DOI: 10.1021/bi060799c. The γ-Secretase Complex: Membrane-Embedded Proteolytic Ensemble

The γ-Secretase Complex: Membrane-Embedded Proteolytic Ensemble

10.1021/bi060799c

Crossref journal-article

American Chemical Society (ACS)

Biochemistry (316)

Bibliography

Wolfe, M. S. (2006). The Î³-Secretase Complex:â Membrane-Embedded Proteolytic Ensemble. Biochemistry, 45(26), 7931â7939.

Authors 1

Michael S. Wolfe (first)

References 105 Referenced 151

{'key': 'bi060799cb00001/bi060799cb00001_1', 'volume-title': 'Biochem. Biophys. Res. Commun. 120, 885−90.', 'author': 'Glenner G. G.', 'year': '1984'} / Biochem. Biophys. Res. Commun. 120, 885−90. by Glenner G. G. (1984)
10.1152/physrev.2001.81.2.741 / Physiol. Rev. by Selkoe D. J. (2001)
{'key': 'bi060799cb00003/bi060799cb00003_1', 'volume-title': 'Trends Neurosci. 20, 154−9.', 'author': 'Hardy J.', 'year': '1997'} / Trends Neurosci. 20, 154−9. by Hardy J. (1997)
{'key': 'bi060799cb00004/bi060799cb00004_1', 'volume-title': 'Nature 360, 672−4.', 'author': 'Citron M.', 'year': '1992'} / Nature 360, 672−4. by Citron M. (1992)
{'key': 'bi060799cb00005/bi060799cb00005_1', 'volume-title': 'Science 259, 514−6.', 'author': 'Cai X. D.', 'year': '1993'} / Science 259, 514−6. by Cai X. D. (1993)
{'key': 'bi060799cb00006/bi060799cb00006_1', 'volume-title': 'Science 264, 1336−40.', 'author': 'Suzuki N.', 'year': '1994'} / Science 264, 1336−40. by Suzuki N. (1994)
{'key': 'bi060799cb00007/bi060799cb00007_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 90', 'author': 'Roher A. E.', 'year': '1993'} / Proc. Natl. Acad. Sci. U.S.A. 90 by Roher A. E. (1993)
10.1016/0896-6273(94)90458-8 / Neuron by Iwatsubo T. (1994)
{'key': 'bi060799cb00009/bi060799cb00009_1', 'volume-title': 'Nature 375, 754−60.', 'author': 'Sherrington R.', 'year': '1995'} / Nature 375, 754−60. by Sherrington R. (1995)
{'key': 'bi060799cb00010/bi060799cb00010_1', 'volume-title': 'Science 269, 973−7.', 'author': 'Levy-Lahad E.', 'year': '1995'} / Science 269, 973−7. by Levy-Lahad E. (1995)
{'key': 'bi060799cb00011/bi060799cb00011_1', 'volume-title': 'Nature 376, 775−8.', 'author': 'Rogaev E. I.', 'year': '1995'} / Nature 376, 775−8. by Rogaev E. I. (1995)
10.1083/jcb.119.1.55 / J. Cell Biol. by L'Hernault S. W. (1992)
{'key': 'bi060799cb00013/bi060799cb00013_1', 'volume-title': '2, 864−70.', 'author': 'Scheuner D.', 'year': '1996'} / 2, 864−70. by Scheuner D. (1996)
{'key': 'bi060799cb00014/bi060799cb00014_1', 'volume-title': 'Nature 383, 710−3.', 'author': 'Duff K.', 'year': '1996'} / Nature 383, 710−3. by Duff K. (1996)
{'key': 'bi060799cb00015/bi060799cb00015_1', 'volume-title': '2, 1146−50.', 'author': 'Lemere C. A.', 'year': '1996'} / 2, 1146−50. by Lemere C. A. (1996)
10.1038/nm0197-67 / Nat. Med. by Citron M. (1997)
{'key': 'bi060799cb00017/bi060799cb00017_1', 'volume-title': 'Cell 120, 545−55.', 'author': 'Tanzi R. E.', 'year': '2005'} / Cell 120, 545−55. by Tanzi R. E. (2005)
{'key': 'bi060799cb00018/bi060799cb00018_1', 'volume-title': 'Nature 391, 387−90.', 'author': 'De Strooper B.', 'year': '1998'} / Nature 391, 387−90. by De Strooper B. (1998)
{'key': 'bi060799cb00019/bi060799cb00019_1', 'volume-title': 'Science 284, 770−6.', 'author': 'Artavanis-Tsakonas S.', 'year': '1999'} / Science 284, 770−6. by Artavanis-Tsakonas S. (1999)
{'key': 'bi060799cb00020/bi060799cb00020_1', 'volume-title': 'Nature 377, 351−4.', 'author': 'Levitan D.', 'year': '1995'} / Nature 377, 351−4. by Levitan D. (1995)
{'key': 'bi060799cb00021/bi060799cb00021_1', 'volume-title': 'Nature 393, 382−6.', 'author': 'Schroeter E. H.', 'year': '1998'} / Nature 393, 382−6. by Schroeter E. H. (1998)
{'key': 'bi060799cb00022/bi060799cb00022_1', 'volume-title': 'Nature 387, 288−92.', 'author': 'Wong P. C.', 'year': '1997'} / Nature 387, 288−92. by Wong P. C. (1997)
{'key': 'bi060799cb00023/bi060799cb00023_1', 'volume-title': 'Cell 89, 629−39.', 'author': 'Shen J.', 'year': '1997'} / Cell 89, 629−39. by Shen J. (1997)
{'key': 'bi060799cb00024/bi060799cb00024_1', 'volume-title': 'Nature 398, 518−22.', 'author': 'De Strooper B.', 'year': '1999'} / Nature 398, 518−22. by De Strooper B. (1999)
{'key': 'bi060799cb00025/bi060799cb00025_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 101', 'author': 'Kim J.', 'year': '2004'} / Proc. Natl. Acad. Sci. U.S.A. 101 by Kim J. (2004)
{'key': 'bi060799cb00026/bi060799cb00026_1', 'volume-title': 'Neuron 17, 1015−21.', 'author': 'Li X.', 'year': '1996'} / Neuron 17, 1015−21. by Li X. (1996)
{'key': 'bi060799cb00027/bi060799cb00027_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 95', 'author': 'Li X.', 'year': '1998'} / Proc. Natl. Acad. Sci. U.S.A. 95 by Li X. (1998)
{'key': 'bi060799cb00028/bi060799cb00028_1', 'volume-title': 'Neuron 17, 1023−30.', 'author': 'Doan A.', 'year': '1996'} / Neuron 17, 1023−30. by Doan A. (1996)
10.1074/jbc.M507217200 / J. Biol. Chem. by Laudon H. (2005)
{'key': 'bi060799cb00030/bi060799cb00030_1', 'volume-title': 'Biochemistry 44, 11821−8.', 'author': 'Oh Y. S.', 'year': '2005'} / Biochemistry 44, 11821−8. by Oh Y. S. (2005)
{'key': 'bi060799cb00031/bi060799cb00031_1', 'volume-title': 'Neuron 17, 181−90.', 'author': 'Thinakaran G.', 'year': '1996'} / Neuron 17, 181−90. by Thinakaran G. (1996)
10.1074/jbc.272.39.24536 / J. Biol. Chem. by Ratovitski T. (1997)
10.1074/jbc.272.45.28415 / J. Biol. Chem. by Thinakaran G. (1997)
{'key': 'bi060799cb00034/bi060799cb00034_1', 'volume-title': 'Biochemistry 38, 4720−7.', 'author': 'Wolfe M. S.', 'year': '1999'} / Biochemistry 38, 4720−7. by Wolfe M. S. (1999)
{'key': 'bi060799cb00035/bi060799cb00035_1', 'volume-title': 'Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity, Biochemistry 39, 8698−704.', 'author': 'Shearman M. S.', 'year': '2000'} / Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity, Biochemistry 39, 8698−704. by Shearman M. S. (2000)
{'key': 'bi060799cb00036/bi060799cb00036_1', 'volume-title': 'Nature 398, 513−7.', 'author': 'Wolfe M. S.', 'year': '1999'} / Nature 398, 513−7. by Wolfe M. S. (1999)
Wolfe, M. S., De Los Angeles, J., Miller, D. D., Xia, W., and Selkoe, D. J. (1999) Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease,Biochemistry38, 11223−30. (10.1021/bi991080q)
{'key': 'bi060799cb00038/bi060799cb00038_1', 'volume-title': 'Nature 405, 689−94.', 'author': 'Li Y. M.', 'year': '2000'} / Nature 405, 689−94. by Li Y. M. (2000)
{'key': 'bi060799cb00039/bi060799cb00039_1', 'volume-title': 'Nat. Cell Biol. 2, 428−34.', 'author': 'Esler W. P.', 'year': '2000'} / Nat. Cell Biol. 2, 428−34. by Esler W. P. (2000)
10.1074/jbc.273.6.3205 / J. Biol. Chem. by Capell A. (1998)
{'key': 'bi060799cb00041/bi060799cb00041_1', 'volume': '273', 'author': 'Yu G.', 'year': '1998', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Yu G. (1998)
{'key': 'bi060799cb00042/bi060799cb00042_1', 'volume-title': 'Science 296, 2215−8.', 'author': 'Weihofen A.', 'year': '2002'} / Science 296, 2215−8. by Weihofen A. (2002)
10.1016/S0092-8674(02)00970-4 / Cell by Kang D. (2002)
10.1038/sj.emboj.7600251 / EMBO J. by Baki L. (2004)
{'key': 'bi060799cb00045/bi060799cb00045_1', 'volume-title': 'Dev. Cell 8, 677−88.', 'author': 'Huppert S. S.', 'year': '2005'} / Dev. Cell 8, 677−88. by Huppert S. S. (2005)
{'key': 'bi060799cb00046/bi060799cb00046_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 96', 'author': 'Song W.', 'year': '1999'} / Proc. Natl. Acad. Sci. U.S.A. 96 by Song W. (1999)
10.1111/j.1471-4159.2005.03578.x / J. Neurochem. by Bentahir M. (2006)
{'key': 'bi060799cb00048/bi060799cb00048_1', 'volume-title': 'Biochemistry 41, 2825−35.', 'author': 'Weidemann A.', 'year': '2002'} / Biochemistry 41, 2825−35. by Weidemann A. (2002)
{'key': 'bi060799cb00049/bi060799cb00049_1', 'volume': '278', 'author': 'Sato T.', 'year': '2003', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Sato T. (2003)
{'key': 'bi060799cb00050/bi060799cb00050_1', 'first-page': '54', 'volume': '407', 'author': 'Yu G.', 'year': '2000', 'journal-title': 'Nature'} / Nature by Yu G. (2000)
{'key': 'bi060799cb00051/bi060799cb00051_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 99', 'author': 'Esler W. P.', 'year': '2002'} / Proc. Natl. Acad. Sci. U.S.A. 99 by Esler W. P. (2002)
{'key': 'bi060799cb00052/bi060799cb00052_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 99', 'author': 'Edbauer D.', 'year': '2002'} / Proc. Natl. Acad. Sci. U.S.A. 99 by Edbauer D. (2002)
10.1046/j.1471-4159.2002.01207.x / J. Neurochem. by Arawaka S. (2002)
10.1074/jbc.M204446200 / J. Biol. Chem. by Kimberly W. T. (2002)
{'key': 'bi060799cb00055/bi060799cb00055_1', 'volume': '277', 'author': 'Leem J. Y.', 'year': '2002', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Leem J. Y. (2002)
{'key': 'bi060799cb00056/bi060799cb00056_1', 'volume-title': 'FEBS Lett. 520, 117−21.', 'author': 'Tomita T.', 'year': '2002'} / FEBS Lett. 520, 117−21. by Tomita T. (2002)
{'key': 'bi060799cb00057/bi060799cb00057_1', 'volume-title': 'Development 127, 2481−92.', 'author': 'Goutte C.', 'year': '2000'} / Development 127, 2481−92. by Goutte C. (2000)
{'key': 'bi060799cb00058/bi060799cb00058_1', 'volume': '23', 'author': 'Li T.', 'year': '2003', 'journal-title': 'J. Neurosci.'} / J. Neurosci. by Li T. (2003)
10.1016/S1534-5807(02)00189-2 / Dev. Cell by Francis R. (2002)
{'key': 'bi060799cb00060/bi060799cb00060_1', 'volume-title': 'Nature 422, 438−41.', 'author': 'Takasugi N.', 'year': '2003'} / Nature 422, 438−41. by Takasugi N. (2003)
{'key': 'bi060799cb00061/bi060799cb00061_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 100', 'author': 'Kimberly W. T.', 'year': '2003'} / Proc. Natl. Acad. Sci. U.S.A. 100 by Kimberly W. T. (2003)
{'key': 'bi060799cb00062/bi060799cb00062_1', 'volume-title': 'Nat. Cell Biol. 5, 486−8.', 'author': 'Edbauer D.', 'year': '2003'} / Nat. Cell Biol. 5, 486−8. by Edbauer D. (2003)
{'key': 'bi060799cb00063/bi060799cb00063_1', 'volume-title': 'Biochemistry 43, 9774−89.', 'author': 'Fraering P. C.', 'year': '2004'} / Biochemistry 43, 9774−89. by Fraering P. C. (2004)
{'key': 'bi060799cb00064/bi060799cb00064_1', 'volume-title': 'Cell 122, 435−47.', 'author': 'Shah S.', 'year': '2005'} / Cell 122, 435−47. by Shah S. (2005)
{'key': 'bi060799cb00065/bi060799cb00065_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 102', 'author': 'Zhou S.', 'year': '2005'} / Proc. Natl. Acad. Sci. U.S.A. 102 by Zhou S. (2005)
{'key': 'bi060799cb00066/bi060799cb00066_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 103', 'author': 'Lazarov V. K.', 'year': '2006'} / Proc. Natl. Acad. Sci. U.S.A. 103 by Lazarov V. K. (2006)
{'key': 'bi060799cb00067/bi060799cb00067_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 100', 'author': 'Schroeter E. H.', 'year': '2003'} / Proc. Natl. Acad. Sci. U.S.A. 100 by Schroeter E. H. (2003)
{'key': 'bi060799cb00068/bi060799cb00068_1', 'volume-title': 'Biochem. Biophys. Res. Commun. 301, 119−26.', 'author': 'Hebert S. S.', 'year': '2003'} / Biochem. Biophys. Res. Commun. 301, 119−26. by Hebert S. S. (2003)
10.1074/jbc.M404832200 / J. Biol. Chem. by Cervantes S. (2004)
{'key': 'bi060799cb00070/bi060799cb00070_1', 'volume': '279', 'author': 'Nyborg A. C.', 'year': '2004', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Nyborg A. C. (2004)
10.1038/nrm1406 / Nat. Rev. Mol. Cell Biol. by Kopan R. (2004)
{'key': 'bi060799cb00072/bi060799cb00072_1', 'volume': '278', 'author': 'Lai M. T.', 'year': '2003', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Lai M. T. (2003)
{'key': 'bi060799cb00073/bi060799cb00073_1', 'volume': '278', 'author': 'Gu Y.', 'year': '2002', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Gu Y. (2002)
{'key': 'bi060799cb00074/bi060799cb00074_1', 'volume': '278', 'author': 'LaVoie M. J.', 'year': '2003', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by LaVoie M. J. (2003)
{'key': 'bi060799cb00075/bi060799cb00075_1', 'volume': '278', 'author': 'Luo W. J.', 'year': '2003', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Luo W. J. (2003)
{'key': 'bi060799cb00076/bi060799cb00076_1', 'volume-title': 'Biochemistry 43, 323−33.', 'author': 'Fraering P. C.', 'year': '2004'} / Biochemistry 43, 323−33. by Fraering P. C. (2004)
{'key': 'bi060799cb00077/bi060799cb00077_1', 'volume': '280', 'author': 'Watanabe N.', 'year': '2005', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Watanabe N. (2005)
{'key': 'bi060799cb00078/bi060799cb00078_1', 'volume': '280', 'author': 'Kim S. H.', 'year': '2005', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Kim S. H. (2005)
10.1074/jbc.C300435200 / J. Biol. Chem. by Capell A. (2003)
10.1074/jbc.M310505200 / J. Biol. Chem. by Fortna R. R. (2004)
10.1074/jbc.M213107200 / J. Biol. Chem. by Crystal A. S. (2003)
{'key': 'bi060799cb00082/bi060799cb00082_1', 'volume-title': 'Science 307, 1425−6.', 'author': 'Mackinnon R.', 'year': '2005'} / Science 307, 1425−6. by Mackinnon R. (2005)
{'key': 'bi060799cb00083/bi060799cb00083_1', 'volume-title': 'Neuron 32, 579−89.', 'author': 'Annaert W. G.', 'year': '2001'} / Neuron 32, 579−89. by Annaert W. G. (2001)
10.1111/j.1471-4159.2005.03278.x / J. Neurochem. by Brunkan A. L. (2005)
{'key': 'bi060799cb00085/bi060799cb00085_1', 'volume-title': 'Biochemistry 45, 7598−7604.', 'author': 'Kornilova A. Y.', 'year': '2006'} / Biochemistry 45, 7598−7604. by Kornilova A. Y. (2006)
10.1074/jbc.M909624199 / J. Biol. Chem. by Saura C. A. (2000)
{'key': 'bi060799cb00087/bi060799cb00087_1', 'volume-title': 'Neurobiol. Dis. 3, 325−37.', 'author': 'Podlisny M. B.', 'year': '1997'} / Neurobiol. Dis. 3, 325−37. by Podlisny M. B. (1997)
10.1074/jbc.M401277200 / J. Biol. Chem. by Laudon H. (2004)
10.1523/JNEUROSCI.19-24-10627.1999 / J. Neurosci. by Tomita T. (1999)
10.1038/sj.emboj.7600478 / EMBO J. by Kaether C. (2004)
{'key': 'bi060799cb00091/bi060799cb00091_1', 'volume': '125', 'author': 'Das C.', 'year': '2003', 'journal-title': 'J. Am. Chem. Soc.'} / J. Am. Chem. Soc. by Das C. (2003)
{'key': 'bi060799cb00092/bi060799cb00092_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 102', 'author': 'Kornilova A. Y.', 'year': '2005'} / Proc. Natl. Acad. Sci. U.S.A. 102 by Kornilova A. Y. (2005)
10.1021/jm049788c / J. Med. Chem. by Bihel F. (2004)
10.1074/jbc.M307757200 / J. Biol. Chem. by Searfoss G. H. (2003)
{'key': 'bi060799cb00095/bi060799cb00095_1', 'volume': '279', 'author': 'Wong G. T.', 'year': '2004', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Wong G. T. (2004)
{'key': 'bi060799cb00096/bi060799cb00096_1', 'volume-title': 'Nature 414, 212−6.', 'author': 'Weggen S.', 'year': '2001'} / Nature 414, 212−6. by Weggen S. (2001)
{'key': 'bi060799cb00097/bi060799cb00097_1', 'volume': '278', 'author': 'Weggen S.', 'year': '2003', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Weggen S. (2003)
10.1074/jbc.M404937200 / J. Biol. Chem. by Beher D. (2004)
10.1074/jbc.M513250200 / J. Biol. Chem. by Okochi M. (2006)
{'key': 'bi060799cb00100/bi060799cb00100_1', 'volume-title': 'Biochemistry 45 (in press).', 'author': 'Sato T.', 'year': '2006'} / Biochemistry 45 (in press). by Sato T. (2006)
{'key': 'bi060799cb00101/bi060799cb00101_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 100', 'author': 'Netzer W. J.', 'year': '2003'} / Proc. Natl. Acad. Sci. U.S.A. 100 by Netzer W. J. (2003)
10.1074/jbc.M501368200 / J. Biol. Chem. by Fraering P. C. (2005)
{'key': 'bi060799cb00103/bi060799cb00103_1', 'volume-title': 'Science 305, 1119−23.', 'author': 'Wolfe M. S.', 'year': '2004'} / Science 305, 1119−23. by Wolfe M. S. (2004)
{'key': 'bi060799cb00104/bi060799cb00104_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 99', 'author': 'Goutte C.', 'year': '2002'} / Proc. Natl. Acad. Sci. U.S.A. 99 by Goutte C. (2002)
{'key': 'bi060799cn00001/bi060799cn00001_1', 'volume-title': 'amyloid β-protein', 'author': 'Abbreviations Aβ'} / amyloid β-protein by Abbreviations Aβ

Dates

Type	When
Created	19 years, 2 months ago (June 10, 2006, 5:16 a.m.)
Deposited	3 years, 10 months ago (Oct. 3, 2021, 12:01 a.m.)
Indexed	1 year ago (Aug. 6, 2024, 4:35 a.m.)
Issued	19 years, 2 months ago (June 10, 2006)
Published	19 years, 2 months ago (June 10, 2006)
Published Online	19 years, 2 months ago (June 10, 2006)
Published Print	19 years, 1 month ago (July 1, 2006)

Funders 0

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BibTeX

@article{Wolfe_2006, title={The γ-Secretase Complex: Membrane-Embedded Proteolytic Ensemble}, volume={45}, ISSN={1520-4995}, url={http://dx.doi.org/10.1021/bi060799c}, DOI={10.1021/bi060799c}, number={26}, journal={Biochemistry}, publisher={American Chemical Society (ACS)}, author={Wolfe, Michael S.}, year={2006}, month=jun, pages={7931–7939} }

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      "key": "bi060799cb00001/bi060799cb00001_1",
      "volume-title": "Biochem. Biophys. Res. Commun. 120, 885\u221290.",
      "author": "Glenner G. G.",
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    {
      "key": "bi060799cb00002/bi060799cb00002_1",
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      "DOI": "10.1152/physrev.2001.81.2.741",
      "volume": "81",
      "author": "Selkoe D. J.",
      "year": "2001",
      "journal-title": "Physiol. Rev."
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    {
      "key": "bi060799cb00003/bi060799cb00003_1",
      "volume-title": "Trends Neurosci. 20, 154\u22129.",
      "author": "Hardy J.",
      "year": "1997"
    },
    {
      "key": "bi060799cb00004/bi060799cb00004_1",
      "volume-title": "Nature 360, 672\u22124.",
      "author": "Citron M.",
      "year": "1992"
    },
    {
      "key": "bi060799cb00005/bi060799cb00005_1",
      "volume-title": "Science 259, 514\u22126.",
      "author": "Cai X. D.",
      "year": "1993"
    },
    {
      "key": "bi060799cb00006/bi060799cb00006_1",
      "volume-title": "Science 264, 1336\u221240.",
      "author": "Suzuki N.",
      "year": "1994"
    },
    {
      "key": "bi060799cb00007/bi060799cb00007_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 90",
      "author": "Roher A. E.",
      "year": "1993"
    },
    {
      "key": "bi060799cb00008/bi060799cb00008_1",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1016/0896-6273(94)90458-8",
      "volume": "13",
      "author": "Iwatsubo T.",
      "year": "1994",
      "journal-title": "Neuron"
    },
    {
      "key": "bi060799cb00009/bi060799cb00009_1",
      "volume-title": "Nature 375, 754\u221260.",
      "author": "Sherrington R.",
      "year": "1995"
    },
    {
      "key": "bi060799cb00010/bi060799cb00010_1",
      "volume-title": "Science 269, 973\u22127.",
      "author": "Levy-Lahad E.",
      "year": "1995"
    },
    {
      "key": "bi060799cb00011/bi060799cb00011_1",
      "volume-title": "Nature 376, 775\u22128.",
      "author": "Rogaev E. I.",
      "year": "1995"
    },
    {
      "key": "bi060799cb00012/bi060799cb00012_1",
      "doi-asserted-by": "crossref",
      "first-page": "68",
      "DOI": "10.1083/jcb.119.1.55",
      "volume": "119",
      "author": "L'Hernault S. W.",
      "year": "1992",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "bi060799cb00013/bi060799cb00013_1",
      "volume-title": "2, 864\u221270.",
      "author": "Scheuner D.",
      "year": "1996"
    },
    {
      "key": "bi060799cb00014/bi060799cb00014_1",
      "volume-title": "Nature 383, 710\u22123.",
      "author": "Duff K.",
      "year": "1996"
    },
    {
      "key": "bi060799cb00015/bi060799cb00015_1",
      "volume-title": "2, 1146\u221250.",
      "author": "Lemere C. A.",
      "year": "1996"
    },
    {
      "key": "bi060799cb00016/bi060799cb00016_1",
      "doi-asserted-by": "crossref",
      "first-page": "72",
      "DOI": "10.1038/nm0197-67",
      "volume": "3",
      "author": "Citron M.",
      "year": "1997",
      "journal-title": "Nat. Med."
    },
    {
      "key": "bi060799cb00017/bi060799cb00017_1",
      "volume-title": "Cell 120, 545\u221255.",
      "author": "Tanzi R. E.",
      "year": "2005"
    },
    {
      "key": "bi060799cb00018/bi060799cb00018_1",
      "volume-title": "Nature 391, 387\u221290.",
      "author": "De Strooper B.",
      "year": "1998"
    },
    {
      "key": "bi060799cb00019/bi060799cb00019_1",
      "volume-title": "Science 284, 770\u22126.",
      "author": "Artavanis-Tsakonas S.",
      "year": "1999"
    },
    {
      "key": "bi060799cb00020/bi060799cb00020_1",
      "volume-title": "Nature 377, 351\u22124.",
      "author": "Levitan D.",
      "year": "1995"
    },
    {
      "key": "bi060799cb00021/bi060799cb00021_1",
      "volume-title": "Nature 393, 382\u22126.",
      "author": "Schroeter E. H.",
      "year": "1998"
    },
    {
      "key": "bi060799cb00022/bi060799cb00022_1",
      "volume-title": "Nature 387, 288\u221292.",
      "author": "Wong P. C.",
      "year": "1997"
    },
    {
      "key": "bi060799cb00023/bi060799cb00023_1",
      "volume-title": "Cell 89, 629\u221239.",
      "author": "Shen J.",
      "year": "1997"
    },
    {
      "key": "bi060799cb00024/bi060799cb00024_1",
      "volume-title": "Nature 398, 518\u221222.",
      "author": "De Strooper B.",
      "year": "1999"
    },
    {
      "key": "bi060799cb00025/bi060799cb00025_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 101",
      "author": "Kim J.",
      "year": "2004"
    },
    {
      "key": "bi060799cb00026/bi060799cb00026_1",
      "volume-title": "Neuron 17, 1015\u221221.",
      "author": "Li X.",
      "year": "1996"
    },
    {
      "key": "bi060799cb00027/bi060799cb00027_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 95",
      "author": "Li X.",
      "year": "1998"
    },
    {
      "key": "bi060799cb00028/bi060799cb00028_1",
      "volume-title": "Neuron 17, 1023\u221230.",
      "author": "Doan A.",
      "year": "1996"
    },
    {
      "key": "bi060799cb00029/bi060799cb00029_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M507217200",
      "volume": "280",
      "author": "Laudon H.",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00030/bi060799cb00030_1",
      "volume-title": "Biochemistry 44, 11821\u22128.",
      "author": "Oh Y. S.",
      "year": "2005"
    },
    {
      "key": "bi060799cb00031/bi060799cb00031_1",
      "volume-title": "Neuron 17, 181\u221290.",
      "author": "Thinakaran G.",
      "year": "1996"
    },
    {
      "key": "bi060799cb00032/bi060799cb00032_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.272.39.24536",
      "volume": "272",
      "author": "Ratovitski T.",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00033/bi060799cb00033_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.272.45.28415",
      "volume": "272",
      "author": "Thinakaran G.",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00034/bi060799cb00034_1",
      "volume-title": "Biochemistry 38, 4720\u22127.",
      "author": "Wolfe M. S.",
      "year": "1999"
    },
    {
      "key": "bi060799cb00035/bi060799cb00035_1",
      "volume-title": "Is a Potent Inhibitor of Amyloid \u03b2-Protein Precursor \u03b3-Secretase Activity, Biochemistry 39, 8698\u2212704.",
      "author": "Shearman M. S.",
      "year": "2000"
    },
    {
      "key": "bi060799cb00036/bi060799cb00036_1",
      "volume-title": "Nature 398, 513\u22127.",
      "author": "Wolfe M. S.",
      "year": "1999"
    },
    {
      "key": "bi060799cb00037/bi060799cb00037_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Wolfe, M. S., De Los Angeles, J., Miller, D. D., Xia, W., and Selkoe, D. J. (1999) Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease,Biochemistry38, 11223\u221230.",
      "DOI": "10.1021/bi991080q"
    },
    {
      "key": "bi060799cb00038/bi060799cb00038_1",
      "volume-title": "Nature 405, 689\u221294.",
      "author": "Li Y. M.",
      "year": "2000"
    },
    {
      "key": "bi060799cb00039/bi060799cb00039_1",
      "volume-title": "Nat. Cell Biol. 2, 428\u221234.",
      "author": "Esler W. P.",
      "year": "2000"
    },
    {
      "key": "bi060799cb00040/bi060799cb00040_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.273.6.3205",
      "volume": "273",
      "author": "Capell A.",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00041/bi060799cb00041_1",
      "volume": "273",
      "author": "Yu G.",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00042/bi060799cb00042_1",
      "volume-title": "Science 296, 2215\u22128.",
      "author": "Weihofen A.",
      "year": "2002"
    },
    {
      "key": "bi060799cb00043/bi060799cb00043_1",
      "doi-asserted-by": "crossref",
      "first-page": "751",
      "DOI": "10.1016/S0092-8674(02)00970-4",
      "volume": "110",
      "author": "Kang D.",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "bi060799cb00044/bi060799cb00044_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1038/sj.emboj.7600251",
      "volume": "23",
      "author": "Baki L.",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "bi060799cb00045/bi060799cb00045_1",
      "volume-title": "Dev. Cell 8, 677\u221288.",
      "author": "Huppert S. S.",
      "year": "2005"
    },
    {
      "key": "bi060799cb00046/bi060799cb00046_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 96",
      "author": "Song W.",
      "year": "1999"
    },
    {
      "key": "bi060799cb00047/bi060799cb00047_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1111/j.1471-4159.2005.03578.x",
      "volume": "96",
      "author": "Bentahir M.",
      "year": "2006",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "bi060799cb00048/bi060799cb00048_1",
      "volume-title": "Biochemistry 41, 2825\u221235.",
      "author": "Weidemann A.",
      "year": "2002"
    },
    {
      "key": "bi060799cb00049/bi060799cb00049_1",
      "volume": "278",
      "author": "Sato T.",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00050/bi060799cb00050_1",
      "first-page": "54",
      "volume": "407",
      "author": "Yu G.",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "bi060799cb00051/bi060799cb00051_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 99",
      "author": "Esler W. P.",
      "year": "2002"
    },
    {
      "key": "bi060799cb00052/bi060799cb00052_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 99",
      "author": "Edbauer D.",
      "year": "2002"
    },
    {
      "key": "bi060799cb00053/bi060799cb00053_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1046/j.1471-4159.2002.01207.x",
      "volume": "83",
      "author": "Arawaka S.",
      "year": "2002",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "bi060799cb00054/bi060799cb00054_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M204446200",
      "volume": "277",
      "author": "Kimberly W. T.",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00055/bi060799cb00055_1",
      "volume": "277",
      "author": "Leem J. Y.",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00056/bi060799cb00056_1",
      "volume-title": "FEBS Lett. 520, 117\u221221.",
      "author": "Tomita T.",
      "year": "2002"
    },
    {
      "key": "bi060799cb00057/bi060799cb00057_1",
      "volume-title": "Development 127, 2481\u221292.",
      "author": "Goutte C.",
      "year": "2000"
    },
    {
      "key": "bi060799cb00058/bi060799cb00058_1",
      "volume": "23",
      "author": "Li T.",
      "year": "2003",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "bi060799cb00059/bi060799cb00059_1",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.1016/S1534-5807(02)00189-2",
      "volume": "3",
      "author": "Francis R.",
      "year": "2002",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "bi060799cb00060/bi060799cb00060_1",
      "volume-title": "Nature 422, 438\u221241.",
      "author": "Takasugi N.",
      "year": "2003"
    },
    {
      "key": "bi060799cb00061/bi060799cb00061_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 100",
      "author": "Kimberly W. T.",
      "year": "2003"
    },
    {
      "key": "bi060799cb00062/bi060799cb00062_1",
      "volume-title": "Nat. Cell Biol. 5, 486\u22128.",
      "author": "Edbauer D.",
      "year": "2003"
    },
    {
      "key": "bi060799cb00063/bi060799cb00063_1",
      "volume-title": "Biochemistry 43, 9774\u221289.",
      "author": "Fraering P. C.",
      "year": "2004"
    },
    {
      "key": "bi060799cb00064/bi060799cb00064_1",
      "volume-title": "Cell 122, 435\u221247.",
      "author": "Shah S.",
      "year": "2005"
    },
    {
      "key": "bi060799cb00065/bi060799cb00065_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 102",
      "author": "Zhou S.",
      "year": "2005"
    },
    {
      "key": "bi060799cb00066/bi060799cb00066_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 103",
      "author": "Lazarov V. K.",
      "year": "2006"
    },
    {
      "key": "bi060799cb00067/bi060799cb00067_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 100",
      "author": "Schroeter E. H.",
      "year": "2003"
    },
    {
      "key": "bi060799cb00068/bi060799cb00068_1",
      "volume-title": "Biochem. Biophys. Res. Commun. 301, 119\u221226.",
      "author": "Hebert S. S.",
      "year": "2003"
    },
    {
      "key": "bi060799cb00069/bi060799cb00069_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M404832200",
      "volume": "279",
      "author": "Cervantes S.",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00070/bi060799cb00070_1",
      "volume": "279",
      "author": "Nyborg A. C.",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00071/bi060799cb00071_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1038/nrm1406",
      "volume": "5",
      "author": "Kopan R.",
      "year": "2004",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "bi060799cb00072/bi060799cb00072_1",
      "volume": "278",
      "author": "Lai M. T.",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00073/bi060799cb00073_1",
      "volume": "278",
      "author": "Gu Y.",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00074/bi060799cb00074_1",
      "volume": "278",
      "author": "LaVoie M. J.",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00075/bi060799cb00075_1",
      "volume": "278",
      "author": "Luo W. J.",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00076/bi060799cb00076_1",
      "volume-title": "Biochemistry 43, 323\u221233.",
      "author": "Fraering P. C.",
      "year": "2004"
    },
    {
      "key": "bi060799cb00077/bi060799cb00077_1",
      "volume": "280",
      "author": "Watanabe N.",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00078/bi060799cb00078_1",
      "volume": "280",
      "author": "Kim S. H.",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00079/bi060799cb00079_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.C300435200",
      "volume": "278",
      "author": "Capell A.",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00080/bi060799cb00080_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M310505200",
      "volume": "279",
      "author": "Fortna R. R.",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00081/bi060799cb00081_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M213107200",
      "volume": "278",
      "author": "Crystal A. S.",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00082/bi060799cb00082_1",
      "volume-title": "Science 307, 1425\u22126.",
      "author": "Mackinnon R.",
      "year": "2005"
    },
    {
      "key": "bi060799cb00083/bi060799cb00083_1",
      "volume-title": "Neuron 32, 579\u221289.",
      "author": "Annaert W. G.",
      "year": "2001"
    },
    {
      "key": "bi060799cb00084/bi060799cb00084_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1111/j.1471-4159.2005.03278.x",
      "volume": "94",
      "author": "Brunkan A. L.",
      "year": "2005",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "bi060799cb00085/bi060799cb00085_1",
      "volume-title": "Biochemistry 45, 7598\u22127604.",
      "author": "Kornilova A. Y.",
      "year": "2006"
    },
    {
      "key": "bi060799cb00086/bi060799cb00086_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M909624199",
      "volume": "275",
      "author": "Saura C. A.",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00087/bi060799cb00087_1",
      "volume-title": "Neurobiol. Dis. 3, 325\u221237.",
      "author": "Podlisny M. B.",
      "year": "1997"
    },
    {
      "key": "bi060799cb00088/bi060799cb00088_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M401277200",
      "volume": "279",
      "author": "Laudon H.",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00089/bi060799cb00089_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1523/JNEUROSCI.19-24-10627.1999",
      "volume": "19",
      "author": "Tomita T.",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "bi060799cb00090/bi060799cb00090_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1038/sj.emboj.7600478",
      "volume": "23",
      "author": "Kaether C.",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "bi060799cb00091/bi060799cb00091_1",
      "volume": "125",
      "author": "Das C.",
      "year": "2003",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "bi060799cb00092/bi060799cb00092_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 102",
      "author": "Kornilova A. Y.",
      "year": "2005"
    },
    {
      "key": "bi060799cb00093/bi060799cb00093_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1021/jm049788c",
      "volume": "47",
      "author": "Bihel F.",
      "year": "2004",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "bi060799cb00094/bi060799cb00094_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M307757200",
      "volume": "278",
      "author": "Searfoss G. H.",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00095/bi060799cb00095_1",
      "volume": "279",
      "author": "Wong G. T.",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00096/bi060799cb00096_1",
      "volume-title": "Nature 414, 212\u22126.",
      "author": "Weggen S.",
      "year": "2001"
    },
    {
      "key": "bi060799cb00097/bi060799cb00097_1",
      "volume": "278",
      "author": "Weggen S.",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi060799cb00098/bi060799cb00098_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M404937200",
      "volume": "279",
      "author": "Beher D.",
      "year": "2004",
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