DOI: 10.1021/ja9824425. Computational Study of Tunneling and Coupled Motion in Alcohol Dehydrogenase-Catalyzed Reactions: Implication for Measured Hydrogen and Carbon Isotope Effects

Computational Study of Tunneling and Coupled Motion in Alcohol Dehydrogenase-Catalyzed Reactions: Implication for Measured Hydrogen and Carbon Isotope Effects

10.1021/ja9824425

Crossref journal-article

American Chemical Society (ACS)

Journal of the American Chemical Society (316)

Authors 2

Joseph Rucker (first)
Judith P. Klinman (additional)

References 70 Referenced 66

10.1021/ja00287a030 / J. Am. Chem. Soc. by Saunders W. H., Jr. (1985)
10.1126/science.2466339 / Science by Cha Y. (1989)
{'key': 'ja9824425b00003/ja9824425b00003_1', 'volume-title': 'yeast alcohol dehydrogenase', 'author': 'The YADH'} / yeast alcohol dehydrogenase by The YADH
{'key': 'ja9824425b00004/ja9824425b00004_1', 'volume-title': 'Reaction Rates of Isotopic Molecules', 'author': 'Melander L.', 'year': '1987'} / Reaction Rates of Isotopic Molecules by Melander L. (1987)
10.1063/1.1746492 / J. Chem. Phys. by Bigeleisen J. (1947)
{'key': 'ja9824425b00006/ja9824425b00006_1', 'first-page': '678', 'volume': '17', 'author': 'Bigeleisen J.', 'year': '1949', 'journal-title': 'J. Chem. Phys.'} / J. Chem. Phys. by Bigeleisen J. (1949)
10.1021/cr60257a006 / Chem. Rev. by Caldin E. F. (1969)
10.1007/978-1-4899-2891-7 / The Tunnel Effect in Chemistry by Bell R. P. (1980)
{'key': 'ja9824425b00009/ja9824425b00009_1', 'first-page': '35', 'volume-title': 'Enzyme Mechanism from Isotope Effects', 'author': 'Sühnel J.', 'year': '1991'} / Enzyme Mechanism from Isotope Effects by Sühnel J. (1991)
10.1021/ja00760a014 / J. Am. Chem. Soc. by Schneider M. E. (1972)
{'key': 'ja9824425b00011/ja9824425b00011_1', 'first-page': '2814', 'volume': '60', 'author': 'Stern M. J.', 'year': '1974', 'journal-title': 'J. Chem. Phys.'} / J. Chem. Phys. by Stern M. J. (1974)
10.1021/ja00044a025 / J. Am. Chem. Soc. by Kim Y. (1992)
{'key': 'ja9824425b00013/ja9824425b00013_1', 'first-page': '6110', 'volume': '116', 'author': 'Lin S.', 'year': '1994', 'journal-title': 'J. Am. Chem. Soc.'} / J. Am. Chem. Soc. by Lin S. (1994)
10.1002/poc.610060703 / J. Phys. Org. Chem. by Amin M. (1993)
10.1021/bi00442a010 / Biochemistry by Grant K. L. (1989)
10.1021/bi00253a026 / Biochemistry by Jonsson T. (1994)
{'key': 'ja9824425b00017/ja9824425b00017_1', 'first-page': '148', 'volume-title': 'Enzyme Mechanism from Isotope Effects', 'author': 'Klinman J. P.', 'year': '1991'} / Enzyme Mechanism from Isotope Effects by Klinman J. P. (1991)
{'key': 'ja9824425b00018/ja9824425b00018_1', 'first-page': '5893', 'volume': '107', 'author': 'Swain C. G.', 'year': '1958', 'journal-title': 'J. Am. Chem. Soc.'} / J. Am. Chem. Soc. by Swain C. G. (1958)
{'key': 'ja9824425b00019/ja9824425b00019_1', 'first-page': '168', 'volume-title': 'Tritium in the Physical and Biological Sciences', 'author': 'Bigeleisen J.', 'year': '1962'} / Tritium in the Physical and Biological Sciences by Bigeleisen J. (1962)
10.1021/ja00748a004 / J. Am. Chem. Soc by Stern M. J. (1971)
{'key': 'ja9824425b00021/ja9824425b00021_1', 'first-page': '4344', 'volume': '90', 'author': 'Lewis E. S.', 'year': '1968', 'journal-title': 'J. Am. Chem. Soc.'} / J. Am. Chem. Soc. by Lewis E. S. (1968)
{'key': 'ja9824425b00022/ja9824425b00022_1', 'first-page': '2821', 'volume': '60', 'author': 'Stern M. J.', 'year': '1974', 'journal-title': 'J. Chem. Phys.'} / J. Chem. Phys. by Stern M. J. (1974)
10.1016/0045-2068(92)90021-T / Bioorg. Chem. by Grant K. L. (1992)
{'key': 'ja9824425b00024/ja9824425b00024_1', 'first-page': '2267', 'volume': '23', 'author': 'Bigeleisen J.', 'year': '1955', 'journal-title': 'J. Chem. Phys.'} / J. Chem. Phys. by Bigeleisen J. (1955)
10.1063/1.432064 / J. Chem. Phys. by Ishida T. (1976)
10.1021/ja00355a038 / J. Am. Chem. Soc. by Huskey W. P. (1983)
10.1063/1.1674461 / J. Chem. Phys. by Wolfsberg M. (1970)
10.1021/ja00364a026 / J. Am. Chem. Soc. by Ostovic D. (1983)
{'key': 'ja9824425b00029/ja9824425b00029_1', 'first-page': '5488', 'volume': '23', 'author': 'Hermes J. D.', 'year': '1984', 'journal-title': 'Biochemistry'} / Biochemistry by Hermes J. D. (1984)
10.1021/ja00335a077 / J. Am. Chem. Soc. by Hermes J. D. (1984)
10.1021/ja00532a036 / J. Am. Chem. Soc by Kurz L. C. (1980)
10.1002/poc.610040607 / Phys. Org. Chem. by Huskey W. P. (1991)
10.1021/ja00167a052 / J. Am. Chem. Soc. by Amin M. (1990)
{'key': 'ja9824425b00034/ja9824425b00034_1', 'first-page': '5507', 'volume': '31', 'author': 'Bahnson B. J.', 'year': '1993', 'journal-title': 'Biochemistry'} / Biochemistry by Bahnson B. J. (1993)
10.1021/bi960831a / J. Biochemistry by Alston W. C. (1996)
{'key': 'ja9824425b00036/ja9824425b00036_1', 'first-page': '264', 'volume-title': 'Enzyme Mechanism for Isotope Effects', 'author': 'Cleland W. W.', 'year': '1991'} / Enzyme Mechanism for Isotope Effects by Cleland W. W. (1991)
{'key': 'ja9824425b00037/ja9824425b00037_1', 'first-page': '259', 'volume-title': 'Isotope Effects:\u2009 Recent Developments in Theory and Experiment', 'volume': '6', 'author': 'Sims L. B.', 'year': '1984'} / Isotope Effects: Recent Developments in Theory and Experiment by Sims L. B. (1984)
{'key': 'ja9824425b00038/ja9824425b00038_1', 'first-page': '4124', 'volume': '45', 'author': 'Stern M. J.', 'year': '1966', 'journal-title': 'J. Chem. Phys.'} / J. Chem. Phys. by Stern M. J. (1966)
Huskey, W. P. Expression of the thermal adaptation of bacteria in the mechanism of lactate dehydrogenase action: experimental isotope effects and related theoretical studies. Ph.D. Dissertation, University of Kansas, 1985.
{'key': 'ja9824425b00040/ja9824425b00040_1', 'volume-title': 'Probes of hydrogen tunneling in enzyme-catalyzed reactions', 'author': 'Rucker J. B.', 'year': '1995'} / Probes of hydrogen tunneling in enzyme-catalyzed reactions by Rucker J. B. (1995)
{'key': 'ja9824425b00041/ja9824425b00041_1', 'first-page': '3143', 'volume': '71', 'author': 'Buddenbaum W. E.', 'year': '1967', 'journal-title': 'J. Phys. Chem.'} / J. Phys. Chem. by Buddenbaum W. E. (1967)
{'key': 'ja9824425b00042/ja9824425b00042_1', 'volume-title': 'IN', 'author': 'Sims L. B.', 'year': '1977'} / IN by Sims L. B. (1977)
10.1016/S0021-9258(20)81798-0 / J. Biol. Chem. by Klinman J. P. (1972)
10.1021/bi00654a032 / Biochemistry by Klinman J. P. (1976)
10.1021/bi00551a001 / Biochemistry by Welsh K. M. (1980)
10.1016/0304-5102(88)85043-0 / J. Mol. Catal. by Tapia O. (1988)
10.1002/qua.560390603 / Int. J. Quantum Chem. by Tapia O. (1991)
{'key': 'ja9824425b00048/ja9824425b00048_1', 'first-page': '5237', 'volume': '33', 'author': 'Ramaswamy S.', 'year': '1994', 'journal-title': 'Biochemistry'} / Biochemistry by Ramaswamy S. (1994)
10.1021/ja00237a051 / J. Am. Chem. Soc. by Wu Y.-D. (1987)
10.1021/ja00241a075 / J. Am. Chem. Soc. by Wu Y.-D. (1987)
10.1021/ja00220a058 / J. Am. Chem. Soc. by Tapia O. (1988)
10.1016/0009-2614(92)85221-U / Chem. Phys. Lett. by Tapia O. (1992)
10.1002/jcc.540110703 / J. Comput. Chem. by Cummins P. L. (1990)
{'key': 'ja9824425b00054/ja9824425b00054_1', 'first-page': '537', 'volume': '112', 'author': 'Williams I. H.', 'year': '1990', 'journal-title': 'J. Am. Chem. Soc.'} / J. Am. Chem. Soc. by Williams I. H. (1990)
{'key': 'ja9824425b00055/ja9824425b00055_1', 'first-page': '1825', 'volume': '20', 'author': 'Cook P. F.', 'year': '1981', 'journal-title': 'Biochemistry'} / Biochemistry by Cook P. F. (1981)
{'key': 'ja9824425b00056/ja9824425b00056_1', 'first-page': '5478', 'volume': '23', 'author': 'Schnarschmidt M.', 'year': '1984', 'journal-title': 'Biochemistry'} / Biochemistry by Schnarschmidt M. (1984)
{'key': 'ja9824425b00057/ja9824425b00057_1', 'first-page': '2332', 'volume': '80', 'author': 'Streitwieser A.', 'year': '1984', 'journal-title': 'J. Am. Chem. Soc.'} / J. Am. Chem. Soc. by Streitwieser A. (1984)
{'key': 'ja9824425b00058/ja9824425b00058_1', 'first-page': '454', 'volume': '415', 'author': 'Klinman J. P.', 'year': '1978', 'journal-title': 'Adv. Enzymol.'} / Adv. Enzymol. by Klinman J. P. (1978)
{'key': 'ja9824425b00060/ja9824425b00060_1', 'first-page': '9310', 'volume': '116', 'author': 'Jensen F.', 'year': '1994', 'journal-title': 'J. Am. Chem. Soc.'} / J. Am. Chem. Soc. by Jensen F. (1994)
10.1021/bi00161a030 / Biochemistry by Rucker J. (1992)
{'key': 'ja9824425b00062/ja9824425b00062_1', 'volume-title': 'Molecular Vibrations', 'author': 'Wilson E. B.', 'year': '1955'} / Molecular Vibrations by Wilson E. B. (1955)
{'key': 'ja9824425b00063/ja9824425b00063_1', 'first-page': '157', 'volume-title': 'Proceedings of the International Symposium on Isotope Separation', 'author': 'Bigeleisen J.', 'year': '1958'} / Proceedings of the International Symposium on Isotope Separation by Bigeleisen J. (1958)
10.1021/bi00010a015 / Biochemistry by Karsten W. E. (1995)
10.1021/bi00174a016 / Biochemistry by Karsten W. E. (1994)
10.1021/bi962128s / Biochemistry by Edens W. A. (1997)
{'key': 'ja9824425b00067/ja9824425b00067_1', 'first-page': '302', 'volume-title': 'The Enzyme Catalysis Process', 'author': 'Borgis D.', 'year': '1989'} / The Enzyme Catalysis Process by Borgis D. (1989)
10.1021/ja00021a003 / J. Am. Chem. Soc. by Kim Y. (1991)
10.1039/FD9929300225 / Faraday Discuss. by Warshel A. (1992)
{'key': 'ja9824425b00070/ja9824425b00070_1', 'first-page': '12802', 'volume': '94', 'author': 'Bahnson B. J.', 'year': '1997', 'journal-title': 'Proc. Natl. Acac. Sci.'} / Proc. Natl. Acac. Sci. by Bahnson B. J. (1997)
{'key': 'ja9824425b00071/ja9824425b00071_1', 'first-page': '4858', 'volume': '19', 'author': 'Cook P. F.', 'year': '1980', 'journal-title': 'Biochemistry'} / Biochemistry by Cook P. F. (1980)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 1:34 a.m.)
Deposited	3 years, 11 months ago (Sept. 22, 2021, 8:07 a.m.)
Indexed	1 year, 5 months ago (March 7, 2024, 4:18 p.m.)
Issued	26 years, 6 months ago (March 1, 1999)
Published	26 years, 6 months ago (March 1, 1999)
Published Online	26 years, 6 months ago (March 2, 1999)
Published Print	26 years, 6 months ago (March 1, 1999)

Funders 0

None

BibTeX

@article{Rucker_1999, title={Computational Study of Tunneling and Coupled Motion in Alcohol Dehydrogenase-Catalyzed Reactions: Implication for Measured Hydrogen and Carbon Isotope Effects}, volume={121}, ISSN={1520-5126}, url={http://dx.doi.org/10.1021/ja9824425}, DOI={10.1021/ja9824425}, number={10}, journal={Journal of the American Chemical Society}, publisher={American Chemical Society (ACS)}, author={Rucker, Joseph and Klinman, Judith P.}, year={1999}, month=mar, pages={1997–2006} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        3,
        7
      ]
    ],
    "date-time": "2024-03-07T21:18:28Z",
    "timestamp": 1709846308401
  },
  "reference-count": 70,
  "publisher": "American Chemical Society (ACS)",
  "issue": "10",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1999,
        3,
        1
      ]
    ]
  },
  "DOI": "10.1021/ja9824425",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T05:34:40Z",
    "timestamp": 1027661680000
  },
  "page": "1997-2006",
  "source": "Crossref",
  "is-referenced-by-count": 66,
  "title": "Computational Study of Tunneling and Coupled Motion in Alcohol Dehydrogenase-Catalyzed Reactions:\u2009 Implication for Measured Hydrogen and Carbon Isotope Effects",
  "prefix": "10.1021",
  "volume": "121",
  "author": [
    {
      "given": "Joseph",
      "family": "Rucker",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Contribution from the Department of Chemistry, University of California, Berkeley, California 94720"
        }
      ]
    },
    {
      "given": "Judith P.",
      "family": "Klinman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Contribution from the Department of Chemistry, University of California, Berkeley, California 94720"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        1999,
        3,
        2
      ]
    ]
  },
  "reference": [
    {
      "key": "ja9824425b00001/ja9824425b00001_1",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1021/ja00287a030",
      "volume": "107",
      "author": "Saunders W. H., Jr.",
      "year": "1985",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00002/ja9824425b00002_1",
      "doi-asserted-by": "crossref",
      "first-page": "1330",
      "DOI": "10.1126/science.2466339",
      "volume": "243",
      "author": "Cha Y.",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "ja9824425b00003/ja9824425b00003_1",
      "volume-title": "yeast alcohol dehydrogenase",
      "author": "The YADH"
    },
    {
      "key": "ja9824425b00004/ja9824425b00004_1",
      "volume-title": "Reaction Rates of Isotopic Molecules",
      "author": "Melander L.",
      "year": "1987"
    },
    {
      "key": "ja9824425b00005/ja9824425b00005_1",
      "doi-asserted-by": "crossref",
      "first-page": "267",
      "DOI": "10.1063/1.1746492",
      "volume": "15",
      "author": "Bigeleisen J.",
      "year": "1947",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "ja9824425b00006/ja9824425b00006_1",
      "first-page": "678",
      "volume": "17",
      "author": "Bigeleisen J.",
      "year": "1949",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "ja9824425b00007/ja9824425b00007_1",
      "doi-asserted-by": "crossref",
      "first-page": "156",
      "DOI": "10.1021/cr60257a006",
      "volume": "69",
      "author": "Caldin E. F.",
      "year": "1969",
      "journal-title": "Chem. Rev."
    },
    {
      "key": "ja9824425b00008/ja9824425b00008_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1007/978-1-4899-2891-7",
      "volume-title": "The Tunnel Effect in Chemistry",
      "author": "Bell R. P.",
      "year": "1980"
    },
    {
      "key": "ja9824425b00009/ja9824425b00009_1",
      "first-page": "35",
      "volume-title": "Enzyme Mechanism from Isotope Effects",
      "author": "S\u00fchnel J.",
      "year": "1991"
    },
    {
      "key": "ja9824425b00010/ja9824425b00010_1",
      "doi-asserted-by": "crossref",
      "first-page": "1522",
      "DOI": "10.1021/ja00760a014",
      "volume": "94",
      "author": "Schneider M. E.",
      "year": "1972",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00011/ja9824425b00011_1",
      "first-page": "2814",
      "volume": "60",
      "author": "Stern M. J.",
      "year": "1974",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "ja9824425b00012/ja9824425b00012_1",
      "doi-asserted-by": "crossref",
      "first-page": "7123",
      "DOI": "10.1021/ja00044a025",
      "volume": "114",
      "author": "Kim Y.",
      "year": "1992",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00013/ja9824425b00013_1",
      "first-page": "6110",
      "volume": "116",
      "author": "Lin S.",
      "year": "1994",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00014/ja9824425b00014_1",
      "doi-asserted-by": "crossref",
      "first-page": "398",
      "DOI": "10.1002/poc.610060703",
      "volume": "6",
      "author": "Amin M.",
      "year": "1993",
      "journal-title": "J. Phys. Org. Chem."
    },
    {
      "key": "ja9824425b00015/ja9824425b00015_1",
      "doi-asserted-by": "crossref",
      "first-page": "6605",
      "DOI": "10.1021/bi00442a010",
      "volume": "28",
      "author": "Grant K. L.",
      "year": "1989",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00016/ja9824425b00016_1",
      "doi-asserted-by": "crossref",
      "first-page": "14878",
      "DOI": "10.1021/bi00253a026",
      "volume": "33",
      "author": "Jonsson T.",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00017/ja9824425b00017_1",
      "first-page": "148",
      "volume-title": "Enzyme Mechanism from Isotope Effects",
      "author": "Klinman J. P.",
      "year": "1991"
    },
    {
      "key": "ja9824425b00018/ja9824425b00018_1",
      "first-page": "5893",
      "volume": "107",
      "author": "Swain C. G.",
      "year": "1958",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00019/ja9824425b00019_1",
      "first-page": "168",
      "volume-title": "Tritium in the Physical and Biological Sciences",
      "author": "Bigeleisen J.",
      "year": "1962"
    },
    {
      "key": "ja9824425b00020/ja9824425b00020_1",
      "doi-asserted-by": "crossref",
      "first-page": "4675",
      "DOI": "10.1021/ja00748a004",
      "volume": "93",
      "author": "Stern M. J.",
      "year": "1971",
      "journal-title": "J. Am. Chem. Soc"
    },
    {
      "key": "ja9824425b00021/ja9824425b00021_1",
      "first-page": "4344",
      "volume": "90",
      "author": "Lewis E. S.",
      "year": "1968",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00022/ja9824425b00022_1",
      "first-page": "2821",
      "volume": "60",
      "author": "Stern M. J.",
      "year": "1974",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "ja9824425b00023/ja9824425b00023_1",
      "doi-asserted-by": "crossref",
      "first-page": "8",
      "DOI": "10.1016/0045-2068(92)90021-T",
      "volume": "20",
      "author": "Grant K. L.",
      "year": "1992",
      "journal-title": "Bioorg. Chem."
    },
    {
      "key": "ja9824425b00024/ja9824425b00024_1",
      "first-page": "2267",
      "volume": "23",
      "author": "Bigeleisen J.",
      "year": "1955",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "ja9824425b00025/ja9824425b00025_1",
      "doi-asserted-by": "crossref",
      "first-page": "4789",
      "DOI": "10.1063/1.432064",
      "volume": "64",
      "author": "Ishida T.",
      "year": "1976",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "ja9824425b00026/ja9824425b00026_1",
      "doi-asserted-by": "crossref",
      "first-page": "5706",
      "DOI": "10.1021/ja00355a038",
      "volume": "105",
      "author": "Huskey W. P.",
      "year": "1983",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00027/ja9824425b00027_1",
      "doi-asserted-by": "crossref",
      "first-page": "3146",
      "DOI": "10.1063/1.1674461",
      "volume": "53",
      "author": "Wolfsberg M.",
      "year": "1970",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "ja9824425b00028/ja9824425b00028_1",
      "doi-asserted-by": "crossref",
      "first-page": "7631",
      "DOI": "10.1021/ja00364a026",
      "volume": "105",
      "author": "Ostovic D.",
      "year": "1983",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00029/ja9824425b00029_1",
      "first-page": "5488",
      "volume": "23",
      "author": "Hermes J. D.",
      "year": "1984",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00030/ja9824425b00030_1",
      "doi-asserted-by": "crossref",
      "first-page": "7264",
      "DOI": "10.1021/ja00335a077",
      "volume": "106",
      "author": "Hermes J. D.",
      "year": "1984",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00031/ja9824425b00031_1",
      "doi-asserted-by": "crossref",
      "first-page": "4203",
      "DOI": "10.1021/ja00532a036",
      "volume": "102",
      "author": "Kurz L. C.",
      "year": "1980",
      "journal-title": "J. Am. Chem. Soc"
    },
    {
      "key": "ja9824425b00032/ja9824425b00032_1",
      "doi-asserted-by": "crossref",
      "first-page": "366",
      "DOI": "10.1002/poc.610040607",
      "volume": "4",
      "author": "Huskey W. P.",
      "year": "1991",
      "journal-title": "Phys. Org. Chem."
    },
    {
      "key": "ja9824425b00033/ja9824425b00033_1",
      "doi-asserted-by": "crossref",
      "first-page": "4471",
      "DOI": "10.1021/ja00167a052",
      "volume": "112",
      "author": "Amin M.",
      "year": "1990",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00034/ja9824425b00034_1",
      "first-page": "5507",
      "volume": "31",
      "author": "Bahnson B. J.",
      "year": "1993",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00035/ja9824425b00035_1",
      "doi-asserted-by": "crossref",
      "first-page": "12881",
      "DOI": "10.1021/bi960831a",
      "volume": "35",
      "author": "Alston W. C.",
      "year": "1996",
      "journal-title": "J. Biochemistry"
    },
    {
      "key": "ja9824425b00036/ja9824425b00036_1",
      "first-page": "264",
      "volume-title": "Enzyme Mechanism for Isotope Effects",
      "author": "Cleland W. W.",
      "year": "1991"
    },
    {
      "key": "ja9824425b00037/ja9824425b00037_1",
      "first-page": "259",
      "volume-title": "Isotope Effects:\u2009 Recent Developments in Theory and Experiment",
      "volume": "6",
      "author": "Sims L. B.",
      "year": "1984"
    },
    {
      "key": "ja9824425b00038/ja9824425b00038_1",
      "first-page": "4124",
      "volume": "45",
      "author": "Stern M. J.",
      "year": "1966",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "ja9824425b00039/ja9824425b00039_1",
      "unstructured": "Huskey, W. P. Expression of the thermal adaptation of bacteria in the mechanism of lactate dehydrogenase action:\u2009 experimental isotope effects and related theoretical studies. Ph.D. Dissertation, University of Kansas, 1985."
    },
    {
      "key": "ja9824425b00040/ja9824425b00040_1",
      "volume-title": "Probes of hydrogen tunneling in enzyme-catalyzed reactions",
      "author": "Rucker J. B.",
      "year": "1995"
    },
    {
      "key": "ja9824425b00041/ja9824425b00041_1",
      "first-page": "3143",
      "volume": "71",
      "author": "Buddenbaum W. E.",
      "year": "1967",
      "journal-title": "J. Phys. Chem."
    },
    {
      "key": "ja9824425b00042/ja9824425b00042_1",
      "volume-title": "IN",
      "author": "Sims L. B.",
      "year": "1977"
    },
    {
      "key": "ja9824425b00043/ja9824425b00043_1",
      "doi-asserted-by": "crossref",
      "first-page": "7987",
      "DOI": "10.1016/S0021-9258(20)81798-0",
      "volume": "247",
      "author": "Klinman J. P.",
      "year": "1972",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "ja9824425b00044/ja9824425b00044_1",
      "doi-asserted-by": "crossref",
      "first-page": "2026",
      "DOI": "10.1021/bi00654a032",
      "volume": "15",
      "author": "Klinman J. P.",
      "year": "1976",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00045/ja9824425b00045_1",
      "doi-asserted-by": "crossref",
      "first-page": "2016",
      "DOI": "10.1021/bi00551a001",
      "volume": "19",
      "author": "Welsh K. M.",
      "year": "1980",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00046/ja9824425b00046_1",
      "doi-asserted-by": "crossref",
      "first-page": "210",
      "DOI": "10.1016/0304-5102(88)85043-0",
      "volume": "47",
      "author": "Tapia O.",
      "year": "1988",
      "journal-title": "J. Mol. Catal."
    },
    {
      "key": "ja9824425b00047/ja9824425b00047_1",
      "doi-asserted-by": "crossref",
      "first-page": "786",
      "DOI": "10.1002/qua.560390603",
      "volume": "39",
      "author": "Tapia O.",
      "year": "1991",
      "journal-title": "Int. J. Quantum Chem."
    },
    {
      "key": "ja9824425b00048/ja9824425b00048_1",
      "first-page": "5237",
      "volume": "33",
      "author": "Ramaswamy S.",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00049/ja9824425b00049_1",
      "doi-asserted-by": "crossref",
      "first-page": "908",
      "DOI": "10.1021/ja00237a051",
      "volume": "109",
      "author": "Wu Y.-D.",
      "year": "1987",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00050/ja9824425b00050_1",
      "doi-asserted-by": "crossref",
      "first-page": "2227",
      "DOI": "10.1021/ja00241a075",
      "volume": "109",
      "author": "Wu Y.-D.",
      "year": "1987",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00051/ja9824425b00051_1",
      "doi-asserted-by": "crossref",
      "first-page": "4047",
      "DOI": "10.1021/ja00220a058",
      "volume": "110",
      "author": "Tapia O.",
      "year": "1988",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00052/ja9824425b00052_1",
      "doi-asserted-by": "crossref",
      "first-page": "400",
      "DOI": "10.1016/0009-2614(92)85221-U",
      "volume": "189",
      "author": "Tapia O.",
      "year": "1992",
      "journal-title": "Chem. Phys. Lett."
    },
    {
      "key": "ja9824425b00053/ja9824425b00053_1",
      "doi-asserted-by": "crossref",
      "first-page": "804",
      "DOI": "10.1002/jcc.540110703",
      "volume": "11",
      "author": "Cummins P. L.",
      "year": "1990",
      "journal-title": "J. Comput. Chem."
    },
    {
      "key": "ja9824425b00054/ja9824425b00054_1",
      "first-page": "537",
      "volume": "112",
      "author": "Williams I. H.",
      "year": "1990",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00055/ja9824425b00055_1",
      "first-page": "1825",
      "volume": "20",
      "author": "Cook P. F.",
      "year": "1981",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00056/ja9824425b00056_1",
      "first-page": "5478",
      "volume": "23",
      "author": "Schnarschmidt M.",
      "year": "1984",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00057/ja9824425b00057_1",
      "first-page": "2332",
      "volume": "80",
      "author": "Streitwieser A.",
      "year": "1984",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00058/ja9824425b00058_1",
      "first-page": "454",
      "volume": "415",
      "author": "Klinman J. P.",
      "year": "1978",
      "journal-title": "Adv. Enzymol."
    },
    {
      "key": "ja9824425b00060/ja9824425b00060_1",
      "first-page": "9310",
      "volume": "116",
      "author": "Jensen F.",
      "year": "1994",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00061/ja9824425b00061_1",
      "doi-asserted-by": "crossref",
      "first-page": "11499",
      "DOI": "10.1021/bi00161a030",
      "volume": "31",
      "author": "Rucker J.",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00062/ja9824425b00062_1",
      "volume-title": "Molecular Vibrations",
      "author": "Wilson E. B.",
      "year": "1955"
    },
    {
      "key": "ja9824425b00063/ja9824425b00063_1",
      "first-page": "157",
      "volume-title": "Proceedings of the International Symposium on Isotope Separation",
      "author": "Bigeleisen J.",
      "year": "1958"
    },
    {
      "key": "ja9824425b00064/ja9824425b00064_1",
      "doi-asserted-by": "crossref",
      "first-page": "3260",
      "DOI": "10.1021/bi00010a015",
      "volume": "34",
      "author": "Karsten W. E.",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00065/ja9824425b00065_1",
      "doi-asserted-by": "crossref",
      "first-page": "2103",
      "DOI": "10.1021/bi00174a016",
      "volume": "33",
      "author": "Karsten W. E.",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00066/ja9824425b00066_1",
      "doi-asserted-by": "crossref",
      "first-page": "1147",
      "DOI": "10.1021/bi962128s",
      "volume": "36",
      "author": "Edens W. A.",
      "year": "1997",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ja9824425b00067/ja9824425b00067_1",
      "first-page": "302",
      "volume-title": "The Enzyme Catalysis Process",
      "author": "Borgis D.",
      "year": "1989"
    },
    {
      "key": "ja9824425b00068/ja9824425b00068_1",
      "doi-asserted-by": "crossref",
      "first-page": "7847",
      "DOI": "10.1021/ja00021a003",
      "volume": "113",
      "author": "Kim Y.",
      "year": "1991",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja9824425b00069/ja9824425b00069_1",
      "doi-asserted-by": "crossref",
      "first-page": "238",
      "DOI": "10.1039/FD9929300225",
      "volume": "93",
      "author": "Warshel A.",
      "year": "1992",
      "journal-title": "Faraday Discuss."
    },
    {
      "key": "ja9824425b00070/ja9824425b00070_1",
      "first-page": "12802",
      "volume": "94",
      "author": "Bahnson B. J.",
      "year": "1997",
      "journal-title": "Proc. Natl. Acac. Sci."
    },
    {
      "key": "ja9824425b00071/ja9824425b00071_1",
      "first-page": "4858",
      "volume": "19",
      "author": "Cook P. F.",
      "year": "1980",
      "journal-title": "Biochemistry"
    }
  ],
  "container-title": "Journal of the American Chemical Society",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/ja9824425",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        9,
        22
      ]
    ],
    "date-time": "2021-09-22T12:07:54Z",
    "timestamp": 1632312474000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/ja9824425"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1999,
        3,
        1
      ]
    ]
  },
  "references-count": 70,
  "journal-issue": {
    "issue": "10",
    "published-print": {
      "date-parts": [
        [
          1999,
          3,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/ja9824425"
  ],
  "URL": "http://dx.doi.org/10.1021/ja9824425",
  "relation": {},
  "ISSN": [
    "0002-7863",
    "1520-5126"
  ],
  "subject": [],
  "container-title-short": "J. Am. Chem. Soc.",
  "published": {
    "date-parts": [
      [
        1999,
        3,
        1
      ]
    ]
  }
}