DOI: 10.1021/jm050943c. Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M

Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M

10.1021/jm050943c

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

Kovalevsky, A. Yu., Tie, Y., Liu, F., Boross, P. I., Wang, Y.-F., Leshchenko, S., Ghosh, A. K., Harrison, R. W., & Weber, I. T. (2006). Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M. Journal of Medicinal Chemistry, 49(4), 1379â1387.

Authors 9

Andrey Yu. Kovalevsky (first)
Yunfeng Tie (additional)
Fengling Liu (additional)
Peter I. Boross (additional)
Yuan-Fang Wang (additional)
Sofiya Leshchenko (additional)
Arun K. Ghosh (additional)
Robert W. Harrison (additional)
Irene T. Weber (additional)

References 41 Referenced 126

{'key': 'jm050943cb00001/jm050943cb00001_1', 'first-page': '1377', 'volume': '15', 'author': 'Barlett J. A.', 'year': '2001', 'journal-title': 'AIDS'} / AIDS by Barlett J. A. (2001)
{'key': 'jm050943cb00002/jm050943cb00002_1', 'first-page': '39', 'volume': '133', 'author': 'Gulick R. M.', 'year': '2000', 'journal-title': 'Ann. Intern. Med.'} / Ann. Intern. Med. by Gulick R. M. (2000)
10.1021/jm040158k / J. Med. Chem. by De Clercq E (2005)
10.1146/annurev.biophys.27.1.249 / Annu. Rev. Biophys. Biomol. Struct. by Wlodawer A. (1998)
10.1016/S0165-6147(02)02028-X / Trends Pharmacol. Sci. by Menedez-Arias L. (2002)
10.2174/1381612053764869 / Curr. Pharm. Des. by Barbaro G. (2005)
{'key': 'jm050943cb00007/jm050943cb00007_1', 'first-page': 'S34', 'volume': '35', 'author': 'Sax P. E', 'year': '2004', 'journal-title': 'J. AIDS'} / J. AIDS by Sax P. E (2004)
10.1097/00002030-200006160-00018 / AIDS by Hertogs K. (2000)
{'key': 'jm050943cb00009/jm050943cb00009_1', 'first-page': '4847', 'volume': '4836', 'author': 'Wu T. D.', 'year': '2003', 'journal-title': 'J. Virol.'} / J. Virol. by Wu T. D. (2003)
10.1016/j.pbiomolbio.2004.07.005 / Prog. Biophys. Mol. Biol. by Ohtaka H. (2005)
{'key': 'jm050943cb00011/jm050943cb00011_1', 'first-page': '3129', 'volume': '3123', 'author': 'Koh Y.', 'year': '2003', 'journal-title': 'Antimicrob. Agents Chemother.'} / Antimicrob. Agents Chemother. by Koh Y. (2003)
{'key': 'jm050943cb00012/jm050943cb00012_1', 'first-page': '1822', 'volume': '48', 'author': 'Surleraux D. L. N. G.', 'year': '2005', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Surleraux D. L. N. G. (2005)
{'key': 'jm050943cb00013/jm050943cb00013_1', 'first-page': '2321', 'volume': '2314', 'author': 'De Meyer S.', 'year': '2005', 'journal-title': 'Antimicrob. Agents Chemother.'} / Antimicrob. Agents Chemother. by De Meyer S. (2005)
{'key': 'jm050943cb00014/jm050943cb00014_1', 'first-page': '886', 'volume': '5', 'author': 'Shurtleff A. C.', 'year': '2004', 'journal-title': 'Curr. Opin. Invest. Drugs'} / Curr. Opin. Invest. Drugs by Shurtleff A. C. (2004)
{'key': 'jm050943cb00015/jm050943cb00015_1', 'first-page': '352', 'volume': '338', 'author': 'Tie Y.', 'year': '2004', 'journal-title': 'J. Mol. Biol.'} / J. Mol. Biol. by Tie Y. (2004)
{'key': 'jm050943cb00016/jm050943cb00016_1', 'first-page': '12021', 'volume': '12012', 'author': 'King N. M.', 'year': '2004', 'journal-title': 'J. Virol.'} / J. Virol. by King N. M. (2004)
10.1006/abbi.2001.2333 / Arch. Biochim. Biophys. by Velazquez-Campoy A. (2001)
10.1016/S0040-6031(01)00671-2 / Thermochim. Acta by Velazquez-Campoy A. (2001)
10.1021/bi049459m / Biochemistry by Clemente J. C. (2004)
10.1111/j.1432-1033.2004.04060.x / Eur. J. Biochem. by Mahalingam B. (2004)
{'key': 'jm050943cb00021/jm050943cb00021_1', 'first-page': '303', 'volume': '31', 'author': 'Rhee S.-Y.', 'year': '2003', 'journal-title': 'Nucleic Acids Res.'} / Nucleic Acids Res. by Rhee S.-Y. (2003)
{'key': 'jm050943cb00022/jm050943cb00022_1', 'first-page': '167', 'volume': '56', 'author': 'Jarvis B.', 'year': '1998', 'journal-title': 'Drugs'} / Drugs by Jarvis B. (1998)
10.1046/j.1432-1327.1999.00514.x / Eur. J. Biochem. by Mahalingam B. (1999)
10.1002/prot.1057 / Proteins by Mahalingam B. (2001)
10.2165/00044011-200020040-00008 / Clin. Drug Invest. by Tisdale M. (2000)
{'key': 'jm050943cb00026/jm050943cb00026_1', 'first-page': '124', 'volume': '12', 'author': 'Johnson V. A.', 'year': '2004', 'journal-title': 'Top. HIV Med.'} / Top. HIV Med. by Johnson V. A. (2004)
10.1126/science.8278813 / Science by Lam P. Y. S. (1994)
{'key': 'jm050943cb00028/jm050943cb00028_1', 'first-page': '3525', 'volume': '39', 'author': 'Lam P. Y. S.', 'year': '1996', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Lam P. Y. S. (1996)
10.1016/S1074-5521(96)90110-6 / Chem. Biol. by Hodge C. N. (1996)
10.1080/08893119608035394 / Crystallogr. Rev. by Steiner T (1996)
10.1110/ps.9.10.1898 / Protein Sci. by Hong L. (2000)
{'key': 'jm050943cb00032/jm050943cb00032_1', 'first-page': '800', 'volume': '354', 'author': 'Liu F.', 'year': '2005', 'journal-title': 'J. Mol. Biol.'} / J. Mol. Biol. by Liu F. (2005)
{'key': 'jm050943cb00033/jm050943cb00033_1', 'first-page': '875', 'volume': '6', 'author': 'Louis J. M.', 'year': '1999', 'journal-title': 'Nat. Struct. Biol.'} / Nat. Struct. Biol. by Louis J. M. (1999)
10.1016/j.jviromet.2004.03.001 / J. Virol. Met. by Bagossi P. (2004)
10.1021/jm00398a022 / J. Med. Chem. by Maibaum J. (1988)
10.1016/S0076-6879(97)76067-1 / Met. Enzymol. by Otwinowski Z. (1997)
10.1107/S0907444994003112 / Acta Crystallogr. D by Collaborative Computational Project, Number 4 (1994)
{'key': 'jm050943cb00038/jm050943cb00038_1', 'first-page': '343', 'volume': '277', 'author': 'Sheldrick G. M.', 'year': '1997', 'journal-title': 'Met. Enzymol.'} / Met. Enzymol. by Sheldrick G. M. (1997)
10.1107/S0108767390010753 / Acta Crystallogr. A by Jones T. A. (1991)
10.1107/S0567739477000862 / Acta Crystallogr. A by Ferro D. R. (1977)
10.1107/S0021889891004399 / J. Appl. Crystallogr. by Kraulis P. J. (1991)

Dates

Type	When
Created	19 years, 6 months ago (Feb. 16, 2006, 12:28 a.m.)
Deposited	2 years, 5 months ago (March 16, 2023, 7:28 p.m.)
Indexed	4 weeks ago (July 24, 2025, 7:53 a.m.)
Issued	19 years, 6 months ago (Feb. 1, 2006)
Published	19 years, 6 months ago (Feb. 1, 2006)
Published Online	19 years, 6 months ago (Feb. 2, 2006)
Published Print	19 years, 6 months ago (Feb. 1, 2006)

Funders 0

None

BibTeX

@article{Kovalevsky_2006, title={Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M}, volume={49}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm050943c}, DOI={10.1021/jm050943c}, number={4}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={Kovalevsky, Andrey Yu. and Tie, Yunfeng and Liu, Fengling and Boross, Peter I. and Wang, Yuan-Fang and Leshchenko, Sofiya and Ghosh, Arun K. and Harrison, Robert W. and Weber, Irene T.}, year={2006}, month=feb, pages={1379–1387} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        24
      ]
    ],
    "date-time": "2025-07-24T11:53:45Z",
    "timestamp": 1753358025038
  },
  "reference-count": 41,
  "publisher": "American Chemical Society (ACS)",
  "issue": "4",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2006,
        2,
        1
      ]
    ]
  },
  "DOI": "10.1021/jm050943c",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        2,
        16
      ]
    ],
    "date-time": "2006-02-16T05:28:17Z",
    "timestamp": 1140067697000
  },
  "page": "1379-1387",
  "source": "Crossref",
  "is-referenced-by-count": 126,
  "title": "Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M",
  "prefix": "10.1021",
  "volume": "49",
  "author": [
    {
      "given": "Andrey Yu.",
      "family": "Kovalevsky",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    },
    {
      "given": "Yunfeng",
      "family": "Tie",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    },
    {
      "given": "Fengling",
      "family": "Liu",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    },
    {
      "given": "Peter I.",
      "family": "Boross",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    },
    {
      "given": "Yuan-Fang",
      "family": "Wang",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    },
    {
      "given": "Sofiya",
      "family": "Leshchenko",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    },
    {
      "given": "Arun K.",
      "family": "Ghosh",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    },
    {
      "given": "Robert W.",
      "family": "Harrison",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    },
    {
      "given": "Irene T.",
      "family": "Weber",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biology and Department of Chemistry, Molecular Basis of Disease, and Department of Computer Science, Georgia State University, Atlanta, Georgia 30303, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, and Department of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2006,
        2,
        2
      ]
    ]
  },
  "reference": [
    {
      "key": "jm050943cb00001/jm050943cb00001_1",
      "first-page": "1377",
      "volume": "15",
      "author": "Barlett J. A.",
      "year": "2001",
      "journal-title": "AIDS"
    },
    {
      "key": "jm050943cb00002/jm050943cb00002_1",
      "first-page": "39",
      "volume": "133",
      "author": "Gulick R. M.",
      "year": "2000",
      "journal-title": "Ann. Intern. Med."
    },
    {
      "key": "jm050943cb00003/jm050943cb00003_1",
      "doi-asserted-by": "crossref",
      "first-page": "17",
      "DOI": "10.1021/jm040158k",
      "volume": "48",
      "author": "De Clercq E",
      "year": "2005",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm050943cb00004/jm050943cb00004_1",
      "doi-asserted-by": "crossref",
      "first-page": "284",
      "DOI": "10.1146/annurev.biophys.27.1.249",
      "volume": "27",
      "author": "Wlodawer A.",
      "year": "1998",
      "journal-title": "Annu. Rev. Biophys. Biomol. Struct."
    },
    {
      "key": "jm050943cb00005/jm050943cb00005_1",
      "doi-asserted-by": "crossref",
      "first-page": "388",
      "DOI": "10.1016/S0165-6147(02)02028-X",
      "volume": "23",
      "author": "Menedez-Arias L.",
      "year": "2002",
      "journal-title": "Trends Pharmacol. Sci."
    },
    {
      "key": "jm050943cb00006/jm050943cb00006_1",
      "doi-asserted-by": "crossref",
      "first-page": "1844",
      "DOI": "10.2174/1381612053764869",
      "volume": "11",
      "author": "Barbaro G.",
      "year": "2005",
      "journal-title": "Curr. Pharm. Des."
    },
    {
      "key": "jm050943cb00007/jm050943cb00007_1",
      "first-page": "S34",
      "volume": "35",
      "author": "Sax P. E",
      "year": "2004",
      "journal-title": "J. AIDS"
    },
    {
      "key": "jm050943cb00008/jm050943cb00008_1",
      "doi-asserted-by": "crossref",
      "first-page": "1210",
      "DOI": "10.1097/00002030-200006160-00018",
      "volume": "14",
      "author": "Hertogs K.",
      "year": "2000",
      "journal-title": "AIDS"
    },
    {
      "key": "jm050943cb00009/jm050943cb00009_1",
      "first-page": "4847",
      "volume": "4836",
      "author": "Wu T. D.",
      "year": "2003",
      "journal-title": "J. Virol."
    },
    {
      "key": "jm050943cb00010/jm050943cb00010_1",
      "doi-asserted-by": "crossref",
      "first-page": "208",
      "DOI": "10.1016/j.pbiomolbio.2004.07.005",
      "volume": "88",
      "author": "Ohtaka H.",
      "year": "2005",
      "journal-title": "Prog. Biophys. Mol. Biol."
    },
    {
      "key": "jm050943cb00011/jm050943cb00011_1",
      "first-page": "3129",
      "volume": "3123",
      "author": "Koh Y.",
      "year": "2003",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "jm050943cb00012/jm050943cb00012_1",
      "first-page": "1822",
      "volume": "48",
      "author": "Surleraux D. L. N. G.",
      "year": "2005",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm050943cb00013/jm050943cb00013_1",
      "first-page": "2321",
      "volume": "2314",
      "author": "De Meyer S.",
      "year": "2005",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "jm050943cb00014/jm050943cb00014_1",
      "first-page": "886",
      "volume": "5",
      "author": "Shurtleff A. C.",
      "year": "2004",
      "journal-title": "Curr. Opin. Invest. Drugs"
    },
    {
      "key": "jm050943cb00015/jm050943cb00015_1",
      "first-page": "352",
      "volume": "338",
      "author": "Tie Y.",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "jm050943cb00016/jm050943cb00016_1",
      "first-page": "12021",
      "volume": "12012",
      "author": "King N. M.",
      "year": "2004",
      "journal-title": "J. Virol."
    },
    {
      "key": "jm050943cb00017/jm050943cb00017_1",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1006/abbi.2001.2333",
      "volume": "390",
      "author": "Velazquez-Campoy A.",
      "year": "2001",
      "journal-title": "Arch. Biochim. Biophys."
    },
    {
      "key": "jm050943cb00018/jm050943cb00018_1",
      "doi-asserted-by": "crossref",
      "first-page": "227",
      "DOI": "10.1016/S0040-6031(01)00671-2",
      "volume": "380",
      "author": "Velazquez-Campoy A.",
      "year": "2001",
      "journal-title": "Thermochim. Acta"
    },
    {
      "key": "jm050943cb00019/jm050943cb00019_1",
      "doi-asserted-by": "crossref",
      "first-page": "12151",
      "DOI": "10.1021/bi049459m",
      "volume": "43",
      "author": "Clemente J. C.",
      "year": "2004",
      "journal-title": "Biochemistry"
    },
    {
      "key": "jm050943cb00020/jm050943cb00020_1",
      "doi-asserted-by": "crossref",
      "first-page": "1524",
      "DOI": "10.1111/j.1432-1033.2004.04060.x",
      "volume": "271",
      "author": "Mahalingam B.",
      "year": "2004",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "jm050943cb00021/jm050943cb00021_1",
      "first-page": "303",
      "volume": "31",
      "author": "Rhee S.-Y.",
      "year": "2003",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "jm050943cb00022/jm050943cb00022_1",
      "first-page": "167",
      "volume": "56",
      "author": "Jarvis B.",
      "year": "1998",
      "journal-title": "Drugs"
    },
    {
      "key": "jm050943cb00023/jm050943cb00023_1",
      "doi-asserted-by": "crossref",
      "first-page": "245",
      "DOI": "10.1046/j.1432-1327.1999.00514.x",
      "volume": "263",
      "author": "Mahalingam B.",
      "year": "1999",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "jm050943cb00024/jm050943cb00024_1",
      "doi-asserted-by": "crossref",
      "first-page": "464",
      "DOI": "10.1002/prot.1057",
      "volume": "43",
      "author": "Mahalingam B.",
      "year": "2001",
      "journal-title": "Proteins"
    },
    {
      "key": "jm050943cb00025/jm050943cb00025_1",
      "doi-asserted-by": "crossref",
      "first-page": "285",
      "DOI": "10.2165/00044011-200020040-00008",
      "volume": "20",
      "author": "Tisdale M.",
      "year": "2000",
      "journal-title": "Clin. Drug Invest."
    },
    {
      "key": "jm050943cb00026/jm050943cb00026_1",
      "first-page": "124",
      "volume": "12",
      "author": "Johnson V. A.",
      "year": "2004",
      "journal-title": "Top. HIV Med."
    },
    {
      "key": "jm050943cb00027/jm050943cb00027_1",
      "doi-asserted-by": "crossref",
      "first-page": "384",
      "DOI": "10.1126/science.8278813",
      "volume": "263",
      "author": "Lam P. Y. S.",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "jm050943cb00028/jm050943cb00028_1",
      "first-page": "3525",
      "volume": "39",
      "author": "Lam P. Y. S.",
      "year": "1996",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm050943cb00029/jm050943cb00029_1",
      "doi-asserted-by": "crossref",
      "first-page": "314",
      "DOI": "10.1016/S1074-5521(96)90110-6",
      "volume": "3",
      "author": "Hodge C. N.",
      "year": "1996",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "jm050943cb00030/jm050943cb00030_1",
      "doi-asserted-by": "crossref",
      "first-page": "51",
      "DOI": "10.1080/08893119608035394",
      "volume": "6",
      "author": "Steiner T",
      "year": "1996",
      "journal-title": "Crystallogr. Rev."
    },
    {
      "key": "jm050943cb00031/jm050943cb00031_1",
      "doi-asserted-by": "crossref",
      "first-page": "1904",
      "DOI": "10.1110/ps.9.10.1898",
      "volume": "9",
      "author": "Hong L.",
      "year": "2000",
      "journal-title": "Protein Sci."
    },
    {
      "key": "jm050943cb00032/jm050943cb00032_1",
      "first-page": "800",
      "volume": "354",
      "author": "Liu F.",
      "year": "2005",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "jm050943cb00033/jm050943cb00033_1",
      "first-page": "875",
      "volume": "6",
      "author": "Louis J. M.",
      "year": "1999",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "jm050943cb00034/jm050943cb00034_1",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1016/j.jviromet.2004.03.001",
      "volume": "119",
      "author": "Bagossi P.",
      "year": "2004",
      "journal-title": "J. Virol. Met."
    },
    {
      "key": "jm050943cb00035/jm050943cb00035_1",
      "doi-asserted-by": "crossref",
      "first-page": "629",
      "DOI": "10.1021/jm00398a022",
      "volume": "31",
      "author": "Maibaum J.",
      "year": "1988",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm050943cb00036/jm050943cb00036_1",
      "doi-asserted-by": "crossref",
      "first-page": "326",
      "DOI": "10.1016/S0076-6879(97)76067-1",
      "volume": "276",
      "author": "Otwinowski Z.",
      "year": "1997",
      "journal-title": "Met. Enzymol."
    },
    {
      "key": "jm050943cb00037/jm050943cb00037_1",
      "doi-asserted-by": "crossref",
      "first-page": "763",
      "DOI": "10.1107/S0907444994003112",
      "volume": "50",
      "author": "Collaborative Computational Project, Number 4",
      "year": "1994",
      "journal-title": "Acta Crystallogr. D"
    },
    {
      "key": "jm050943cb00038/jm050943cb00038_1",
      "first-page": "343",
      "volume": "277",
      "author": "Sheldrick G. M.",
      "year": "1997",
      "journal-title": "Met. Enzymol."
    },
    {
      "key": "jm050943cb00039/jm050943cb00039_1",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1107/S0108767390010753",
      "volume": "47",
      "author": "Jones T. A.",
      "year": "1991",
      "journal-title": "Acta Crystallogr. A"
    },
    {
      "key": "jm050943cb00040/jm050943cb00040_1",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1107/S0567739477000862",
      "volume": "33",
      "author": "Ferro D. R.",
      "year": "1977",
      "journal-title": "Acta Crystallogr. A"
    },
    {
      "key": "jm050943cb00041/jm050943cb00041_1",
      "doi-asserted-by": "crossref",
      "first-page": "950",
      "DOI": "10.1107/S0021889891004399",
      "volume": "24",
      "author": "Kraulis P. J.",
      "year": "1991",
      "journal-title": "J. Appl. Crystallogr."
    }
  ],
  "container-title": "Journal of Medicinal Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/jm050943c",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        3,
        16
      ]
    ],
    "date-time": "2023-03-16T23:28:54Z",
    "timestamp": 1679009334000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/jm050943c"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006,
        2,
        1
      ]
    ]
  },
  "references-count": 41,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2006,
          2,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/jm050943c"
  ],
  "URL": "http://dx.doi.org/10.1021/jm050943c",
  "relation": {},
  "ISSN": [
    "0022-2623",
    "1520-4804"
  ],
  "subject": [],
  "container-title-short": "J. Med. Chem.",
  "published": {
    "date-parts": [
      [
        2006,
        2,
        1
      ]
    ]
  }
}