DOI: 10.1021/jm049137g. Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells

10.1021/jm049137g

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

Grasberger, B. L., Lu, T., Schubert, C., Parks, D. J., Carver, T. E., Koblish, H. K., Cummings, M. D., LaFrance, L. V., Milkiewicz, K. L., Calvo, R. R., Maguire, D., Lattanze, J., Franks, C. F., Zhao, S., Ramachandren, K., Bylebyl, G. R., Zhang, M., Manthey, C. L., Petrella, E. C., â¦ Bone, R. F. (2005). Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells. Journal of Medicinal Chemistry, 48(4), 909â912.

Authors 26

Bruce L. Grasberger (first)
Tianbao Lu (additional)
Carsten Schubert (additional)
Daniel J. Parks (additional)
Theodore E. Carver (additional)
Holly K. Koblish (additional)
Maxwell D. Cummings (additional)
Louis V. LaFrance (additional)
Karen L. Milkiewicz (additional)
Raul R. Calvo (additional)
Diane Maguire (additional)
Jennifer Lattanze (additional)
Carol F. Franks (additional)
Shuyuan Zhao (additional)
Kannan Ramachandren (additional)
Gwendolyn R. Bylebyl (additional)
Marie Zhang (additional)
Carl L. Manthey (additional)
Eugene C. Petrella (additional)
Michael W. Pantoliano (additional)
Ingrid C. Deckman (additional)
John C. Spurlino (additional)
Anna C. Maroney (additional)
Bruce E. Tomczuk (additional)
Christopher J. Molloy (additional)
Roger F. Bone (additional)

References 24 Referenced 364

10.1016/S0092-8674(00)81871-1 / Cell by Levine A. J. (1997)
10.1038/sj.onc.1201880 / Oncogene by Blaydes J. P. (1998)
10.1006/jmbi.2000.3738 / J. Mol. Biol. by Chene P. (2000)
10.1016/S0960-9822(06)00374-5 / Curr. Biol. by Bottger A. (1997)
10.1038/sj.onc.1202528 / Oncogene by Wasylyk C. (1999)
{'key': 'jm049137gb00006/jm049137gb00006_1', 'first-page': '3624', 'volume': '7', 'author': 'Wang H.', 'year': '2001', 'journal-title': 'Clin. Cancer Res.'} / Clin. Cancer Res. by Wang H. (2001)
10.1126/science.274.5289.948 / Science by Kussie P. H. (1996)
10.1093/nar/26.15.3453 / Nucleic Acids Res. by Momand J. (1998)
10.1021/bi000930v / Biochemistry by Stoll R. (2001)
{'key': 'jm049137gb00010/jm049137gb00010_1', 'first-page': '77', 'volume': '183', 'author': 'Zhao J, W. M.', 'year': '2002', 'journal-title': 'Cancer Lett.'} / Cancer Lett. by Zhao J, W. M. (2002)
10.1021/jm034182u / J. Med. Chem. by Galatin P. S. (2004)
10.1126/science.1092472 / Science by Vassilev L. T. (2004)
10.1016/S1093-3263(00)00063-2 / Mol. Graphics Modell. by Rassokhin D. N. (2000)
10.1021/ci9700337 / J. Chem. Info. Comput. Sci. by Agrafiotis D. K (1997)
10.1038/nrd791 / Nat. Rev. Drug Discovery by Agrafiotis D. K. (2002)
10.1177/108705710100600609 / J. Biomol. Screen. by Pantoliano M. W. (2001)
{'key': 'jm049137gb00017/jm049137gb00017_1', 'first-page': '2147', 'volume': '13', 'author': 'Bottger V.', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene by Bottger V. (1996)
10.1006/jmbi.1997.1078 / J. Mol. Biol. by Bottger A. (1997)
{'key': 'jm049137gb00019/jm049137gb00019_1', 'author': 'Parks D. J.', 'journal-title': 'Bioorg Med. Chem. Lett., in press.'} / Bioorg Med. Chem. Lett., in press. by Parks D. J.
10.1021/jm010468s / J. Med. Chem. by Toogood P. L (2002)
10.1021/ja026861k / J. Am. Chem. Soc. by Kutzki O. (2002)
10.1021/ja0025548 / J. Am. Chem. Soc. by Orner B. P. (2001)
10.1016/S0022-2836(02)00852-5 / J. Mol. Biol. by Schon O. (2002)
10.1073/pnas.0334477100 / Proc. Natl. Acad. Sci. U. S. A. by McCoy M. A. (2003)

Dates

Type	When
Created	20 years, 6 months ago (Feb. 17, 2005, 12:25 a.m.)
Deposited	3 years, 10 months ago (Oct. 17, 2021, 8:06 p.m.)
Indexed	1 month, 1 week ago (July 8, 2025, 11:30 a.m.)
Issued	20 years, 6 months ago (Feb. 1, 2005)
Published	20 years, 6 months ago (Feb. 1, 2005)
Published Online	20 years, 6 months ago (Feb. 1, 2005)
Published Print	20 years, 6 months ago (Feb. 1, 2005)

Funders 0

None

BibTeX

@article{Grasberger_2005, title={Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells}, volume={48}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm049137g}, DOI={10.1021/jm049137g}, number={4}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={Grasberger, Bruce L. and Lu, Tianbao and Schubert, Carsten and Parks, Daniel J. and Carver, Theodore E. and Koblish, Holly K. and Cummings, Maxwell D. and LaFrance, Louis V. and Milkiewicz, Karen L. and Calvo, Raul R. and Maguire, Diane and Lattanze, Jennifer and Franks, Carol F. and Zhao, Shuyuan and Ramachandren, Kannan and Bylebyl, Gwendolyn R. and Zhang, Marie and Manthey, Carl L. and Petrella, Eugene C. and Pantoliano, Michael W. and Deckman, Ingrid C. and Spurlino, John C. and Maroney, Anna C. and Tomczuk, Bruce E. and Molloy, Christopher J. and Bone, Roger F.}, year={2005}, month=feb, pages={909–912} }

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    "1520-4804"
  ],
  "subject": [],
  "container-title-short": "J. Med. Chem.",
  "published": {
    "date-parts": [
      [
        2005,
        2,
        1
      ]
    ]
  }
}