DOI: 10.1021/jm049024x. Pharmacophore, Drug Metabolism, and Pharmacokinetics Models on Non-Peptide AT1, AT2, and AT1/AT2 Angiotensin II Receptor Antagonists

Pharmacophore, Drug Metabolism, and Pharmacokinetics Models on Non-Peptide AT1, AT2, and AT1/AT2 Angiotensin II Receptor Antagonists

10.1021/jm049024x

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

Berellini, G., Cruciani, G., & Mannhold, R. (2005). Pharmacophore, Drug Metabolism, and Pharmacokinetics Models on Non-Peptide AT1, AT2, and AT1/AT2 Angiotensin II Receptor Antagonists. Journal of Medicinal Chemistry, 48(13), 4389â4399.

Authors 3

Giuliano Berellini (first)
Gabriele Cruciani (additional)
Raimund Mannhold (additional)

References 45 Referenced 46

{'key': 'jm049024xb00001/jm049024xb00001_1', 'first-page': '1317', 'volume-title': 'Hypertension:\u2009 Pathopysiology, Diagnosis and Management', 'author': 'Sealey J. E.', 'year': '1990'} / Hypertension: Pathopysiology, Diagnosis and Management by Sealey J. E. (1990)
10.1021/jm9504722 / J. Med. Chem. by Wexler R. R. (1996)
{'key': 'jm049024xb00003/jm049024xb00003_1', 'volume-title': 'Patent 4,340,598', 'author': 'Furakawa Y.', 'year': '1982'} / Patent 4,340,598 by Furakawa Y. (1982)
{'key': 'jm049024xb00004/jm049024xb00004_1', 'first-page': '7', 'volume': '247', 'author': 'Wong P. C.', 'year': '1988', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. by Wong P. C. (1988)
{'key': 'jm049024xb00005/jm049024xb00005_1', 'first-page': '2270', 'volume': '46', 'author': 'Schmidt B.', 'year': '2003', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Schmidt B. (2003)
{'key': 'jm049024xb00006/jm049024xb00006_1', 'first-page': '758', 'volume-title': 'The Pharmacological Basis of Therapeutics', 'author': 'Jackson E. K.', 'year': '1995', 'edition': '9'} / The Pharmacological Basis of Therapeutics by Jackson E. K. (1995)
{'issue': '3', 'key': 'jm049024xb00007/jm049024xb00007_1', 'first-page': '251', 'volume': '45', 'author': 'Timmermans P. B. M. W. M.', 'year': '1993', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. by Timmermans P. B. M. W. M. (1993)
10.1097/00004872-199715022-00005 / J. Hypertens. by Ruilope L. (1997)
{'issue': '3', 'key': 'jm049024xb00009/jm049024xb00009_1', 'first-page': '295', 'volume': '3', 'author': 'Yoo S.', 'year': '1995', 'journal-title': 'Bioorg. Med. Chem.'} / Bioorg. Med. Chem. by Yoo S. (1995)
10.1016/S0021-9258(18)47374-7 / J. Biol. Chem. by Hjorth S. A. (1994)
{'issue': '5', 'key': 'jm049024xb00011/jm049024xb00011_1', 'first-page': '2289', 'volume': '279', 'author': 'Noda K.', 'year': '1995', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Noda K. (1995)
{'key': 'jm049024xb00012/jm049024xb00012_1', 'first-page': '65', 'volume-title': 'PCT Int. Appl. WO1994US07837', 'author': 'Reilly C. F.', 'year': '1995'} / PCT Int. Appl. WO1994US07837 by Reilly C. F. (1995)
{'issue': '10', 'key': 'jm049024xb00013/jm049024xb00013_1', 'first-page': '2028', 'volume': '3', 'author': 'Wu M. T.', 'year': '1993', 'journal-title': 'Med. Chem. Lett.'} / Med. Chem. Lett. by Wu M. T. (1993)
10.1016/1074-5521(94)90013-2 / Chem. Biol. by Underwood D. J. (1994)
10.1021/jm00019a004 / J. Med. Chem. by Chang L. L. (1995)
10.1021/bi00178a016 / Biochemistry by Nikiforovich G. V. (1994)
10.1006/bbrc.2001.5526 / Biochem. Biophys. Res. Commun. by Nikiforovich G. V. (2001)
10.1021/jm000941m / J. Med. Chem. by Pastor M. (2000)
10.1021/jm021032v / J. Med. Chem. by Krovat E. V. (2003)
{'key': 'jm049024xb00020/jm049024xb00020_1', 'volume-title': 'National Meeting of the American Chemical Society', 'author': 'Pearlman R. S.', 'year': '1998'} / National Meeting of the American Chemical Society by Pearlman R. S. (1998)
{'key': 'jm049024xb00022/jm049024xb00022_1', 'first-page': '20', 'volume': '12', 'author': 'Baroni M.', 'year': '1993', 'journal-title': 'Quant.−Struct. Act. Relat.'} / Quant.−Struct. Act. Relat. by Baroni M. (1993)
{'key': 'jm049024xb00023/jm049024xb00023_1', 'first-page': '1464', 'volume': '40', 'author': 'Pastor M.', 'year': '1997', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Pastor M. (1997)
10.1021/jm990968+ / J. Med. Chem. by Crivori P. (2000)
Rowland, M.; Tozer, T. N.Clinical Pharmacokinetics. Concepts andApplications, 3rd ed.; Lippincott, Williams and Wilkins: Philadelphia, PA, 1995; pp 143−155.
10.1021/jm030408h / J. Med. Chem. by Lombardo F. (2004)
{'key': 'jm049024xb00027/jm049024xb00027_1', 'first-page': '649', 'volume': '58', 'author': 'Lo M. W.', 'year': '1995', 'journal-title': 'Clin. Pharmacol. Ther.'} / Clin. Pharmacol. Ther. by Lo M. W. (1995)
10.1007/s002280050259 / Eur. J. Clin. Pharmacol. by Flesch G. (1997)
{'key': 'jm049024xb00029/jm049024xb00029_1', 'first-page': '707', 'volume': '38', 'author': 'Vachharajani N. N.', 'year': '1998', 'journal-title': 'J. Clin. Pharmacol.'} / J. Clin. Pharmacol. by Vachharajani N. N. (1998)
10.1002/(SICI)1099-081X(199809)19:6<351::AID-BDD115>3.0.CO;2-V / Biopharm. Drug Dispos. by Tenero D. (1998)
{'key': 'jm049024xb00031/jm049024xb00031_1', 'first-page': '1364', 'volume': '40', 'author': 'Stangier J.', 'year': '2000', 'journal-title': 'J. Clin. Pharmacol.'} / J. Clin. Pharmacol. by Stangier J. (2000)
10.1021/jm021104i / J. Med. Chem. by Zamora I. (2003)
{'issue': '2', 'key': 'jm049024xb00033/jm049024xb00033_1', 'first-page': '139', 'volume': '20', 'author': 'Song J. C.', 'year': '2000', 'journal-title': 'Pharmacotherapy'} / Pharmacotherapy by Song J. C. (2000)
10.1007/s002280050731 / Eur. J. Clin. Pharmacol. by Taavitsainen P. (2000)
10.1097/00007691-200108000-00008 / Ther. Drug Monit. by Zaidenstein R. (2001)
{'key': 'jm049024xb00036/jm049024xb00036_1', 'first-page': '236', 'volume-title': 'Proceedings of the 7th North American ISSX Meeting', 'volume': '10', 'author': 'Wong B. K.', 'year': '1996'} / Proceedings of the 7th North American ISSX Meeting by Wong B. K. (1996)
{'key': 'jm049024xb00037/jm049024xb00037_1', 'first-page': '385', 'volume-title': 'Proceedings of the 7th North American ISSX Meeting', 'volume': '10', 'author': 'Stearns R. A.', 'year': '1996'} / Proceedings of the 7th North American ISSX Meeting by Stearns R. A. (1996)
{'issue': '7', 'key': 'jm049024xb00038/jm049024xb00038_1', 'first-page': '1056', 'volume': '29', 'author': 'Yasar U.', 'year': '2001', 'journal-title': 'Drug Metab. Dispos.'} / Drug Metab. Dispos. by Yasar U. (2001)
{'key': 'jm049024xb00039/jm049024xb00039_1', 'first-page': '296', 'volume': '27', 'author': 'Bourrie M.', 'year': '1999', 'journal-title': 'Drug Metab. Dispos.'} / Drug Metab. Dispos. by Bourrie M. (1999)
10.1021/jm00145a002 / J. Med. Chem. by Goodford P. J (1985)
10.1021/jm0498349 / J. Med. Chem. by Carosati E. (2004)
10.1021/jm981047m / J. Med. Chem. by Mannhold R. (1999)
{'key': 'jm049024xb00043/jm049024xb00043_1', 'volume-title': 'Molecular fields in quantitative structure-permeation relationships:\u2009 The VolSurf approach. J. Mol. Struct.:\u2009 THEOCHEM', 'author': 'Cruciani G.', 'year': '2000'} / Molecular fields in quantitative structure-permeation relationships: The VolSurf approach. J. Mol. Struct.: THEOCHEM by Cruciani G. (2000)
10.1021/jm030986y / J. Med. Chem. by Cianchetta G. (2004)
10.1023/B:JCAM.0000035184.11906.c2 / J. Comput.-Aided Mol. Des. by Crivori P. (2004)
{'issue': '9', 'key': 'jm049024xb00046/jm049024xb00046_1', 'first-page': '920', 'volume': '20', 'author': 'Carbó-Dorca R.', 'year': '1999', 'journal-title': 'J. Comput. Chem.'} / J. Comput. Chem. by Carbó-Dorca R. (1999)

Dates

Type	When
Created	20 years, 2 months ago (June 23, 2005, 2:34 a.m.)
Deposited	3 years, 11 months ago (Sept. 23, 2021, 11:40 p.m.)
Indexed	4 months ago (April 25, 2025, 3:48 a.m.)
Issued	20 years, 2 months ago (June 1, 2005)
Published	20 years, 2 months ago (June 1, 2005)
Published Online	20 years, 2 months ago (June 3, 2005)
Published Print	20 years, 2 months ago (June 1, 2005)

Funders 0

None

BibTeX

@article{Berellini_2005, title={Pharmacophore, Drug Metabolism, and Pharmacokinetics Models on Non-Peptide AT1, AT2, and AT1/AT2 Angiotensin II Receptor Antagonists}, volume={48}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm049024x}, DOI={10.1021/jm049024x}, number={13}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={Berellini, Giuliano and Cruciani, Gabriele and Mannhold, Raimund}, year={2005}, month=jun, pages={4389–4399} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        25
      ]
    ],
    "date-time": "2025-04-25T07:48:21Z",
    "timestamp": 1745567301798
  },
  "reference-count": 45,
  "publisher": "American Chemical Society (ACS)",
  "issue": "13",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2005,
        6,
        1
      ]
    ]
  },
  "DOI": "10.1021/jm049024x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        6,
        23
      ]
    ],
    "date-time": "2005-06-23T06:34:18Z",
    "timestamp": 1119508458000
  },
  "page": "4389-4399",
  "source": "Crossref",
  "is-referenced-by-count": 46,
  "title": "Pharmacophore, Drug Metabolism, and Pharmacokinetics Models on Non-Peptide AT<sub>1</sub>, AT<sub>2</sub>, and AT<sub>1</sub>/AT<sub>2</sub> Angiotensin II Receptor Antagonists",
  "prefix": "10.1021",
  "volume": "48",
  "author": [
    {
      "given": "Giuliano",
      "family": "Berellini",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Laboratory for Chemometrics and Cheminformatics, Department of Chemistry, University of Perugia, Via Elce di sotto 10, I-06123 Perugia, Italy, and Department of Laser Medicine, Molecular Drug Research Group, Heinrich-Heine-Universit\u00e4t, Universit\u00e4tsstrasse 1, 40225 D\u00fcsseldorf, Germany"
        }
      ]
    },
    {
      "given": "Gabriele",
      "family": "Cruciani",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory for Chemometrics and Cheminformatics, Department of Chemistry, University of Perugia, Via Elce di sotto 10, I-06123 Perugia, Italy, and Department of Laser Medicine, Molecular Drug Research Group, Heinrich-Heine-Universit\u00e4t, Universit\u00e4tsstrasse 1, 40225 D\u00fcsseldorf, Germany"
        }
      ]
    },
    {
      "given": "Raimund",
      "family": "Mannhold",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory for Chemometrics and Cheminformatics, Department of Chemistry, University of Perugia, Via Elce di sotto 10, I-06123 Perugia, Italy, and Department of Laser Medicine, Molecular Drug Research Group, Heinrich-Heine-Universit\u00e4t, Universit\u00e4tsstrasse 1, 40225 D\u00fcsseldorf, Germany"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2005,
        6,
        3
      ]
    ]
  },
  "reference": [
    {
      "key": "jm049024xb00001/jm049024xb00001_1",
      "first-page": "1317",
      "volume-title": "Hypertension:\u2009 Pathopysiology, Diagnosis and Management",
      "author": "Sealey J. E.",
      "year": "1990"
    },
    {
      "key": "jm049024xb00002/jm049024xb00002_1",
      "doi-asserted-by": "crossref",
      "first-page": "656",
      "DOI": "10.1021/jm9504722",
      "volume": "39",
      "author": "Wexler R. R.",
      "year": "1996",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00003/jm049024xb00003_1",
      "volume-title": "Patent 4,340,598",
      "author": "Furakawa Y.",
      "year": "1982"
    },
    {
      "key": "jm049024xb00004/jm049024xb00004_1",
      "first-page": "7",
      "volume": "247",
      "author": "Wong P. C.",
      "year": "1988",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "jm049024xb00005/jm049024xb00005_1",
      "first-page": "2270",
      "volume": "46",
      "author": "Schmidt B.",
      "year": "2003",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00006/jm049024xb00006_1",
      "first-page": "758",
      "volume-title": "The Pharmacological Basis of Therapeutics",
      "author": "Jackson E. K.",
      "year": "1995",
      "edition": "9"
    },
    {
      "issue": "3",
      "key": "jm049024xb00007/jm049024xb00007_1",
      "first-page": "251",
      "volume": "45",
      "author": "Timmermans P. B. M. W. M.",
      "year": "1993",
      "journal-title": "Pharmacol. Rev."
    },
    {
      "key": "jm049024xb00008/jm049024xb00008_1",
      "doi-asserted-by": "crossref",
      "first-page": "S20",
      "DOI": "10.1097/00004872-199715022-00005",
      "volume": "15",
      "author": "Ruilope L.",
      "year": "1997",
      "journal-title": "J. Hypertens."
    },
    {
      "issue": "3",
      "key": "jm049024xb00009/jm049024xb00009_1",
      "first-page": "295",
      "volume": "3",
      "author": "Yoo S.",
      "year": "1995",
      "journal-title": "Bioorg. Med. Chem."
    },
    {
      "issue": "49",
      "key": "jm049024xb00010/jm049024xb00010_1",
      "doi-asserted-by": "crossref",
      "first-page": "30959",
      "DOI": "10.1016/S0021-9258(18)47374-7",
      "volume": "269",
      "author": "Hjorth S. A.",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "issue": "5",
      "key": "jm049024xb00011/jm049024xb00011_1",
      "first-page": "2289",
      "volume": "279",
      "author": "Noda K.",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "jm049024xb00012/jm049024xb00012_1",
      "first-page": "65",
      "volume-title": "PCT Int. Appl. WO1994US07837",
      "author": "Reilly C. F.",
      "year": "1995"
    },
    {
      "issue": "10",
      "key": "jm049024xb00013/jm049024xb00013_1",
      "first-page": "2028",
      "volume": "3",
      "author": "Wu M. T.",
      "year": "1993",
      "journal-title": "Med. Chem. Lett."
    },
    {
      "key": "jm049024xb00014/jm049024xb00014_1",
      "doi-asserted-by": "crossref",
      "first-page": "221",
      "DOI": "10.1016/1074-5521(94)90013-2",
      "volume": "1",
      "author": "Underwood D. J.",
      "year": "1994",
      "journal-title": "Chem. Biol."
    },
    {
      "key": "jm049024xb00015/jm049024xb00015_1",
      "doi-asserted-by": "crossref",
      "first-page": "3758",
      "DOI": "10.1021/jm00019a004",
      "volume": "38",
      "author": "Chang L. L.",
      "year": "1995",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00016/jm049024xb00016_1",
      "doi-asserted-by": "crossref",
      "first-page": "3598",
      "DOI": "10.1021/bi00178a016",
      "volume": "33",
      "author": "Nikiforovich G. V.",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
      "key": "jm049024xb00017/jm049024xb00017_1",
      "doi-asserted-by": "crossref",
      "first-page": "1211",
      "DOI": "10.1006/bbrc.2001.5526",
      "volume": "286",
      "author": "Nikiforovich G. V.",
      "year": "2001",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "jm049024xb00018/jm049024xb00018_1",
      "doi-asserted-by": "crossref",
      "first-page": "3243",
      "DOI": "10.1021/jm000941m",
      "volume": "43",
      "author": "Pastor M.",
      "year": "2000",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00019/jm049024xb00019_1",
      "doi-asserted-by": "crossref",
      "first-page": "726",
      "DOI": "10.1021/jm021032v",
      "volume": "46",
      "author": "Krovat E. V.",
      "year": "2003",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00020/jm049024xb00020_1",
      "volume-title": "National Meeting of the American Chemical Society",
      "author": "Pearlman R. S.",
      "year": "1998"
    },
    {
      "key": "jm049024xb00022/jm049024xb00022_1",
      "first-page": "20",
      "volume": "12",
      "author": "Baroni M.",
      "year": "1993",
      "journal-title": "Quant.\u2212Struct. Act. Relat."
    },
    {
      "key": "jm049024xb00023/jm049024xb00023_1",
      "first-page": "1464",
      "volume": "40",
      "author": "Pastor M.",
      "year": "1997",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00024/jm049024xb00024_1",
      "doi-asserted-by": "crossref",
      "first-page": "2216",
      "DOI": "10.1021/jm990968+",
      "volume": "43",
      "author": "Crivori P.",
      "year": "2000",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00025/jm049024xb00025_1",
      "unstructured": "Rowland, M.; Tozer, T. N.Clinical Pharmacokinetics. Concepts andApplications, 3rd ed.; Lippincott, Williams and Wilkins:\u2009 Philadelphia, PA, 1995; pp 143\u2212155."
    },
    {
      "issue": "5",
      "key": "jm049024xb00026/jm049024xb00026_1",
      "doi-asserted-by": "crossref",
      "first-page": "1250",
      "DOI": "10.1021/jm030408h",
      "volume": "47",
      "author": "Lombardo F.",
      "year": "2004",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00027/jm049024xb00027_1",
      "first-page": "649",
      "volume": "58",
      "author": "Lo M. W.",
      "year": "1995",
      "journal-title": "Clin. Pharmacol. Ther."
    },
    {
      "key": "jm049024xb00028/jm049024xb00028_1",
      "doi-asserted-by": "crossref",
      "first-page": "120",
      "DOI": "10.1007/s002280050259",
      "volume": "52",
      "author": "Flesch G.",
      "year": "1997",
      "journal-title": "Eur. J. Clin. Pharmacol."
    },
    {
      "key": "jm049024xb00029/jm049024xb00029_1",
      "first-page": "707",
      "volume": "38",
      "author": "Vachharajani N. N.",
      "year": "1998",
      "journal-title": "J. Clin. Pharmacol."
    },
    {
      "key": "jm049024xb00030/jm049024xb00030_1",
      "doi-asserted-by": "crossref",
      "first-page": "356",
      "DOI": "10.1002/(SICI)1099-081X(199809)19:6<351::AID-BDD115>3.0.CO;2-V",
      "volume": "19",
      "author": "Tenero D.",
      "year": "1998",
      "journal-title": "Biopharm. Drug Dispos."
    },
    {
      "key": "jm049024xb00031/jm049024xb00031_1",
      "first-page": "1364",
      "volume": "40",
      "author": "Stangier J.",
      "year": "2000",
      "journal-title": "J. Clin. Pharmacol."
    },
    {
      "issue": "12",
      "key": "jm049024xb00032/jm049024xb00032_1",
      "doi-asserted-by": "crossref",
      "first-page": "2324",
      "DOI": "10.1021/jm021104i",
      "volume": "46",
      "author": "Zamora I.",
      "year": "2003",
      "journal-title": "J. Med. Chem."
    },
    {
      "issue": "2",
      "key": "jm049024xb00033/jm049024xb00033_1",
      "first-page": "139",
      "volume": "20",
      "author": "Song J. C.",
      "year": "2000",
      "journal-title": "Pharmacotherapy"
    },
    {
      "key": "jm049024xb00034/jm049024xb00034_1",
      "doi-asserted-by": "crossref",
      "first-page": "140",
      "DOI": "10.1007/s002280050731",
      "volume": "56",
      "author": "Taavitsainen P.",
      "year": "2000",
      "journal-title": "Eur. J. Clin. Pharmacol."
    },
    {
      "issue": "4",
      "key": "jm049024xb00035/jm049024xb00035_1",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1097/00007691-200108000-00008",
      "volume": "23",
      "author": "Zaidenstein R.",
      "year": "2001",
      "journal-title": "Ther. Drug Monit."
    },
    {
      "key": "jm049024xb00036/jm049024xb00036_1",
      "first-page": "236",
      "volume-title": "Proceedings of the 7th North American ISSX Meeting",
      "volume": "10",
      "author": "Wong B. K.",
      "year": "1996"
    },
    {
      "key": "jm049024xb00037/jm049024xb00037_1",
      "first-page": "385",
      "volume-title": "Proceedings of the 7th North American ISSX Meeting",
      "volume": "10",
      "author": "Stearns R. A.",
      "year": "1996"
    },
    {
      "issue": "7",
      "key": "jm049024xb00038/jm049024xb00038_1",
      "first-page": "1056",
      "volume": "29",
      "author": "Yasar U.",
      "year": "2001",
      "journal-title": "Drug Metab. Dispos."
    },
    {
      "key": "jm049024xb00039/jm049024xb00039_1",
      "first-page": "296",
      "volume": "27",
      "author": "Bourrie M.",
      "year": "1999",
      "journal-title": "Drug Metab. Dispos."
    },
    {
      "key": "jm049024xb00040/jm049024xb00040_1",
      "doi-asserted-by": "crossref",
      "first-page": "857",
      "DOI": "10.1021/jm00145a002",
      "volume": "28",
      "author": "Goodford P. J",
      "year": "1985",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00041/jm049024xb00041_1",
      "doi-asserted-by": "crossref",
      "first-page": "5125",
      "DOI": "10.1021/jm0498349",
      "volume": "47",
      "author": "Carosati E.",
      "year": "2004",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00042/jm049024xb00042_1",
      "doi-asserted-by": "crossref",
      "first-page": "991",
      "DOI": "10.1021/jm981047m",
      "volume": "42",
      "author": "Mannhold R.",
      "year": "1999",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm049024xb00043/jm049024xb00043_1",
      "volume-title": "Molecular fields in quantitative structure-permeation relationships:\u2009 The VolSurf approach. J. Mol. Struct.:\u2009 THEOCHEM",
      "author": "Cruciani G.",
      "year": "2000"
    },
    {
      "issue": "12",
      "key": "jm049024xb00044/jm049024xb00044_1",
      "doi-asserted-by": "crossref",
      "first-page": "3201",
      "DOI": "10.1021/jm030986y",
      "volume": "47",
      "author": "Cianchetta G.",
      "year": "2004",
      "journal-title": "J. Med. Chem."
    },
    {
      "issue": "3",
      "key": "jm049024xb00045/jm049024xb00045_1",
      "doi-asserted-by": "crossref",
      "first-page": "166",
      "DOI": "10.1023/B:JCAM.0000035184.11906.c2",
      "volume": "18",
      "author": "Crivori P.",
      "year": "2004",
      "journal-title": "J. Comput.-Aided Mol. Des."
    },
    {
      "issue": "9",
      "key": "jm049024xb00046/jm049024xb00046_1",
      "first-page": "920",
      "volume": "20",
      "author": "Carb\u00f3-Dorca R.",
      "year": "1999",
      "journal-title": "J. Comput. Chem."
    }
  ],
  "container-title": "Journal of Medicinal Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/jm049024x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        9,
        24
      ]
    ],
    "date-time": "2021-09-24T03:40:52Z",
    "timestamp": 1632454852000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/jm049024x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2005,
        6,
        1
      ]
    ]
  },
  "references-count": 45,
  "journal-issue": {
    "issue": "13",
    "published-print": {
      "date-parts": [
        [
          2005,
          6,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/jm049024x"
  ],
  "URL": "http://dx.doi.org/10.1021/jm049024x",
  "relation": {},
  "ISSN": [
    "0022-2623",
    "1520-4804"
  ],
  "subject": [],
  "container-title-short": "J. Med. Chem.",
  "published": {
    "date-parts": [
      [
        2005,
        6,
        1
      ]
    ]
  }
}