
      "journal-title": "Saishin Igaku"
    },
    {
      "key": "jm991172db00012/jm991172db00012_1",
      "doi-asserted-by": "crossref",
      "first-page": "509",
      "DOI": "10.1016/S1367-5931(99)80073-8",
      "volume": "3",
      "author": "Buolamwini J. K",
      "year": "1999",
      "journal-title": "Curr. Opin. Chem. Biol."
    },
    {
      "key": "jm991172db00013/jm991172db00013_1",
      "first-page": "595",
      "volume": "2",
      "author": "Estrada E.",
      "year": "1998",
      "journal-title": "J. Comput.-Aided Mol. Des."
    },
    {
      "key": "jm991172db00014/jm991172db00014_1",
      "first-page": "849",
      "volume": "36",
      "author": "Estrada E",
      "year": "1996",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "jm991172db00015/jm991172db00015_1",
      "doi-asserted-by": "crossref",
      "first-page": "328",
      "DOI": "10.1021/ci960113v",
      "volume": "37",
      "author": "Estrada E",
      "year": "1997",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "jm991172db00016/jm991172db00016_1",
      "first-page": "27",
      "volume": "38",
      "author": "Estrada E",
      "year": "1998",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "jm991172db00017/jm991172db00017_1",
      "doi-asserted-by": "crossref",
      "first-page": "1411",
      "DOI": "10.1039/a709032c",
      "volume": "94",
      "author": "Estrada E",
      "year": "1998",
      "journal-title": "J. Chem. Soc., Faraday Trans."
    },
    {
      "key": "jm991172db00018/jm991172db00018_1",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1016/S0021-9673(99)00808-0",
      "volume": "858",
      "author": "Estrada E.",
      "year": "1999",
      "journal-title": "J. Chromatogr. A"
    },
    {
      "key": "jm991172db00019/jm991172db00019_1",
      "first-page": "33",
      "volume": "35",
      "author": "Estrada E",
      "year": "1995",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "jm991172db00020/jm991172db00020_1",
      "unstructured": "Ferguson, L. N.The Modern Structural Theory of Organic Chemstry; Prentice Hall:\u2009 Englewood Cliffs, NJ, 1963; pp 200\u2212203."
    },
    {
      "key": "jm991172db00021/jm991172db00021_1",
      "doi-asserted-by": "crossref",
      "first-page": "73",
      "DOI": "10.1080/10629360008033229",
      "volume": "11",
      "author": "Estrada E",
      "year": "2000",
      "journal-title": "SAR QSAR Environ. Res."
    },
    {
      "key": "jm991172db00022/jm991172db00022_1",
      "volume-title": "The Physico-Chemical Basis of Therapy",
      "author": "Albert A.",
      "year": "1984"
    },
    {
      "key": "jm991172db00023/jm991172db00023_1",
      "first-page": "996",
      "volume": "38",
      "author": "Willet P.",
      "year": "1998",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "jm991172db00024/jm991172db00024_1",
      "doi-asserted-by": "crossref",
      "first-page": "718",
      "DOI": "10.1016/S0009-2614(00)00158-5",
      "volume": "319",
      "author": "Estrada E",
      "year": "2000",
      "journal-title": "Chem. Phys. Lett."
    },
    {
      "key": "jm991172db00025/jm991172db00025_1",
      "first-page": "95",
      "volume": "39",
      "author": "Estrada E",
      "year": "1999",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "jm991172db00026/jm991172db00026_1",
      "first-page": "687",
      "volume": "37",
      "author": "Randic M",
      "year": "1997",
      "journal-title": "J. Chem. Inf. Comput. Sci."
    },
    {
      "key": "jm991172db00027/jm991172db00027_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1515/9783112478622-001",
      "volume-title": "Organic-Chemical Drugs and their Synonyms",
      "author": "Negwer M.",
      "year": "1987"
    },
    {
      "key": "jm991172db00028/jm991172db00028_1",
      "volume-title": "version 4.13",
      "author": "STATISTICA",
      "year": "1993"
    },
    {
      "key": "jm991172db00029/jm991172db00029_1",
      "first-page": "666",
      "volume-title": "Comprehensive Medicinal Chemistry. The Rational Design, Mechanistic Study & Therapeutic Application of Chemical Compounds.",
      "volume": "4",
      "author": "Craig P. N.",
      "year": "1990"
    },
    {
      "key": "jm991172db00030/jm991172db00030_1",
      "first-page": "545",
      "volume": "18",
      "author": "Chu K. C.",
      "year": "1975",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm991172db00031/jm991172db00031_1",
      "first-page": "2990",
      "volume": "40",
      "author": "Leonard D. M.",
      "year": "1997",
      "journal-title": "A New Therapeutic Target. J. Med. Chem."
    },
    {
      "key": "jm991172db00032/jm991172db00032_1",
      "doi-asserted-by": "crossref",
      "first-page": "203",
      "DOI": "10.1016/S1367-5931(97)80010-5",
      "volume": "1",
      "author": "Gibbs J. B.",
      "year": "1997",
      "journal-title": "Curr. Opin. Biol. Chem."
    },
    {
      "key": "jm991172db00033/jm991172db00033_1",
      "doi-asserted-by": "crossref",
      "first-page": "2076",
      "DOI": "10.1016/S0960-894X(98)00371-0",
      "volume": "8",
      "author": "Singh S. B.",
      "year": "1998",
      "journal-title": "Bioog. Med. Chem. Lett."
    },
    {
      "key": "jm991172db00034/jm991172db00034_1",
      "first-page": "4112",
      "volume": "40",
      "author": "Kaminski J. J.",
      "year": "1997",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm991172db00035/jm991172db00035_1",
      "unstructured": "Teijeira, M. Nucleosidos carboc\u00edclicos 1,2-disubstituidos. Ph.D. Thesis, Universidad de Santiago de Compostela, Spain, 1996."
    },
    {
      "key": "jm991172db00036/jm991172db00036_1",
      "first-page": "1020",
      "volume": "13",
      "author": "Shealy Y. F.",
      "year": "1976",
      "journal-title": "J. Heterocycl. Chem."
    },
    {
      "key": "jm991172db00037/jm991172db00037_1",
      "first-page": "2797",
      "volume": "63",
      "author": "Hronowski L. J. J.",
      "year": "1985",
      "journal-title": "Can. J. Chem."
    },
    {
      "key": "jm991172db00038/jm991172db00038_1",
      "doi-asserted-by": "crossref",
      "first-page": "555",
      "DOI": "10.1021/jm50001a004",
      "volume": "28",
      "author": "Herdewijn P.",
      "year": "1985",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm991172db00039/jm991172db00039_1",
      "doi-asserted-by": "crossref",
      "first-page": "1886",
      "DOI": "10.1021/jm00088a026",
      "volume": "35",
      "author": "Katagiri N.",
      "year": "1992",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm991172db00040/jm991172db00040_1",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.1021/jm00163a004",
      "volume": "33",
      "author": "Vince R.",
      "year": "1990",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm991172db00041/jm991172db00041_1",
      "doi-asserted-by": "crossref",
      "first-page": "295",
      "DOI": "10.1002/jhet.5570360146",
      "volume": "36",
      "author": "Santana L.",
      "year": "1999",
      "journal-title": "J. Heterocycl. Chem."
    },
    {
      "key": "jm991172db00042/jm991172db00042_1",
      "doi-asserted-by": "crossref",
      "first-page": "1187",
      "DOI": "10.1080/07328319608007386",
      "volume": "15",
      "author": "Santana L.",
      "year": "1996",
      "journal-title": "Nucleosides Nucleotides"
    },
    {
      "key": "jm991172db00043/jm991172db00043_1",
      "first-page": "125",
      "volume-title": "vivo and ex vivo test systems to rationalize drug design and delivery",
      "author": "De Clercq",
      "year": "1994"
    }
  ],
  "container-title": "Journal of Medicinal Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/jm991172d",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        3,
        24
      ]
    ],
    "date-time": "2023-03-24T06:36:49Z",
    "timestamp": 1679639809000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/jm991172d"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        4,
        22
      ]
    ]
  },
  "references-count": 43,
  "journal-issue": {
    "issue": "10",
    "published-print": {
      "date-parts": [
        [
          2000,
          5,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/jm991172d"
  ],
  "URL": "http://dx.doi.org/10.1021/jm991172d",
  "relation": {},
  "ISSN": [
    "0022-2623",
    "1520-4804"
  ],
  "subject": [],
  "container-title-short": "J. Med. Chem.",
  "published": {
    "date-parts": [
      [
        2000,
        4,
        22
      ]
    ]
  }
}