DOI: 10.1021/jm030247h. Human β-Secretase (BACE) and BACE Inhibitors

Human β-Secretase (BACE) and BACE Inhibitors

10.1021/jm030247h

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

John, V., Beck, J. P., Bienkowski, M. J., Sinha, S., & Heinrikson, R. L. (2003). Human Î²-Secretase (BACE) and BACE Inhibitors. Journal of Medicinal Chemistry, 46(22), 4625â4630.

Authors 5

Varghese John (first)
James P. Beck (additional)
Michael J. Bienkowski (additional)
Sukanto Sinha (additional)
Robert L. Heinrikson (additional)

References 42 Referenced 124

10.1016/S0006-291X(84)80190-4 / Biochem. Biophys. Res. Commun. by Glenner G. G. (1984)
10.1126/science.286.5440.735 / Science by Vassar R. (1999)
10.1038/990114 / Nature by Yan R. (1999)
10.1038/990114 / Nature by Sinha S. (1999)
{'key': 'jm030247hb00005/jm030247hb00005_1', 'first-page': '234', 'volume': '4', 'author': 'Cai H.', 'year': '2001', 'journal-title': 'Nat. Neurosci.'} / Nat. Neurosci. by Cai H. (2001)
{'key': 'jm030247hb00006/jm030247hb00006_1', 'first-page': '36796', 'volume': '276', 'author': 'Yan R.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Yan R. (2001)
{'key': 'jm030247hb00007/jm030247hb00007_1', 'first-page': '10373', 'volume': '267', 'author': 'Shi X.-P.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Shi X.-P. (2001)
10.1093/hmg/10.12.1317 / Hum. Mol. Genet. by Roberds S. L. (2001)
{'key': 'jm030247hb00009/jm030247hb00009_1', 'first-page': '33737', 'volume': '275', 'author': 'Huse J. T.', 'year': '2000', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Huse J. T. (2000)
{'key': 'jm030247hb00010/jm030247hb00010_1', 'first-page': '37717', 'volume': '275', 'author': 'Bennett B. D.', 'year': '2000', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Bennett B. D. (2000)
10.1016/S0014-5793(00)01192-3 / FEBS Lett. by Acquati F. (2000)
10.1126/science.1691865 / Science by Sisodia S. S. (1990)
10.1126/science.1064638 / Science by Esler W. P. (2001)
10.1038/nrn785 / Nat. Rev. Neurosci. by Sisodia S. S. (2002)
10.1002/cbic.200200532 / ChemBioChem by Schmidt B (2003)
10.1126/science.290.5489.150 / Science by Hong L. (2000)
10.1021/jm0101803 / J. Med. Chem. by Ghosh A. K. (2001)
{'key': 'jm030247hb00017/jm030247hb00017_1', 'first-page': '262', 'volume': '45', 'author': 'Tung J. S.', 'year': '2002', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Tung J. S. (2002)
{'key': 'jm030247hb00018/jm030247hb00018_1', 'first-page': '1802', 'volume': '46', 'author': 'Hom R. K.', 'year': '2003', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Hom R. K. (2003)
{'key': 'jm030247hb00019/jm030247hb00019_1', 'volume-title': 'Patent WO 00/077030', 'author': 'John V.', 'year': '2000'} / Patent WO 00/077030 by John V. (2000)
{'key': 'jm030247hb00019/jm030247hb00019_2', 'volume-title': 'Patent WO 01/070672', 'author': 'Hom R.', 'year': '2001'} / Patent WO 01/070672 by Hom R. (2001)
{'key': 'jm030247hb00019/jm030247hb00019_3', 'volume-title': 'Patent WO 02/002505', 'author': 'Fang L. Y.', 'year': '2002'} / Patent WO 02/002505 by Fang L. Y. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_4', 'volume-title': 'Patent WO 02/002506', 'author': 'Fang L. Y.', 'year': '2002'} / Patent WO 02/002506 by Fang L. Y. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_5', 'volume-title': 'Patent WO 02/002512', 'author': 'Maillaird M.', 'year': '2002'} / Patent WO 02/002512 by Maillaird M. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_6', 'volume-title': 'Patent WO 02/002520', 'author': 'Beck J. P.', 'year': '2002'} / Patent WO 02/002520 by Beck J. P. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_7', 'volume-title': 'Patent WO 02/094768', 'author': 'Schostarez H.', 'year': '2002'} / Patent WO 02/094768 by Schostarez H. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_8', 'volume-title': 'Patent WO 02/098849', 'author': 'Freskos J. N.', 'year': '2002'} / Patent WO 02/098849 by Freskos J. N. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_9', 'volume-title': 'Patent WO 02/100399', 'author': 'Pulley S. R.', 'year': '2002'} / Patent WO 02/100399 by Pulley S. R. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_10', 'volume-title': 'Patent WO 02/100818', 'author': 'Schostarez H. J.', 'year': '2002'} / Patent WO 02/100818 by Schostarez H. J. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_11', 'volume-title': 'Patent WO 02/100820', 'author': 'Maillaird M.', 'year': '2002'} / Patent WO 02/100820 by Maillaird M. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_12', 'volume-title': 'Patent WO 02/100856', 'author': 'Pulley S. R.', 'year': '2002'} / Patent WO 02/100856 by Pulley S. R. (2002)
{'key': 'jm030247hb00019/jm030247hb00019_13', 'volume-title': 'Patent WO 03/002122', 'author': 'John V.', 'year': '2003'} / Patent WO 03/002122 by John V. (2003)
{'key': 'jm030247hb00019/jm030247hb00019_14', 'volume-title': 'Patent WO 03/006013', 'author': 'Schostarez H. J.', 'year': '2003'} / Patent WO 03/006013 by Schostarez H. J. (2003)
{'key': 'jm030247hb00019/jm030247hb00019_15', 'volume-title': 'Patent WO 03/006021', 'author': 'Schostarez H. J.', 'year': '2003'} / Patent WO 03/006021 by Schostarez H. J. (2003)
{'key': 'jm030247hb00019/jm030247hb00019_16', 'volume-title': 'Patent WO 03/006423', 'author': 'Gailunas A.', 'year': '2003'} / Patent WO 03/006423 by Gailunas A. (2003)
{'key': 'jm030247hb00019/jm030247hb00019_17', 'volume-title': 'Patent WO 03/006453', 'author': 'Schostarez J. H.', 'year': '2003'} / Patent WO 03/006453 by Schostarez J. H. (2003)
{'key': 'jm030247hb00019/jm030247hb00019_18', 'volume-title': 'Patent WO 03/027068', 'author': 'Gailunas A.', 'year': '2003'} / Patent WO 03/027068 by Gailunas A. (2003)
{'key': 'jm030247hb00020/jm030247hb00020_1', 'volume-title': 'Patent WO 02/53594', 'author': 'Tang J. N.', 'year': '2002'} / Patent WO 02/53594 by Tang J. N. (2002)
{'key': 'jm030247hb00020/jm030247hb00020_2', 'volume-title': 'Patent WO 01/00665', 'author': 'Tang J. J. N.', 'year': '2001'} / Patent WO 01/00665 by Tang J. J. N. (2001)
{'key': 'jm030247hb00021/jm030247hb00021_1', 'volume-title': 'Patent WO 01/187293', 'author': 'Miyamoto M.', 'year': '2001'} / Patent WO 01/187293 by Miyamoto M. (2001)
{'key': 'jm030247hb00022/jm030247hb00022_1', 'volume-title': 'Patent WO 02/96897', 'author': 'Qiao L.', 'year': '2002'} / Patent WO 02/96897 by Qiao L. (2002)
{'key': 'jm030247hb00023/jm030247hb00023_1', 'volume-title': 'Patent WO 02/88101', 'author': 'Bhisetti G. R.', 'year': '2002'} / Patent WO 02/88101 by Bhisetti G. R. (2002)

Dates

Type	When
Created	21 years, 10 months ago (Oct. 28, 2003, 8:04 a.m.)
Deposited	2 years, 5 months ago (March 24, 2023, 11:43 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 19, 2024, 10:57 a.m.)
Issued	21 years, 11 months ago (Sept. 24, 2003)
Published	21 years, 11 months ago (Sept. 24, 2003)
Published Online	21 years, 11 months ago (Sept. 24, 2003)
Published Print	21 years, 11 months ago (Oct. 1, 2003)

Funders 0

None

BibTeX

@article{John_2003, title={Human β-Secretase (BACE) and BACE Inhibitors}, volume={46}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm030247h}, DOI={10.1021/jm030247h}, number={22}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={John, Varghese and Beck, James P. and Bienkowski, Michael J. and Sinha, Sukanto and Heinrikson, Robert L.}, year={2003}, month=sep, pages={4625–4630} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        9,
        19
      ]
    ],
    "date-time": "2024-09-19T14:57:20Z",
    "timestamp": 1726757840537
  },
  "reference-count": 42,
  "publisher": "American Chemical Society (ACS)",
  "issue": "22",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        10,
        1
      ]
    ]
  },
  "DOI": "10.1021/jm030247h",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        10,
        28
      ]
    ],
    "date-time": "2003-10-28T13:04:06Z",
    "timestamp": 1067346246000
  },
  "page": "4625-4630",
  "source": "Crossref",
  "is-referenced-by-count": 124,
  "title": "Human \u03b2-Secretase (BACE) and BACE Inhibitors",
  "prefix": "10.1021",
  "volume": "46",
  "author": [
    {
      "given": "Varghese",
      "family": "John",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, and Pfizer Corporation, 301 Henrietta Street, Kalamazoo, Michigan 49007"
        }
      ]
    },
    {
      "given": "James P.",
      "family": "Beck",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, and Pfizer Corporation, 301 Henrietta Street, Kalamazoo, Michigan 49007"
        }
      ]
    },
    {
      "given": "Michael J.",
      "family": "Bienkowski",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, and Pfizer Corporation, 301 Henrietta Street, Kalamazoo, Michigan 49007"
        }
      ]
    },
    {
      "given": "Sukanto",
      "family": "Sinha",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, and Pfizer Corporation, 301 Henrietta Street, Kalamazoo, Michigan 49007"
        }
      ]
    },
    {
      "given": "Robert L.",
      "family": "Heinrikson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, California 94080, and Pfizer Corporation, 301 Henrietta Street, Kalamazoo, Michigan 49007"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2003,
        9,
        24
      ]
    ]
  },
  "reference": [
    {
      "key": "jm030247hb00001/jm030247hb00001_1",
      "doi-asserted-by": "crossref",
      "first-page": "890",
      "DOI": "10.1016/S0006-291X(84)80190-4",
      "volume": "120",
      "author": "Glenner G. G.",
      "year": "1984",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "jm030247hb00002/jm030247hb00002_1",
      "doi-asserted-by": "crossref",
      "first-page": "741",
      "DOI": "10.1126/science.286.5440.735",
      "volume": "286",
      "author": "Vassar R.",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "jm030247hb00003/jm030247hb00003_1",
      "doi-asserted-by": "crossref",
      "first-page": "537",
      "DOI": "10.1038/990114",
      "volume": "402",
      "author": "Yan R.",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "jm030247hb00004/jm030247hb00004_1",
      "doi-asserted-by": "crossref",
      "first-page": "540",
      "DOI": "10.1038/990114",
      "volume": "402",
      "author": "Sinha S.",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "jm030247hb00005/jm030247hb00005_1",
      "first-page": "234",
      "volume": "4",
      "author": "Cai H.",
      "year": "2001",
      "journal-title": "Nat. Neurosci."
    },
    {
      "key": "jm030247hb00006/jm030247hb00006_1",
      "first-page": "36796",
      "volume": "276",
      "author": "Yan R.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "jm030247hb00007/jm030247hb00007_1",
      "first-page": "10373",
      "volume": "267",
      "author": "Shi X.-P.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "jm030247hb00008/jm030247hb00008_1",
      "doi-asserted-by": "crossref",
      "first-page": "1324",
      "DOI": "10.1093/hmg/10.12.1317",
      "volume": "10",
      "author": "Roberds S. L.",
      "year": "2001",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "jm030247hb00009/jm030247hb00009_1",
      "first-page": "33737",
      "volume": "275",
      "author": "Huse J. T.",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "jm030247hb00010/jm030247hb00010_1",
      "first-page": "37717",
      "volume": "275",
      "author": "Bennett B. D.",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "jm030247hb00011/jm030247hb00011_1",
      "doi-asserted-by": "crossref",
      "first-page": "64",
      "DOI": "10.1016/S0014-5793(00)01192-3",
      "volume": "468",
      "author": "Acquati F.",
      "year": "2000",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "jm030247hb00012/jm030247hb00012_1",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1126/science.1691865",
      "volume": "248",
      "author": "Sisodia S. S.",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "jm030247hb00013/jm030247hb00013_1",
      "doi-asserted-by": "crossref",
      "first-page": "1454",
      "DOI": "10.1126/science.1064638",
      "volume": "293",
      "author": "Esler W. P.",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "jm030247hb00014/jm030247hb00014_1",
      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.1038/nrn785",
      "volume": "3",
      "author": "Sisodia S. S.",
      "year": "2002",
      "journal-title": "Nat. Rev. Neurosci."
    },
    {
      "key": "jm030247hb00014/jm030247hb00014_2",
      "doi-asserted-by": "crossref",
      "first-page": "378",
      "DOI": "10.1002/cbic.200200532",
      "volume": "4",
      "author": "Schmidt B",
      "year": "2003",
      "journal-title": "ChemBioChem"
    },
    {
      "key": "jm030247hb00015/jm030247hb00015_1",
      "doi-asserted-by": "crossref",
      "first-page": "153",
      "DOI": "10.1126/science.290.5489.150",
      "volume": "290",
      "author": "Hong L.",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "jm030247hb00016/jm030247hb00016_1",
      "doi-asserted-by": "crossref",
      "first-page": "2868",
      "DOI": "10.1021/jm0101803",
      "volume": "44",
      "author": "Ghosh A. K.",
      "year": "2001",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm030247hb00017/jm030247hb00017_1",
      "first-page": "262",
      "volume": "45",
      "author": "Tung J. S.",
      "year": "2002",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm030247hb00018/jm030247hb00018_1",
      "first-page": "1802",
      "volume": "46",
      "author": "Hom R. K.",
      "year": "2003",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_1",
      "volume-title": "Patent WO 00/077030",
      "author": "John V.",
      "year": "2000"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_2",
      "volume-title": "Patent WO 01/070672",
      "author": "Hom R.",
      "year": "2001"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_3",
      "volume-title": "Patent WO 02/002505",
      "author": "Fang L. Y.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_4",
      "volume-title": "Patent WO 02/002506",
      "author": "Fang L. Y.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_5",
      "volume-title": "Patent WO 02/002512",
      "author": "Maillaird M.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_6",
      "volume-title": "Patent WO 02/002520",
      "author": "Beck J. P.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_7",
      "volume-title": "Patent WO 02/094768",
      "author": "Schostarez H.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_8",
      "volume-title": "Patent WO 02/098849",
      "author": "Freskos J. N.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_9",
      "volume-title": "Patent WO 02/100399",
      "author": "Pulley S. R.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_10",
      "volume-title": "Patent WO 02/100818",
      "author": "Schostarez H. J.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_11",
      "volume-title": "Patent WO 02/100820",
      "author": "Maillaird M.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_12",
      "volume-title": "Patent WO 02/100856",
      "author": "Pulley S. R.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_13",
      "volume-title": "Patent WO 03/002122",
      "author": "John V.",
      "year": "2003"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_14",
      "volume-title": "Patent WO 03/006013",
      "author": "Schostarez H. J.",
      "year": "2003"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_15",
      "volume-title": "Patent WO 03/006021",
      "author": "Schostarez H. J.",
      "year": "2003"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_16",
      "volume-title": "Patent WO 03/006423",
      "author": "Gailunas A.",
      "year": "2003"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_17",
      "volume-title": "Patent WO 03/006453",
      "author": "Schostarez J. H.",
      "year": "2003"
    },
    {
      "key": "jm030247hb00019/jm030247hb00019_18",
      "volume-title": "Patent WO 03/027068",
      "author": "Gailunas A.",
      "year": "2003"
    },
    {
      "key": "jm030247hb00020/jm030247hb00020_1",
      "volume-title": "Patent WO 02/53594",
      "author": "Tang J. N.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00020/jm030247hb00020_2",
      "volume-title": "Patent WO 01/00665",
      "author": "Tang J. J. N.",
      "year": "2001"
    },
    {
      "key": "jm030247hb00021/jm030247hb00021_1",
      "volume-title": "Patent WO 01/187293",
      "author": "Miyamoto M.",
      "year": "2001"
    },
    {
      "key": "jm030247hb00022/jm030247hb00022_1",
      "volume-title": "Patent WO 02/96897",
      "author": "Qiao L.",
      "year": "2002"
    },
    {
      "key": "jm030247hb00023/jm030247hb00023_1",
      "volume-title": "Patent WO 02/88101",
      "author": "Bhisetti G. R.",
      "year": "2002"
    }
  ],
  "container-title": "Journal of Medicinal Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/jm030247h",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        3,
        24
      ]
    ],
    "date-time": "2023-03-24T15:43:06Z",
    "timestamp": 1679672586000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/jm030247h"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        9,
        24
      ]
    ]
  },
  "references-count": 42,
  "journal-issue": {
    "issue": "22",
    "published-print": {
      "date-parts": [
        [
          2003,
          10,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/jm030247h"
  ],
  "URL": "http://dx.doi.org/10.1021/jm030247h",
  "relation": {},
  "ISSN": [
    "0022-2623",
    "1520-4804"
  ],
  "subject": [],
  "container-title-short": "J. Med. Chem.",
  "published": {
    "date-parts": [
      [
        2003,
        9,
        24
      ]
    ]
  }
}