DOI: 10.1021/bi049979h. Role of Individual Methionines in the Fibrillation of Methionine-Oxidized α-Synuclein

Role of Individual Methionines in the Fibrillation of Methionine-Oxidized α-Synuclein

10.1021/bi049979h

Crossref journal-article

American Chemical Society (ACS)

Biochemistry (316)

Bibliography

Hokenson, M. J., Uversky, V. N., Goers, J., Yamin, G., Munishkina, L. A., & Fink, A. L. (2004). Role of Individual Methionines in the Fibrillation of Methionine-Oxidized Î±-Synuclein. Biochemistry, 43(15), 4621â4633.

Authors 6

Mark J. Hokenson (first)
Vladimir N. Uversky (additional)
John Goers (additional)
Ghiam Yamin (additional)
Larissa A. Munishkina (additional)
Anthony L. Fink (additional)

References 90 Referenced 86

10.1523/JNEUROSCI.08-08-02804.1988 / J. Neurosci. by Maroteaux L. (1988)
{'volume-title': 'Neuron 14, 467−475.', 'year': '1995', 'author': 'Iwai A.', 'key': 'bi049979hb00002/bi049979hb00002_1'} / Neuron 14, 467−475. by Iwai A. (1995)
{'volume-title': 'Biochemistry 35, 13709−13715.', 'year': '1996', 'author': 'Weinreb P. H.', 'key': 'bi049979hb00003/bi049979hb00003_1'} / Biochemistry 35, 13709−13715. by Weinreb P. H. (1996)
{'key': 'bi049979hb00004/bi049979hb00004_1', 'volume': '276', 'author': 'Uversky V. N.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Uversky V. N. (2001)
{'volume-title': 'Why are “natively unfolded', 'year': '2000', 'author': 'Uversky V. N.', 'key': 'bi049979hb00005/bi049979hb00005_1'} / Why are “natively unfolded by Uversky V. N. (2000)
{'volume-title': '39, 308−312.', 'year': '2001', 'author': 'Goedert M.', 'key': 'bi049979hb00006/bi049979hb00006_1'} / 39, 308−312. by Goedert M. (2001)
{'volume-title': 'Ann. N.Y. Acad. Sci. 991, 107−110.', 'year': '2003', 'author': 'Trojanowski J. Q.', 'key': 'bi049979hb00007/bi049979hb00007_1'} / Ann. N.Y. Acad. Sci. 991, 107−110. by Trojanowski J. Q. (2003)
{'volume-title': 'Nature 388, 839−840.', 'year': '1997', 'author': 'Spillantini M. G.', 'key': 'bi049979hb00008/bi049979hb00008_1'} / Nature 388, 839−840. by Spillantini M. G. (1997)
{'volume-title': 'in Handbuch der Neurologie', 'year': '1912', 'author': 'Lewy F. H.', 'key': 'bi049979hb00009/bi049979hb00009_1'} / in Handbuch der Neurologie by Lewy F. H. (1912)
10.1097/00005072-199603000-00001 / J. Neuropathol. Exp. Neurol. by Forno L. S. (1996)
{'volume-title': 'Science 276', 'year': '1997', 'author': 'Polymeropoulos M. H.', 'key': 'bi049979hb00011/bi049979hb00011_1'} / Science 276 by Polymeropoulos M. H. (1997)
{'volume-title': 'Nat. Genet. 18, 106−108.', 'year': '1998', 'author': 'Kruger R.', 'key': 'bi049979hb00012/bi049979hb00012_1'} / Nat. Genet. 18, 106−108. by Kruger R. (1998)
10.1126/science.1090278 / Science by Singleton A. B. (2003)
{'volume-title': 'Science 287, 1265−1269.', 'year': '2000', 'author': 'Masliah E.', 'key': 'bi049979hb00014/bi049979hb00014_1'} / Science 287, 1265−1269. by Masliah E. (2000)
{'volume-title': 'Nature 404, 394−398.', 'year': '2000', 'author': 'Feany M. B.', 'key': 'bi049979hb00015/bi049979hb00015_1'} / Nature 404, 394−398. by Feany M. B. (2000)
Conway, K. A., Harper, J. D., and Lansbury, P. T. (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease,Nat. Med.4, 1318−1320. (10.1038/3311)
{'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 97, 571−576.', 'year': '2000', 'author': 'Conway K. A.', 'key': 'bi049979hb00017/bi049979hb00017_1'} / Proc. Natl. Acad. Sci. U.S.A. 97, 571−576. by Conway K. A. (2000)
10.1016/S0014-5793(98)01146-6 / FEBS Lett. by Crowther R. A. (1998)
10.1074/jbc.274.12.7619 / J. Biol. Chem. by Giasson B. I. (1999)
{'key': 'bi049979hb00020/bi049979hb00020_1', 'volume': '274', 'author': 'Wood S. J.', 'year': '1999', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Wood S. J. (1999)
{'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 97', 'year': '2000', 'author': 'Serpell L. C.', 'key': 'bi049979hb00021/bi049979hb00021_1'} / Proc. Natl. Acad. Sci. U.S.A. 97 by Serpell L. C. (2000)
{'volume-title': 'Toxicol. Ind. Health 9, 187−196.', 'year': '1993', 'author': 'Stadtman E. R.', 'key': 'bi049979hb00022/bi049979hb00022_1'} / Toxicol. Ind. Health 9, 187−196. by Stadtman E. R. (1993)
{'volume-title': 'Chem. Res. Toxicol. 10, 485−494.', 'year': '1997', 'author': 'Stadtman E. R.', 'key': 'bi049979hb00023/bi049979hb00023_1'} / Chem. Res. Toxicol. 10, 485−494. by Stadtman E. R. (1997)
{'key': 'bi049979hb00024/bi049979hb00024_1', 'volume': '43', 'author': 'Leeuwenburgh C.', 'year': '1998', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Leeuwenburgh C. (1998)
{'volume-title': 'Life Sci. 65', 'year': '1999', 'author': 'Butterfield D. A.', 'key': 'bi049979hb00025/bi049979hb00025_1'} / Life Sci. 65 by Butterfield D. A. (1999)
{'volume-title': 'Proc. Natl. Acad. Sci U.S.A. 88', 'year': '1991', 'author': 'Smith C. D.', 'key': 'bi049979hb00026/bi049979hb00026_1'} / Proc. Natl. Acad. Sci U.S.A. 88 by Smith C. D. (1991)
{'volume-title': 'Dementia Geriatr. Cognit. Disord. 10, 158−165.', 'year': '1999', 'author': 'Aksenova M. V.', 'key': 'bi049979hb00027/bi049979hb00027_1'} / Dementia Geriatr. Cognit. Disord. 10, 158−165. by Aksenova M. V. (1999)
{'volume-title': 'Brain Pathol. 9, 133−146.', 'year': '1999', 'author': 'Markesbery W. R.', 'key': 'bi049979hb00028/bi049979hb00028_1'} / Brain Pathol. 9, 133−146. by Markesbery W. R. (1999)
{'key': 'bi049979hb00029/bi049979hb00029_1', 'volume': '157', 'author': 'Duda J. E.', 'year': '2000', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. by Duda J. E. (2000)
{'volume-title': "Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease", 'year': '1992', 'author': 'Jenner P.', 'key': 'bi049979hb00030/bi049979hb00030_1'} / Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease by Jenner P. (1992)
{'volume-title': 'Ann. Neurol. 53 (Suppl. 3), S26−S36.', 'year': '2003', 'author': 'Jenner P.', 'key': 'bi049979hb00031/bi049979hb00031_1'} / Ann. Neurol. 53 (Suppl. 3), S26−S36. by Jenner P. (2003)
{'key': 'bi049979hb00032/bi049979hb00032_1', 'volume': '71', 'author': 'Lyras L.', 'year': '1998', 'journal-title': 'J. Neurochem.'} / J. Neurochem. by Lyras L. (1998)
{'volume-title': 'Brain Pathol. 9, 147−163.', 'year': '1999', 'author': 'Browne S. E.', 'key': 'bi049979hb00033/bi049979hb00033_1'} / Brain Pathol. 9, 147−163. by Browne S. E. (1999)
{'volume-title': 'Brain Pathol. 9, 165−186.', 'year': '1999', 'author': 'Cookson M. R.', 'key': 'bi049979hb00034/bi049979hb00034_1'} / Brain Pathol. 9, 165−186. by Cookson M. R. (1999)
10.1016/0891-5849(94)00158-G / Free Radical Biol. Med. by Vogt W. (1995)
{'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 93', 'year': '1996', 'author': 'Moskovitz J.', 'key': 'bi049979hb00036/bi049979hb00036_1'} / Proc. Natl. Acad. Sci. U.S.A. 93 by Moskovitz J. (1996)
{'volume-title': 'Biochemistry 38, 105−112.', 'year': '1999', 'author': 'Sun H.', 'key': 'bi049979hb00037/bi049979hb00037_1'} / Biochemistry 38, 105−112. by Sun H. (1999)
{'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 93', 'year': '1996', 'author': 'Levine R. L.', 'key': 'bi049979hb00038/bi049979hb00038_1'} / Proc. Natl. Acad. Sci. U.S.A. 93 by Levine R. L. (1996)
{'volume-title': 'Neurotoxicology 23, 527−536.', 'year': '2002', 'author': 'Uversky V. N.', 'key': 'bi049979hb00039/bi049979hb00039_1'} / Neurotoxicology 23, 527−536. by Uversky V. N. (2002)
{'volume-title': 'Recent Research Developments in Proteins', 'year': '2002', 'author': 'Uversky V. N.', 'key': 'bi049979hb00040/bi049979hb00040_1'} / Recent Research Developments in Proteins by Uversky V. N. (2002)
{'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 93', 'year': '1996', 'author': 'Yoritaka A.', 'key': 'bi049979hb00041/bi049979hb00041_1'} / Proc. Natl. Acad. Sci. U.S.A. 93 by Yoritaka A. (1996)
{'key': 'bi049979hb00042/bi049979hb00042_1', 'volume': '57', 'author': 'Good P. F.', 'year': '1998', 'journal-title': 'J Neuropathol. Exp. Neurol.'} / J Neuropathol. Exp. Neurol. by Good P. F. (1998)
{'volume-title': 'Science 290, 985−989.', 'year': '2000', 'author': 'Giasson B. I.', 'key': 'bi049979hb00043/bi049979hb00043_1'} / Science 290, 985−989. by Giasson B. I. (2000)
{'volume-title': 'Arch. Biochem. Biophys. 378, 269−277.', 'year': '2000', 'author': 'Paik S. R.', 'key': 'bi049979hb00044/bi049979hb00044_1'} / Arch. Biochem. Biophys. 378, 269−277. by Paik S. R. (2000)
{'volume-title': 'Science 294, 1346−1349.', 'year': '2001', 'author': 'Conway K. A.', 'key': 'bi049979hb00045/bi049979hb00045_1'} / Science 294, 1346−1349. by Conway K. A. (2001)
10.1016/S0014-5793(02)02638-8 / FEBS Lett. by Uversky V. N. (2002)
10.1006/abio.1997.2486 / Anal. Biochem. by Oberg K. A. (1998)
{'volume-title': 'Biochemistry 40, 6036−6046.', 'year': '2001', 'author': 'Nielsen L.', 'key': 'bi049979hb00048/bi049979hb00048_1'} / Biochemistry 40, 6036−6046. by Nielsen L. (2001)
{'volume-title': 'Biochemistry 40, 11604−11613.', 'year': '2001', 'author': 'Li J.', 'key': 'bi049979hb00049/bi049979hb00049_1'} / Biochemistry 40, 11604−11613. by Li J. (2001)
10.1074/jbc.M109541200 / J. Biol. Chem. by Uversky V. N. (2002)
{'volume-title': 'Biochemistry 42, 2720−2730.', 'year': '2003', 'author': 'Munishkina L. A.', 'key': 'bi049979hb00051/bi049979hb00051_1'} / Biochemistry 42, 2720−2730. by Munishkina L. A. (2003)
{'volume-title': 'Lab. Invest. 62, 768−773.', 'year': '1990', 'author': 'Naiki H.', 'key': 'bi049979hb00052/bi049979hb00052_1'} / Lab. Invest. 62, 768−773. by Naiki H. (1990)
{'volume-title': 'Anal. Biochem. 177, 244−249.', 'year': '1989', 'author': 'Naiki H.', 'key': 'bi049979hb00053/bi049979hb00053_1'} / Anal. Biochem. 177, 244−249. by Naiki H. (1989)
{'volume-title': 'Lab. Invest. 65, 104−110.', 'year': '1991', 'author': 'Naiki H.', 'key': 'bi049979hb00054/bi049979hb00054_1'} / Lab. Invest. 65, 104−110. by Naiki H. (1991)
{'volume-title': 'Protein Eng. 14, 343−347.', 'year': '2001', 'author': 'Kim Y. H.', 'key': 'bi049979hb00055/bi049979hb00055_1'} / Protein Eng. 14, 343−347. by Kim Y. H. (2001)
10.1074/jbc.M109541200 / J. Biol. Chem. by Uversky V. N. (2002)
10.1074/jbc.M303302200 / J. Biol. Chem by Yamin G. (2003)
{'volume-title': 'Protein Sci. 8, 161−173.', 'year': '1999', 'author': 'Uversky V. N.', 'key': 'bi049979hb00058/bi049979hb00058_1'} / Protein Sci. 8, 161−173. by Uversky V. N. (1999)
10.1016/S0006-3495(99)77111-0 / Biophys. J. by Kuznetsova I. M. (1999)
10.1074/jbc.M109541200 / J. Biol. Chem. by Uversky V. N. (2002)
10.1016/0022-2836(82)90515-0 / J. Mol. Biol. by Kyte J. (1982)
{'volume-title': 'in Infrared Analysis of Peptides and Proteins', 'year': '1999', 'author': 'Fink A. L.', 'key': 'bi049979hb00062/bi049979hb00062_1'} / in Infrared Analysis of Peptides and Proteins by Fink A. L. (1999)
{'volume-title': 'Biochemistry 33, 2628−2634.', 'year': '1994', 'author': 'Oberg K.', 'key': 'bi049979hb00063/bi049979hb00063_1'} / Biochemistry 33, 2628−2634. by Oberg K. (1994)
10.1016/0167-4838(92)90353-F / Biochim. Biophys. Acta by Ismail A. A. (1992)
{'volume-title': 'Protein Eng. 7, 131−136.', 'year': '1994', 'author': 'Przybycien T. M.', 'key': 'bi049979hb00065/bi049979hb00065_1'} / Protein Eng. 7, 131−136. by Przybycien T. M. (1994)
10.1021/js9801384 / J. Pharm. Sci. by Kendrick B. S. (1998)
{'key': 'bi049979hb00067/bi049979hb00067_1', 'volume': '17', 'author': 'Clark A. H.', 'year': '1981', 'journal-title': 'Int. J. Pept. Protein Res.'} / Int. J. Pept. Protein Res. by Clark A. H. (1981)
{'key': 'bi049979hb00068/bi049979hb00068_1', 'first-page': '15', 'volume': '3', 'author': 'Fink A. L.', 'year': '1998', 'journal-title': 'Folding Des.'} / Folding Des. by Fink A. L. (1998)
10.1002/1520-6017(200101)90:1<29::AID-JPS4>3.0.CO;2-4 / J. Pharm. Sci. by Nielsen L. (2001)
{'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 90', 'year': '1993', 'author': 'Ueda K.', 'key': 'bi049979hb00070/bi049979hb00070_1'} / Proc. Natl. Acad. Sci. U.S.A. 90 by Ueda K. (1993)
{'volume-title': 'Chem. Biol. 2, 163−169.', 'year': '1995', 'author': 'Han H.', 'key': 'bi049979hb00071/bi049979hb00071_1'} / Chem. Biol. 2, 163−169. by Han H. (1995)
{'volume-title': 'Neuron 32, 213−223.', 'year': '2001', 'author': 'Hashimoto M.', 'key': 'bi049979hb00072/bi049979hb00072_1'} / Neuron 32, 213−223. by Hashimoto M. (2001)
10.1074/jbc.M109541200 / J. Biol. Chem. by Uversky V. N. (2002)
{'volume-title': 'Biochemistry 42, 3696−3700.', 'year': '2003', 'author': 'Park J. Y.', 'key': 'bi049979hb00074/bi049979hb00074_1'} / Biochemistry 42, 3696−3700. by Park J. Y. (2003)
10.1074/jbc.M008919200 / J. Biol. Chem. by Giasson B. I. (2001)
10.1046/j.1471-4159.2001.00408.x / J. Neurochem. by Bodles A. M. (2001)
10.1046/j.1432-1327.2000.01219.x / Eur. J. Biochem. by Bodles A. M. (2000)
10.1042/bst026s036 / Biochem. Soc. Trans. by Irvine G. B. (1998)
10.1046/j.1432-1327.1998.2580157.x / Eur. J. Biochem. by El Agnaf O. M. (1998)
{'volume-title': 'Trends Neurosci. 21, 249−254.', 'year': '1998', 'author': 'Clayton D. F.', 'key': 'bi049979hb00080/bi049979hb00080_1'} / Trends Neurosci. 21, 249−254. by Clayton D. F. (1998)
{'volume-title': 'Neuron 15, 361−372.', 'year': '1995', 'author': 'George J. M.', 'key': 'bi049979hb00081/bi049979hb00081_1'} / Neuron 15, 361−372. by George J. M. (1995)
{'volume-title': 'Biochemistry 42, 672−678.', 'year': '2003', 'author': 'Kessler J. C.', 'key': 'bi049979hb00082/bi049979hb00082_1'} / Biochemistry 42, 672−678. by Kessler J. C. (2003)
Conway, K. A., Harper, J. D., and Lansbury, P. T., Jr. (2000) Fibrils formed in vitro from alfa-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid,Biochemistry39, 2552−2563. (10.1021/bi991447r)
10.1074/jbc.274.14.9843 / J. Biol. Chem. by Narhi L. (1999)
{'volume-title': 'Neurotoxicology 23, 553−567.', 'year': '2002', 'author': 'Li J.', 'key': 'bi049979hb00085/bi049979hb00085_1'} / Neurotoxicology 23, 553−567. by Li J. (2002)
10.1016/S0014-5793(02)02883-1 / FEBS Lett. by Uversky V. N. (2002)
10.1111/j.1749-6632.2000.tb05561.x / Ann. N.Y. Acad. Sci. by Trojanowski J. Q. (2000)
{'key': 'bi049979hb00088/bi049979hb00088_1', 'volume': '277', 'author': 'Hou L.', 'year': '2002', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Hou L. (2002)
{'journal-title': 'J. Am. Chem. Soc. (in press).', 'year': '2004', 'author': 'Hou L.', 'key': 'bi049979hb00089/bi049979hb00089_1'} / J. Am. Chem. Soc. (in press). by Hou L. (2004)
{'volume-title': "Parkinson's disease", 'author': 'Abbreviations PD', 'key': 'bi049979hn00001/bi049979hn00001_1'} / Parkinson's disease by Abbreviations PD

Dates

Type	When
Created	21 years, 4 months ago (April 13, 2004, 12:28 a.m.)
Deposited	8 months, 2 weeks ago (Dec. 15, 2024, 3:42 p.m.)
Indexed	5 months ago (March 31, 2025, 7:23 a.m.)
Issued	21 years, 5 months ago (March 26, 2004)
Published	21 years, 5 months ago (March 26, 2004)
Published Online	21 years, 5 months ago (March 26, 2004)
Published Print	21 years, 5 months ago (April 1, 2004)

Funders 0

None

BibTeX

@article{Hokenson_2004, title={Role of Individual Methionines in the Fibrillation of Methionine-Oxidized α-Synuclein}, volume={43}, ISSN={1520-4995}, url={http://dx.doi.org/10.1021/bi049979h}, DOI={10.1021/bi049979h}, number={15}, journal={Biochemistry}, publisher={American Chemical Society (ACS)}, author={Hokenson, Mark J. and Uversky, Vladimir N. and Goers, John and Yamin, Ghiam and Munishkina, Larissa A. and Fink, Anthony L.}, year={2004}, month=mar, pages={4621–4633} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        3,
        31
      ]
    ],
    "date-time": "2025-03-31T11:23:34Z",
    "timestamp": 1743420214499,
    "version": "3.30.2"
  },
  "reference-count": 90,
  "publisher": "American Chemical Society (ACS)",
  "issue": "15",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        4,
        1
      ]
    ]
  },
  "DOI": "10.1021/bi049979h",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        13
      ]
    ],
    "date-time": "2004-04-13T04:28:02Z",
    "timestamp": 1081830482000
  },
  "page": "4621-4633",
  "source": "Crossref",
  "is-referenced-by-count": 86,
  "title": "Role of Individual Methionines in the Fibrillation of Methionine-Oxidized \u03b1-Synuclein",
  "prefix": "10.1021",
  "volume": "43",
  "author": [
    {
      "given": "Mark J.",
      "family": "Hokenson",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064"
        }
      ]
    },
    {
      "given": "Vladimir N.",
      "family": "Uversky",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064"
        }
      ]
    },
    {
      "given": "John",
      "family": "Goers",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064"
        }
      ]
    },
    {
      "given": "Ghiam",
      "family": "Yamin",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064"
        }
      ]
    },
    {
      "given": "Larissa A.",
      "family": "Munishkina",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064"
        }
      ]
    },
    {
      "given": "Anthony L.",
      "family": "Fink",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2004,
        3,
        26
      ]
    ]
  },
  "reference": [
    {
      "key": "bi049979hb00001/bi049979hb00001_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1523/JNEUROSCI.08-08-02804.1988",
      "volume": "8",
      "author": "Maroteaux L.",
      "year": "1988",
      "journal-title": "J. Neurosci."
    },
    {
      "volume-title": "Neuron 14, 467\u2212475.",
      "year": "1995",
      "author": "Iwai A.",
      "key": "bi049979hb00002/bi049979hb00002_1"
    },
    {
      "volume-title": "Biochemistry 35, 13709\u221213715.",
      "year": "1996",
      "author": "Weinreb P. H.",
      "key": "bi049979hb00003/bi049979hb00003_1"
    },
    {
      "key": "bi049979hb00004/bi049979hb00004_1",
      "volume": "276",
      "author": "Uversky V. N.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "volume-title": "Why are \u201cnatively unfolded",
      "year": "2000",
      "author": "Uversky V. N.",
      "key": "bi049979hb00005/bi049979hb00005_1"
    },
    {
      "volume-title": "39, 308\u2212312.",
      "year": "2001",
      "author": "Goedert M.",
      "key": "bi049979hb00006/bi049979hb00006_1"
    },
    {
      "volume-title": "Ann. N.Y. Acad. Sci. 991, 107\u2212110.",
      "year": "2003",
      "author": "Trojanowski J. Q.",
      "key": "bi049979hb00007/bi049979hb00007_1"
    },
    {
      "volume-title": "Nature 388, 839\u2212840.",
      "year": "1997",
      "author": "Spillantini M. G.",
      "key": "bi049979hb00008/bi049979hb00008_1"
    },
    {
      "volume-title": "in Handbuch der Neurologie",
      "year": "1912",
      "author": "Lewy F. H.",
      "key": "bi049979hb00009/bi049979hb00009_1"
    },
    {
      "key": "bi049979hb00010/bi049979hb00010_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1097/00005072-199603000-00001",
      "volume": "55",
      "author": "Forno L. S.",
      "year": "1996",
      "journal-title": "J. Neuropathol. Exp. Neurol."
    },
    {
      "volume-title": "Science 276",
      "year": "1997",
      "author": "Polymeropoulos M. H.",
      "key": "bi049979hb00011/bi049979hb00011_1"
    },
    {
      "volume-title": "Nat. Genet. 18, 106\u2212108.",
      "year": "1998",
      "author": "Kruger R.",
      "key": "bi049979hb00012/bi049979hb00012_1"
    },
    {
      "key": "bi049979hb00013/bi049979hb00013_1",
      "doi-asserted-by": "crossref",
      "first-page": "841",
      "DOI": "10.1126/science.1090278",
      "volume": "302",
      "author": "Singleton A. B.",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "volume-title": "Science 287, 1265\u22121269.",
      "year": "2000",
      "author": "Masliah E.",
      "key": "bi049979hb00014/bi049979hb00014_1"
    },
    {
      "volume-title": "Nature 404, 394\u2212398.",
      "year": "2000",
      "author": "Feany M. B.",
      "key": "bi049979hb00015/bi049979hb00015_1"
    },
    {
      "key": "bi049979hb00016/bi049979hb00016_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Conway, K. A., Harper, J. D., and Lansbury, P. T. (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease,Nat. Med.4, 1318\u22121320.",
      "DOI": "10.1038/3311"
    },
    {
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 97, 571\u2212576.",
      "year": "2000",
      "author": "Conway K. A.",
      "key": "bi049979hb00017/bi049979hb00017_1"
    },
    {
      "key": "bi049979hb00018/bi049979hb00018_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/S0014-5793(98)01146-6",
      "volume": "436",
      "author": "Crowther R. A.",
      "year": "1998",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "bi049979hb00019/bi049979hb00019_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.274.12.7619",
      "volume": "274",
      "author": "Giasson B. I.",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi049979hb00020/bi049979hb00020_1",
      "volume": "274",
      "author": "Wood S. J.",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 97",
      "year": "2000",
      "author": "Serpell L. C.",
      "key": "bi049979hb00021/bi049979hb00021_1"
    },
    {
      "volume-title": "Toxicol. Ind. Health 9, 187\u2212196.",
      "year": "1993",
      "author": "Stadtman E. R.",
      "key": "bi049979hb00022/bi049979hb00022_1"
    },
    {
      "volume-title": "Chem. Res. Toxicol. 10, 485\u2212494.",
      "year": "1997",
      "author": "Stadtman E. R.",
      "key": "bi049979hb00023/bi049979hb00023_1"
    },
    {
      "key": "bi049979hb00024/bi049979hb00024_1",
      "volume": "43",
      "author": "Leeuwenburgh C.",
      "year": "1998",
      "journal-title": "Am. J. Physiol."
    },
    {
      "volume-title": "Life Sci. 65",
      "year": "1999",
      "author": "Butterfield D. A.",
      "key": "bi049979hb00025/bi049979hb00025_1"
    },
    {
      "volume-title": "Proc. Natl. Acad. Sci U.S.A. 88",
      "year": "1991",
      "author": "Smith C. D.",
      "key": "bi049979hb00026/bi049979hb00026_1"
    },
    {
      "volume-title": "Dementia Geriatr. Cognit. Disord. 10, 158\u2212165.",
      "year": "1999",
      "author": "Aksenova M. V.",
      "key": "bi049979hb00027/bi049979hb00027_1"
    },
    {
      "volume-title": "Brain Pathol. 9, 133\u2212146.",
      "year": "1999",
      "author": "Markesbery W. R.",
      "key": "bi049979hb00028/bi049979hb00028_1"
    },
    {
      "key": "bi049979hb00029/bi049979hb00029_1",
      "volume": "157",
      "author": "Duda J. E.",
      "year": "2000",
      "journal-title": "Am. J. Pathol."
    },
    {
      "volume-title": "Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease",
      "year": "1992",
      "author": "Jenner P.",
      "key": "bi049979hb00030/bi049979hb00030_1"
    },
    {
      "volume-title": "Ann. Neurol. 53 (Suppl. 3), S26\u2212S36.",
      "year": "2003",
      "author": "Jenner P.",
      "key": "bi049979hb00031/bi049979hb00031_1"
    },
    {
      "key": "bi049979hb00032/bi049979hb00032_1",
      "volume": "71",
      "author": "Lyras L.",
      "year": "1998",
      "journal-title": "J. Neurochem."
    },
    {
      "volume-title": "Brain Pathol. 9, 147\u2212163.",
      "year": "1999",
      "author": "Browne S. E.",
      "key": "bi049979hb00033/bi049979hb00033_1"
    },
    {
      "volume-title": "Brain Pathol. 9, 165\u2212186.",
      "year": "1999",
      "author": "Cookson M. R.",
      "key": "bi049979hb00034/bi049979hb00034_1"
    },
    {
      "key": "bi049979hb00035/bi049979hb00035_1",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1016/0891-5849(94)00158-G",
      "volume": "18",
      "author": "Vogt W.",
      "year": "1995",
      "journal-title": "Free Radical Biol. Med."
    },
    {
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 93",
      "year": "1996",
      "author": "Moskovitz J.",
      "key": "bi049979hb00036/bi049979hb00036_1"
    },
    {
      "volume-title": "Biochemistry 38, 105\u2212112.",
      "year": "1999",
      "author": "Sun H.",
      "key": "bi049979hb00037/bi049979hb00037_1"
    },
    {
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 93",
      "year": "1996",
      "author": "Levine R. L.",
      "key": "bi049979hb00038/bi049979hb00038_1"
    },
    {
      "volume-title": "Neurotoxicology 23, 527\u2212536.",
      "year": "2002",
      "author": "Uversky V. N.",
      "key": "bi049979hb00039/bi049979hb00039_1"
    },
    {
      "volume-title": "Recent Research Developments in Proteins",
      "year": "2002",
      "author": "Uversky V. N.",
      "key": "bi049979hb00040/bi049979hb00040_1"
    },
    {
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 93",
      "year": "1996",
      "author": "Yoritaka A.",
      "key": "bi049979hb00041/bi049979hb00041_1"
    },
    {
      "key": "bi049979hb00042/bi049979hb00042_1",
      "volume": "57",
      "author": "Good P. F.",
      "year": "1998",
      "journal-title": "J Neuropathol. Exp. Neurol."
    },
    {
      "volume-title": "Science 290, 985\u2212989.",
      "year": "2000",
      "author": "Giasson B. I.",
      "key": "bi049979hb00043/bi049979hb00043_1"
    },
    {
      "volume-title": "Arch. Biochem. Biophys. 378, 269\u2212277.",
      "year": "2000",
      "author": "Paik S. R.",
      "key": "bi049979hb00044/bi049979hb00044_1"
    },
    {
      "volume-title": "Science 294, 1346\u22121349.",
      "year": "2001",
      "author": "Conway K. A.",
      "key": "bi049979hb00045/bi049979hb00045_1"
    },
    {
      "key": "bi049979hb00046/bi049979hb00046_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/S0014-5793(02)02638-8",
      "volume": "517",
      "author": "Uversky V. N.",
      "year": "2002",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "bi049979hb00047/bi049979hb00047_1",
      "doi-asserted-by": "crossref",
      "first-page": "106",
      "DOI": "10.1006/abio.1997.2486",
      "volume": "256",
      "author": "Oberg K. A.",
      "year": "1998",
      "journal-title": "Anal. Biochem."
    },
    {
      "volume-title": "Biochemistry 40, 6036\u22126046.",
      "year": "2001",
      "author": "Nielsen L.",
      "key": "bi049979hb00048/bi049979hb00048_1"
    },
    {
      "volume-title": "Biochemistry 40, 11604\u221211613.",
      "year": "2001",
      "author": "Li J.",
      "key": "bi049979hb00049/bi049979hb00049_1"
    },
    {
      "key": "bi049979hb00050/bi049979hb00050_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M109541200",
      "volume": "277",
      "author": "Uversky V. N.",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "volume-title": "Biochemistry 42, 2720\u22122730.",
      "year": "2003",
      "author": "Munishkina L. A.",
      "key": "bi049979hb00051/bi049979hb00051_1"
    },
    {
      "volume-title": "Lab. Invest. 62, 768\u2212773.",
      "year": "1990",
      "author": "Naiki H.",
      "key": "bi049979hb00052/bi049979hb00052_1"
    },
    {
      "volume-title": "Anal. Biochem. 177, 244\u2212249.",
      "year": "1989",
      "author": "Naiki H.",
      "key": "bi049979hb00053/bi049979hb00053_1"
    },
    {
      "volume-title": "Lab. Invest. 65, 104\u2212110.",
      "year": "1991",
      "author": "Naiki H.",
      "key": "bi049979hb00054/bi049979hb00054_1"
    },
    {
      "volume-title": "Protein Eng. 14, 343\u2212347.",
      "year": "2001",
      "author": "Kim Y. H.",
      "key": "bi049979hb00055/bi049979hb00055_1"
    },
    {
      "key": "bi049979hb00056/bi049979hb00056_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M109541200",
      "volume": "277",
      "author": "Uversky V. N.",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi049979hb00057/bi049979hb00057_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M303302200",
      "volume": "278",
      "author": "Yamin G.",
      "year": "2003",
      "journal-title": "J. Biol. Chem"
    },
    {
      "volume-title": "Protein Sci. 8, 161\u2212173.",
      "year": "1999",
      "author": "Uversky V. N.",
      "key": "bi049979hb00058/bi049979hb00058_1"
    },
    {
      "key": "bi049979hb00059/bi049979hb00059_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/S0006-3495(99)77111-0",
      "volume": "77",
      "author": "Kuznetsova I. M.",
      "year": "1999",
      "journal-title": "Biophys. J."
    },
    {
      "key": "bi049979hb00060/bi049979hb00060_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M109541200",
      "volume": "277",
      "author": "Uversky V. N.",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi049979hb00061/bi049979hb00061_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/0022-2836(82)90515-0",
      "volume": "157",
      "author": "Kyte J.",
      "year": "1982",
      "journal-title": "J. Mol. Biol."
    },
    {
      "volume-title": "in Infrared Analysis of Peptides and Proteins",
      "year": "1999",
      "author": "Fink A. L.",
      "key": "bi049979hb00062/bi049979hb00062_1"
    },
    {
      "volume-title": "Biochemistry 33, 2628\u22122634.",
      "year": "1994",
      "author": "Oberg K.",
      "key": "bi049979hb00063/bi049979hb00063_1"
    },
    {
      "key": "bi049979hb00064/bi049979hb00064_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/0167-4838(92)90353-F",
      "volume": "1121",
      "author": "Ismail A. A.",
      "year": "1992",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "volume-title": "Protein Eng. 7, 131\u2212136.",
      "year": "1994",
      "author": "Przybycien T. M.",
      "key": "bi049979hb00065/bi049979hb00065_1"
    },
    {
      "key": "bi049979hb00066/bi049979hb00066_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1021/js9801384",
      "volume": "87",
      "author": "Kendrick B. S.",
      "year": "1998",
      "journal-title": "J. Pharm. Sci."
    },
    {
      "key": "bi049979hb00067/bi049979hb00067_1",
      "volume": "17",
      "author": "Clark A. H.",
      "year": "1981",
      "journal-title": "Int. J. Pept. Protein Res."
    },
    {
      "key": "bi049979hb00068/bi049979hb00068_1",
      "first-page": "15",
      "volume": "3",
      "author": "Fink A. L.",
      "year": "1998",
      "journal-title": "Folding Des."
    },
    {
      "key": "bi049979hb00069/bi049979hb00069_1",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1002/1520-6017(200101)90:1<29::AID-JPS4>3.0.CO;2-4",
      "volume": "90",
      "author": "Nielsen L.",
      "year": "2001",
      "journal-title": "J. Pharm. Sci."
    },
    {
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 90",
      "year": "1993",
      "author": "Ueda K.",
      "key": "bi049979hb00070/bi049979hb00070_1"
    },
    {
      "volume-title": "Chem. Biol. 2, 163\u2212169.",
      "year": "1995",
      "author": "Han H.",
      "key": "bi049979hb00071/bi049979hb00071_1"
    },
    {
      "volume-title": "Neuron 32, 213\u2212223.",
      "year": "2001",
      "author": "Hashimoto M.",
      "key": "bi049979hb00072/bi049979hb00072_1"
    },
    {
      "key": "bi049979hb00073/bi049979hb00073_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M109541200",
      "volume": "277",
      "author": "Uversky V. N.",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "volume-title": "Biochemistry 42, 3696\u22123700.",
      "year": "2003",
      "author": "Park J. Y.",
      "key": "bi049979hb00074/bi049979hb00074_1"
    },
    {
      "key": "bi049979hb00075/bi049979hb00075_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.M008919200",
      "volume": "276",
      "author": "Giasson B. I.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bi049979hb00076/bi049979hb00076_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1046/j.1471-4159.2001.00408.x",
      "volume": "78",
      "author": "Bodles A. M.",
      "year": "2001",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "bi049979hb00077/bi049979hb00077_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1046/j.1432-1327.2000.01219.x",
      "volume": "267",
      "author": "Bodles A. M.",
      "year": "2000",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "bi049979hb00078/bi049979hb00078_1",
      "doi-asserted-by": "crossref",
      "first-page": "S36",
      "DOI": "10.1042/bst026s036",
      "volume": "26",
      "author": "Irvine G. B.",
      "year": "1998",
      "journal-title": "Biochem. Soc. Trans."
    },
    {
      "key": "bi049979hb00079/bi049979hb00079_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1046/j.1432-1327.1998.2580157.x",
      "volume": "258",
      "author": "El Agnaf O. M.",
      "year": "1998",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "volume-title": "Trends Neurosci. 21, 249\u2212254.",
      "year": "1998",
      "author": "Clayton D. F.",
      "key": "bi049979hb00080/bi049979hb00080_1"
    },
    {
      "volume-title": "Neuron 15, 361\u2212372.",
      "year": "1995",
      "author": "George J. M.",
      "key": "bi049979hb00081/bi049979hb00081_1"
    },
    {
      "volume-title": "Biochemistry 42, 672\u2212678.",
      "year": "2003",
      "author": "Kessler J. C.",
      "key": "bi049979hb00082/bi049979hb00082_1"
    },
    {
      "key": "bi049979hb00083/bi049979hb00083_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Conway, K. A., Harper, J. D., and Lansbury, P. T., Jr. (2000) Fibrils formed in vitro from alfa-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid,Biochemistry39, 2552\u22122563.",
      "DOI": "10.1021/bi991447r"
    },
    {
      "key": "bi049979hb00084/bi049979hb00084_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1074/jbc.274.14.9843",
      "volume": "274",
      "author": "Narhi L.",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "volume-title": "Neurotoxicology 23, 553\u2212567.",
      "year": "2002",
      "author": "Li J.",
      "key": "bi049979hb00085/bi049979hb00085_1"
    },
    {
      "key": "bi049979hb00086/bi049979hb00086_1",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1016/S0014-5793(02)02883-1",
      "volume": "522",
      "author": "Uversky V. N.",
      "year": "2002",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "bi049979hb00087/bi049979hb00087_1",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1111/j.1749-6632.2000.tb05561.x",
      "volume": "924",
      "author": "Trojanowski J. Q.",
      "year": "2000",
      "journal-title": "Ann. N.Y. Acad. Sci."
    },
    {
      "key": "bi049979hb00088/bi049979hb00088_1",
      "volume": "277",
      "author": "Hou L.",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "journal-title": "J. Am. Chem. Soc. (in press).",
      "year": "2004",
      "author": "Hou L.",
      "key": "bi049979hb00089/bi049979hb00089_1"
    },
    {
      "volume-title": "Parkinson's disease",
      "author": "Abbreviations PD",
      "key": "bi049979hn00001/bi049979hn00001_1"
    }
  ],
  "container-title": "Biochemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/bi049979h",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        12,
        15
      ]
    ],
    "date-time": "2024-12-15T20:42:32Z",
    "timestamp": 1734295352000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/bi049979h"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        3,
        26
      ]
    ]
  },
  "references-count": 90,
  "journal-issue": {
    "issue": "15",
    "published-print": {
      "date-parts": [
        [
          2004,
          4,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/bi049979h"
  ],
  "URL": "http://dx.doi.org/10.1021/bi049979h",
  "relation": {},
  "ISSN": [
    "0006-2960",
    "1520-4995"
  ],
  "subject": [],
  "container-title-short": "Biochemistry",
  "published": {
    "date-parts": [
      [
        2004,
        3,
        26
      ]
    ]
  }
}