DOI: 10.1021/bc0001488. Different Strategies for Formation of PEGylated EGF-Conjugated PEI/DNA Complexes for Targeted Gene Delivery

Different Strategies for Formation of PEGylated EGF-Conjugated PEI/DNA Complexes for Targeted Gene Delivery

10.1021/bc0001488

Crossref journal-article

American Chemical Society (ACS)

Bioconjugate Chemistry (316)

Bibliography

Blessing, T., Kursa, M., Holzhauser, R., Kircheis, R., & Wagner, E. (2001). Different Strategies for Formation of PEGylated EGF-Conjugated PEI/DNA Complexes for Targeted Gene Delivery. Bioconjugate Chemistry, 12(4), 529â537.

Authors 5

Thomas Blessing (first)
Malgorzata Kursa (additional)
Robert Holzhauser (additional)
Ralf Kircheis (additional)
Ernst Wagner (additional)

References 61 Referenced 204

{'key': 'bc0001488b00001/bc0001488b00001_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 92', 'author': 'Boussif O.', 'year': '1995'} / Proc. Natl. Acad. Sci. U.S.A. 92 by Boussif O. (1995)
{'key': 'bc0001488b00002/bc0001488b00002_1', 'volume-title': 'Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold. Gene Ther. 3, 1074−1080', 'author': 'Boussif O.', 'year': '1996'} / Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold. Gene Ther. 3, 1074−1080 by Boussif O. (1996)
10.1016/B978-012358465-6/50021-9 / Polyethylenimines: A family of potent polymers for nucleic acid delivery. Non viral vectors for gene therapy by Kichler A. (1999)
{'key': 'bc0001488b00004/bc0001488b00004_1', 'volume-title': 'Ovarian carcinoma cells are effectively transfected by polyethylenimine (PEI) derivatives. Cancer Gene Ther. 7, 644−652', 'author': 'Poulain L.', 'year': '2000'} / Ovarian carcinoma cells are effectively transfected by polyethylenimine (PEI) derivatives. Cancer Gene Ther. 7, 644−652 by Poulain L. (2000)
{'key': 'bc0001488b00005/bc0001488b00005_1', 'volume-title': 'vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjugate Chem. 8, 839−844', 'author': 'Zanta M. A.', 'year': '1997'} / vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjugate Chem. 8, 839−844 by Zanta M. A. (1997)
{'key': 'bc0001488b00006/bc0001488b00006_1', 'volume-title': 'Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes. Bioconjugate Chem. 10, 558−561', 'author': 'Bettinger T.', 'year': '1999'} / Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes. Bioconjugate Chem. 10, 558−561 by Bettinger T. (1999)
{'key': 'bc0001488b00007/bc0001488b00007_1', 'volume-title': 'Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Hum. Gene Ther. 10, 775−786', 'author': 'Diebold S. S.', 'year': '1999'} / Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Hum. Gene Ther. 10, 775−786 by Diebold S. S. (1999)
10.1074/jbc.274.27.19087 / J. Biol. Chem. by Diebold S. S. (1999)
{'key': 'bc0001488b00009/bc0001488b00009_1', 'volume-title': 'Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther. 6, 138−145', 'author': 'Erbacher P.', 'year': '1999'} / Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther. 6, 138−145 by Erbacher P. (1999)
{'key': 'bc0001488b00010/bc0001488b00010_1', 'volume-title': 'Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther. 4, 409−418', 'author': 'Kircheis R.', 'year': '1997'} / Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther. 4, 409−418 by Kircheis R. (1997)
10.1089/hum.1996.7.16-1947 / A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum. Gene Ther. 7 by Abdallah B. (1996)
{'key': 'bc0001488b00012/bc0001488b00012_1', 'volume-title': 'ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Ther. 4, 1100−1106', 'author': 'Ferrari S.', 'year': '1997'} / ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Ther. 4, 1100−1106 by Ferrari S. (1997)
{'key': 'bc0001488b00013/bc0001488b00013_1', 'volume-title': 'Nonviral gene delivery to the rat kidney with polyethylenimine. Hum. Gene Ther. 8, 1243−1251', 'author': 'Boletta A.', 'year': '1997'} / Nonviral gene delivery to the rat kidney with polyethylenimine. Hum. Gene Ther. 8, 1243−1251 by Boletta A. (1997)
{'key': 'bc0001488b00014/bc0001488b00014_1', 'volume-title': 'Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther. 5, 712−717', 'author': 'Goula D.', 'year': '1998'} / Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther. 5, 712−717 by Goula D. (1998)
10.1046/j.1365-2893.1998.00126.x / J. Viral Hepat. by Chemin I. (1998)
{'key': 'bc0001488b00016/bc0001488b00016_1', 'volume-title': 'vivo delivery to tumors of DNA complexed with linear polyethylenimine. Hum. Gene Ther. 10, 1659−1666', 'author': 'Coll J. L.', 'year': '1999'} / vivo delivery to tumors of DNA complexed with linear polyethylenimine. Hum. Gene Ther. 10, 1659−1666 by Coll J. L. (1999)
10.1038/sj.gt.3300800 / Gene Ther. by Turunen M. P. (1999)
{'key': 'bc0001488b00018/bc0001488b00018_1', 'volume-title': 'Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther. 5, 1291−1295', 'author': 'Goula D.', 'year': '1998'} / Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther. 5, 1291−1295 by Goula D. (1998)
{'key': 'bc0001488b00019/bc0001488b00019_1', 'volume': '2', 'author': 'Zou S. M.', 'year': '2000', 'journal-title': 'J. Gene Med.'} / J. Gene Med. by Zou S. M. (2000)
{'key': 'bc0001488b00020/bc0001488b00020_1', 'volume-title': 'PEGylated DNA/transferrin-PEI complexes:\u2009 reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6, 595−605', 'author': 'Ogris M.', 'year': '1999'} / PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6, 595−605 by Ogris M. (1999)
10.1002/(SICI)1521-2254(199903/04)1:2<111::AID-JGM22>3.0.CO;2-Y / J. Gene Med. by Kircheis R. (1999)
{'key': 'bc0001488b00022/bc0001488b00022_1', 'first-page': '87', 'volume': '253', 'author': 'Kim H.', 'year': '1999', 'journal-title': 'Exp. Cell Res.'} / Exp. Cell Res. by Kim H. (1999)
10.1038/bjc.1991.286 / Br. J. Cancer by Kwok T. (1991)
{'key': 'bc0001488b00024/bc0001488b00024_1', 'volume-title': 'Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjugate Chem. 3, 533−539', 'author': 'Plank C.', 'year': '1992'} / Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjugate Chem. 3, 533−539 by Plank C. (1992)
{'key': 'bc0001488b00025/bc0001488b00025_1', 'volume-title': 'Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction. Anal. Biochem. 117, 147−157', 'author': 'Sarin V. K.', 'year': '1981'} / Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction. Anal. Biochem. 117, 147−157 by Sarin V. K. (1981)
10.1042/bj1730723 / Biochem. J. by Carlsson J. (1978)
10.1016/0003-2697(79)90792-9 / Anal. Biochem. by Riddles P. W. (1979)
{'key': 'bc0001488b00028/bc0001488b00028_1', 'volume-title': 'Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors. Oncogene 18, 1711−1721', 'author': 'Schmidt M.', 'year': '1999'} / Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors. Oncogene 18, 1711−1721 by Schmidt M. (1999)
{'key': 'bc0001488b00029/bc0001488b00029_1', 'volume': '270', 'author': 'French A. R.', 'year': '1995', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by French A. R. (1995)
10.1002/jcb.240410202 / J. Cell Biochem. by Spitzer E. (1989)
{'key': 'bc0001488b00031/bc0001488b00031_1', 'volume-title': 'The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 5, 1425−1433', 'author': 'Ogris M.', 'year': '1998'} / The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 5, 1425−1433 by Ogris M. (1998)
10.1016/0014-5793(94)80357-9 / FEBS Lett. by Chen J. (1994)
{'key': 'bc0001488b00033/bc0001488b00033_1', 'volume-title': 'Immunogene approach toward cancer therapy using erythrocyte growth factor receptor-mediated gene delivery. Cancer Gene Ther. 3, 113−120', 'author': 'Shimizu N.', 'year': '1996'} / Immunogene approach toward cancer therapy using erythrocyte growth factor receptor-mediated gene delivery. Cancer Gene Ther. 3, 113−120 by Shimizu N. (1996)
{'key': 'bc0001488b00034/bc0001488b00034_1', 'first-page': '10', 'volume': '3', 'author': 'Cristiano R. J.', 'year': '1996', 'journal-title': 'Cancer Gene Ther.'} / Cancer Gene Ther. by Cristiano R. J. (1996)
{'key': 'bc0001488b00035/bc0001488b00035_1', 'volume-title': 'The contribution of poly-l-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation. Gene Ther. 5, 1235−1243', 'author': 'Xu B.', 'year': '1998'} / The contribution of poly-l-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation. Gene Ther. 5, 1235−1243 by Xu B. (1998)
{'key': 'bc0001488b00036/bc0001488b00036_1', 'volume': '273', 'author': 'Schaffer D. V.', 'year': '1998', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Schaffer D. V. (1998)
{'key': 'bc0001488b00037/bc0001488b00037_1', 'volume-title': 'A chimeric fusion protein containing transforming growth factor-alpha mediates gene transfer via binding to the EGF receptor. Gene Ther. 5, 521−530', 'author': 'Fominaya J.', 'year': '1998'} / A chimeric fusion protein containing transforming growth factor-alpha mediates gene transfer via binding to the EGF receptor. Gene Ther. 5, 521−530 by Fominaya J. (1998)
{'key': 'bc0001488b00038/bc0001488b00038_1', 'volume-title': 'Efficient gene transfer to EGF receptor overexpressing cancer cells by means of EGF-labeled cationic liposomes. Biochem. Biophys. Res. Commun. 227, 666−671', 'author': 'Kikuchi A.', 'year': '1996'} / Efficient gene transfer to EGF receptor overexpressing cancer cells by means of EGF-labeled cationic liposomes. Biochem. Biophys. Res. Commun. 227, 666−671 by Kikuchi A. (1996)
10.1038/sj.cgt.7700092 / Cancer Gene Ther. by Yanagihara K. (2000)
{'key': 'bc0001488b00040/bc0001488b00040_1', 'volume-title': 'Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 4, 372−379', 'author': 'Haensler J.', 'year': '1993'} / Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 4, 372−379 by Haensler J. (1993)
{'key': 'bc0001488b00041/bc0001488b00041_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 93', 'author': 'Kukowska Latallo J. F.', 'year': '1996'} / Proc. Natl. Acad. Sci. U.S.A. 93 by Kukowska Latallo J. F. (1996)
{'key': 'bc0001488b00042/bc0001488b00042_1', 'first-page': '58', 'volume': '12', 'author': 'Behr J. P.', 'year': '1996', 'journal-title': 'M/S-Med. Sci.'} / M/S-Med. Sci. by Behr J. P. (1996)
{'key': 'bc0001488b00043/bc0001488b00043_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 94', 'author': 'Hara T.', 'year': '1997'} / Proc. Natl. Acad. Sci. U.S.A. 94 by Hara T. (1997)
{'key': 'bc0001488b00044/bc0001488b00044_1', 'volume-title': 'Proc. Natl. Acad. Sci. U.S.A. 95', 'author': 'Blessing T.', 'year': '1998'} / Proc. Natl. Acad. Sci. U.S.A. 95 by Blessing T. (1998)
10.1021/ja980620o / J. Am. Chem. Soc. by Blessing T. (1998)
{'key': 'bc0001488b00046/bc0001488b00046_1', 'volume-title': 'Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration. Bioconjugate Chem. 11, 104−112', 'author': 'Ouyang M.', 'year': '2000'} / Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration. Bioconjugate Chem. 11, 104−112 by Ouyang M. (2000)
{'key': 'bc0001488b00047/bc0001488b00047_1', 'volume-title': 'Activation of the complement system by synthetic DNA complexes:\u2009 a potential barrier for intravenous gene delivery. Hum. Gene Ther. 7, 1437−1446', 'author': 'Plank C.', 'year': '1996'} / Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum. Gene Ther. 7, 1437−1446 by Plank C. (1996)
{'key': 'bc0001488b00048/bc0001488b00048_1', 'volume-title': 'L Lactic Acid). Bioconjugate Chem. 8, 735−742.', 'author': 'Maruyama A.', 'year': '1997'} / L Lactic Acid). Bioconjugate Chem. 8, 735−742. by Maruyama A. (1997)
10.1089/hum.1996.7.17-2123 / Hum. Gene Ther. by Wolfert M. A. (1996)
{'key': 'bc0001488b00050/bc0001488b00050_1', 'volume-title': 'Water Soluble Polyion Complex Associates Of Dna and Poly(Ethylene Glycol) Poly(L Lysine) Block Copolymer. Bioconjugate Chem. 8, 702−707', 'author': 'Katayose S.', 'year': '1997'} / Water Soluble Polyion Complex Associates Of Dna and Poly(Ethylene Glycol) Poly(L Lysine) Block Copolymer. Bioconjugate Chem. 8, 702−707 by Katayose S. (1997)
{'key': 'bc0001488b00051/bc0001488b00051_1', 'volume-title': 'Lactose-poly(ethylene glycol)-grafted poly-l-lysine as hepatoma cell-tapgeted gene carrier. Bioconjugate Chem. 9, 708−718', 'author': 'Choi Y. H.', 'year': '1998'} / Lactose-poly(ethylene glycol)-grafted poly-l-lysine as hepatoma cell-tapgeted gene carrier. Bioconjugate Chem. 9, 708−718 by Choi Y. H. (1998)
{'key': 'bc0001488b00052/bc0001488b00052_1', 'volume': '1380', 'author': 'Toncheva V.', 'year': '1998', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta by Toncheva V. (1998)
{'key': 'bc0001488b00053/bc0001488b00053_1', 'volume-title': 'Characterization of a targeted gene carrier, lactose-poly(ethylene glycol)-grafted poly-l-lysine and its complex with plasmid DNA. Hum. Gene Ther. 10, 2657−2665', 'author': 'Choi Y. H.', 'year': '1999'} / Characterization of a targeted gene carrier, lactose-poly(ethylene glycol)-grafted poly-l-lysine and its complex with plasmid DNA. Hum. Gene Ther. 10, 2657−2665 by Choi Y. H. (1999)
{'key': 'bc0001488b00054/bc0001488b00054_1', 'volume-title': 'Folate copolymer-mediated transfection of cultured cells. Bioconjugate Chem. 10, 947−957', 'author': 'Leamon C. P.', 'year': '1999'} / Folate copolymer-mediated transfection of cultured cells. Bioconjugate Chem. 10, 947−957 by Leamon C. P. (1999)
10.1002/(SICI)1521-2254(199905/06)1:3<210::AID-JGM30>3.0.CO;2-U / J. Gene Med. by Erbacher P. (1999)
{'key': 'bc0001488b00056/bc0001488b00056_1', 'volume-title': 'Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Ther. 7, 126−138', 'author': 'Nguyen H. K.', 'year': '2000'} / Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Ther. 7, 126−138 by Nguyen H. K. (2000)
10.1016/0014-5793(91)80699-4 / FEBS Lett. by Mori A. (1991)
{'key': 'bc0001488b00058/bc0001488b00058_1', 'volume': '1062', 'author': 'Klibanov A. L.', 'year': '1991', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta by Klibanov A. L. (1991)
{'key': 'bc0001488b00059/bc0001488b00059_1', 'volume': '1149', 'author': 'Blume G.', 'year': '1993', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta by Blume G. (1993)
{'key': 'bc0001488b00060/bc0001488b00060_1', 'first-page': '80', 'volume': '1234', 'author': 'Maruyama K.', 'year': '1995', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta by Maruyama K. (1995)
10.3109/10611869408996815 / J. Drug Target. by Woodle M. C. (1994)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:39 a.m.)
Deposited	2 years, 5 months ago (March 23, 2023, 4:09 a.m.)
Indexed	4 weeks ago (Aug. 2, 2025, 1:11 a.m.)
Issued	24 years, 2 months ago (June 23, 2001)
Published	24 years, 2 months ago (June 23, 2001)
Published Online	24 years, 2 months ago (June 23, 2001)
Published Print	24 years, 1 month ago (July 1, 2001)

Funders 0

None

BibTeX

@article{Blessing_2001, title={Different Strategies for Formation of PEGylated EGF-Conjugated PEI/DNA Complexes for Targeted Gene Delivery}, volume={12}, ISSN={1520-4812}, url={http://dx.doi.org/10.1021/bc0001488}, DOI={10.1021/bc0001488}, number={4}, journal={Bioconjugate Chemistry}, publisher={American Chemical Society (ACS)}, author={Blessing, Thomas and Kursa, Malgorzata and Holzhauser, Robert and Kircheis, Ralf and Wagner, Ernst}, year={2001}, month=jun, pages={529–537} }

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      "author": "Kichler A.",
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      "key": "bc0001488b00004/bc0001488b00004_1",
      "volume-title": "Ovarian carcinoma cells are effectively transfected by polyethylenimine (PEI) derivatives. Cancer Gene Ther. 7, 644\u2212652",
      "author": "Poulain L.",
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    {
      "key": "bc0001488b00005/bc0001488b00005_1",
      "volume-title": "vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjugate Chem. 8, 839\u2212844",
      "author": "Zanta M. A.",
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      "key": "bc0001488b00006/bc0001488b00006_1",
      "volume-title": "Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes. Bioconjugate Chem. 10, 558\u2212561",
      "author": "Bettinger T.",
      "year": "1999"
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    {
      "key": "bc0001488b00007/bc0001488b00007_1",
      "volume-title": "Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Hum. Gene Ther. 10, 775\u2212786",
      "author": "Diebold S. S.",
      "year": "1999"
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      "key": "bc0001488b00008/bc0001488b00008_1",
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      "DOI": "10.1074/jbc.274.27.19087",
      "volume": "274",
      "author": "Diebold S. S.",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
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      "key": "bc0001488b00009/bc0001488b00009_1",
      "volume-title": "Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther. 6, 138\u2212145",
      "author": "Erbacher P.",
      "year": "1999"
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    {
      "key": "bc0001488b00010/bc0001488b00010_1",
      "volume-title": "Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther. 4, 409\u2212418",
      "author": "Kircheis R.",
      "year": "1997"
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      "author": "Abdallah B.",
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      "year": "1997"
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    {
      "key": "bc0001488b00013/bc0001488b00013_1",
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    {
      "key": "bc0001488b00014/bc0001488b00014_1",
      "volume-title": "Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther. 5, 712\u2212717",
      "author": "Goula D.",
      "year": "1998"
    },
    {
      "key": "bc0001488b00015/bc0001488b00015_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1046/j.1365-2893.1998.00126.x",
      "volume": "5",
      "author": "Chemin I.",
      "year": "1998",
      "journal-title": "J. Viral Hepat."
    },
    {
      "key": "bc0001488b00016/bc0001488b00016_1",
      "volume-title": "vivo delivery to tumors of DNA complexed with linear polyethylenimine. Hum. Gene Ther. 10, 1659\u22121666",
      "author": "Coll J. L.",
      "year": "1999"
    },
    {
      "key": "bc0001488b00017/bc0001488b00017_1",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1038/sj.gt.3300800",
      "volume": "6",
      "author": "Turunen M. P.",
      "year": "1999",
      "journal-title": "Gene Ther."
    },
    {
      "key": "bc0001488b00018/bc0001488b00018_1",
      "volume-title": "Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther. 5, 1291\u22121295",
      "author": "Goula D.",
      "year": "1998"
    },
    {
      "key": "bc0001488b00019/bc0001488b00019_1",
      "volume": "2",
      "author": "Zou S. M.",
      "year": "2000",
      "journal-title": "J. Gene Med."
    },
    {
      "key": "bc0001488b00020/bc0001488b00020_1",
      "volume-title": "PEGylated DNA/transferrin-PEI complexes:\u2009 reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6, 595\u2212605",
      "author": "Ogris M.",
      "year": "1999"
    },
    {
      "key": "bc0001488b00021/bc0001488b00021_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1002/(SICI)1521-2254(199903/04)1:2<111::AID-JGM22>3.0.CO;2-Y",
      "volume": "1",
      "author": "Kircheis R.",
      "year": "1999",
      "journal-title": "J. Gene Med."
    },
    {
      "key": "bc0001488b00022/bc0001488b00022_1",
      "first-page": "87",
      "volume": "253",
      "author": "Kim H.",
      "year": "1999",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "bc0001488b00023/bc0001488b00023_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1038/bjc.1991.286",
      "volume": "64",
      "author": "Kwok T.",
      "year": "1991",
      "journal-title": "Br. J. Cancer"
    },
    {
      "key": "bc0001488b00024/bc0001488b00024_1",
      "volume-title": "Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjugate Chem. 3, 533\u2212539",
      "author": "Plank C.",
      "year": "1992"
    },
    {
      "key": "bc0001488b00025/bc0001488b00025_1",
      "volume-title": "Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction. Anal. Biochem. 117, 147\u2212157",
      "author": "Sarin V. K.",
      "year": "1981"
    },
    {
      "key": "bc0001488b00026/bc0001488b00026_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1042/bj1730723",
      "volume": "173",
      "author": "Carlsson J.",
      "year": "1978",
      "journal-title": "Biochem. J."
    },
    {
      "key": "bc0001488b00027/bc0001488b00027_1",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1016/0003-2697(79)90792-9",
      "volume": "94",
      "author": "Riddles P. W.",
      "year": "1979",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "bc0001488b00028/bc0001488b00028_1",
      "volume-title": "Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors. Oncogene 18, 1711\u22121721",
      "author": "Schmidt M.",
      "year": "1999"
    },
    {
      "key": "bc0001488b00029/bc0001488b00029_1",
      "volume": "270",
      "author": "French A. R.",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bc0001488b00030/bc0001488b00030_1",
      "doi-asserted-by": "crossref",
      "first-page": "56",
      "DOI": "10.1002/jcb.240410202",
      "volume": "41",
      "author": "Spitzer E.",
      "year": "1989",
      "journal-title": "J. Cell Biochem."
    },
    {
      "key": "bc0001488b00031/bc0001488b00031_1",
      "volume-title": "The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 5, 1425\u22121433",
      "author": "Ogris M.",
      "year": "1998"
    },
    {
      "key": "bc0001488b00032/bc0001488b00032_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/0014-5793(94)80357-9",
      "volume": "338",
      "author": "Chen J.",
      "year": "1994",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "bc0001488b00033/bc0001488b00033_1",
      "volume-title": "Immunogene approach toward cancer therapy using erythrocyte growth factor receptor-mediated gene delivery. Cancer Gene Ther. 3, 113\u2212120",
      "author": "Shimizu N.",
      "year": "1996"
    },
    {
      "key": "bc0001488b00034/bc0001488b00034_1",
      "first-page": "10",
      "volume": "3",
      "author": "Cristiano R. J.",
      "year": "1996",
      "journal-title": "Cancer Gene Ther."
    },
    {
      "key": "bc0001488b00035/bc0001488b00035_1",
      "volume-title": "The contribution of poly-l-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation. Gene Ther. 5, 1235\u22121243",
      "author": "Xu B.",
      "year": "1998"
    },
    {
      "key": "bc0001488b00036/bc0001488b00036_1",
      "volume": "273",
      "author": "Schaffer D. V.",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "bc0001488b00037/bc0001488b00037_1",
      "volume-title": "A chimeric fusion protein containing transforming growth factor-alpha mediates gene transfer via binding to the EGF receptor. Gene Ther. 5, 521\u2212530",
      "author": "Fominaya J.",
      "year": "1998"
    },
    {
      "key": "bc0001488b00038/bc0001488b00038_1",
      "volume-title": "Efficient gene transfer to EGF receptor overexpressing cancer cells by means of EGF-labeled cationic liposomes. Biochem. Biophys. Res. Commun. 227, 666\u2212671",
      "author": "Kikuchi A.",
      "year": "1996"
    },
    {
      "key": "bc0001488b00039/bc0001488b00039_1",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1038/sj.cgt.7700092",
      "volume": "7",
      "author": "Yanagihara K.",
      "year": "2000",
      "journal-title": "Cancer Gene Ther."
    },
    {
      "key": "bc0001488b00040/bc0001488b00040_1",
      "volume-title": "Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 4, 372\u2212379",
      "author": "Haensler J.",
      "year": "1993"
    },
    {
      "key": "bc0001488b00041/bc0001488b00041_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 93",
      "author": "Kukowska Latallo J. F.",
      "year": "1996"
    },
    {
      "key": "bc0001488b00042/bc0001488b00042_1",
      "first-page": "58",
      "volume": "12",
      "author": "Behr J. P.",
      "year": "1996",
      "journal-title": "M/S-Med. Sci."
    },
    {
      "key": "bc0001488b00043/bc0001488b00043_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 94",
      "author": "Hara T.",
      "year": "1997"
    },
    {
      "key": "bc0001488b00044/bc0001488b00044_1",
      "volume-title": "Proc. Natl. Acad. Sci. U.S.A. 95",
      "author": "Blessing T.",
      "year": "1998"
    },
    {
      "key": "bc0001488b00045/bc0001488b00045_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1021/ja980620o",
      "volume": "120",
      "author": "Blessing T.",
      "year": "1998",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "bc0001488b00046/bc0001488b00046_1",
      "volume-title": "Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration. Bioconjugate Chem. 11, 104\u2212112",
      "author": "Ouyang M.",
      "year": "2000"
    },
    {
      "key": "bc0001488b00047/bc0001488b00047_1",
      "volume-title": "Activation of the complement system by synthetic DNA complexes:\u2009 a potential barrier for intravenous gene delivery. Hum. Gene Ther. 7, 1437\u22121446",
      "author": "Plank C.",
      "year": "1996"
    },
    {
      "key": "bc0001488b00048/bc0001488b00048_1",
      "volume-title": "L Lactic Acid). Bioconjugate Chem. 8, 735\u2212742.",
      "author": "Maruyama A.",
      "year": "1997"
    },
    {
      "key": "bc0001488b00049/bc0001488b00049_1",
      "doi-asserted-by": "crossref",
      "first-page": "2123",
      "DOI": "10.1089/hum.1996.7.17-2123",
      "volume": "7",
      "author": "Wolfert M. A.",
      "year": "1996",
      "journal-title": "Hum. Gene Ther."
    },
    {
      "key": "bc0001488b00050/bc0001488b00050_1",
      "volume-title": "Water Soluble Polyion Complex Associates Of Dna and Poly(Ethylene Glycol) Poly(L Lysine) Block Copolymer. Bioconjugate Chem. 8, 702\u2212707",
      "author": "Katayose S.",
      "year": "1997"
    },
    {
      "key": "bc0001488b00051/bc0001488b00051_1",
      "volume-title": "Lactose-poly(ethylene glycol)-grafted poly-l-lysine as hepatoma cell-tapgeted gene carrier. Bioconjugate Chem. 9, 708\u2212718",
      "author": "Choi Y. H.",
      "year": "1998"
    },
    {
      "key": "bc0001488b00052/bc0001488b00052_1",
      "volume": "1380",
      "author": "Toncheva V.",
      "year": "1998",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "bc0001488b00053/bc0001488b00053_1",
      "volume-title": "Characterization of a targeted gene carrier, lactose-poly(ethylene glycol)-grafted poly-l-lysine and its complex with plasmid DNA. Hum. Gene Ther. 10, 2657\u22122665",
      "author": "Choi Y. H.",
      "year": "1999"
    },
    {
      "key": "bc0001488b00054/bc0001488b00054_1",
      "volume-title": "Folate copolymer-mediated transfection of cultured cells. Bioconjugate Chem. 10, 947\u2212957",
      "author": "Leamon C. P.",
      "year": "1999"
    },
    {
      "key": "bc0001488b00055/bc0001488b00055_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1002/(SICI)1521-2254(199905/06)1:3<210::AID-JGM30>3.0.CO;2-U",
      "volume": "1",
      "author": "Erbacher P.",
      "year": "1999",
      "journal-title": "J. Gene Med."
    },
    {
      "key": "bc0001488b00056/bc0001488b00056_1",
      "volume-title": "Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Ther. 7, 126\u2212138",
      "author": "Nguyen H. K.",
      "year": "2000"
    },
    {
      "key": "bc0001488b00057/bc0001488b00057_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1016/0014-5793(91)80699-4",
      "volume": "284",
      "author": "Mori A.",
      "year": "1991",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "bc0001488b00058/bc0001488b00058_1",
      "volume": "1062",
      "author": "Klibanov A. L.",
      "year": "1991",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "bc0001488b00059/bc0001488b00059_1",
      "volume": "1149",
      "author": "Blume G.",
      "year": "1993",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "bc0001488b00060/bc0001488b00060_1",
      "first-page": "80",
      "volume": "1234",
      "author": "Maruyama K.",
      "year": "1995",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "bc0001488b00061/bc0001488b00061_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.3109/10611869408996815",
      "volume": "2",
      "author": "Woodle M. C.",
      "year": "1994",
      "journal-title": "J. Drug Target."
    }
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