DOI: 10.1021/ac060572n. Achieving Uniform Mixing in a Microfluidic Device: Hydrodynamic Focusing Prior to Mixing

Achieving Uniform Mixing in a Microfluidic Device: Hydrodynamic Focusing Prior to Mixing

10.1021/ac060572n

Crossref journal-article

American Chemical Society (ACS)

Analytical Chemistry (316)

Bibliography

Park, H. Y., Qiu, X., Rhoades, E., Korlach, J., Kwok, L. W., Zipfel, W. R., Webb, W. W., & Pollack, L. (2006). Achieving Uniform Mixing in a Microfluidic Device:â Hydrodynamic Focusing Prior to Mixing. Analytical Chemistry, 78(13), 4465â4473.

Authors 8

Hye Yoon Park (first)
Xiangyun Qiu (additional)
Elizabeth Rhoades (additional)
Jonas Korlach (additional)
Lisa W. Kwok (additional)
Warren R. Zipfel (additional)
Watt W. Webb (additional)
Lois Pollack (additional)

References 40 Referenced 119

10.1146/annurev.biophys.29.1.327 / Annu. Rev. Biophys. Biomol. Struct. by Eaton W. A. (2000)
10.1016/S0959-440X(99)00015-9 / Curr. Opin. Struct. Biol. by Roder H. (1999)
10.1063/1.1138345 / Rev. Sci. Instrum. by Regenfuss P. (1985)
{'key': 'ac060572nb00004/ac060572nb00004_1', 'first-page': '50', 'volume': '4', 'author': 'Takahashi S.', 'year': '1997', 'journal-title': 'Nat. Struct. Biol.'} / Nat. Struct. Biol. by Takahashi S. (1997)
{'key': 'ac060572nb00005/ac060572nb00005_1', 'first-page': '1784', 'volume': '94', 'author': 'Chan C. K.', 'year': '1997', 'journal-title': 'Proc. Natl. Acad. Sci. U.S.A.'} / Proc. Natl. Acad. Sci. U.S.A. by Chan C. K. (1997)
{'key': 'ac060572nb00006/ac060572nb00006_1', 'first-page': '2721', 'volume': '74', 'author': 'Shastry M. C. R.', 'year': '1998', 'journal-title': 'Biophys. J.'} / Biophys. J. by Shastry M. C. R. (1998)
10.1016/S0006-3495(00)76814-7 / Biophys. J. by Grigoryants V. M. (2000)
{'key': 'ac060572nb00008/ac060572nb00008_1', 'first-page': '1334', 'volume': '99', 'author': 'Akiyama S.', 'year': '2002', 'journal-title': 'Proc. Natl. Acad. Sci. U.S.A.'} / Proc. Natl. Acad. Sci. U.S.A. by Akiyama S. (2002)
10.1063/1.1834698 / Rev. Sci. Instrum. by Bilsel O. (2005)
10.1021/ac9708250 / Anal. Chem. by Bökenkamp D. (1998)
{'key': 'ac060572nb00011/ac060572nb00011_1', 'first-page': '5386', 'volume': '75', 'author': 'Lin Y.', 'year': '2003', 'journal-title': 'Anal. Chem.'} / Anal. Chem. by Lin Y. (2003)
10.1016/S0006-3495(96)79538-3 / Biophys. J. by Brody J. P. (1996)
10.1103/PhysRevLett.80.3863 / Phys. Rev. Lett. by Knight J. B. (1998)
10.1073/pnas.96.18.10115 / Proc. Natl. Acad. Sci. U.S.A. by Pollack L. (1999)
10.1103/PhysRevLett.86.4962 / J. Phys. Rev. Lett. by Pollack L. (2001)
{'key': 'ac060572nb00016/ac060572nb00016_1', 'first-page': '4271', 'volume': '99', 'author': 'Russell R.', 'year': '2002', 'journal-title': 'Proc. Natl. Acad. Sci. U.S.A.'} / Proc. Natl. Acad. Sci. U.S.A. by Russell R. (2002)
10.1073/pnas.101122898 / Proc. Natl. Acad. Sci.U.S.A. by Kauffmann E. (2001)
10.1016/S0006-3495(02)75296-X / Biophys. J. by Pabit S. A. (2002)
10.1126/science.1085399 / Science by Lipman E. A. (2003)
10.1039/B406899H / Phys. Chem. Chem. Phys. by Dittrich P. S. (2004)
10.1021/ac048661s / Anal. Chem. by Hertzog D. E. (2004)
10.1039/b407765b / Lab Chip by Munson M. S. (2004)
10.1021/ac025777k / Anal. Chem. by Hofmann O. (2002)
10.1109/JMEMS.2004.832196 / J. Microelectromech. Syst. by Sundararajan N. (2004)
10.1039/b507548c / Lab Chip by Nguyen N. T. (2005)
10.1038/nbt899 / Nat. Biotechnol. by Zipfel W. R. (2003)
10.1021/ac001533t / Anal. Chem. by Kameoka J. (2001)
10.1002/bip.1978.360170208 / Biopolymers by Magde D. (1978)
10.1021/ac991448p / Anal. Chem. by Gösch M. (2000)
10.1021/ac025625p / Anal. Chem. by Dittrich P. S. (2002)
10.1021/ac011076w / Anal. Chem. by Foquet M. (2002)
10.1002/1438-5171(200208)3:4<194::AID-SIMO194>3.0.CO;2-0 / Single Mol. by Lenne P. F. (2002)
10.1366/0003702042335957 / Appl. Spectrosc. by Kuricheti K. K. (2004)
{'key': 'ac060572nb00034/ac060572nb00034_1', 'first-page': '2317', 'volume': '83', 'author': 'Hess S. T.', 'year': '2002', 'journal-title': 'Biophys. J.'} / Biophys. J. by Hess S. T. (2002)
10.1007/978-1-4757-3061-6 / Principles of Fluorescence Spectroscopy by Lakowicz J. R. (1999)
Landau, L. D.; Lifshitz, E. M.Fluid Mechanics; Pergamon Press: London, 1959.
{'key': 'ac060572nb00037/ac060572nb00037_1', 'volume-title': 'CRC Handbook Chemistry and Physics', 'author': 'Lide D. R.', 'year': '2004', 'edition': '85'} / CRC Handbook Chemistry and Physics by Lide D. R. (2004)
10.1039/B500129C / Lab Chip by Brister P. C. (2005)
10.1016/j.cej.2003.10.017 / Chem. Eng. J. by Engler M. (2004)
{'key': 'ac060572nb00040/ac060572nb00040_1', 'volume-title': 'Biophysical Chemistry', 'author': 'Cantor C. R.', 'year': '1980'} / Biophysical Chemistry by Cantor C. R. (1980)

Dates

Type	When
Created	19 years, 2 months ago (June 10, 2006, 1:17 p.m.)
Deposited	3 years, 10 months ago (Oct. 16, 2021, 4:23 p.m.)
Indexed	2 months ago (June 19, 2025, 5:25 a.m.)
Issued	19 years, 3 months ago (May 17, 2006)
Published	19 years, 3 months ago (May 17, 2006)
Published Online	19 years, 3 months ago (May 17, 2006)
Published Print	19 years, 1 month ago (July 1, 2006)

Funders 0

None

BibTeX

@article{Park_2006, title={Achieving Uniform Mixing in a Microfluidic Device: Hydrodynamic Focusing Prior to Mixing}, volume={78}, ISSN={1520-6882}, url={http://dx.doi.org/10.1021/ac060572n}, DOI={10.1021/ac060572n}, number={13}, journal={Analytical Chemistry}, publisher={American Chemical Society (ACS)}, author={Park, Hye Yoon and Qiu, Xiangyun and Rhoades, Elizabeth and Korlach, Jonas and Kwok, Lisa W. and Zipfel, Warren R. and Webb, Watt W. and Pollack, Lois}, year={2006}, month=may, pages={4465–4473} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        19
      ]
    ],
    "date-time": "2025-06-19T09:25:06Z",
    "timestamp": 1750325106002
  },
  "reference-count": 40,
  "publisher": "American Chemical Society (ACS)",
  "issue": "13",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2006,
        7,
        1
      ]
    ]
  },
  "DOI": "10.1021/ac060572n",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        6,
        10
      ]
    ],
    "date-time": "2006-06-10T17:17:53Z",
    "timestamp": 1149959873000
  },
  "page": "4465-4473",
  "source": "Crossref",
  "is-referenced-by-count": 119,
  "title": "Achieving Uniform Mixing in a Microfluidic Device:\u2009 Hydrodynamic Focusing Prior to Mixing",
  "prefix": "10.1021",
  "volume": "78",
  "author": [
    {
      "given": "Hye Yoon",
      "family": "Park",
      "sequence": "first",
      "affiliation": [
        {
          "name": "School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853"
        }
      ]
    },
    {
      "given": "Xiangyun",
      "family": "Qiu",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853"
        }
      ]
    },
    {
      "given": "Elizabeth",
      "family": "Rhoades",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853"
        }
      ]
    },
    {
      "given": "Jonas",
      "family": "Korlach",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853"
        }
      ]
    },
    {
      "given": "Lisa W.",
      "family": "Kwok",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853"
        }
      ]
    },
    {
      "given": "Warren R.",
      "family": "Zipfel",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853"
        }
      ]
    },
    {
      "given": "Watt W.",
      "family": "Webb",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853"
        }
      ]
    },
    {
      "given": "Lois",
      "family": "Pollack",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853"
        }
      ]
    }
  ],
  "member": "316",
  "published-online": {
    "date-parts": [
      [
        2006,
        5,
        17
      ]
    ]
  },
  "reference": [
    {
      "key": "ac060572nb00001/ac060572nb00001_1",
      "doi-asserted-by": "crossref",
      "first-page": "359",
      "DOI": "10.1146/annurev.biophys.29.1.327",
      "volume": "29",
      "author": "Eaton W. A.",
      "year": "2000",
      "journal-title": "Annu. Rev. Biophys. Biomol. Struct."
    },
    {
      "key": "ac060572nb00002/ac060572nb00002_1",
      "doi-asserted-by": "crossref",
      "first-page": "626",
      "DOI": "10.1016/S0959-440X(99)00015-9",
      "volume": "9",
      "author": "Roder H.",
      "year": "1999",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "ac060572nb00003/ac060572nb00003_1",
      "doi-asserted-by": "crossref",
      "first-page": "290",
      "DOI": "10.1063/1.1138345",
      "volume": "56",
      "author": "Regenfuss P.",
      "year": "1985",
      "journal-title": "Rev. Sci. Instrum."
    },
    {
      "key": "ac060572nb00004/ac060572nb00004_1",
      "first-page": "50",
      "volume": "4",
      "author": "Takahashi S.",
      "year": "1997",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "ac060572nb00005/ac060572nb00005_1",
      "first-page": "1784",
      "volume": "94",
      "author": "Chan C. K.",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "ac060572nb00006/ac060572nb00006_1",
      "first-page": "2721",
      "volume": "74",
      "author": "Shastry M. C. R.",
      "year": "1998",
      "journal-title": "Biophys. J."
    },
    {
      "key": "ac060572nb00007/ac060572nb00007_1",
      "doi-asserted-by": "crossref",
      "first-page": "2708",
      "DOI": "10.1016/S0006-3495(00)76814-7",
      "volume": "78",
      "author": "Grigoryants V. M.",
      "year": "2000",
      "journal-title": "Biophys. J."
    },
    {
      "key": "ac060572nb00008/ac060572nb00008_1",
      "first-page": "1334",
      "volume": "99",
      "author": "Akiyama S.",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "ac060572nb00009/ac060572nb00009_1",
      "doi-asserted-by": "crossref",
      "first-page": "014302",
      "DOI": "10.1063/1.1834698",
      "volume": "76",
      "author": "Bilsel O.",
      "year": "2005",
      "journal-title": "Rev. Sci. Instrum."
    },
    {
      "key": "ac060572nb00010/ac060572nb00010_1",
      "doi-asserted-by": "crossref",
      "first-page": "236",
      "DOI": "10.1021/ac9708250",
      "volume": "70",
      "author": "B\u00f6kenkamp D.",
      "year": "1998",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "ac060572nb00011/ac060572nb00011_1",
      "first-page": "5386",
      "volume": "75",
      "author": "Lin Y.",
      "year": "2003",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "ac060572nb00012/ac060572nb00012_1",
      "doi-asserted-by": "crossref",
      "first-page": "3441",
      "DOI": "10.1016/S0006-3495(96)79538-3",
      "volume": "71",
      "author": "Brody J. P.",
      "year": "1996",
      "journal-title": "Biophys. J."
    },
    {
      "key": "ac060572nb00013/ac060572nb00013_1",
      "doi-asserted-by": "crossref",
      "first-page": "3866",
      "DOI": "10.1103/PhysRevLett.80.3863",
      "volume": "80",
      "author": "Knight J. B.",
      "year": "1998",
      "journal-title": "Phys. Rev. Lett."
    },
    {
      "key": "ac060572nb00014/ac060572nb00014_1",
      "doi-asserted-by": "crossref",
      "first-page": "10117",
      "DOI": "10.1073/pnas.96.18.10115",
      "volume": "96",
      "author": "Pollack L.",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "ac060572nb00015/ac060572nb00015_1",
      "doi-asserted-by": "crossref",
      "first-page": "4965",
      "DOI": "10.1103/PhysRevLett.86.4962",
      "volume": "86",
      "author": "Pollack L.",
      "year": "2001",
      "journal-title": "J. Phys. Rev. Lett."
    },
    {
      "key": "ac060572nb00016/ac060572nb00016_1",
      "first-page": "4271",
      "volume": "99",
      "author": "Russell R.",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "ac060572nb00017/ac060572nb00017_1",
      "doi-asserted-by": "crossref",
      "first-page": "6649",
      "DOI": "10.1073/pnas.101122898",
      "volume": "98",
      "author": "Kauffmann E.",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci.U.S.A."
    },
    {
      "key": "ac060572nb00018/ac060572nb00018_1",
      "doi-asserted-by": "crossref",
      "first-page": "2878",
      "DOI": "10.1016/S0006-3495(02)75296-X",
      "volume": "83",
      "author": "Pabit S. A.",
      "year": "2002",
      "journal-title": "Biophys. J."
    },
    {
      "key": "ac060572nb00019/ac060572nb00019_1",
      "doi-asserted-by": "crossref",
      "first-page": "1235",
      "DOI": "10.1126/science.1085399",
      "volume": "301",
      "author": "Lipman E. A.",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "ac060572nb00020/ac060572nb00020_1",
      "doi-asserted-by": "crossref",
      "first-page": "4420",
      "DOI": "10.1039/B406899H",
      "volume": "6",
      "author": "Dittrich P. S.",
      "year": "2004",
      "journal-title": "Phys. Chem. Chem. Phys."
    },
    {
      "key": "ac060572nb00021/ac060572nb00021_1",
      "doi-asserted-by": "crossref",
      "first-page": "7178",
      "DOI": "10.1021/ac048661s",
      "volume": "76",
      "author": "Hertzog D. E.",
      "year": "2004",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "ac060572nb00022/ac060572nb00022_1",
      "doi-asserted-by": "crossref",
      "first-page": "445",
      "DOI": "10.1039/b407765b",
      "volume": "4",
      "author": "Munson M. S.",
      "year": "2004",
      "journal-title": "Lab Chip"
    },
    {
      "key": "ac060572nb00023/ac060572nb00023_1",
      "doi-asserted-by": "crossref",
      "first-page": "5250",
      "DOI": "10.1021/ac025777k",
      "volume": "74",
      "author": "Hofmann O.",
      "year": "2002",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "ac060572nb00024/ac060572nb00024_1",
      "doi-asserted-by": "crossref",
      "first-page": "567",
      "DOI": "10.1109/JMEMS.2004.832196",
      "volume": "13",
      "author": "Sundararajan N.",
      "year": "2004",
      "journal-title": "J. Microelectromech. Syst."
    },
    {
      "key": "ac060572nb00025/ac060572nb00025_1",
      "doi-asserted-by": "crossref",
      "first-page": "1326",
      "DOI": "10.1039/b507548c",
      "volume": "5",
      "author": "Nguyen N. T.",
      "year": "2005",
      "journal-title": "Lab Chip"
    },
    {
      "key": "ac060572nb00026/ac060572nb00026_1",
      "doi-asserted-by": "crossref",
      "first-page": "1377",
      "DOI": "10.1038/nbt899",
      "volume": "21",
      "author": "Zipfel W. R.",
      "year": "2003",
      "journal-title": "Nat. Biotechnol."
    },
    {
      "key": "ac060572nb00027/ac060572nb00027_1",
      "doi-asserted-by": "crossref",
      "first-page": "1941",
      "DOI": "10.1021/ac001533t",
      "volume": "73",
      "author": "Kameoka J.",
      "year": "2001",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "ac060572nb00028/ac060572nb00028_1",
      "doi-asserted-by": "crossref",
      "first-page": "376",
      "DOI": "10.1002/bip.1978.360170208",
      "volume": "17",
      "author": "Magde D.",
      "year": "1978",
      "journal-title": "Biopolymers"
    },
    {
      "key": "ac060572nb00029/ac060572nb00029_1",
      "doi-asserted-by": "crossref",
      "first-page": "3265",
      "DOI": "10.1021/ac991448p",
      "volume": "72",
      "author": "G\u00f6sch M.",
      "year": "2000",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "ac060572nb00030/ac060572nb00030_1",
      "doi-asserted-by": "crossref",
      "first-page": "4479",
      "DOI": "10.1021/ac025625p",
      "volume": "74",
      "author": "Dittrich P. S.",
      "year": "2002",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "ac060572nb00031/ac060572nb00031_1",
      "doi-asserted-by": "crossref",
      "first-page": "1422",
      "DOI": "10.1021/ac011076w",
      "volume": "74",
      "author": "Foquet M.",
      "year": "2002",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "ac060572nb00032/ac060572nb00032_1",
      "doi-asserted-by": "crossref",
      "first-page": "200",
      "DOI": "10.1002/1438-5171(200208)3:4<194::AID-SIMO194>3.0.CO;2-0",
      "volume": "3",
      "author": "Lenne P. F.",
      "year": "2002",
      "journal-title": "Single Mol."
    },
    {
      "key": "ac060572nb00033/ac060572nb00033_1",
      "doi-asserted-by": "crossref",
      "first-page": "1186",
      "DOI": "10.1366/0003702042335957",
      "volume": "58",
      "author": "Kuricheti K. K.",
      "year": "2004",
      "journal-title": "Appl. Spectrosc."
    },
    {
      "key": "ac060572nb00034/ac060572nb00034_1",
      "first-page": "2317",
      "volume": "83",
      "author": "Hess S. T.",
      "year": "2002",
      "journal-title": "Biophys. J."
    },
    {
      "key": "ac060572nb00035/ac060572nb00035_1",
      "doi-asserted-by": "crossref",
      "DOI": "10.1007/978-1-4757-3061-6",
      "volume-title": "Principles of Fluorescence Spectroscopy",
      "author": "Lakowicz J. R.",
      "year": "1999",
      "edition": "2"
    },
    {
      "key": "ac060572nb00036/ac060572nb00036_1",
      "unstructured": "Landau, L. D.; Lifshitz, E. M.Fluid Mechanics; Pergamon Press:\u2009 London, 1959."
    },
    {
      "key": "ac060572nb00037/ac060572nb00037_1",
      "volume-title": "CRC Handbook Chemistry and Physics",
      "author": "Lide D. R.",
      "year": "2004",
      "edition": "85"
    },
    {
      "key": "ac060572nb00038/ac060572nb00038_1",
      "doi-asserted-by": "crossref",
      "first-page": "791",
      "DOI": "10.1039/B500129C",
      "volume": "5",
      "author": "Brister P. C.",
      "year": "2005",
      "journal-title": "Lab Chip"
    },
    {
      "key": "ac060572nb00039/ac060572nb00039_1",
      "doi-asserted-by": "crossref",
      "first-page": "322",
      "DOI": "10.1016/j.cej.2003.10.017",
      "volume": "101",
      "author": "Engler M.",
      "year": "2004",
      "journal-title": "Chem. Eng. J."
    },
    {
      "key": "ac060572nb00040/ac060572nb00040_1",
      "volume-title": "Biophysical Chemistry",
      "author": "Cantor C. R.",
      "year": "1980"
    }
  ],
  "container-title": "Analytical Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pubs.acs.org/doi/pdf/10.1021/ac060572n",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        10,
        16
      ]
    ],
    "date-time": "2021-10-16T20:23:35Z",
    "timestamp": 1634415815000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pubs.acs.org/doi/10.1021/ac060572n"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006,
        5,
        17
      ]
    ]
  },
  "references-count": 40,
  "journal-issue": {
    "issue": "13",
    "published-print": {
      "date-parts": [
        [
          2006,
          7,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1021/ac060572n"
  ],
  "URL": "http://dx.doi.org/10.1021/ac060572n",
  "relation": {},
  "ISSN": [
    "0003-2700",
    "1520-6882"
  ],
  "subject": [],
  "container-title-short": "Anal. Chem.",
  "published": {
    "date-parts": [
      [
        2006,
        5,
        17
      ]
    ]
  }
}