DOI: 10.1021/ja0680257. Organically Modified Silica Nanoparticles Co-encapsulating Photosensitizing Drug and Aggregation-Enhanced Two-Photon Absorbing Fluorescent Dye Aggregates for Two-Photon Photodynamic Therapy

Organically Modified Silica Nanoparticles Co-encapsulating Photosensitizing Drug and Aggregation-Enhanced Two-Photon Absorbing Fluorescent Dye Aggregates for Two-Photon Photodynamic Therapy

10.1021/ja0680257

Crossref journal-article

American Chemical Society (ACS)

Journal of the American Chemical Society (316)

Bibliography

Kim, S., Ohulchanskyy, T. Y., Pudavar, H. E., Pandey, R. K., & Prasad, P. N. (2007). Organically Modified Silica Nanoparticles Co-encapsulating Photosensitizing Drug and Aggregation-Enhanced Two-Photon Absorbing Fluorescent Dye Aggregates for Two-Photon Photodynamic Therapy. Journal of the American Chemical Society, 129(9), 2669â2675.

Authors 5

Sehoon Kim (first)
Tymish Y. Ohulchanskyy (additional)
Haridas E. Pudavar (additional)
Ravindra K. Pandey (additional)
Paras N. Prasad (additional)

References 39 Referenced 623

10.1002/0471465380 / Introduction to Biophotonics by Prasad P. N. (2003)
10.1111/j.1751-1097.1987.tb07898.x / J. Photochem. Photobiol. by Dougherty T. (1987)
10.1111/j.1751-1097.1992.tb04222.x / J. Photochem. Photobiol. by Henderson B. W. (1992)
10.1111/j.1751-1097.1996.tb01828.x / Photochem. Photobiol. by Levy J. G. (1996)
10.1111/j.1751-1097.1997.tb08636.x / Photochem. Photobiol. by Fisher W. G. (1997)
10.1109/2944.983301 / IEEE J. Sel. Top. Quantum Electron. by Karotki A. (2001)
10.1021/ja003468a / J. Am. Chem. Soc. by Frederiksen P. K. (2001)
10.1364/JOSAB.20.000321 / J. Opt. Soc. Am. B by Karotki A. (2003)
10.1021/ja0452020 / J. Am. Chem. Soc. by Frederiksen P. K. (2005)
10.1021/jo0482099 / J. Org. Chem. by Mcllroy S. P. (2005)
10.1089/clm.1997.15.201 / J. Clin. Laser Med. Surg. by Bhawalkar J. D. (1997)
10.1021/ja031647x / J. Am. Chem. Soc. by Dichtel W. R. (2004)
10.1021/cm047825i / Chem. Mater. by Oar M. A. (2005)
10.1016/S1011-1344(01)00267-6 / J. Photochem. Photobiol., B by Konan Y. N. (2002)
10.1016/j.addr.2003.07.013 / Adv. Drug Deliv. Rev. by van Nostrum C. F. (2004)
10.1039/b311429e / J. Mater. Chem. by Wang S. (2004)
10.1016/S0168-3659(99)00248-5 / J. Control. Release by Maeda H. (2000)
Prasad, P. N.Nanophotonics; John Wiley & Sons: Hoboken, New Jersey, 2004.
{'key': 'ja0680257b00008/ja0680257b00008_1', 'first-page': '109', 'volume': '15', 'author': 'Shimada M.', 'year': '1995', 'journal-title': 'Anticancer Res.'} / Anticancer Res. by Shimada M. (1995)
10.1021/cm000178k / Chem. Mater. by Lal M. (2000)
10.1002/adma.200305622 / Adv. Mater. by Zhao X. (2004)
10.1021/ja973849x / J. Am. Chem. Soc. by Jain T. K. (1998)
10.1073/pnas.0408039101 / Natl. Acad. Sci. U.S.A. by Roy I. (2005)
10.1021/ja0343095 / J. Am. Chem. Soc. by Roy I. (2003)
10.1021/ja003959v / J. Am. Chem. Soc. by Levitus M. (2001)
10.1063/1.1345840 / Appl. Phys. Lett. by Belton C. (2001)
10.1039/b105159h / Chem. Commun. by Luo J. (2001)
10.1021/ja0269082 / J. Am. Chem. Soc. by An B.-K. (2002)
10.1021/ja028674s / J. Am. Chem. Soc. by Xiao D. (2003)
10.1039/b311648d / Chem. Commun. by Ryu S. Y. (2004)
10.1002/anie.200461172 / Angew. Chem., Int. Ed. by Lim S.-J. (2004)
10.1002/adfm.200500928 / Adv. Funct. Mater. by Kim S. (2006)
{'key': 'ja0680257b00013/ja0680257b00013_1', 'first-page': '4000', 'volume': '57', 'author': 'Henderson B. W.', 'year': '1997', 'journal-title': 'J. Cancer Res.'} / J. Cancer Res. by Henderson B. W. (1997)
10.1002/jemt.10421 / Microsc. Res. Tech. by Becker W. (2004)
{'key': 'ja0680257b00014/ja0680257b00014_2', 'volume-title': 'Proc. SPIE-Int. Soc. Opt. Eng.', 'author': 'Becker W.', 'year': '2004'} / Proc. SPIE-Int. Soc. Opt. Eng. by Becker W. (2004)
10.1002/1521-3773(20011203)40:23<4330::AID-ANIE4330>3.0.CO;2-W / Angew. Chem., Int. Ed. by Horn D. (2001)
10.1021/ja00537a030 / J. Am. Chem. Soc. by Lindig B. A. (1980)
10.1017/S1431927606060235 / Microsc. Microanal. by Rizzo M. A. (2006)
10.1016/S1011-1344(97)00070-5 / J. Photochem. Photobiol., B by Mekler V. M. (1997)

Dates

Type	When
Created	18 years, 6 months ago (Feb. 9, 2007, 5:56 a.m.)
Deposited	3 years, 11 months ago (Sept. 21, 2021, 4:06 a.m.)
Indexed	3 days, 2 hours ago (Aug. 26, 2025, 2:40 a.m.)
Issued	18 years, 6 months ago (Feb. 9, 2007)
Published	18 years, 6 months ago (Feb. 9, 2007)
Published Online	18 years, 6 months ago (Feb. 9, 2007)
Published Print	18 years, 5 months ago (March 1, 2007)

Funders 0

None

BibTeX

@article{Kim_2007, title={Organically Modified Silica Nanoparticles Co-encapsulating Photosensitizing Drug and Aggregation-Enhanced Two-Photon Absorbing Fluorescent Dye Aggregates for Two-Photon Photodynamic Therapy}, volume={129}, ISSN={1520-5126}, url={http://dx.doi.org/10.1021/ja0680257}, DOI={10.1021/ja0680257}, number={9}, journal={Journal of the American Chemical Society}, publisher={American Chemical Society (ACS)}, author={Kim, Sehoon and Ohulchanskyy, Tymish Y. and Pudavar, Haridas E. and Pandey, Ravindra K. and Prasad, Paras N.}, year={2007}, month=feb, pages={2669–2675} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        26
      ]
    ],
    "date-time": "2025-08-26T06:40:04Z",
    "timestamp": 1756190404569
  },
  "reference-count": 39,
  "publisher": "American Chemical Society (ACS)",
  "issue": "9",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        3,
        1
      ]
    ]
  },
  "DOI": "10.1021/ja0680257",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        2,
        9
      ]
    ],
    "date-time": "2007-02-09T10:56:27Z",
    "timestamp": 1171018587000
  },
  "page": "2669-2675",
  "source": "Crossref",
  "is-referenced-by-count": 623,
  "title": "Organically Modified Silica Nanoparticles Co-encapsulating Photosensitizing Drug and Aggregation-Enhanced Two-Photon Absorbing Fluorescent Dye Aggregates for Two-Photon Photodynamic Therapy",
  "prefix": "10.1021",
  "volume": "129",
  "author": [
    {
      "given": "Sehoon",
      "family": "Kim",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Contribution from the Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, and Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263"
        }
      ]
    },
    {
      "given": "Tymish Y.",
      "family": "Ohulchanskyy",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Contribution from the Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, and Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263"
        }
      ]
    },
    {
      "given": "Haridas E.",
      "family": "Pudavar",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Contribution from the Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, and Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263"
        }
      ]
    },
    {
      "given": "Ravindra K.",
      "family": "Pandey",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Contribution from the Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, and Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263"
        }
      ]
    },
    {
      "given": "Paras N.",
      "family": "Prasad",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Contribution from the Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, and Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2007,
        2,
        9
      ]
    ]
  },
  "reference": [
    {
      "key": "ja0680257b00001/ja0680257b00001_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1002/0471465380",
      "volume-title": "Introduction to Biophotonics",
      "author": "Prasad P. N.",
      "year": "2003"
    },
    {
      "key": "ja0680257b00002/ja0680257b00002_1",
      "doi-asserted-by": "crossref",
      "first-page": "879",
      "DOI": "10.1111/j.1751-1097.1987.tb07898.x",
      "volume": "45",
      "author": "Dougherty T.",
      "year": "1987",
      "journal-title": "J. Photochem. Photobiol."
    },
    {
      "key": "ja0680257b00002/ja0680257b00002_2",
      "doi-asserted-by": "crossref",
      "first-page": "145",
      "DOI": "10.1111/j.1751-1097.1992.tb04222.x",
      "volume": "55",
      "author": "Henderson B. W.",
      "year": "1992",
      "journal-title": "J. Photochem. Photobiol."
    },
    {
      "key": "ja0680257b00002/ja0680257b00002_3",
      "doi-asserted-by": "crossref",
      "first-page": "737",
      "DOI": "10.1111/j.1751-1097.1996.tb01828.x",
      "volume": "64",
      "author": "Levy J. G.",
      "year": "1996",
      "journal-title": "Photochem. Photobiol."
    },
    {
      "key": "ja0680257b00003/ja0680257b00003_1",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1111/j.1751-1097.1997.tb08636.x",
      "volume": "66",
      "author": "Fisher W. G.",
      "year": "1997",
      "journal-title": "Photochem. Photobiol."
    },
    {
      "key": "ja0680257b00003/ja0680257b00003_2",
      "doi-asserted-by": "crossref",
      "first-page": "971",
      "DOI": "10.1109/2944.983301",
      "volume": "7",
      "author": "Karotki A.",
      "year": "2001",
      "journal-title": "IEEE J. Sel. Top. Quantum Electron."
    },
    {
      "key": "ja0680257b00003/ja0680257b00003_3",
      "doi-asserted-by": "crossref",
      "first-page": "1215",
      "DOI": "10.1021/ja003468a",
      "volume": "123",
      "author": "Frederiksen P. K.",
      "year": "2001",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00003/ja0680257b00003_4",
      "doi-asserted-by": "crossref",
      "first-page": "321",
      "DOI": "10.1364/JOSAB.20.000321",
      "volume": "20",
      "author": "Karotki A.",
      "year": "2003",
      "journal-title": "J. Opt. Soc. Am. B"
    },
    {
      "key": "ja0680257b00003/ja0680257b00003_5",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1021/ja0452020",
      "volume": "127",
      "author": "Frederiksen P. K.",
      "year": "2005",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00003/ja0680257b00003_6",
      "doi-asserted-by": "crossref",
      "first-page": "1134",
      "DOI": "10.1021/jo0482099",
      "volume": "70",
      "author": "Mcllroy S. P.",
      "year": "2005",
      "journal-title": "J. Org. Chem."
    },
    {
      "key": "ja0680257b00004/ja0680257b00004_1",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1089/clm.1997.15.201",
      "volume": "15",
      "author": "Bhawalkar J. D.",
      "year": "1997",
      "journal-title": "J. Clin. Laser Med. Surg."
    },
    {
      "key": "ja0680257b00004/ja0680257b00004_2",
      "doi-asserted-by": "crossref",
      "first-page": "5380",
      "DOI": "10.1021/ja031647x",
      "volume": "126",
      "author": "Dichtel W. R.",
      "year": "2004",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00004/ja0680257b00004_3",
      "doi-asserted-by": "crossref",
      "first-page": "2267",
      "DOI": "10.1021/cm047825i",
      "volume": "17",
      "author": "Oar M. A.",
      "year": "2005",
      "journal-title": "Chem. Mater."
    },
    {
      "key": "ja0680257b00005/ja0680257b00005_1",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1016/S1011-1344(01)00267-6",
      "volume": "66",
      "author": "Konan Y. N.",
      "year": "2002",
      "journal-title": "J. Photochem. Photobiol., B"
    },
    {
      "key": "ja0680257b00005/ja0680257b00005_2",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1016/j.addr.2003.07.013",
      "volume": "56",
      "author": "van Nostrum C. F.",
      "year": "2004",
      "journal-title": "Adv. Drug Deliv. Rev."
    },
    {
      "key": "ja0680257b00005/ja0680257b00005_3",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.1039/b311429e",
      "volume": "14",
      "author": "Wang S.",
      "year": "2004",
      "journal-title": "J. Mater. Chem."
    },
    {
      "key": "ja0680257b00006/ja0680257b00006_1",
      "doi-asserted-by": "crossref",
      "first-page": "271",
      "DOI": "10.1016/S0168-3659(99)00248-5",
      "volume": "65",
      "author": "Maeda H.",
      "year": "2000",
      "journal-title": "J. Control. Release"
    },
    {
      "key": "ja0680257b00007/ja0680257b00007_1",
      "unstructured": "Prasad, P. N.Nanophotonics; John Wiley & Sons:\u2009 Hoboken, New Jersey, 2004."
    },
    {
      "key": "ja0680257b00008/ja0680257b00008_1",
      "first-page": "109",
      "volume": "15",
      "author": "Shimada M.",
      "year": "1995",
      "journal-title": "Anticancer Res."
    },
    {
      "key": "ja0680257b00008/ja0680257b00008_2",
      "doi-asserted-by": "crossref",
      "first-page": "2632",
      "DOI": "10.1021/cm000178k",
      "volume": "12",
      "author": "Lal M.",
      "year": "2000",
      "journal-title": "Chem. Mater."
    },
    {
      "key": "ja0680257b00008/ja0680257b00008_3",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1002/adma.200305622",
      "volume": "16",
      "author": "Zhao X.",
      "year": "2004",
      "journal-title": "Adv. Mater."
    },
    {
      "key": "ja0680257b00009/ja0680257b00009_1",
      "doi-asserted-by": "crossref",
      "first-page": "11092",
      "DOI": "10.1021/ja973849x",
      "volume": "120",
      "author": "Jain T. K.",
      "year": "1998",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00009/ja0680257b00009_2",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1073/pnas.0408039101",
      "volume": "102",
      "author": "Roy I.",
      "year": "2005",
      "journal-title": "Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "ja0680257b00010/ja0680257b00010_1",
      "doi-asserted-by": "crossref",
      "first-page": "7860",
      "DOI": "10.1021/ja0343095",
      "volume": "125",
      "author": "Roy I.",
      "year": "2003",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00011/ja0680257b00011_1",
      "doi-asserted-by": "crossref",
      "first-page": "4259",
      "DOI": "10.1021/ja003959v",
      "volume": "123",
      "author": "Levitus M.",
      "year": "2001",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00011/ja0680257b00011_2",
      "doi-asserted-by": "crossref",
      "first-page": "1059",
      "DOI": "10.1063/1.1345840",
      "volume": "78",
      "author": "Belton C.",
      "year": "2001",
      "journal-title": "Appl. Phys. Lett."
    },
    {
      "key": "ja0680257b00011/ja0680257b00011_3",
      "doi-asserted-by": "crossref",
      "first-page": "1740",
      "DOI": "10.1039/b105159h",
      "author": "Luo J.",
      "year": "2001",
      "journal-title": "Chem. Commun."
    },
    {
      "key": "ja0680257b00011/ja0680257b00011_4",
      "doi-asserted-by": "crossref",
      "first-page": "14410",
      "DOI": "10.1021/ja0269082",
      "volume": "124",
      "author": "An B.-K.",
      "year": "2002",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00011/ja0680257b00011_5",
      "doi-asserted-by": "crossref",
      "first-page": "6740",
      "DOI": "10.1021/ja028674s",
      "volume": "125",
      "author": "Xiao D.",
      "year": "2003",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00011/ja0680257b00011_6",
      "doi-asserted-by": "crossref",
      "first-page": "70",
      "DOI": "10.1039/b311648d",
      "author": "Ryu S. Y.",
      "year": "2004",
      "journal-title": "Chem. Commun."
    },
    {
      "key": "ja0680257b00011/ja0680257b00011_7",
      "doi-asserted-by": "crossref",
      "first-page": "6346",
      "DOI": "10.1002/anie.200461172",
      "volume": "43",
      "author": "Lim S.-J.",
      "year": "2004",
      "journal-title": "Angew. Chem., Int. Ed."
    },
    {
      "key": "ja0680257b00012/ja0680257b00012_1",
      "doi-asserted-by": "crossref",
      "first-page": "2317",
      "DOI": "10.1002/adfm.200500928",
      "volume": "16",
      "author": "Kim S.",
      "year": "2006",
      "journal-title": "Adv. Funct. Mater."
    },
    {
      "key": "ja0680257b00013/ja0680257b00013_1",
      "first-page": "4000",
      "volume": "57",
      "author": "Henderson B. W.",
      "year": "1997",
      "journal-title": "J. Cancer Res."
    },
    {
      "key": "ja0680257b00014/ja0680257b00014_1",
      "doi-asserted-by": "crossref",
      "first-page": "58",
      "DOI": "10.1002/jemt.10421",
      "volume": "63",
      "author": "Becker W.",
      "year": "2004",
      "journal-title": "Microsc. Res. Tech."
    },
    {
      "key": "ja0680257b00014/ja0680257b00014_2",
      "volume-title": "Proc. SPIE-Int. Soc. Opt. Eng.",
      "author": "Becker W.",
      "year": "2004"
    },
    {
      "key": "ja0680257b00015/ja0680257b00015_1",
      "doi-asserted-by": "crossref",
      "first-page": "4330",
      "DOI": "10.1002/1521-3773(20011203)40:23<4330::AID-ANIE4330>3.0.CO;2-W",
      "volume": "40",
      "author": "Horn D.",
      "year": "2001",
      "journal-title": "Angew. Chem., Int. Ed."
    },
    {
      "key": "ja0680257b00016/ja0680257b00016_1",
      "doi-asserted-by": "crossref",
      "first-page": "5590",
      "DOI": "10.1021/ja00537a030",
      "volume": "102",
      "author": "Lindig B. A.",
      "year": "1980",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "ja0680257b00017/ja0680257b00017_1",
      "doi-asserted-by": "crossref",
      "first-page": "238",
      "DOI": "10.1017/S1431927606060235",
      "volume": "12",
      "author": "Rizzo M. A.",
      "year": "2006",
      "journal-title": "Microsc. Microanal."
    },
    {
      "key": "ja0680257b00017/ja0680257b00017_2",
      "doi-asserted-by": "crossref",
      "first-page": "278",
      "DOI": "10.1016/S1011-1344(97)00070-5",
      "volume": "40",
      "author": "Mekler V. M.",
      "year": "1997",
      "journal-title": "J. Photochem. Photobiol., B"
    }
  ],
  "container-title": "Journal of the American Chemical Society",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/ja0680257",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        9,
        21
      ]
    ],
    "date-time": "2021-09-21T08:06:34Z",
    "timestamp": 1632211594000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/ja0680257"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        2,
        9
      ]
    ]
  },
  "references-count": 39,
  "journal-issue": {
    "issue": "9",
    "published-print": {
      "date-parts": [
        [
          2007,
          3,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/ja0680257"
  ],
  "URL": "http://dx.doi.org/10.1021/ja0680257",
  "relation": {},
  "ISSN": [
    "0002-7863",
    "1520-5126"
  ],
  "subject": [],
  "container-title-short": "J. Am. Chem. Soc.",
  "published": {
    "date-parts": [
      [
        2007,
        2,
        9
      ]
    ]
  }
}