DOI: 10.1021/jm960305h. Development of Novel, Potent, and Selective Dopamine Reuptake Inhibitors through Alteration of the Piperazine Ring of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909)

Development of Novel, Potent, and Selective Dopamine Reuptake Inhibitors through Alteration of the Piperazine Ring of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909)

10.1021/jm960305h

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

Matecka, D., Rothman, R. B., Radesca, L., de Costa, B. R., Dersch, C. M., Partilla, J. S., Pert, A., Glowa, J. R., Wojnicki, F. H. E., & Rice, K. C. (1996). Development of Novel, Potent, and Selective Dopamine Reuptake Inhibitors through Alteration of the Piperazine Ring of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909). Journal of Medicinal Chemistry, 39(24), 4704â4716.

Authors 10

Dorota Matecka (first)
Richard B. Rothman (additional)
Lilian Radesca (additional)
Brian R. de Costa (additional)
Christina M. Dersch (additional)
John S. Partilla (additional)
Agu Pert (additional)
John R. Glowa (additional)
Francis H. E. Wojnicki (additional)
Kenner C. Rice (additional)

References 65 Referenced 66

{'key': 'jm960305hb00001/jm960305hb00001_1', 'first-page': '52', 'volume': '41', 'author': 'Johanson C.-E.', 'year': '1989', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. by Johanson C.-E. (1989)
10.1111/j.1600-0773.1993.tb01331.x / Pharmacol. Toxicol. by Benowitz N. L (1993)
{'key': 'jm960305hb00003/jm960305hb00003_1', 'first-page': '310', 'volume': '33', 'author': 'Das G', 'year': '1993', 'journal-title': 'J. Clin. Pharmacol.'} / J. Clin. Pharmacol. by Das G (1993)
10.1038/scientificamerican0791-40 / Sci. Am. by Musto D. F. (1991)
10.7326/0003-4819-119-3-199308010-00009 / Ann. Intern. Med. by Warner E. A. (1993)
{'key': 'jm960305hb00006/jm960305hb00006_1', 'first-page': '14', 'volume-title': 'Cocaine Treatment: Research and Clinical Perspectives', 'author': 'Tims F. M.', 'year': '1993'} / Cocaine Treatment: Research and Clinical Perspectives by Tims F. M. (1993)
10.1021/jm00084a002 / J. Med. Chem. by Carroll F. I. (1992)
10.1016/0166-2236(91)90141-G / Trends Neurosci. by Kuhar M. J. (1991)
10.1126/science.237.4819.1223 / Science by Ritz M. C. (1987)
{'key': 'jm960305hb00010/jm960305hb00010_1', 'first-page': '247', 'volume': '152', 'author': 'Wise R. A', 'year': '1978', 'journal-title': 'Brain Res.'} / Brain Res. by Wise R. A (1978)
{'key': 'jm960305hb00011/jm960305hb00011_1', 'first-page': '166', 'volume-title': 'Drug Design for Neuroscience', 'author': 'Carroll F. I.', 'year': '1993'} / Drug Design for Neuroscience by Carroll F. I. (1993)
10.1007/BF02740836 / Mol. Neurobiol. by Rothman R. B. (1995)
{'key': 'jm960305hb00013/jm960305hb00013_1', 'first-page': '492', 'volume': '94', 'author': 'Wise R. A.', 'year': '1987', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. by Wise R. A. (1987)
{'key': 'jm960305hb00014/jm960305hb00014_1', 'first-page': '16', 'volume': '1', 'author': 'Carroll F. I.', 'year': '1994', 'journal-title': 'Pharm. News'} / Pharm. News by Carroll F. I. (1994)
10.1126/science.2772637 / Science by Mello N. K. (1989)
10.1001/archpsyc.1992.01820110064010 / Arch. Gen. Psychiatry by Meyer R. E (1992)
{'key': 'jm960305hb00017/jm960305hb00017_1', 'first-page': '70', 'volume-title': 'Cocaine Treatment: Research and Clinical Perspectives', 'author': 'Johnson D. N.', 'year': '1993'} / Cocaine Treatment: Research and Clinical Perspectives by Johnson D. N. (1993)
{'key': 'jm960305hb00018/jm960305hb00018_1', 'first-page': '1284', 'volume': '6', 'author': 'Reid L. D.', 'year': '1995', 'journal-title': 'NeuroReport'} / NeuroReport by Reid L. D. (1995)
10.1016/0149-7634(94)90042-6 / Neurosci. Biobehav. Rev. by Witkin J. M (1994)
{'key': 'jm960305hb00020/jm960305hb00020_1', 'first-page': '317', 'volume': '261', 'author': 'Winger G.', 'year': '1992', 'journal-title': 'J. Pharm. Exp. Ther.'} / J. Pharm. Exp. Ther. by Winger G. (1992)
{'key': 'jm960305hb00021/jm960305hb00021_1', 'first-page': '320', 'volume': '79', 'author': 'Koob G. F.', 'year': '1987', 'journal-title': 'Neurosci. Lett.'} / Neurosci. Lett. by Koob G. F. (1987)
{'key': 'jm960305hb00022/jm960305hb00022_1', 'first-page': '40', 'volume': '103', 'author': 'Katz J. L.', 'year': '1991', 'journal-title': 'Psychopharmacology'} / Psychopharmacology by Katz J. L. (1991)
{'key': 'jm960305hb00023/jm960305hb00023_1', 'first-page': '291', 'volume': '262', 'author': 'Preston K. L.', 'year': '1992', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. by Preston K. L. (1992)
{'key': 'jm960305hb00024/jm960305hb00024_1', 'first-page': '87', 'volume': '145', 'author': 'Rothman R. B', 'year': '1994', 'journal-title': 'NIDA Res. Monogr.'} / NIDA Res. Monogr. by Rothman R. B (1994)
{'key': 'jm960305hb00025/jm960305hb00025_1', 'first-page': '44', 'volume': '26', 'author': 'Javitch J. A.', 'year': '1984', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Javitch J. A. (1984)
10.1016/0014-2999(85)90724-1 / Eur. J. Pharmacol. by Janowsky A. (1985)
{'key': 'jm960305hb00027/jm960305hb00027_1', 'first-page': '4081', 'volume': '36', 'author': 'He X.-S.', 'year': '1993', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by He X.-S. (1993)
10.1021/jm00020a006 / J. Med. Chem. by Newman A. H. (1995)
10.1021/jm950463t / J. Med. Chem. by Meltzer P. C. (1996)
10.1111/j.1471-4159.1987.tb05752.x / J. Neurochem. by Andersen P. H (1987)
10.1016/0014-2999(89)90363-4 / Eur. J. Pharmacol. by Andersen P. H (1989)
{'key': 'jm960305hb00032/jm960305hb00032_1', 'first-page': '370', 'volume': '15', 'author': 'Van der Zee P.', 'year': '1980', 'journal-title': 'Eur. J. Med. Chem.'} / Eur. J. Med. Chem. by Van der Zee P. (1980)
10.1016/0014-5793(89)81566-2 / FEBS Lett. by Rothman B. R. (1989)
10.1016/0024-3205(90)90466-5 / Life Sci. by Rothman R. B (1990)
10.1016/0091-3057(91)90570-R / Pharmacol. Biochem. Behav. by Rothman R. B. (1991)
{'key': 'jm960305hb00036/jm960305hb00036_1', 'first-page': '1222', 'volume': '271', 'author': 'Baumann M. H.', 'year': '1994', 'journal-title': 'J. Pharm. Exp. Ther.'} / J. Pharm. Exp. Ther. by Baumann M. H. (1994)
{'key': 'jm960305hb00037/jm960305hb00037_1', 'first-page': '231', 'volume': '3', 'author': 'Glowa J. R.', 'year': '1995', 'journal-title': 'Exp. Clin. Psychopharmacol.'} / Exp. Clin. Psychopharmacol. by Glowa J. R. (1995)
{'key': 'jm960305hb00038/jm960305hb00038_1', 'first-page': '239', 'volume': '3', 'author': 'Glowa J. R.', 'year': '1995', 'journal-title': 'Exp. Clin. Psychopharmacol.'} / Exp. Clin. Psychopharmacol. by Glowa J. R. (1995)
10.1016/0091-3057(92)90493-Y / Pharmacol. Biochem. Behav. by Rothman R. B. (1992)
10.1097/00004850-199010000-00001 / Int. Clin. Psychopharmacol. by Sogaard U. (1990)
{'key': 'jm960305hb00041/jm960305hb00041_1', 'first-page': '600', 'volume': '19', 'author': 'Foulon C.', 'year': '1992', 'journal-title': 'Nucl. Med. Biol.'} / Nucl. Med. Biol. by Foulon C. (1992)
10.1016/0014-2999(92)90745-P / Eur. J. Pharm. by Deutsch H. M. (1992)
{'key': 'jm960305hb00043/jm960305hb00043_1', 'first-page': '222', 'volume': '3', 'author': 'Dutta A. K.', 'year': '1993', 'journal-title': 'Med. Chem. Res.'} / Med. Chem. Res. by Dutta A. K. (1993)
{'key': 'jm960305hb00044/jm960305hb00044_1', 'first-page': '756', 'volume': '39', 'author': 'Dutta A. K.', 'year': '1996', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Dutta A. K. (1996)
10.1002/syn.890140106 / Synapse by Rothman R. B. (1993)
{'key': 'jm960305hb00046/jm960305hb00046_1', 'first-page': '381', 'volume': '132', 'author': 'Matecka D.', 'year': '1993', 'journal-title': 'NIDA Res. Monogr.'} / NIDA Res. Monogr. by Matecka D. (1993)
{'key': 'jm960305hb00047/jm960305hb00047_1', 'first-page': '53', 'volume': '5', 'author': 'Matecka D.', 'year': '1995', 'journal-title': 'Med. Chem. Res.'} / Med. Chem. Res. by Matecka D. (1995)
{'key': 'jm960305hb00048/jm960305hb00048_1', 'first-page': '209', 'volume': '121', 'author': 'Bonnet J.-J.', 'year': '1986', 'journal-title': 'Eur. J. Pharmacol.'} / Eur. J. Pharmacol. by Bonnet J.-J. (1986)
10.1002/med.2610060404 / Med. Res. Rev. by Ariens E. J. (1986)
10.1016/0024-3205(90)90446-X / Life Sci. by Contreras P. C. (1990)
{'key': 'jm960305hb00051/jm960305hb00051_1', 'first-page': '173', 'volume': '29', 'author': 'de Costa B. R', 'year': '1991', 'journal-title': 'J. Labelled Comp. Radiopharm.'} / J. Labelled Comp. Radiopharm. by de Costa B. R (1991)
10.1016/0014-2999(88)90058-1 / Eur. J. Pharmacol. by Sharkey J. (1988)
10.1016/0014-2999(91)90355-T / Eur. J. Pharmacol. by Menkel M. (1991)
{'key': 'jm960305hb00054/jm960305hb00054_1', 'first-page': '482', 'volume': '266', 'author': 'Witkin J. M.', 'year': '1993', 'journal-title': 'J. Pharm. Exp. Ther.'} / J. Pharm. Exp. Ther. by Witkin J. M. (1993)
Tam, S. W. Potential Therapeutic Application of σ Receptor Antagonists. In σReceptors; Itzhak, Y., Ed.; Academic Press Inc. San Diego, 1994; pp 191−204.
{'key': 'jm960305hb00056/jm960305hb00056_1', 'first-page': '126', 'volume': '3', 'author': 'Bowen W. D.', 'year': '1993', 'journal-title': 'Mol. Neuropharmacol.'} / Mol. Neuropharmacol. by Bowen W. D. (1993)
de Costa, B. R.; He, X. Structure-Activity Relationships and Evolution of σ Receptor Ligands (1976-present). In σReceptors; Itzhak, Y., Ed.; Academic Press Inc. San Diego, 1994; pp 45−111.
10.1016/0024-3205(93)90602-Y / Life Sci. by Rothman R. B. (1993)
10.1021/ja00752a081 / J. Am. Chem. Soc. by Windridge G. C. (1971)
{'key': 'jm960305hb00060/jm960305hb00060_1', 'first-page': '1475', 'volume': '268', 'author': 'Akunne H. C.', 'year': '1994', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. by Akunne H. C. (1994)
{'key': 'jm960305hb00061/jm960305hb00061_1', 'first-page': '309', 'volume': '270', 'author': 'Rothman R. B.', 'year': '1994', 'journal-title': 'J. Pharm. Exp. Ther.'} / J. Pharm. Exp. Ther. by Rothman R. B. (1994)
{'key': 'jm960305hb00062/jm960305hb00062_1', 'first-page': '232', 'volume': '39', 'author': 'Rothman R. B.', 'year': '1991', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Rothman R. B. (1991)
10.1093/clinchem/22.3.350 / Clin. Chem. by Rodbard D. (1976)
{'key': 'jm960305hb00064/jm960305hb00064_1', 'volume-title': 'Online 1972 International Conference', 'author': 'Knott G. D.'} / Online 1972 International Conference by Knott G. D.
{'key': 'jm960305hb00065/jm960305hb00065_1', 'first-page': '404', 'volume': '132', 'author': 'Lewis B. H.', 'year': '1993', 'journal-title': 'NIDA Res. Monogr.'} / NIDA Res. Monogr. by Lewis B. H. (1993)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 1:03 a.m.)
Deposited	2 years, 4 months ago (April 7, 2023, 8:47 a.m.)
Indexed	1 year, 1 month ago (July 27, 2024, 7:12 p.m.)
Issued	29 years, 7 months ago (Jan. 1, 1996)
Published	29 years, 7 months ago (Jan. 1, 1996)
Published Online	28 years, 9 months ago (Nov. 22, 1996)
Published Print	29 years, 7 months ago (Jan. 1, 1996)

Funders 0

None

BibTeX

@article{Matecka_1996, title={Development of Novel, Potent, and Selective Dopamine Reuptake Inhibitors through Alteration of the Piperazine Ring of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909)}, volume={39}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm960305h}, DOI={10.1021/jm960305h}, number={24}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={Matecka, Dorota and Rothman, Richard B. and Radesca, Lilian and de Costa, Brian R. and Dersch, Christina M. and Partilla, John S. and Pert, Agu and Glowa, John R. and Wojnicki, Francis H. E. and Rice, Kenner C.}, year={1996}, month=jan, pages={4704–4716} }

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      "key": "jm960305hb00001/jm960305hb00001_1",
      "first-page": "52",
      "volume": "41",
      "author": "Johanson C.-E.",
      "year": "1989",
      "journal-title": "Pharmacol. Rev."
    },
    {
      "key": "jm960305hb00002/jm960305hb00002_1",
      "doi-asserted-by": "crossref",
      "first-page": "12",
      "DOI": "10.1111/j.1600-0773.1993.tb01331.x",
      "volume": "72",
      "author": "Benowitz N. L",
      "year": "1993",
      "journal-title": "Pharmacol. Toxicol."
    },
    {
      "key": "jm960305hb00003/jm960305hb00003_1",
      "first-page": "310",
      "volume": "33",
      "author": "Das G",
      "year": "1993",
      "journal-title": "J. Clin. Pharmacol."
    },
    {
      "key": "jm960305hb00004/jm960305hb00004_1",
      "doi-asserted-by": "crossref",
      "first-page": "47",
      "DOI": "10.1038/scientificamerican0791-40",
      "volume": "265",
      "author": "Musto D. F.",
      "year": "1991",
      "journal-title": "Sci. Am."
    },
    {
      "key": "jm960305hb00005/jm960305hb00005_1",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.7326/0003-4819-119-3-199308010-00009",
      "volume": "119",
      "author": "Warner E. A.",
      "year": "1993",
      "journal-title": "Ann. Intern. Med."
    },
    {
      "key": "jm960305hb00006/jm960305hb00006_1",
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      "year": "1993"
    },
    {
      "key": "jm960305hb00007/jm960305hb00007_1",
      "doi-asserted-by": "crossref",
      "first-page": "981",
      "DOI": "10.1021/jm00084a002",
      "volume": "35",
      "author": "Carroll F. I.",
      "year": "1992",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm960305hb00008/jm960305hb00008_1",
      "doi-asserted-by": "crossref",
      "first-page": "302",
      "DOI": "10.1016/0166-2236(91)90141-G",
      "volume": "14",
      "author": "Kuhar M. J.",
      "year": "1991",
      "journal-title": "Trends Neurosci."
    },
    {
      "key": "jm960305hb00009/jm960305hb00009_1",
      "doi-asserted-by": "crossref",
      "first-page": "1223",
      "DOI": "10.1126/science.237.4819.1223",
      "volume": "237",
      "author": "Ritz M. C.",
      "year": "1987",
      "journal-title": "Science"
    },
    {
      "key": "jm960305hb00010/jm960305hb00010_1",
      "first-page": "247",
      "volume": "152",
      "author": "Wise R. A",
      "year": "1978",
      "journal-title": "Brain Res."
    },
    {
      "key": "jm960305hb00011/jm960305hb00011_1",
      "first-page": "166",
      "volume-title": "Drug Design for Neuroscience",
      "author": "Carroll F. I.",
      "year": "1993"
    },
    {
      "key": "jm960305hb00012/jm960305hb00012_1",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1007/BF02740836",
      "volume": "10",
      "author": "Rothman R. B.",
      "year": "1995",
      "journal-title": "Mol. Neurobiol."
    },
    {
      "key": "jm960305hb00013/jm960305hb00013_1",
      "first-page": "492",
      "volume": "94",
      "author": "Wise R. A.",
      "year": "1987",
      "journal-title": "Pharmacol. Rev."
    },
    {
      "key": "jm960305hb00014/jm960305hb00014_1",
      "first-page": "16",
      "volume": "1",
      "author": "Carroll F. I.",
      "year": "1994",
      "journal-title": "Pharm. News"
    },
    {
      "key": "jm960305hb00015/jm960305hb00015_1",
      "doi-asserted-by": "crossref",
      "first-page": "862",
      "DOI": "10.1126/science.2772637",
      "volume": "245",
      "author": "Mello N. K.",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "jm960305hb00016/jm960305hb00016_1",
      "doi-asserted-by": "crossref",
      "first-page": "904",
      "DOI": "10.1001/archpsyc.1992.01820110064010",
      "volume": "49",
      "author": "Meyer R. E",
      "year": "1992",
      "journal-title": "Arch. Gen. Psychiatry"
    },
    {
      "key": "jm960305hb00017/jm960305hb00017_1",
      "first-page": "70",
      "volume-title": "Cocaine Treatment: Research and Clinical Perspectives",
      "author": "Johnson D. N.",
      "year": "1993"
    },
    {
      "key": "jm960305hb00018/jm960305hb00018_1",
      "first-page": "1284",
      "volume": "6",
      "author": "Reid L. D.",
      "year": "1995",
      "journal-title": "NeuroReport"
    },
    {
      "key": "jm960305hb00019/jm960305hb00019_1",
      "doi-asserted-by": "crossref",
      "first-page": "142",
      "DOI": "10.1016/0149-7634(94)90042-6",
      "volume": "18",
      "author": "Witkin J. M",
      "year": "1994",
      "journal-title": "Neurosci. Biobehav. Rev."
    },
    {
      "key": "jm960305hb00020/jm960305hb00020_1",
      "first-page": "317",
      "volume": "261",
      "author": "Winger G.",
      "year": "1992",
      "journal-title": "J. Pharm. Exp. Ther."
    },
    {
      "key": "jm960305hb00021/jm960305hb00021_1",
      "first-page": "320",
      "volume": "79",
      "author": "Koob G. F.",
      "year": "1987",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "jm960305hb00022/jm960305hb00022_1",
      "first-page": "40",
      "volume": "103",
      "author": "Katz J. L.",
      "year": "1991",
      "journal-title": "Psychopharmacology"
    },
    {
      "key": "jm960305hb00023/jm960305hb00023_1",
      "first-page": "291",
      "volume": "262",
      "author": "Preston K. L.",
      "year": "1992",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "jm960305hb00024/jm960305hb00024_1",
      "first-page": "87",
      "volume": "145",
      "author": "Rothman R. B",
      "year": "1994",
      "journal-title": "NIDA Res. Monogr."
    },
    {
      "key": "jm960305hb00025/jm960305hb00025_1",
      "first-page": "44",
      "volume": "26",
      "author": "Javitch J. A.",
      "year": "1984",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "jm960305hb00026/jm960305hb00026_1",
      "doi-asserted-by": "crossref",
      "first-page": "191",
      "DOI": "10.1016/0014-2999(85)90724-1",
      "volume": "108",
      "author": "Janowsky A.",
      "year": "1985",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "jm960305hb00027/jm960305hb00027_1",
      "first-page": "4081",
      "volume": "36",
      "author": "He X.-S.",
      "year": "1993",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm960305hb00028/jm960305hb00028_1",
      "doi-asserted-by": "crossref",
      "first-page": "3940",
      "DOI": "10.1021/jm00020a006",
      "volume": "38",
      "author": "Newman A. H.",
      "year": "1995",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm960305hb00029/jm960305hb00029_1",
      "doi-asserted-by": "crossref",
      "first-page": "379",
      "DOI": "10.1021/jm950463t",
      "volume": "39",
      "author": "Meltzer P. C.",
      "year": "1996",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm960305hb00030/jm960305hb00030_1",
      "doi-asserted-by": "crossref",
      "first-page": "1896",
      "DOI": "10.1111/j.1471-4159.1987.tb05752.x",
      "volume": "48",
      "author": "Andersen P. H",
      "year": "1987",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "jm960305hb00031/jm960305hb00031_1",
      "doi-asserted-by": "crossref",
      "first-page": "504",
      "DOI": "10.1016/0014-2999(89)90363-4",
      "volume": "166",
      "author": "Andersen P. H",
      "year": "1989",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "jm960305hb00032/jm960305hb00032_1",
      "first-page": "370",
      "volume": "15",
      "author": "Van der Zee P.",
      "year": "1980",
      "journal-title": "Eur. J. Med. Chem."
    },
    {
      "key": "jm960305hb00033/jm960305hb00033_1",
      "doi-asserted-by": "crossref",
      "first-page": "344",
      "DOI": "10.1016/0014-5793(89)81566-2",
      "volume": "257",
      "author": "Rothman B. R.",
      "year": "1989",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "jm960305hb00034/jm960305hb00034_1",
      "doi-asserted-by": "crossref",
      "first-page": "L221",
      "DOI": "10.1016/0024-3205(90)90466-5",
      "volume": "46",
      "author": "Rothman R. B",
      "year": "1990",
      "journal-title": "Life Sci."
    },
    {
      "key": "jm960305hb00035/jm960305hb00035_1",
      "doi-asserted-by": "crossref",
      "first-page": "397",
      "DOI": "10.1016/0091-3057(91)90570-R",
      "volume": "40",
      "author": "Rothman R. B.",
      "year": "1991",
      "journal-title": "Pharmacol. Biochem. Behav."
    },
    {
      "key": "jm960305hb00036/jm960305hb00036_1",
      "first-page": "1222",
      "volume": "271",
      "author": "Baumann M. H.",
      "year": "1994",
      "journal-title": "J. Pharm. Exp. Ther."
    },
    {
      "key": "jm960305hb00037/jm960305hb00037_1",
      "first-page": "231",
      "volume": "3",
      "author": "Glowa J. R.",
      "year": "1995",
      "journal-title": "Exp. Clin. Psychopharmacol."
    },
    {
      "key": "jm960305hb00038/jm960305hb00038_1",
      "first-page": "239",
      "volume": "3",
      "author": "Glowa J. R.",
      "year": "1995",
      "journal-title": "Exp. Clin. Psychopharmacol."
    },
    {
      "key": "jm960305hb00039/jm960305hb00039_1",
      "doi-asserted-by": "crossref",
      "first-page": "1142",
      "DOI": "10.1016/0091-3057(92)90493-Y",
      "volume": "43",
      "author": "Rothman R. B.",
      "year": "1992",
      "journal-title": "Pharmacol. Biochem. Behav."
    },
    {
      "key": "jm960305hb00040/jm960305hb00040_1",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1097/00004850-199010000-00001",
      "volume": "5",
      "author": "Sogaard U.",
      "year": "1990",
      "journal-title": "Int. Clin. Psychopharmacol."
    },
    {
      "key": "jm960305hb00041/jm960305hb00041_1",
      "first-page": "600",
      "volume": "19",
      "author": "Foulon C.",
      "year": "1992",
      "journal-title": "Nucl. Med. Biol."
    },
    {
      "key": "jm960305hb00042/jm960305hb00042_1",
      "doi-asserted-by": "crossref",
      "first-page": "180",
      "DOI": "10.1016/0014-2999(92)90745-P",
      "volume": "220",
      "author": "Deutsch H. M.",
      "year": "1992",
      "journal-title": "Eur. J. Pharm."
    },
    {
      "key": "jm960305hb00043/jm960305hb00043_1",
      "first-page": "222",
      "volume": "3",
      "author": "Dutta A. K.",
      "year": "1993",
      "journal-title": "Med. Chem. Res."
    },
    {
      "key": "jm960305hb00044/jm960305hb00044_1",
      "first-page": "756",
      "volume": "39",
      "author": "Dutta A. K.",
      "year": "1996",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm960305hb00045/jm960305hb00045_1",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.1002/syn.890140106",
      "volume": "14",
      "author": "Rothman R. B.",
      "year": "1993",
      "journal-title": "Synapse"
    },
    {
      "key": "jm960305hb00046/jm960305hb00046_1",
      "first-page": "381",
      "volume": "132",
      "author": "Matecka D.",
      "year": "1993",
      "journal-title": "NIDA Res. Monogr."
    },
    {
      "key": "jm960305hb00047/jm960305hb00047_1",
      "first-page": "53",
      "volume": "5",
      "author": "Matecka D.",
      "year": "1995",
      "journal-title": "Med. Chem. Res."
    },
    {
      "key": "jm960305hb00048/jm960305hb00048_1",
      "first-page": "209",
      "volume": "121",
      "author": "Bonnet J.-J.",
      "year": "1986",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "jm960305hb00049/jm960305hb00049_1",
      "doi-asserted-by": "crossref",
      "first-page": "466",
      "DOI": "10.1002/med.2610060404",
      "volume": "6",
      "author": "Ariens E. J.",
      "year": "1986",
      "journal-title": "Med. Res. Rev."
    },
    {
      "key": "jm960305hb00050/jm960305hb00050_1",
      "doi-asserted-by": "crossref",
      "first-page": "L137",
      "DOI": "10.1016/0024-3205(90)90446-X",
      "volume": "47",
      "author": "Contreras P. C.",
      "year": "1990",
      "journal-title": "Life Sci."
    },
    {
      "key": "jm960305hb00051/jm960305hb00051_1",
      "first-page": "173",
      "volume": "29",
      "author": "de Costa B. R",
      "year": "1991",
      "journal-title": "J. Labelled Comp. Radiopharm."
    },
    {
      "key": "jm960305hb00052/jm960305hb00052_1",
      "doi-asserted-by": "crossref",
      "first-page": "174",
      "DOI": "10.1016/0014-2999(88)90058-1",
      "volume": "149",
      "author": "Sharkey J.",
      "year": "1988",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "jm960305hb00053/jm960305hb00053_1",
      "doi-asserted-by": "crossref",
      "first-page": "252",
      "DOI": "10.1016/0014-2999(91)90355-T",
      "volume": "201",
      "author": "Menkel M.",
      "year": "1991",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "jm960305hb00054/jm960305hb00054_1",
      "first-page": "482",
      "volume": "266",
      "author": "Witkin J. M.",
      "year": "1993",
      "journal-title": "J. Pharm. Exp. Ther."
    },
    {
      "key": "jm960305hb00055/jm960305hb00055_1",
      "unstructured": "Tam, S. W. Potential Therapeutic Application of \u03c3 Receptor Antagonists. In \u03c3Receptors; Itzhak, Y., Ed.; Academic Press Inc.\u2009 San Diego, 1994; pp 191\u2212204."
    },
    {
      "key": "jm960305hb00056/jm960305hb00056_1",
      "first-page": "126",
      "volume": "3",
      "author": "Bowen W. D.",
      "year": "1993",
      "journal-title": "Mol. Neuropharmacol."
    },
    {
      "key": "jm960305hb00057/jm960305hb00057_1",
      "unstructured": "de Costa, B. R.; He, X. Structure-Activity Relationships and Evolution of \u03c3 Receptor Ligands (1976-present). In \u03c3Receptors; Itzhak, Y., Ed.; Academic Press Inc.\u2009 San Diego, 1994; pp 45\u2212111."
    },
    {
      "key": "jm960305hb00058/jm960305hb00058_1",
      "doi-asserted-by": "crossref",
      "first-page": "L267",
      "DOI": "10.1016/0024-3205(93)90602-Y",
      "volume": "53",
      "author": "Rothman R. B.",
      "year": "1993",
      "journal-title": "Life Sci."
    },
    {
      "key": "jm960305hb00059/jm960305hb00059_1",
      "doi-asserted-by": "crossref",
      "first-page": "6319",
      "DOI": "10.1021/ja00752a081",
      "volume": "93",
      "author": "Windridge G. C.",
      "year": "1971",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "jm960305hb00060/jm960305hb00060_1",
      "first-page": "1475",
      "volume": "268",
      "author": "Akunne H. C.",
      "year": "1994",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "jm960305hb00061/jm960305hb00061_1",
      "first-page": "309",
      "volume": "270",
      "author": "Rothman R. B.",
      "year": "1994",
      "journal-title": "J. Pharm. Exp. Ther."
    },
    {
      "key": "jm960305hb00062/jm960305hb00062_1",
      "first-page": "232",
      "volume": "39",
      "author": "Rothman R. B.",
      "year": "1991",
      "journal-title": "Mol. Pharmacol."
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    {
      "key": "jm960305hb00063/jm960305hb00063_1",
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      "first-page": "358",
      "DOI": "10.1093/clinchem/22.3.350",
      "volume": "22",
      "author": "Rodbard D.",
      "year": "1976",
      "journal-title": "Clin. Chem."
    },
    {
      "key": "jm960305hb00064/jm960305hb00064_1",
      "volume-title": "Online 1972 International Conference",
      "author": "Knott G. D."
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      "first-page": "404",
      "volume": "132",
      "author": "Lewis B. H.",
      "year": "1993",
      "journal-title": "NIDA Res. Monogr."
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