DOI: 10.1021/jm025553u. Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

10.1021/jm025553u

Crossref journal-article

American Chemical Society (ACS)

Journal of Medicinal Chemistry (316)

Bibliography

Zhuang, L., Wai, J. S., Embrey, M. W., Fisher, T. E., Egbertson, M. S., Payne, L. S., Guare, J. P., Vacca, J. P., Hazuda, D. J., Felock, P. J., Wolfe, A. L., Stillmock, K. A., Witmer, M. V., Moyer, G., Schleif, W. A., Gabryelski, L. J., Leonard, Y. M., Lynch, J. J., Michelson, S. R., & Young, S. D. (2003). Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells. Journal of Medicinal Chemistry, 46(4), 453â456.

Authors 20

Linghang Zhuang (first)
John S. Wai (additional)
Mark W. Embrey (additional)
Thorsten E. Fisher (additional)
Melissa S. Egbertson (additional)
Linda S. Payne (additional)
James P. Guare, (additional)
Joseph P. Vacca (additional)
Daria J. Hazuda (additional)
Peter J. Felock (additional)
Abigail L. Wolfe (additional)
Kara A. Stillmock (additional)
Marc V. Witmer (additional)
Gregory Moyer (additional)
William A. Schleif (additional)
Lori J. Gabryelski (additional)
Yvonne M. Leonard (additional)
Joseph J. Lynch, (additional)
Stuart R. Michelson (additional)
Steven D. Young (additional)

References 17 Referenced 241

{'key': 'jm025553ub00001/jm025553ub00001_1', 'first-page': '1199', 'volume': '10', 'year': '2000', 'journal-title': 'Expert Opin. Ther. Pat.'} / Expert Opin. Ther. Pat. (2000)
{'key': 'jm025553ub00002/jm025553ub00002_1', 'first-page': '477', 'volume': '7', 'year': '2000', 'journal-title': 'Curr. Med. Chem.'} / Curr. Med. Chem. (2000)
{'key': 'jm025553ub00003/jm025553ub00003_1', 'first-page': '333', 'volume': '52', 'year': '1999', 'journal-title': 'Adv. Virus Res.'} / Adv. Virus Res. (1999)
{'key': 'jm025553ub00004/jm025553ub00004_1', 'first-page': '4926', 'volume': '43', 'author': 'Wai J. S.', 'year': '2000', 'journal-title': 'J. Med. Chem.'} / J. Med. Chem. by Wai J. S. (2000)
10.1073/pnas.092056199 / Proc. Natl. Acad. Sci. U.S.A. by Grobler J. A. (2002)
10.1126/science.287.5453.646 / Science by Hazuda D. J. (2000)
{'key': 'jm025553ub00006/jm025553ub00006_1', 'first-page': '7011', 'volume': '71', 'author': 'Hazuda D. J.', 'year': '1997', 'journal-title': 'J. Virol.'} / J. Virol. by Hazuda D. J. (1997)
10.1016/0006-2952(96)00250-X / Biochem. Pharmacol. by Stanwell C. (1996)
{'key': 'jm025553ub00008/jm025553ub00008_1', 'volume-title': 'Preparation of 1,3-diaryl-1,3-propanediones as HIV integrase inhibitors. Patent WO0100578 A1', 'author': 'Payne L. S.'} / Preparation of 1,3-diaryl-1,3-propanediones as HIV integrase inhibitors. Patent WO0100578 A1 by Payne L. S.
{'key': 'jm025553ub00008/jm025553ub00008_2', 'volume-title': 'Preparation of aromatic heterocycle compounds having HIV integrase inhibiting activities. Patent WO0039086 A1', 'author': 'Fujishita T.'} / Preparation of aromatic heterocycle compounds having HIV integrase inhibiting activities. Patent WO0039086 A1 by Fujishita T.
10.1073/pnas.91.9.4096 / Proc. Natl. Acad. Sci. U.S.A. by Vacca J. P. (1994)
{'key': 'jm025553ub00011/jm025553ub00011_1', 'first-page': '513', 'volume': '505', 'author': 'Albert A.', 'year': '1954', 'journal-title': 'J. Chem. Soc.'} / J. Chem. Soc. by Albert A. (1954)
{'key': 'jm025553ub00013/jm025553ub00013_1', 'first-page': '1597', 'volume': '32', 'author': 'Read M. W.', 'year': '1995', 'journal-title': 'J. Heterocycl. Chem.'} / J. Heterocycl. Chem. by Read M. W. (1995)
{'key': 'jm025553ub00014/jm025553ub00014_1', 'first-page': '5942', 'volume': '25', 'author': 'Head R. A.', 'year': '1984', 'journal-title': 'Tetrahedron Lett.'} / Tetrahedron Lett. by Head R. A. (1984)
10.1080/00397919408010207 / Synth. Commun. by Smonou I (1994)
10.1021/jo01047a065 / J. Org. Chem. by Bliss A. D. (1963)
10.1016/S0040-4039(00)74321-8 / Tetrahedron Lett. by Cabri W. (1991)

Dates

Type	When
Created	22 years, 7 months ago (Feb. 6, 2003, 12:37 a.m.)
Deposited	2 years, 5 months ago (March 24, 2023, 11:36 a.m.)
Indexed	1 month ago (Aug. 6, 2025, 9:28 a.m.)
Issued	22 years, 7 months ago (Jan. 9, 2003)
Published	22 years, 7 months ago (Jan. 9, 2003)
Published Online	22 years, 7 months ago (Jan. 9, 2003)
Published Print	22 years, 7 months ago (Feb. 1, 2003)

Funders 0

None

BibTeX

@article{Zhuang_2003,_Vacca_Hazuda_Felock_et al._2003, title={Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells}, volume={46}, ISSN={1520-4804}, url={http://dx.doi.org/10.1021/jm025553u}, DOI={10.1021/jm025553u}, number={4}, journal={Journal of Medicinal Chemistry}, publisher={American Chemical Society (ACS)}, author={Zhuang, Linghang and Wai, John S. and Embrey, Mark W. and Fisher, Thorsten E. and Egbertson, Melissa S. and Payne, Linda S. and Guare, James P. and Vacca, Joseph P. and Hazuda, Daria J. and Felock, Peter J. and Wolfe, Abigail L. and Stillmock, Kara A. and Witmer, Marc V. and Moyer, Gregory and Schleif, William A. and Gabryelski, Lori J. and Leonard, Yvonne M. and Lynch, Joseph J. and Michelson, Stuart R. and Young, Steven D.}, year={2003}, month=jan, pages={453–456} }

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