DOI: 10.1021/jm070897b. Novel Di- and Tetracarboxylatoplatinum(IV) Complexes. Synthesis, Characterization, Cytotoxic Activity, and DNA Platination

Novel Di- and Tetracarboxylatoplatinum(IV) Complexes. Synthesis, Characterization, Cytotoxic Activity, and DNA Platination

10.1021/jm070897b

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

Reithofer, M. R., Valiahdi, S. M., Jakupec, M. A., Arion, V. B., Egger, A., Galanski, M. S., & Keppler, B. K. (2007). Novel Di- and Tetracarboxylatoplatinum(IV) Complexes. Synthesis, Characterization, Cytotoxic Activity, and DNA Platination. Journal of Medicinal Chemistry, 50(26), 6692â6699.

Authors 7

Michael R. Reithofer (first)
Seied M. Valiahdi (additional)
Michael A. Jakupec (additional)
Vladimir B. Arion (additional)
Alexander Egger (additional)
Mathea Sophia Galanski (additional)
Bernhard K. Keppler (additional)

References 32 Referenced 86

10.1007/s10254-002-0001-x / Rev. Physiol. Biochem. Pharmacol. by Jakupec M. A. (2003)
10.2174/0929867054637626 / Curr. Med. Chem. by Galanski M. (2005)
10.2174/1381612033454180 / Curr. Pharm. Des. by Galanski M. (2003)
10.1021/cr980422f / Chem. Rev. by Reedijk J. (1999)
10.1201/b12414-6 / Met. Ions Biol. Syst. by Jakupec M. A. (2004)
10.2174/187152007779314062 / Anti-Cancer Agents Med. Chem. by Wang X. (2007)
{'key': 'ref7/cit7', 'first-page': '709', 'volume': '54', 'author': 'Schilder R. J.', 'year': '1994', 'journal-title': 'Cancer Res.'} / Cancer Res. by Schilder R. J. (1994)
10.1200/JCO.1991.9.7.1131 / J. Clin. Oncol. by Trask C. (1991)
10.1201/b12414-9 / Met. Ions Biol. Syst. by Hall M. D. (2004)
10.2174/187152007779314017 / Anti-Cancer Agents Med. Chem. by Galanski M. (2007)
10.1023/B:DRUG.0000047109.76766.84 / Invest. New Drugs by Latif T. (2005)
10.1159/000084201 / Oncology by Sternberg C. N. (2005)
10.1016/j.bcp.2004.09.005 / Biochem. Pharmacol. by Kozubik A. (2005)
10.1021/jm070280u / J. Med. Chem. by Hall M. D. (2007)
10.1021/ic00109a004 / Inorg. Chem. by Giandomenico C. M. (1995)
10.1021/ic9509490 / Inorg. Chem. by Galanski M. (1996)
10.1016/S0020-1693(97)05639-9 / Inorg. Chim. Acta by Galanski M. (1997)
10.1021/ja0432618 / J. Am. Chem. Soc. by Ang W. H. (2005)
10.1021/jm010968l / J. Med. Chem. by Alvarez-Valdes A. (2002)
10.1016/j.chembiol.2004.03.024 / Chem. Biol. by Barnes K. R. (2004)
10.1021/jm0506468 / J. Med. Chem. by Ang W. H. (2005)
10.1002/ejic.200600108 / Eur. J. Inorg. Chem. by Reithofer M. (2006)
10.1021/ja073231f / J. Am. Chem. Soc. by Feazell R. P. (2007)
10.1021/jm960587l / J. Med. Chem. by Khokhar A. R. (1997)
10.1016/j.ejmech.2004.04.003 / Eur. J. Med. Chem. by Galanski M. (2004)
Bulten, E. J.; Verbeek, F. Platinum (IV)-diamine Complexes as Antitumor Agents. U.S. Patent 4482569, 1984.
10.1016/0162-0134(94)85122-0 / J. Inorg. Biochem. by Khokhar A. R. (1994)
{'key': 'ref28/cit28', 'volume-title': 'SAINT-Plus', 'year': '2004', 'edition': '7'} / SAINT-Plus (2004)
{'key': 'ref29/cit29', 'volume-title': 'SHELXS-97, Program for Crystal Structure Solution', 'author': 'Sheldrick G. M.', 'year': '1997'} / SHELXS-97, Program for Crystal Structure Solution by Sheldrick G. M. (1997)
{'key': 'ref30/cit30', 'volume-title': 'SHELXL-97, Program for Crystal Structure Refinement', 'author': 'Sheldrick G. M.', 'year': '1997'} / SHELXL-97, Program for Crystal Structure Refinement by Sheldrick G. M. (1997)
Johnson, G. K. Report ORNL-5138; Oak Ridge National Laboratory: Oak Ridge, TN, 1976.
{'key': 'ref32/cit32', 'volume-title': 'International Tables for X-ray Crystallography', 'year': '1992'} / International Tables for X-ray Crystallography (1992)

Dates

Type	When
Created	17 years, 9 months ago (Nov. 22, 2007, 2 a.m.)
Deposited	2 years, 5 months ago (March 16, 2023, 7:14 p.m.)
Indexed	1 month, 1 week ago (July 14, 2025, 11:46 p.m.)
Issued	17 years, 9 months ago (Nov. 22, 2007)
Published	17 years, 9 months ago (Nov. 22, 2007)
Published Online	17 years, 9 months ago (Nov. 22, 2007)
Published Print	17 years, 7 months ago (Dec. 27, 2007)

Funders 0

None

BibTeX

@article{Reithofer_2007, title={Novel Di- and Tetracarboxylatoplatinum(IV) Complexes. Synthesis, Characterization, Cytotoxic Activity, and DNA Platination}, volume={50}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm070897b}, DOI={10.1021/jm070897b}, number={26}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={Reithofer, Michael R. and Valiahdi, Seied M. and Jakupec, Michael A. and Arion, Vladimir B. and Egger, Alexander and Galanski, Mathea Sophia and Keppler, Bernhard K.}, year={2007}, month=nov, pages={6692–6699} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        15
      ]
    ],
    "date-time": "2025-07-15T03:46:03Z",
    "timestamp": 1752551163477
  },
  "reference-count": 32,
  "publisher": "American Chemical Society (ACS)",
  "issue": "26",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            11,
            22
          ]
        ],
        "date-time": "2007-11-22T00:00:00Z",
        "timestamp": 1195689600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            11,
            22
          ]
        ],
        "date-time": "2007-11-22T00:00:00Z",
        "timestamp": 1195689600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            11,
            22
          ]
        ],
        "date-time": "2007-11-22T00:00:00Z",
        "timestamp": 1195689600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-045"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        12,
        27
      ]
    ]
  },
  "DOI": "10.1021/jm070897b",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        11,
        22
      ]
    ],
    "date-time": "2007-11-22T07:00:32Z",
    "timestamp": 1195714832000
  },
  "page": "6692-6699",
  "source": "Crossref",
  "is-referenced-by-count": 86,
  "title": "Novel Di- and Tetracarboxylatoplatinum(IV) Complexes. Synthesis, Characterization, Cytotoxic Activity, and DNA Platination",
  "prefix": "10.1021",
  "volume": "50",
  "author": [
    {
      "given": "Michael R.",
      "family": "Reithofer",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer\rStrasse 42, A-1090 Vienna, Austria"
        }
      ]
    },
    {
      "given": "Seied M.",
      "family": "Valiahdi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer\rStrasse 42, A-1090 Vienna, Austria"
        }
      ]
    },
    {
      "given": "Michael A.",
      "family": "Jakupec",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer\rStrasse 42, A-1090 Vienna, Austria"
        }
      ]
    },
    {
      "given": "Vladimir B.",
      "family": "Arion",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer\rStrasse 42, A-1090 Vienna, Austria"
        }
      ]
    },
    {
      "given": "Alexander",
      "family": "Egger",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer\rStrasse 42, A-1090 Vienna, Austria"
        }
      ]
    },
    {
      "given": "Mathea Sophia",
      "family": "Galanski",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer\rStrasse 42, A-1090 Vienna, Austria"
        }
      ]
    },
    {
      "given": "Bernhard K.",
      "family": "Keppler",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute of Inorganic Chemistry, University of Vienna, W\u00e4hringer\rStrasse 42, A-1090 Vienna, Austria"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2007,
        11,
        22
      ]
    ]
  },
  "reference": [
    {
      "key": "ref1/cit1",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1007/s10254-002-0001-x",
      "volume": "146",
      "author": "Jakupec M. A.",
      "year": "2003",
      "journal-title": "Rev. Physiol. Biochem. Pharmacol."
    },
    {
      "key": "ref2/cit2",
      "doi-asserted-by": "crossref",
      "first-page": "2075",
      "DOI": "10.2174/0929867054637626",
      "volume": "12",
      "author": "Galanski M.",
      "year": "2005",
      "journal-title": "Curr. Med. Chem."
    },
    {
      "key": "ref3/cit3",
      "doi-asserted-by": "crossref",
      "first-page": "2078",
      "DOI": "10.2174/1381612033454180",
      "volume": "9",
      "author": "Galanski M.",
      "year": "2003",
      "journal-title": "Curr. Pharm. Des."
    },
    {
      "key": "ref4/cit4",
      "doi-asserted-by": "crossref",
      "first-page": "2499",
      "DOI": "10.1021/cr980422f",
      "volume": "99",
      "author": "Reedijk J.",
      "year": "1999",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "ref5/cit5",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1201/b12414-6",
      "volume": "42",
      "author": "Jakupec M. A.",
      "year": "2004",
      "journal-title": "Met. Ions Biol. Syst."
    },
    {
      "key": "ref6/cit6",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.2174/187152007779314062",
      "volume": "7",
      "author": "Wang X.",
      "year": "2007",
      "journal-title": "Anti-Cancer Agents Med. Chem."
    },
    {
      "key": "ref7/cit7",
      "first-page": "709",
      "volume": "54",
      "author": "Schilder R. J.",
      "year": "1994",
      "journal-title": "Cancer Res."
    },
    {
      "key": "ref8/cit8",
      "doi-asserted-by": "crossref",
      "first-page": "1131",
      "DOI": "10.1200/JCO.1991.9.7.1131",
      "volume": "9",
      "author": "Trask C.",
      "year": "1991",
      "journal-title": "J. Clin. Oncol."
    },
    {
      "key": "ref9/cit9",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1201/b12414-9",
      "volume": "42",
      "author": "Hall M. D.",
      "year": "2004",
      "journal-title": "Met. Ions Biol. Syst."
    },
    {
      "key": "ref10/cit10",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.2174/187152007779314017",
      "volume": "7",
      "author": "Galanski M.",
      "year": "2007",
      "journal-title": "Anti-Cancer Agents Med. Chem."
    },
    {
      "key": "ref11/cit11",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1023/B:DRUG.0000047109.76766.84",
      "volume": "23",
      "author": "Latif T.",
      "year": "2005",
      "journal-title": "Invest. New Drugs"
    },
    {
      "key": "ref12/cit12",
      "doi-asserted-by": "crossref",
      "first-page": "2",
      "DOI": "10.1159/000084201",
      "volume": "68",
      "author": "Sternberg C. N.",
      "year": "2005",
      "journal-title": "Oncology"
    },
    {
      "key": "ref13/cit13",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1016/j.bcp.2004.09.005",
      "volume": "69",
      "author": "Kozubik A.",
      "year": "2005",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "ref14/cit14",
      "doi-asserted-by": "crossref",
      "first-page": "3403",
      "DOI": "10.1021/jm070280u",
      "volume": "50",
      "author": "Hall M. D.",
      "year": "2007",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "ref15/cit15",
      "doi-asserted-by": "crossref",
      "first-page": "1015",
      "DOI": "10.1021/ic00109a004",
      "volume": "34",
      "author": "Giandomenico C. M.",
      "year": "1995",
      "journal-title": "Inorg. Chem."
    },
    {
      "key": "ref16/cit16",
      "doi-asserted-by": "crossref",
      "first-page": "1709",
      "DOI": "10.1021/ic9509490",
      "volume": "35",
      "author": "Galanski M.",
      "year": "1996",
      "journal-title": "Inorg. Chem."
    },
    {
      "key": "ref17/cit17",
      "doi-asserted-by": "crossref",
      "first-page": "271",
      "DOI": "10.1016/S0020-1693(97)05639-9",
      "volume": "265",
      "author": "Galanski M.",
      "year": "1997",
      "journal-title": "Inorg. Chim. Acta"
    },
    {
      "key": "ref18/cit18",
      "doi-asserted-by": "crossref",
      "first-page": "1382",
      "DOI": "10.1021/ja0432618",
      "volume": "127",
      "author": "Ang W. H.",
      "year": "2005",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ref19/cit19",
      "doi-asserted-by": "crossref",
      "first-page": "1835",
      "DOI": "10.1021/jm010968l",
      "volume": "45",
      "author": "Alvarez-Valdes A.",
      "year": "2002",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "ref20/cit20",
      "doi-asserted-by": "crossref",
      "first-page": "557",
      "DOI": "10.1016/j.chembiol.2004.03.024",
      "volume": "11",
      "author": "Barnes K. R.",
      "year": "2004",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "ref21/cit21",
      "doi-asserted-by": "crossref",
      "first-page": "8060",
      "DOI": "10.1021/jm0506468",
      "volume": "48",
      "author": "Ang W. H.",
      "year": "2005",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "ref22/cit22",
      "doi-asserted-by": "crossref",
      "first-page": "2612",
      "DOI": "10.1002/ejic.200600108",
      "author": "Reithofer M.",
      "year": "2006",
      "journal-title": "Eur. J. Inorg. Chem."
    },
    {
      "key": "ref23/cit23",
      "doi-asserted-by": "crossref",
      "first-page": "8438",
      "DOI": "10.1021/ja073231f",
      "volume": "129",
      "author": "Feazell R. P.",
      "year": "2007",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ref24/cit24",
      "doi-asserted-by": "crossref",
      "first-page": "112",
      "DOI": "10.1021/jm960587l",
      "volume": "40",
      "author": "Khokhar A. R.",
      "year": "1997",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "ref25/cit25",
      "doi-asserted-by": "crossref",
      "first-page": "707",
      "DOI": "10.1016/j.ejmech.2004.04.003",
      "volume": "39",
      "author": "Galanski M.",
      "year": "2004",
      "journal-title": "Eur. J. Med. Chem."
    },
    {
      "key": "ref26/cit26",
      "unstructured": "Bulten, E. J.; Verbeek, F. Platinum (IV)-diamine Complexes as Antitumor Agents. U.S. Patent 4482569, 1984."
    },
    {
      "key": "ref27/cit27",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.1016/0162-0134(94)85122-0",
      "volume": "54",
      "author": "Khokhar A. R.",
      "year": "1994",
      "journal-title": "J. Inorg. Biochem."
    },
    {
      "key": "ref28/cit28",
      "volume-title": "SAINT-Plus",
      "year": "2004",
      "edition": "7"
    },
    {
      "key": "ref29/cit29",
      "volume-title": "SHELXS-97, Program for Crystal Structure Solution",
      "author": "Sheldrick G. M.",
      "year": "1997"
    },
    {
      "key": "ref30/cit30",
      "volume-title": "SHELXL-97, Program for Crystal Structure Refinement",
      "author": "Sheldrick G. M.",
      "year": "1997"
    },
    {
      "key": "ref31/cit31",
      "unstructured": "Johnson, G. K. Report ORNL-5138; Oak Ridge National Laboratory: Oak Ridge, TN, 1976."
    },
    {
      "key": "ref32/cit32",
      "volume-title": "International Tables for X-ray Crystallography",
      "year": "1992"
    }
  ],
  "container-title": "Journal of Medicinal Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/jm070897b",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "unspecified"
    },
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/jm070897b",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        3,
        16
      ]
    ],
    "date-time": "2023-03-16T23:14:06Z",
    "timestamp": 1679008446000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/jm070897b"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        11,
        22
      ]
    ]
  },
  "references-count": 32,
  "journal-issue": {
    "issue": "26",
    "published-print": {
      "date-parts": [
        [
          2007,
          12,
          27
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/jm070897b"
  ],
  "URL": "http://dx.doi.org/10.1021/jm070897b",
  "relation": {},
  "ISSN": [
    "0022-2623",
    "1520-4804"
  ],
  "subject": [],
  "container-title-short": "J. Med. Chem.",
  "published": {
    "date-parts": [
      [
        2007,
        11,
        22
      ]
    ]
  }
}