DOI: 10.1021/jm950395a. The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

10.1021/jm950395a

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

Willson, T. M., Cobb, J. E., Cowan, D. J., Wiethe, R. W., Correa, I. D., Prakash, S. R., Beck, K. D., Moore, L. B., Kliewer, S. A., & Lehmann, J. M. (1996). The StructureâActivity Relationship between Peroxisome Proliferator-Activated Receptor Î³ Agonism and the Antihyperglycemic Activity of Thiazolidinediones. Journal of Medicinal Chemistry, 39(3), 665â668.

Authors 10

Timothy M. Willson (first)
Jeffery E. Cobb (additional)
David J. Cowan (additional)
Robert W. Wiethe (additional)
Itzela D. Correa (additional)
Shimoga R. Prakash (additional)
Kelli D. Beck (additional)
Linda B. Moore (additional)
Steven A. Kliewer (additional)
Jürgen M. Lehmann (additional)

References 30 Referenced 530

10.1097/00041552-199212000-00015 / Curr. Opin. Nephrol. Hypertens. by Ferrannini E (1992)
10.7326/0003-4819-113-12-909 / Ann. Intern. Med. by Warram J. H. (1990)
10.1056/NEJM199312303292703 / N. Engl. J. Med. by Lillioja S. (1993)
{'key': 'jm950395ab00003/jm950395ab00003_1', 'first-page': '226', 'volume-title': 'Annual Reports in Medicinal Chemistry', 'volume': '27', 'author': 'Colca J. R.', 'year': '1992'} / Annual Reports in Medicinal Chemistry by Colca J. R. (1992)
10.2337/diab.32.9.804 / Diabetes by Fujita T. (1983)
{'key': 'jm950395ab00004/jm950395ab00004_2', 'first-page': '838', 'volume': '32', 'author': 'Chang A. Y.', 'year': '1983', 'journal-title': 'Diabetes'} / Diabetes by Chang A. Y. (1983)
{'key': 'jm950395ab00004/jm950395ab00004_3', 'first-page': '267', 'volume': '40', 'author': 'Sugiyama Y.', 'year': '1990', 'journal-title': 'Arzneim. Forsch./Drug Res.'} / Arzneim. Forsch./Drug Res. by Sugiyama Y. (1990)
10.2337/diab.39.10.1218 / Diabetes by Stevenson R. W. (1990)
10.1056/NEJM199411033311803 / N. Engl. J. Med. by Nolan J. J. (1994)
10.1055/s-0028-1093469 / Horm. Metab. Res. by Ferrari C. (1978)
10.1111/j.1365-2125.1977.tb00761.x / Br. J. Clin. Pharmacol. by Barnett D. (1977)
{'key': 'jm950395ab00007/jm950395ab00007_1', 'first-page': '459', 'volume': '30', 'author': 'Kawamatsu Y.', 'year': '1980', 'journal-title': 'Arzneim.-Forsch./Drug Res.'} / Arzneim.-Forsch./Drug Res. by Kawamatsu Y. (1980)
{'key': 'jm950395ab00007/jm950395ab00007_2', 'first-page': '3600', 'volume': '30', 'author': 'Sohda T.', 'year': '1982', 'journal-title': 'Chem. Pharm. Bull.'} / Chem. Pharm. Bull. by Sohda T. (1982)
{'key': 'jm950395ab00008/jm950395ab00008_1', 'first-page': '58', 'volume': '31', 'author': 'Hulin B', 'year': '1994', 'journal-title': 'Prog. Med. Chem.'} / Prog. Med. Chem. by Hulin B (1994)
{'key': 'jm950395ab00009/jm950395ab00009_1', 'first-page': '42', 'volume': '40', 'author': 'Shoda T.', 'year': '1990', 'journal-title': 'Arzneim.-Forsch./Drug Res.'} / Arzneim.-Forsch./Drug Res. by Shoda T. (1990)
{'key': 'jm950395ab00010/jm950395ab00010_1', 'first-page': '3985', 'volume': '37', 'author': 'Cantello B. C. C.', 'year': '1994', 'journal-title': 'Med. Chem.'} / Med. Chem. by Cantello B. C. C. (1994)
{'key': 'jm950395ab00010/jm950395ab00010_2', 'first-page': '1184', 'volume': '10', 'author': 'Cantello B. C. C.', 'year': '1994', 'journal-title': 'Bioorg. Med. Chem. Lett.'} / Bioorg. Med. Chem. Lett. by Cantello B. C. C. (1994)
10.1021/jm00105a051 / J. Med. Chem. by Clark D. A. (1991)
10.1038/347645a0 / Nature by Isseman I. (1990)
{'key': 'jm950395ab00012/jm950395ab00012_2', 'first-page': '41', 'volume': '6', 'author': 'Schmidt A.', 'year': '1992', 'journal-title': 'Mol. Endocrinol.'} / Mol. Endocrinol. by Schmidt A. (1992)
10.1073/pnas.91.15.7355 / Proc. Natl. Acad. Sci. U.S.A. by Kliewer S. A. (1994)
Desvergne, B.; Wahli, W. PPAR: a Key Nuclear Factor in Nutrient/Gene Interactions? InInducible Gene Expression; Baeuerle, P., Ed.; Birkhäuse: Boston, 1995; pp 142−176. (10.1007/978-1-4684-6840-3_5)
{'key': 'jm950395ab00014/jm950395ab00014_1', 'first-page': '12956', 'volume': '270', 'author': 'Lehmann J. M.', 'year': '1995', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Lehmann J. M. (1995)
{'key': 'jm950395ab00015/jm950395ab00015_1', 'first-page': '1326', 'volume': '1323', 'author': 'Thorpe J. M', 'year': '1962', 'journal-title': 'Lancet'} / Lancet by Thorpe J. M (1962)
{'key': 'jm950395ab00016/jm950395ab00016_1', 'volume-title': 'A.', 'author': 'Compound FAAR', 'year': '1994'} / A. by Compound FAAR (1994)
10.1210/endo.135.2.8033830 / Endocrinology by Chawla A. (1994)
10.1016/0092-8674(94)90006-X / Cell by Tontonoz P. (1994)
10.1016/0092-8674(95)90445-X / Cell by Flier J. S (1995)
10.1016/0378-1119(88)90219-3 / Gene by Berger J. (1988)
{'key': 'jm950395ab00023/jm950395ab00023_1', 'first-page': '270', 'volume': '26', 'author': 'Pfahl', 'year': '1990', 'journal-title': 'Methods Enzymol.'} / Methods Enzymol. by Pfahl (1990)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 1:03 a.m.)
Deposited	3 years, 11 months ago (Sept. 21, 2021, 6:20 p.m.)
Indexed	2 months ago (June 25, 2025, 8:10 p.m.)
Issued	29 years, 7 months ago (Jan. 1, 1996)
Published	29 years, 7 months ago (Jan. 1, 1996)
Published Online	29 years, 6 months ago (Feb. 2, 1996)
Published Print	29 years, 7 months ago (Jan. 1, 1996)

Funders 0

None

BibTeX

@article{Willson_1996, title={The StructureвҲ’Activity Relationship between Peroxisome Proliferator-Activated Receptor Оі Agonism and the Antihyperglycemic Activity of Thiazolidinediones}, volume={39}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm950395a}, DOI={10.1021/jm950395a}, number={3}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={Willson, Timothy M. and Cobb, Jeffery E. and Cowan, David J. and Wiethe, Robert W. and Correa, Itzela D. and Prakash, Shimoga R. and Beck, Kelli D. and Moore, Linda B. and Kliewer, Steven A. and Lehmann, JГјrgen M.}, year={1996}, month=jan, pages={665вҖ“668} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        26
      ]
    ],
    "date-time": "2025-06-26T00:10:06Z",
    "timestamp": 1750896606314
  },
  "reference-count": 30,
  "publisher": "American Chemical Society (ACS)",
  "issue": "3",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  },
  "DOI": "10.1021/jm950395a",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T05:03:09Z",
    "timestamp": 1027659789000
  },
  "page": "665-668",
  "source": "Crossref",
  "is-referenced-by-count": 530,
  "title": "The Structure\u2212Activity Relationship between Peroxisome Proliferator-Activated Receptor \u03b3 Agonism and the Antihyperglycemic Activity of Thiazolidinediones",
  "prefix": "10.1021",
  "volume": "39",
  "author": [
    {
      "given": "Timothy M.",
      "family": "Willson",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "Jeffery E.",
      "family": "Cobb",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "David J.",
      "family": "Cowan",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "Robert W.",
      "family": "Wiethe",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "Itzela D.",
      "family": "Correa",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "Shimoga R.",
      "family": "Prakash",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "Kelli D.",
      "family": "Beck",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "Linda B.",
      "family": "Moore",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "Steven A.",
      "family": "Kliewer",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    },
    {
      "given": "J\u00fcrgen M.",
      "family": "Lehmann",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        1996,
        2,
        2
      ]
    ]
  },
  "reference": [
    {
      "key": "jm950395ab00001/jm950395ab00001_1",
      "doi-asserted-by": "crossref",
      "first-page": "298",
      "DOI": "10.1097/00041552-199212000-00015",
      "volume": "1",
      "author": "Ferrannini E",
      "year": "1992",
      "journal-title": "Curr. Opin. Nephrol. Hypertens."
    },
    {
      "key": "jm950395ab00002/jm950395ab00002_1",
      "doi-asserted-by": "crossref",
      "first-page": "915",
      "DOI": "10.7326/0003-4819-113-12-909",
      "volume": "113",
      "author": "Warram J. H.",
      "year": "1990",
      "journal-title": "Ann. Intern. Med."
    },
    {
      "key": "jm950395ab00002/jm950395ab00002_2",
      "doi-asserted-by": "crossref",
      "first-page": "1992",
      "DOI": "10.1056/NEJM199312303292703",
      "volume": "329",
      "author": "Lillioja S.",
      "year": "1993",
      "journal-title": "N. Engl. J. Med."
    },
    {
      "key": "jm950395ab00003/jm950395ab00003_1",
      "first-page": "226",
      "volume-title": "Annual Reports in Medicinal Chemistry",
      "volume": "27",
      "author": "Colca J. R.",
      "year": "1992"
    },
    {
      "key": "jm950395ab00004/jm950395ab00004_1",
      "doi-asserted-by": "crossref",
      "first-page": "810",
      "DOI": "10.2337/diab.32.9.804",
      "volume": "32",
      "author": "Fujita T.",
      "year": "1983",
      "journal-title": "Diabetes"
    },
    {
      "key": "jm950395ab00004/jm950395ab00004_2",
      "first-page": "838",
      "volume": "32",
      "author": "Chang A. Y.",
      "year": "1983",
      "journal-title": "Diabetes"
    },
    {
      "key": "jm950395ab00004/jm950395ab00004_3",
      "first-page": "267",
      "volume": "40",
      "author": "Sugiyama Y.",
      "year": "1990",
      "journal-title": "Arzneim. Forsch./Drug Res."
    },
    {
      "key": "jm950395ab00004/jm950395ab00004_4",
      "doi-asserted-by": "crossref",
      "first-page": "1227",
      "DOI": "10.2337/diab.39.10.1218",
      "volume": "39",
      "author": "Stevenson R. W.",
      "year": "1990",
      "journal-title": "Diabetes"
    },
    {
      "key": "jm950395ab00005/jm950395ab00005_1",
      "doi-asserted-by": "crossref",
      "first-page": "1193",
      "DOI": "10.1056/NEJM199411033311803",
      "volume": "331",
      "author": "Nolan J. J.",
      "year": "1994",
      "journal-title": "N. Engl. J. Med."
    },
    {
      "key": "jm950395ab00006/jm950395ab00006_1",
      "doi-asserted-by": "crossref",
      "first-page": "6",
      "DOI": "10.1055/s-0028-1093469",
      "volume": "10",
      "author": "Ferrari C.",
      "year": "1978",
      "journal-title": "Horm. Metab. Res."
    },
    {
      "key": "jm950395ab00006/jm950395ab00006_2",
      "doi-asserted-by": "crossref",
      "first-page": "458",
      "DOI": "10.1111/j.1365-2125.1977.tb00761.x",
      "volume": "4",
      "author": "Barnett D.",
      "year": "1977",
      "journal-title": "Br. J. Clin. Pharmacol."
    },
    {
      "key": "jm950395ab00007/jm950395ab00007_1",
      "first-page": "459",
      "volume": "30",
      "author": "Kawamatsu Y.",
      "year": "1980",
      "journal-title": "Arzneim.-Forsch./Drug Res."
    },
    {
      "key": "jm950395ab00007/jm950395ab00007_2",
      "first-page": "3600",
      "volume": "30",
      "author": "Sohda T.",
      "year": "1982",
      "journal-title": "Chem. Pharm. Bull."
    },
    {
      "key": "jm950395ab00008/jm950395ab00008_1",
      "first-page": "58",
      "volume": "31",
      "author": "Hulin B",
      "year": "1994",
      "journal-title": "Prog. Med. Chem."
    },
    {
      "key": "jm950395ab00009/jm950395ab00009_1",
      "first-page": "42",
      "volume": "40",
      "author": "Shoda T.",
      "year": "1990",
      "journal-title": "Arzneim.-Forsch./Drug Res."
    },
    {
      "key": "jm950395ab00010/jm950395ab00010_1",
      "first-page": "3985",
      "volume": "37",
      "author": "Cantello B. C. C.",
      "year": "1994",
      "journal-title": "Med. Chem."
    },
    {
      "key": "jm950395ab00010/jm950395ab00010_2",
      "first-page": "1184",
      "volume": "10",
      "author": "Cantello B. C. C.",
      "year": "1994",
      "journal-title": "Bioorg. Med. Chem. Lett."
    },
    {
      "key": "jm950395ab00011/jm950395ab00011_1",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1021/jm00105a051",
      "volume": "34",
      "author": "Clark D. A.",
      "year": "1991",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm950395ab00012/jm950395ab00012_1",
      "doi-asserted-by": "crossref",
      "first-page": "650",
      "DOI": "10.1038/347645a0",
      "volume": "347",
      "author": "Isseman I.",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "jm950395ab00012/jm950395ab00012_2",
      "first-page": "41",
      "volume": "6",
      "author": "Schmidt A.",
      "year": "1992",
      "journal-title": "Mol. Endocrinol."
    },
    {
      "key": "jm950395ab00012/jm950395ab00012_3",
      "doi-asserted-by": "crossref",
      "first-page": "7359",
      "DOI": "10.1073/pnas.91.15.7355",
      "volume": "91",
      "author": "Kliewer S. A.",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "jm950395ab00013/jm950395ab00013_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Desvergne, B.; Wahli, W. PPAR:\u2009 a Key Nuclear Factor in Nutrient/Gene Interactions? InInducible Gene Expression; Baeuerle, P., Ed.; Birkh\u00e4use:\u2009 Boston, 1995; pp 142\u2212176.",
      "DOI": "10.1007/978-1-4684-6840-3_5"
    },
    {
      "key": "jm950395ab00014/jm950395ab00014_1",
      "first-page": "12956",
      "volume": "270",
      "author": "Lehmann J. M.",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "jm950395ab00015/jm950395ab00015_1",
      "first-page": "1326",
      "volume": "1323",
      "author": "Thorpe J. M",
      "year": "1962",
      "journal-title": "Lancet"
    },
    {
      "key": "jm950395ab00016/jm950395ab00016_1",
      "volume-title": "A.",
      "author": "Compound FAAR",
      "year": "1994"
    },
    {
      "key": "jm950395ab00019/jm950395ab00019_1",
      "doi-asserted-by": "crossref",
      "first-page": "800",
      "DOI": "10.1210/endo.135.2.8033830",
      "volume": "135",
      "author": "Chawla A.",
      "year": "1994",
      "journal-title": "Endocrinology"
    },
    {
      "key": "jm950395ab00020/jm950395ab00020_1",
      "doi-asserted-by": "crossref",
      "first-page": "20",
      "DOI": "10.1016/0092-8674(94)90006-X",
      "volume": "79",
      "author": "Tontonoz P.",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "jm950395ab00021/jm950395ab00021_1",
      "doi-asserted-by": "crossref",
      "first-page": "18",
      "DOI": "10.1016/0092-8674(95)90445-X",
      "volume": "80",
      "author": "Flier J. S",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "jm950395ab00022/jm950395ab00022_1",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "DOI": "10.1016/0378-1119(88)90219-3",
      "volume": "66",
      "author": "Berger J.",
      "year": "1988",
      "journal-title": "Gene"
    },
    {
      "key": "jm950395ab00023/jm950395ab00023_1",
      "first-page": "270",
      "volume": "26",
      "author": "Pfahl",
      "year": "1990",
      "journal-title": "Methods Enzymol."
    }
  ],
  "container-title": "Journal of Medicinal Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/jm950395a",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        9,
        21
      ]
    ],
    "date-time": "2021-09-21T22:20:43Z",
    "timestamp": 1632262843000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/jm950395a"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  },
  "references-count": 30,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1996,
          1,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/jm950395a"
  ],
  "URL": "http://dx.doi.org/10.1021/jm950395a",
  "relation": {},
  "ISSN": [
    "0022-2623",
    "1520-4804"
  ],
  "subject": [],
  "container-title-short": "J. Med. Chem.",
  "published": {
    "date-parts": [
      [
        1996,
        1,
        1
      ]
    ]
  }
}